129 research outputs found
Mindfulness, Acceptance, and Meaning in Life for Adults with Advanced Cancer
No full textIntroduction
When cancer is advanced and life-threatening, it has both physical and psychological effects, and for many people creates existential concerns. Mindfulness as a therapeutic endeavour is widely used in psychological interventions within clinical settings. People with cancer are likely to benefit from psychological interventions. However, there appear to be few intervention studies with advanced cancer populations, potentially due to ethical, methodological, and logistical issues. The purpose of this doctoral thesis was therefore to address this gap by designing and delivering a low-burden, easily accessible mindfulness-based intervention developed by the investigator, designed to provide psychological and emotional support to patients with advanced cancer, and research the intervention’s effectiveness. The intervention is called “Coping with Cancer Mindfully” (CCM) and focuses on mindful coping skills, acquiring an acceptance stance and reflection on meaning in the patients’ life.
Methods
This study is a one group pre-post test design with a convergent parallel mixed methods approach for data analysis. Twenty adults with advanced cancer (stage III or IV) were recruited via public hospital oncology services and other cancer-related service providers in Christchurch, New Zealand. Three short questionnaires evaluated participants’ levels of mindful coping skills (Mindful Coping Scale), acceptance stance (Acceptance and Action Questionnaire – II) and meaning in their lives (Meaning in Life Questionnaire). Pre-post semi-structured interviews explored participants’ perspectives about their advanced diagnosis and how they experienced the intervention. Statistical analysis was conducted and participants’ interview responses were coded and themed. The two strands of data (quantitative and qualitative) were collected concurrently, analysed separately and the findings and results were merged in a side-by-side comparison analysis.
Results
Twenty adults participated in the study, and adherence to the CCM treatment was 100%, with 19/20 post-intervention questionnaires completed. There was variability in age and time since their advanced cancer diagnosis. At baseline, those diagnosed for longer had higher levels of acceptance but age was not related to scores on any of the measures. Results from the statistical analysis (intention to treat and completer analyses) identified moderate to large effect sizes, with improvement in participants’ mindful coping skills of awareness and constructive self-distraction, their level of acceptance and the extent of presence of meaning in life.
Findings from the thematic analysis were that at baseline, participants as a group were experiencing distress but very few had been offered psychological support. After the CCM intervention, participants’ observant awareness of their life experiences was related to a change of perspective in order to better adapt to their advanced diagnosis, and new actions, skills and attitudes were evident. Their changed perspectives were conceptualized as shifting from a position of Vulnerability in Battle to Vulnerability in Peace, with the bridge between these positions being their use of mindful coping skills, acquisition of an acceptance stance, and reflections on meaning in life. The mixed methods integrated findings were largely convergent with only minor inconsistencies, the qualitative data supported the quantitative findings regarding change in key outcomes after this intervention. The qualitative data went beyond this however, providing rich contextual information about participants’ past experiences and coping as well as rich detail about what changed and how they used the CCM intervention.
Discussion
A key finding from the merged results of this study was that although the majority of participants diagnosed with advanced cancer related experiencing emotional distress and the need to psychologically adapt to having a limited amount of time left to live, the majority were not offered psychological support. The analyses highlighted the presence and impact of vulnerability in the face of the advanced cancer, and for most participants, the absence of appropriate professional support. These findings indicated that these participants benefitted from the psychological support from the CCM intervention at this intense period in their lives - they reported investing time in reflections on meaning in life, acknowledged the support of others, pursued reconciliation with others, and undertook other subjective and fulfilling actions.
Most participants demonstrated increased psychological flexibility: they not only reflected on the uncertainties and adversities that they were living with, but took actions as well, demonstrating increased emotional strength and flexibility to manage their lives in the best ways they could during the disease course.
Results from this study suggest that a brief, individual home-delivery, low-burden, mindfulness-based intervention is a viable psychological support option that could be offered by healthcare providers to address the gap in services for patients with advanced cancer. Participants’ feedback indicates that the nature and delivery of the CCM intervention made this original mindfulness-based brief intervention a readily accessible psychological aid to assist them to better cope with their current reality, and a valuable self-management resource to help these patients cope with further adversity.
