235 research outputs found
Kontrolle des Verwaltungsrates : eine Untersuchung der internen und externen Kontrollinstitutionen, -instrumente und -mechanismen
No full textEine wichtige Erkenntnis dieser Arbeit ist, dass eine effiziente und effektive Kontrolle des Verwaltungsrates nur über das Zusammenspiel der internen körperschaftlichen Kontrollinstitutionen und -instrumente mit den externen Kontrollinstitutionen und Kontrollmechanismen des Marktes erreicht wird.
Die Vorschriften der VegüV betreffend transparente Entschädigungspolitik und unabhängige Stimmrechtsvertreter sowie die in der Aktienrechtsrevision angestrebte Stärkung der Informations-, Mitwirkungs- und Klagerechte des Aktionärs sind zu begrüssen. Insbesondere die Modernisierung des Instituts der Generalversammlung ist überfällig. Die formellen und administrativen Hürden für die Stimmrechtsausübung müssen gesenkt, die prohibitiv hohen Klagekosten für Aktionäre und Gläubiger, die die Verwaltungsräte vor Verantwortlichkeitsklagen schützen, reduziert werden. All diese Massnahmen reichen jedoch nicht aus, um die Probleme der Informationsasymmetrie, der «collective action» und des «free riding» zu lösen.
Gemäss Ansicht des Autors können diese kritischen Punkte durch die institutionellen Investoren und die Stimmrechtsberater und -vertreter effizient angegangen werden. Sie werden in Zukunft der grosse Gegenspieler des Verwaltungsrates sein, da sie dem Aktionär eine weniger aufwendige und risikolosere Machtausübung ermöglichen. Hier wird es Aufgabe des Gesetzgebers und von Organisationen sein, deren Macht zu regulieren und die rechtlichen Grenzen ihrer Einflussnahme zu definieren.
Eine verstärkte Kontrolle verursacht immer Kosten. Dabei gilt es, bei jeder neu vorgeschlagenen Kontrollinstitution und jedem propagierten Kontrollinstrument zu prüfen, wie das Kosten-Nutzen-Verhältnis ausfällt. Überwiegen die Kosten den Nutzen, wie beispielsweise beim Aktionärsausschuss, sollte darauf verzichtet werden. Letztlich steht jede Gesellschaftsform im Wettbewerb mit anderen in- und ausländischen Gesellschaftsformen. Insbesondere die zunehmende weltweite Vernetzung der Kapitalmärkte trägt zu einem verstärkten internationalen Wettbewerb bei. Reguliert man eine Gesellschaftsform zu stark, hat sie im internationalen Wettbewerb schlechtere Erfolgschancen. Die nationalen Gesetzgeber scheinen sich dessen bewusst zu sein. So verzichten heutzutage immer mehr Staaten auf zwingende gesetzliche Vorschriften im Bereich der Corporate Governance. Das Wahlmodell des italienischen Gesellschaftsrechts und der Societas Europaea sowie die unzähligen Differenzierungsmöglichkeiten, die das neue japanische Gesellschaftsrecht den Gesellschaften bietet, sind Ausdruck dafür.
Auf keinen Fall darf der Schweizer Gesetzgeber den Unternehmen eine Zwangsjacke anziehen. Jede Gesellschaft soll die Möglichkeit haben, eigene Gestaltungsideen zu verwirklichen. Vorschriften auf Verfassungsebene mit unpräzisen Handlungsanweisungen und Verbote in Verbindung mit rigorosen Strafandrohungen sind der falsche Weg. Dies schadet dem schweizerischen Kapitalmarkt, der Kapitalbeschaffung von Unternehmen und der Schweizer Wirtschaft als Ganzem.
Anstelle der nationalen Gesetze treten Vereinbarungen und Vorschriften von Organisationen und Börsen, Kodizes, Selbstregulierungsinstrumente und Richtlinien, die keine strengen rechtlichen Bindungen erzeugen – sogenanntes «soft law», basierend auf dem Grundsatz «comply or explain». Der Druck der Marktteilnehmer und die drohende adverse Publizität sorgen dafür, dass die Unternehmen der Einhaltung der Bestimmungen des «soft law» hohes Gewicht beimessen. Diese Regelsysteme definieren den Handlungsspielraum der Unternehmen und deren Verwaltungsräte somit stark und beeinflussen bspw. die Sorgfalts-Definition von Art. 717 OR und das diskretionäre Verhalten des Verwaltungsrates wesentlich.
Dies ist zwar der Rechtssicherheit und der Kohärenz des Gesellschaftsrechts nicht immer dienlich. Angesichts des schnellen Wandels und der geforderten Flexibilität im Gesellschaftsrecht sind solche Minimalstandards aber geeignet, für eine gewisse Ordnung zu sorgen und gleich lange Spiesse zu gewährleisten.
Der Gesetzgeber darf Organisationen und Börsen das Feld aber keinesfalls ganz überlassen. Vielmehr muss ein guter Mix zwischen staatlichen und privatautonomen Regulierungen gefunden werden
Holomorphy of Igusa's and topological zeta functions for homogeneous polynomials
No full textLet F be a number eld and f 2 F [x 1 ; : : : ; x n ] n F . To any completion K of F and any character of the group of units of the valuation ring of K one associates Igusa's local zeta function Z (; f; s). The holomorphy conjecture states that for all except a nite number of completions K of F we have that if the order of does not divide the order of any eigenvalue of the local monodromy of f at any complex point (; f; s) is holomorphic on C . The second author already showed that this conjecture is true for curves, i.e. for n = 2. Here we look at the case of an homogeneous polynomial f , so we can consider ff = 0g P . Under the condition that (P C n ff = 0g) 6= 0 we prove the holomorphy conjecture. Together with some results in the case when (P C n ff = 0g) = 0, we can conclude that the holomorphy conjecture is true for an arbitrary homogeneous polynomial in three variables
Destilação por película para misturas binárias
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2013A operação de colunas de destilação é um processo dispendioso em vários sentidos. Há grande gasto de energia vaporizando componentes a serem separados e também exige grande espaço físico. A própria coluna de destilação em si é um equipamento de enorme diâmetro e altura, ocupando grande espaço. Se forem levados em conta os equipamentos auxiliares, como refervedores, condensadores, bombas, pré-flash, dentre outros muitos, têm-se um volume ainda maior. Tal fato levou alguns pesquisadores como Saifutdinov (1999), Arrison (2000), Iwakabe (2006) buscar alternativas para redução de tamanho e aumento de eficiência do processo de destilação convencional. Uma das possibilidades é a destilação por película (fallingfilm). Assim, o objetivo deste trabalho é avaliar a viabilidade da utilização de coluna de destilação por película assistida por câmara de vapor em substituição às colunas de destilação convencionais, visando redução de dimensões e consumo energético. O desenvolvimento do trabalho partiu da concepção, projeto e construção de uma unidade de destilação por filme líquido descendente operando com mistura etanol/água. Os experimentos foram conduzidos com duas formas de operação distintas: uma isotérmica, onde a temperatura da câmara externa permanece constante durante o processo e outra com perfil de temperatura ao longo da câmara. Os resultados permitem concluir que a câmara operando com perfil leva a resultados melhores, obtendo concentração de etanol no destilado em torno de 14% maior. Pode-se também concluir que este tipo de processo viabiliza a redução das dimensões de colunas de destilação, visto que 1m de tubo de destilação realiza a mesma separação que sete estágios de uma coluna convencional (aproximadamente 1,70m), em concentração de etanol.Abstract: The operation of distillation columns is a costly process in many ways. There are large energy expenditure vaporizing components to be separated and also requires large physical space. The very distillation column itself has a huge diameter and height, occupying great space. If taken into account auxiliary equipment such as reboilers, condensers, pumps, preflash, among many others, it can be a greater volume. This fact has led some researchers as Saifutdinov (1999), Arrison (2000), Iwakabe (2006) seek alternatives to reduce size and increase efficiency on conventional distillation. One possibility is the falling film distillation. Thus, the objective of this study is to evaluate the viability of using a falling film distillation column assisted by vapor chamber, replacing the conventional distillation columns, in order to reduce size and power consumption. The development of the work departed from conception, design and construction of a distillation unit for liquid film descending operating with ethanol/water mixture. The experiments were conducted with two distinct modes of operation: an isothermal, where the temperature of the outer chamber remained constant during the process and, in another, the temperature profile varied throughout the chamber. The results allowed to conclude that operating chamber with temperature profile leads to better results, obtaining concentration of ethanol in the distillate around 14% higher. It can also be concluded that this type of process enables reduction of distillation columns dimensions, since 1m tube distillation performs the same separation that seven stages of a conventional column (approximately 1.70 m), in ethanol concentration