Conclusion
Based on the preliminary findings of this study, it is concluded that the participants’ perspective of their illness shifted as a result of the CCM intervention, from an initial state of vulnerability to one that encouraged and produced positive perspectives and actions in relation to the participants’ cancer experience, despite their ongoing vulnerability. These findings suggest that those with advanced cancer should be offered suitable options of psychological support that they can access at any stage post-diagnosis
Mindfulness, Acceptance, and Meaning in Life for Adults with Advanced Cancer
No full textIntroduction
When cancer is advanced and life-threatening, it has both physical and psychological effects, and for many people creates existential concerns. Mindfulness as a therapeutic endeavour is widely used in psychological interventions within clinical settings. People with cancer are likely to benefit from psychological interventions. However, there appear to be few intervention studies with advanced cancer populations, potentially due to ethical, methodological, and logistical issues. The purpose of this doctoral thesis was therefore to address this gap by designing and delivering a low-burden, easily accessible mindfulness-based intervention developed by the investigator, designed to provide psychological and emotional support to patients with advanced cancer, and research the intervention’s effectiveness. The intervention is called “Coping with Cancer Mindfully” (CCM) and focuses on mindful coping skills, acquiring an acceptance stance and reflection on meaning in the patients’ life.
Methods
This study is a one group pre-post test design with a convergent parallel mixed methods approach for data analysis. Twenty adults with advanced cancer (stage III or IV) were recruited via public hospital oncology services and other cancer-related service providers in Christchurch, New Zealand. Three short questionnaires evaluated participants’ levels of mindful coping skills (Mindful Coping Scale), acceptance stance (Acceptance and Action Questionnaire – II) and meaning in their lives (Meaning in Life Questionnaire). Pre-post semi-structured interviews explored participants’ perspectives about their advanced diagnosis and how they experienced the intervention. Statistical analysis was conducted and participants’ interview responses were coded and themed. The two strands of data (quantitative and qualitative) were collected concurrently, analysed separately and the findings and results were merged in a side-by-side comparison analysis.
Results
Twenty adults participated in the study, and adherence to the CCM treatment was 100%, with 19/20 post-intervention questionnaires completed. There was variability in age and time since their advanced cancer diagnosis. At baseline, those diagnosed for longer had higher levels of acceptance but age was not related to scores on any of the measures. Results from the statistical analysis (intention to treat and completer analyses) identified moderate to large effect sizes, with improvement in participants’ mindful coping skills of awareness and constructive self-distraction, their level of acceptance and the extent of presence of meaning in life.
Findings from the thematic analysis were that at baseline, participants as a group were experiencing distress but very few had been offered psychological support. After the CCM intervention, participants’ observant awareness of their life experiences was related to a change of perspective in order to better adapt to their advanced diagnosis, and new actions, skills and attitudes were evident. Their changed perspectives were conceptualized as shifting from a position of Vulnerability in Battle to Vulnerability in Peace, with the bridge between these positions being their use of mindful coping skills, acquisition of an acceptance stance, and reflections on meaning in life. The mixed methods integrated findings were largely convergent with only minor inconsistencies, the qualitative data supported the quantitative findings regarding change in key outcomes after this intervention. The qualitative data went beyond this however, providing rich contextual information about participants’ past experiences and coping as well as rich detail about what changed and how they used the CCM intervention.
Discussion
A key finding from the merged results of this study was that although the majority of participants diagnosed with advanced cancer related experiencing emotional distress and the need to psychologically adapt to having a limited amount of time left to live, the majority were not offered psychological support. The analyses highlighted the presence and impact of vulnerability in the face of the advanced cancer, and for most participants, the absence of appropriate professional support. These findings indicated that these participants benefitted from the psychological support from the CCM intervention at this intense period in their lives - they reported investing time in reflections on meaning in life, acknowledged the support of others, pursued reconciliation with others, and undertook other subjective and fulfilling actions.
Most participants demonstrated increased psychological flexibility: they not only reflected on the uncertainties and adversities that they were living with, but took actions as well, demonstrating increased emotional strength and flexibility to manage their lives in the best ways they could during the disease course.
Results from this study suggest that a brief, individual home-delivery, low-burden, mindfulness-based intervention is a viable psychological support option that could be offered by healthcare providers to address the gap in services for patients with advanced cancer. Participants’ feedback indicates that the nature and delivery of the CCM intervention made this original mindfulness-based brief intervention a readily accessible psychological aid to assist them to better cope with their current reality, and a valuable self-management resource to help these patients cope with further adversity.