Measurement of the cross-section ratio σ(χc2)/σ(χc1) for prompt χc production at √s=7 TeV
No full textThe prompt production of the charmonium χc1 and χc2 mesons has been studied in proton–proton collisions at the Large Hadron Collider at a centre-of-mass energy of . The χc mesons are identified through their decays χc→J/ψγ with J/ψ→μ+μ− using 36 pb−1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for the two χc spin states, σ(χc2)/σ(χc1), has been determined as a function of the J/ψ transverse momentum, , in the range from 2 to 15 GeV/c. The results are in agreement with the next-to-leading order non-relativistic QCD model at high and lie consistently above the pure leading-order colour-singlet prediction
Pharmacological treatment of heart failure at hospital discharge : a retrospective study in an inpatient internal medicine unit
No full textTrabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023Introdução: A Insuficiência Cardíaca (IC) apresenta uma prevalência de 4,36% em Portugal. A incidência aumenta com a idade e é a principal causa de hospitalização nos países desenvolvidos, após os 65 anos. O desenvolvimento das classes farmacológicas, os inibidores dos receptores da angiotensina-neprilisina (ARNI) e os inibidores do co-transportador sódio-glicose tipo 2 (iSGLT2), reduziu significativamente o internamento e a mortalidade nos doentes com IC, levando a uma mudança de paradigma na terapêutica, refletida nas recomendações de 2021 da Sociedade Europeia de Cardiologia (ESC). No entanto, os estudos que levaram à alteração das recomendações não incluíram doentes com mais comorbilidades e idade avançada. Assim, continua a faltar informação sobre o benefício e tolerância destes fármacos modificadores do prognóstico.
Objetivos: Caraterizar a população de doentes internados com diagnóstico de IC e suas comorbilidades. Analisar a terapêutica prescrita no momento de alta.
Metodologia: Análise retrospetiva das notas de alta dos doentes internados no Serviço de Medicina I do Centro Hospitalar Universitário de Lisboa Norte (CHLN) diagnosticados com IC, quanto à sua demografia, comorbilidades, características da IC e hábitos de prescrição médica, no período de um ano após a publicação das Recomendações da ESC.
Resultados: A caraterização da população com IC revelou uma faixa etária entre os 65 e os 100 anos, uma mediana de 84 anos e um número médio de 6 comorbilidades por doente. Assim, 6% dos doentes estavam a utilizar a terapêutica Fantastic Four (FF). Verificou-se uma associação significativa entre a utilização da terapêutica FF e a idade (p=0,012) e com a Fração de Ejeção (FE) (p = 0,022). O uso de ARNI e SGLT2i foi observado em 7% e 36% dos pacientes e seu uso foi significativamente associado à classe de FE (p < 0,01).
Conclusões: Os resultados demonstram a importância de considerar as características individuais do doente na determinação da terapia farmacológica para a IC.Introduction: Heart Failure (HF) has an estimated prevalence of 4.36% in Portugal. Its incidence increases with age and is the main cause of hospitalization in developed countries above the age of 65 years. The development of two major pharmacological classes, angiotensin receptor-neprilysin inhibitors (ARNI) and sodium-glucose co-transporter type 2 inhibitors (SGLT2i), has significantly reduced hospitalization and mortality in patients with HF, leading to a paradigm shift in therapy reflected in the 2021 recommendations of the European Society of Cardiology (ESC). However, the studies that led to the change in recommendations did not include patients with more comorbidities and advanced age. Therefore, information about their benefit and tolerance of these new prognostic-modifying drugs is still missing.
Objectives: Characterize the population of inpatients diagnosed with HF and their comorbidities. To analyze the therapy prescribed at discharge.
Methodology: Retrospective analysis of the discharge notes of patients admitted to the Department of Medicine I of the Norte Lisbon University Hospital Center (NLUHC) diagnosed with HF, in terms of patient demographics, comorbidities, HF characteristics, and physician prescription habits, within one year after the publication of the ESC Recommendations.
Results: The characterization of the population with HF revealed an age range between 65 and 100 years with a median of 84 years and an average number of 6 comorbidities per patient. Of this sample, 6% of the patients were using the Fantastic Four therapy. There was a significant association between the use of FF therapy and age (p=0.012) and with Ejection Fraction (EF) (p = 0.022). The use of ARNI and SGLT2i was observed in 7% and 36% of patients and their use was significantly associated with the EF class (p < 0.01).