Conclusion
Based on the preliminary findings of this study, it is concluded that the participants’ perspective of their illness shifted as a result of the CCM intervention, from an initial state of vulnerability to one that encouraged and produced positive perspectives and actions in relation to the participants’ cancer experience, despite their ongoing vulnerability. These findings suggest that those with advanced cancer should be offered suitable options of psychological support that they can access at any stage post-diagnosis
POJAM MEĐUNARODNOG KRIVIČNOG DELA I NJEGOVA EVOLUCIJA
No full textThe concept of international crime evolved in the course of history. The debate about its notion and its key features divided scholars and other professionals. The first part of this paper deals with its historical development, while the second part is focused on the examination of the general notion of international crime and its key features. The third part of the article is devoted to the analysis of the notion of international crimes in the sense of the Rome Statute explaining its main characteristics, as well as main features of four international crimes covered by the Rome Statute. Finally, the author in the concluding part of the paper sums up the identified problems and ofers the solutions for their improvement.Rasprave o pojmu međunarodnog krivičnog dela su još uvek aktuelne. Njegova evolucija, kao i evolucija pojedinih oblika međunarodnih krivičnih dela i dalje je prisutna i praćena brojnim polemikama. Autor u prvom delu rada sažeto predstavlja istorijski razvoj međunarodnih krivičnih dela, dok se nakon toga, u drugom delu, posvećuje istraživanju koncepta međunarodnog krivičnog dela i njegovih ključnih karakteristika. U trećem delu rada, autor proučava koncept međunarodnog krivičnog dela na način na koji je postavljen u Rimskom statutu, kao i ključne karakteristike četiri međunarodna krivična dela koja su sadržana u Rimskom statutu. U završnom delu, autor ukazuje na probleme i nastoji da pruži predloge za njihova unapređenja
Serpents, amarus and symbols: kuti’s instrumentalization in “A nuestro padre creador Tupac Amaru” by José María Arguedas
No full text Jose Maria Arguedas’s poetic space and his artistic work reproduce at a micro-level the correpondece relations of the Ande. Therefore we are interested in the identification of the relational dynamics between the poetic voice and the existing others. We will address his relationship with the Amaru’s image, the serpent-god, which has a direct correspondence with the kuti due to its serpentine shape. For the analysis, we will borrow the image of the “Indian, astrologer, poet...” from Guaman Poma de Ayala, perchance the most appropriate reading key to the Arguedian art. The Peruvian author composes, in a ch\u27ixi ritual process, a text which is fertile soil where he “strategically” spreads (like a farmer) significant symbols of Andean thought. This journey has also a seminal sense in which the poet\u27s experience and knowledge are the seed and source of his intellectual and artistic work. Consideramos que el espacio poético y el hacer artístico de José María Arguedas reproducen, a un nivel micro, las relaciones de correspondencia del Ande. Por ello, nos interesa identificar las dinámicas relacionales entre la voz poética y los otros existentes. Especialmente, abordaremos su relación con la imagen del dios-serpiente, Amaru, que tiene correspondencia directa con el kuti por su forma serpenteante. Para el análisis, tomaremos prestada la imagen del “Indio, astrólogo, poeta...” de Guaman Poma de Ayala, pues pensamos que ella podría ser la clave de lectura adecuada para abordar el arte de José María Arguedas. El autor peruano compone, en un proceso ritual ch’ixi, un texto que es tierra fértil en el que esparce, como el agricultor, “estratégicamente” símbolos significativos del pensamiento andino. Este recorrido tiene también un sentido seminal en el que la experiencia y saberes del poeta son semilla y fuente de su hacer intelectual y artístico
Conflito civil e liberdade no pensamento republicano de maquiavel
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-Graduação em Filosofia, Florianópolis, 2015Nosso propósito é refletir as condições da liberdade partindo da teoria do conflito civil em Maquiavel. Para cumprir essa finalidade, analisamos dois segmentos sociais que se confrontam em toda cidade, os grandes e o povo (grandi e plebe), aos quais correspondem dois humores (umori) de característica heterogênea: os grandes que desejam dominar o povo e o do povo que deseja unicamente viver em liberdade. Desse natural e ineliminável conflito, Maquiavel concebe as relações sociais em dissenso, ligeiramente distanciadas da concordia ordinum. Há, com esse pressuposto, uma relativa igualdade política na dinâmica do próprio enfrentamento desses humores que, ao serem acolhidos e recriados pelas instituições republicanas, se traduzem em leis e liberdade que beneficiam o conjunto da cidade. A teoria do conflito civil, ao esboçar certa autonomia em relação ao modelo polibiano da anacyclosis, ainda muito reproduzida pela tradição do pensamento político, acaba positivando o desejo do povo - ao lado do humor dos grandes - gerando reações aristocráticas diante de um presumível republicanismo popular do autor - Francesco Guicciardini confirma essa perspectiva. O desafio está em compreender que aspectos efetivamente concorrem nesse processo que vai, desde a anulação do bom e positivo conflito civil, para um convívio determinado por relações de subordinação e servidão (vivere servo). Mobilizando alguns capítulos centrais dos Discursos sobre a primeira década de Tito Lívio e de História de Florença - mas não sem remissões pontuais a outras obras do autor que subsidiem a discussão -, mostramos que a demanda por ações extraordinárias (straordinari) em situações de repúblicas corrompidíssimas, se deve à ingerência de relações desiguais e facciosas entre os distintos segmentos. À desigualdade nessas relações, atribui-se relativa inflexão do conteúdo político dos humores em direção a aspectos e fenômenos de natureza econômica. Trata-se de mostrar, em Maquiavel, que o próprio núcleo da teoria do conflito civil é permeado por uma clivagem social e econômica que sugere uma medida mais flexível de leitura de sua própria teoria do conflito civil e da liberdade.Abstract: Our purpose is to reflect the conditions of liberty based on the theory of civil conflict in Machiavelli. To accomplish this purpose, we analyzed two social sectors which are faced in every city, the big ones and the people (grandi and plebs), that correspond to two moods (umori) of heterogeneous feature: the big ones that wish to master the people and the people who only want to live in liberty. From this natural and non-eliminable conflict, Machiavelli conceives social relations in dissent, slightly away from concordia ordinum. There is, with this assumption, a relative political equality in the dynamics of the own confrontation of these moods that, when received and recreated by republican institutions, are translated into laws and liberty that benefit the entire city. The civil conflict theory, when showing certain autonomy from the Polybian model of anacyclosis, still very reproduced by the tradition of political thought, ended up achieving the will of the people - next to the big ones mood - generating aristocratic reactions to a presumable republicanism popular of the author - Francesco Guicciardini confirms this perspective. The challenge is to understand what aspects effectively compete in this process which is, since the abolishment of good and positive civil conflict, to a coexistence determined by relations of subordination and servitude (vivere servo). Mobilizing some central chapters of Discourses on Titus Livy's first ten books [Discorsi sopra la prima deca di Tito Livio] and Florentine Histories [Istorie Fiorentine] - but not without occasional references to other works of the author who subsidize the discussion - we showed that the demand for extraordinary actions (straordinari) in situations of corrupted republics, is due to the interference of unequal and unfair relations between different segments. To the inequality in these relations is attributed inflection of the political content of moods toward aspects and phenomena of an economic nature. This is to show, in Machiavelli, that the core of the civil conflict theory is permeated by a social and economic cleavage suggesting a more flexible measure of reading his own theory of civil conflict and liberty
Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer’s disease in Colombia