Conclusion: The results demonstrate the importance of considering the individual patients characteristics when determining pharmacological therapy for HF
Pharmacological treatment of heart failure at hospital discharge : a retrospective study in an inpatient internal medicine unit
No full textTrabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023Introdução: A Insuficiência Cardíaca (IC) apresenta uma prevalência de 4,36% em Portugal. A incidência aumenta com a idade e é a principal causa de hospitalização nos países desenvolvidos, após os 65 anos. O desenvolvimento das classes farmacológicas, os inibidores dos receptores da angiotensina-neprilisina (ARNI) e os inibidores do co-transportador sódio-glicose tipo 2 (iSGLT2), reduziu significativamente o internamento e a mortalidade nos doentes com IC, levando a uma mudança de paradigma na terapêutica, refletida nas recomendações de 2021 da Sociedade Europeia de Cardiologia (ESC). No entanto, os estudos que levaram à alteração das recomendações não incluíram doentes com mais comorbilidades e idade avançada. Assim, continua a faltar informação sobre o benefício e tolerância destes fármacos modificadores do prognóstico.
Objetivos: Caraterizar a população de doentes internados com diagnóstico de IC e suas comorbilidades. Analisar a terapêutica prescrita no momento de alta.
Metodologia: Análise retrospetiva das notas de alta dos doentes internados no Serviço de Medicina I do Centro Hospitalar Universitário de Lisboa Norte (CHLN) diagnosticados com IC, quanto à sua demografia, comorbilidades, características da IC e hábitos de prescrição médica, no período de um ano após a publicação das Recomendações da ESC.
Resultados: A caraterização da população com IC revelou uma faixa etária entre os 65 e os 100 anos, uma mediana de 84 anos e um número médio de 6 comorbilidades por doente. Assim, 6% dos doentes estavam a utilizar a terapêutica Fantastic Four (FF). Verificou-se uma associação significativa entre a utilização da terapêutica FF e a idade (p=0,012) e com a Fração de Ejeção (FE) (p = 0,022). O uso de ARNI e SGLT2i foi observado em 7% e 36% dos pacientes e seu uso foi significativamente associado à classe de FE (p < 0,01).
Conclusões: Os resultados demonstram a importância de considerar as características individuais do doente na determinação da terapia farmacológica para a IC.Introduction: Heart Failure (HF) has an estimated prevalence of 4.36% in Portugal. Its incidence increases with age and is the main cause of hospitalization in developed countries above the age of 65 years. The development of two major pharmacological classes, angiotensin receptor-neprilysin inhibitors (ARNI) and sodium-glucose co-transporter type 2 inhibitors (SGLT2i), has significantly reduced hospitalization and mortality in patients with HF, leading to a paradigm shift in therapy reflected in the 2021 recommendations of the European Society of Cardiology (ESC). However, the studies that led to the change in recommendations did not include patients with more comorbidities and advanced age. Therefore, information about their benefit and tolerance of these new prognostic-modifying drugs is still missing.
Objectives: Characterize the population of inpatients diagnosed with HF and their comorbidities. To analyze the therapy prescribed at discharge.
Methodology: Retrospective analysis of the discharge notes of patients admitted to the Department of Medicine I of the Norte Lisbon University Hospital Center (NLUHC) diagnosed with HF, in terms of patient demographics, comorbidities, HF characteristics, and physician prescription habits, within one year after the publication of the ESC Recommendations.
Results: The characterization of the population with HF revealed an age range between 65 and 100 years with a median of 84 years and an average number of 6 comorbidities per patient. Of this sample, 6% of the patients were using the Fantastic Four therapy. There was a significant association between the use of FF therapy and age (p=0.012) and with Ejection Fraction (EF) (p = 0.022). The use of ARNI and SGLT2i was observed in 7% and 36% of patients and their use was significantly associated with the EF class (p < 0.01).
Conclusion: The results demonstrate the importance of considering the individual patients characteristics when determining pharmacological therapy for HF
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Hagenulopsis minuta Spieth 1943
No full textHagenulopsis minuta Spieth, 1943 (Figs 2E, 11A–F) Hagenulopsis minuta Spieth, 1943: 10 (description); Traver 1946: 247 (note); Peters & Domínguez 2001: 354 (revision). Material examined. BRAZIL, Bahia, Uruçuca, Serra Grande, Parque Estadual Serra do Conduru, Cachoeira da trilha principal, (14°29′48.5″S, 39°07′53.1″ W; 227 m a.s.l) 18.i.2014, Light pan trap, Dias E. & Pereira T. leg., 5 s ♂♂, 2 ♂♂ (MHNBA); same data as for preceding, except for: Chapada diamantina, Capão, Riacho do Morro Branco; (19°39′13.8″S, 41°29′14.3″W; 917 m a.s.l.), 12.v.2014, Entomological net, Salles FF. & Nascimento J. leg., 3 ♂♂ (UFVB); same data as for preceding, except for: Varzedo, Serra da Jiboia Fazenda Baixa Grande, Propriedade do Sr. Getúlio, Córrego Cai Camarão, (12°57′45.3″S, 39°27′13.1″W; 280 m a.s.l.), 09.iv.2015, Malaise trap, Dias E. & Campos R. leg., 1 ♂ (MHNBA); same data as for preceding, except for: Piauí, Piripiri municipality, Cachoeira do Bota-Fora (04°12′51.1″S, 41°40′01.7″ W; 162m a.s.l.), 01.vi.2019, Entomological net, Lima LRC. & Rodrigues JAO. leg., 11 ♂♂ (CEHJ) and 6 ♂♂ (CLBA); same data as preceding, except for: 10.II.2018, 2 ♂♂ (CEHJ); same data as preceding, except for: 15.XII.2018, 1 ♂ (CEHJ); same data as preceding, except for: Espírito Santo, Santa Nova Lombardia, Capitel de Santo Antônio, Córrego Grande, (19°52′30.8″ S, 40°31′49.1″ W), 19.ii.2009, CEUNES, leg., 1♂, 1 ♀ (UFVB); same data as preceding, except for: Minas Gerais, Conceição do Mato Dentro, Peixe tolo, (19°00′05″S, 43°36′04″W), 30.xi.2020; Entomological net, Salles FF. leg., 3 ♂♂ (UFVB); same data as preceding, except for: Mato Grosso, Bonito, Fazenda da ONG Brasil Bonito, Rio Taquaral (20°52′14″S, 56°35′19″W; 466m a.s.l.), 27.vi.2009, Light Pan trap, Lecci L., Schulz G. & Stefan G. leg., 1 ♂ (MZUESC-Eph0034). COLOMBIA, Putumayo, Puerto Asís, Quebrada Água Negras (0°31′36.3″N, 76°31′38.3″W), 19.xii.2015, light trap, Dias L. leg., 12 ♂♂, 2♀♀ (UFVB). Remarks. The males imagos sampled in Piauí State (Fig. 11A–D) were caught up in the evening at the riparian environment under a dense canopy cover. Instead of a well-developed bridge between the stalks of the compound eyes, as reported in the literature or based on examined material from Bahia state (Fig. 11E) and Colombia (Fig. 11F), some of these imagos from Piaui state (n = 4) present only a small protuberance. According to Peters & Domínguez (2001), the presence of these protuberances is a subimaginal character, which in imagos develop to the bridge characteristic of the species. In order to complement the description of the species, herein we report the absence of this bridge in some of the examined imagos (Fig. 11C–D). Distribution. Brazil (Amazonas, Bahia, Espírito Santo, Mato Grosso [new record], Minas Gerais [new record], Roraima, and Piauí [new record]), Colombia, Guyana, Suriname, Venezuela.Published as part of Campos, Rogério, Rodrigues, Jackson A. O., Lima, Lucas R. C., Mariano, Rodolfo, Costa, Vini- Cius, Marulanda, Jhon & Salles, Frederico F., 2022, Hagenulopsis Ulmer (Ephemeroptera: Leptophlebiidae): re-description, morphological notes and a new species from South America, Brazil, pp. 73-88 in Zootaxa 5100 (1) on page 86, DOI: 10.11646/zootaxa.5100.1.3, http://zenodo.org/record/612776
Characterization of selected gene expression patterns as potential markers for oocyte quality in young versus old mares
No full text2010 Summer.Includes bibliographic references (pages 64-77).As a female ages a series of alterations in normal physiology take place, during this process fecundity decreases. The reproductive system starts to shut down as a consequence of hormonal, histological and anatomical changes, and in the middle of this process, playing a critical role, is the oocyte. As in women, fertility decreases with aging in mares. Recently the mare has been suggested as a promising model to study age-related infertility in women due to similarities in the reproductive cycle and similar age-associated reproductive changes. During the last decades the use of assisted reproductive techniques (ART) in human and veterinary medicine to treat infertility has increased. Unfortunately, ART can only partially compensate for declining fertility- particularly the age related decline in fertility. Therefore, we