No full textAlzheimer’s disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. This study aimed to validate the Uniform Data Set neuropsychological battery version 3.0 (UDS 3.0) in a Colombian cohort. This study is a cross-sectional type, consecutive, incidental, with 143 persons, divided into two groups: 48 diagnosed AD cases and 95 healthy controls, between the ages of 50 and 80+, and between 1 and 19+ years of education.The results indicate differences between the control group and the AD group in most battery tests. A significant correlation was found between the Montreal Cognitive Assessment (MoCA), Multilingual Naming Test (MINT), Craft Story, Benson Figure Test, P-word and F-word Phonemic Fluency Test, and their respective reference tests. Cutoff points were found based on the Youden index for each sub-test. The results indicate that all sub-tests are above the reference line of the ROC curve. The use of the UDS 3.0 in Colombia would help improving clinical diagnostic routes because of its high accuracy and high correlation with tests that measure general impairment; it has good sensitivity and specificity, and it can be a useful tool for AD.Porto, Maria Fernanda-will be generated-orcid-0000-0002-9313-1215-600Benitez Agudelo, Juan Camilo-will be generated-orcid-0000-0003-1995-1300-600Aguirre-Acevedo, Daniel Camilo-will be generated-orcid-0000-0002-8195-8821-600Barceló-Martinez, ErnestoAllegri, Ricardo Francisco-will be generated-orcid-0000-0001-7166-1234-60
Retraction of health science articles by researchers in Latin America and the Caribbean: A scoping review
No full textWe aimed to conduct a scoping review to assess the profile of retracted health sciences articles authored by individuals affiliated with academic institutions in Latin America and the Caribbean (LAC). We systematically searched seven databases (PubMed, Scopus, Web of Science, Embase, Medline/Ovid, Scielo, and LILACS). We included articles published in peer-reviewed journals between 2003 and 2022 that had at least one author with an institutional affiliation in LAC. Data were collected on the year of publication, study design, authors' countries of origin, number of authors, subject matter of the manuscript, scientific journals of publication, retraction characteristics, and reasons for retraction. We included 147 articles, the majority being observational studies (41.5%). The LAC countries with the highest number of retractions were Brazil (n = 69), Colombia (n = 16), and Mexico (n = 15). The areas of study with the highest number of retractions were infectology (n = 21) and basic sciences (n = 15). A retraction label was applied to 89.1% of the articles, 70.7% were retracted by journal editors, and 89.1% followed international retraction guidelines. The primary reasons for retraction included errors in procedures or data collection (n = 39), inconsistency in results or conclusions (n = 37), plagiarism (n = 21), and suspected scientific fraud (n = 19). In conclusion, most retractions of scientific publications in health sciences in LAC adhered to international guidelines and were linked to methodological issues in execution and scientific misconduct. Efforts should be directed toward ensuring the integrity of scientific research in the field of health.Revisión por paresODS 2: Hambre CeroODS 13: Acción por el ClimaODS 15: Vida de Ecosistemas Terrestre
Clinical Presentation and Outcome of COVID-19 in a Latin American Versus Spanish Population: Matched Case-Control Study
No full textPublisher Copyright: © 2022, The Author(s).Introduction: Increased mortality has been reported in the Latin American population. The objective is to compare the clinical characteristics and outcome of Latin American and Spanish populations in a cohort of patients hospitalized with COVID-19 during the first year of the pandemic. Methods: We retrospectively analysed all the Latin American patients (born in South or Central America) hospitalized in our centre from February 2020 to February 2021 and compared them with an age- and gender-matched group of Spanish subjects. Variables included were demographics, co-morbidities, clinical and analytical parameters at admission and treatment received. The primary outcomes were ICU admission and mortality at 60 days. A conditional regression analysis was performed to evaluate the independent baseline predictors of both outcomes. Results: From the 3216 patients in the whole cohort, 216 pairs of case-controls (Latin American and Spanish patients, respectively) with same age and gender were analysed. COPD was more frequent in the Spanish group, while HIV was more prevalent in the Latin American group. Other co-morbidities showed no significant difference. Both groups presented with similar numbers of days from symptom onset, but the Latin American population had a higher respiratory rate (21 vs. 