need to understand the mechanisms involved in age-associated infertility and improve both the diagnostic tools and the techniques currently used in ART. In that regard the identification of reliable oocyte quality markers is of great interest, specifically of extrinsic markers in follicular cells and follicular fluid (FF). Follistatin (FS1) and anti-müllerian hormone (AMH) have been suggested as potential oocyte quality markers. In addition, the rate of apoptosis in follicular cells has also been suggested to be a good indicator of oocyte quality In this study, our goal was to use the young and old mare model to obtain competent and incompetent oocytes, respectively, to try and elucidate the involvement of apoptosis of follicular cells and/or of the oocyte in the determination of oocyte quality. Oocytes, follicular fluid, granulosa and cumulus cells were collected through transvaginal follicular aspirations from young ( 4-10 years) and old (>20 years) mares. Preovulatory follicles were aspirated 30-36 h post induction of follicular maturation, which was performed by administration (i.v) of a combination of deslorelin and hCG when the biggest follicle reached 35 mm. We used real time PCR to examine expression of pro-apoptotic ( CASP2, CASP 3) and pro-survival (XIAP) genes, as well as of FST and AMH expression in these cell types. In addition we measured androgens and estrogens in FF and calculated the androgens to estrogens ratio to assess follicular atresia. We also sought to determine FF concentrations of FST and AMH, and relate it to oocyte quality. There was no difference in CASP3 expression levels in granulosa and cumulus cells between the two age groups. In addition, there was no difference in CASP2 and CASP3 mRNA expression in oocytes from young and old mares. XIAP mRNA levels were expressed 3.3 fold higher in oocytes from young when compared to old mares, and there was a tendency for XIAP to be more highly expressed in granulosa cells of young mares. In contrast, the levels of XIAP mRNA in cumulus cells were 1.46 fold higher in old when compared to young mares. There was no difference in the expression levels of AMH in granulosa cells between young and old mares, but in cumulus cells there was a tendency for AMH to be higher expressed in cells from old vs. young mares. Unfortunately we were not able to analyze AMH FF concentrations. FST mRNA levels in oocytes were similar between the age groups, but FST concentrations in FF of preovulatory follicles from young mares (197 ± 16.7 ng/mL) were higher (p=0.02) than in FF from old (153.3 ± 22.7 ng/mL) mares. In both age groups FST FF concentrations in preovulatory follicles significantly decreased when compared to mid-estrus and post-deviation follicles. In conclusion, we believe that our data suggest that FST follicular fluid levels can be a non-invasive marker to assess oocyte quality in the horse, and that FST levels decrease in preovulatory follicles of the horse. In addition, expression levels of caspase-3 in follicular cells, and caspases 3 and 2 in the oocyte, does not seem to be involved in the mechanism of fertility loss in the old mare. Finally, XIAP mRNA levels may be important for oocyte quality in the horse
O ritual da plenitude poética: uma análise da obra de E. T. A. Hoffmann, a partir do conto "Der goldene topf - ein märchen aus der neuesten zeit" (O pote de ouro - um conto de fadas atual) /
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Nesta dissertação, discuto um aspecto que considero importante da obra de E. T. A. Hoffmann (1776-1822), a partir da leitura e análise do conto "O Pote de Ouro". O estudante Anselmo, herói desse "conto de fadas dos dias atuais", cumpre um ritual de iniciação, passando por uma "transformação ontológica", que é seu primeiro contato com o mundo maravilhoso. Ao longo de 12 vigílias, Anselmo distancia-se, gradualmente, da dimensão terrena da vida e ascende ao reino da Atlântida. Personagens de outros contos hoffmannianos, como o jovem artista Kreisler, o anacoreta Serapião e o famoso compositor Ritter Gluck, também perseguem a utopia da Atlântida, que é o final da jornada de todos eles. Será uma referência à criação estética, à alienação ou à loucura? Comparando os estágios da aventura de Anselmo com as experiências desses protagonistas de outros contos, tento circunscrever o possível sentido simbólico da Atlântida. Meu propósito é compreender o significado dessa procura na literatura de Hoffmann
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