20 bpm, P = 0.041), CRP (9.13 vs. 6.22 mg/dl, P = 0.001), ferritin (571 vs. 383 ng/ml, P = 0.012) and procalcitonin (0.10 vs. 0.07 ng/ml, P = 0.020) at admission and lower cycle threshold of PCR (27 vs. 28.8, P = 0.045). While ICU admission and IVM were higher in the Latin American group (17.1% vs. 13% and 9.7% vs. 5.1%, respectively), this was not statistically significant. Latin American patients received remdesivir and anti-inflammatory therapies more often, and no difference in the 60-day mortality rate was found (3.2% for both groups). Conclusion: Latin American patients with COVID-19 have more severe disease than Spanish patients, requiring ICU admission, antiviral and anti-inflammatory therapies more frequently. However, the mortality rate was similar in both groups.This work was financed by ad hoc patronage funds for research on COVID-19 from donations from citizens and organizations to the Hospital Clínic de Barcelona-Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain. No funding or sponsorship was received for the publication of this article. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Rodrigo Alonso and Ana M. Camon both were responsible for reviewing the data, and they prepared the database including the matching analysis as well as a first draft of the article. Celia Cardozo, Laia Albiach, Daiana Agüero, M. Angeles Marcos, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena de la Mora, Nicole Garcia-Pouton, Gerard Dueñas, Marta Hernandez-Meneses, Alexy Inciarte, Genoveva Cuesta, Fernanda Meira, and Laura Morata made significant contributions to the manuscript. Pedro Puerta-Accalde, Sabina Herrera, and Gemma Sanjuan performed the statistical analysis and made significant contributions to the final manuscript. Montse Tuset, Pedro Castro, Sergio Prieto-Gonzalez, Josep Mensa, and José Antonio Martínez collaborated on the design of the study and critically reviewed the article. J.M. Nicolas, A. Del Rio, Jordi Vila, Felipe Garcia, Carolina Garcia-Vidal, and Alex Soriano were responsible for the design of the study and made significant contributions to the final version of the article. Alex Soriano, as the corresponding author, answered the reviewers' questions. Hospital Clinic of Barcelona COVID-19 Research Group: Infectious Diseases’ Research Group : J. L. Blanco, J. Mallolas, E. Martínez, M. Martínez, J. M. Miró, A. Moreno, M. Solá, A. Ugarte, Ana Gonzalez-Cordón, Montse Laguno, Lorna Leal, John Rojas, Berta Torres, and all the staff members. Medical Intensive Care Unit : S. Fernandez, A. Tellez, F. Fuentes, E. Sancho, M. Ayala. Department of International Health : D. Campubri, M. T. de Alba, M. Fernandez, E. Ferrer, B. Grau, H. Marti, M. Muelas, M. J. Pinazo, N. Rodriguez, M. Roldan, C. Subira, I. Vera, N. Williams, A. Almuedo-Riera, J. Muñoz, and all the staff members. Department of Internal Medicine : A. Aldea, M. Camafort, J. Calvo, A. Capdevila, F. Cardellach, I. Carbonell, E. Coloma, A. Foncillas, R. Estruch, M. Feliu, J. Fernández-Solá, I. Fuertes, C. Gabara, I. Grafia, A. Ladino, R. López-Alfaro, A. López-Soto, I. Macaya, F. Masanés, A. Matas, M. Navarro, J. Marco-Hernández, L. Miguel, J. C. Milisenda, P. Moreno, J. Naval, D. Nicolás, H. Oberoi, J. Padrosa, S. Prieto-González, M. Pellicé, J. Ribot, O. Rodríguez-Núnez, E. Sacanella, F. Seguí, C. Sierra, A. Tomé, M. Torres, H. Ventosa, C. Zamora-Martínez, and all the staff members. Department of Microbiology : M. Almela, M. Alvarez, J. Bosch, J. Costa, G. Cuesta, B. Fidalgo, J. Gonzàlez, F. Marco, S. Narvaez, C. Pitart, E. Rubio, A. Vergara, M. E. Valls, Y. Zboromyrska and all the staff members. Department of Farmacy : E. López, and all the staff members. Carol García-Vidal has received honoraria for talks on behalf of Gilead Science, MSD, Novartis, Pfizer, Jannsen, and Lilly, as well as a grant from Gilead Science and MSD. Laura Morata has received honoraria for talks on behalf of Merck Sharp and Dohme, Pfizer and Angelini. Pedro Puerta-Alcalde has received honoraria for talks on behalf of Gilead Science and MSD. Montse Tuset has received grants from Janssen, Gilead, ViiV and Merck Sharp and Dohme. Josep Mensa has received honoraria for talks on behalf of Merck Sharp and Dohme, Pfizer, Novartis and Angelini. Álex Soriano has received honoraria for talks on behalf of Merck Sharp and Dohme, Pfizer, Novartis, Gilead, Menarini and Angelini as well as grant support from Pfizer and Gilead. Rodrigo Alonso, Ana M Camón, Celia Cardozo, Laia Albiach, Daiana Agüero, M Ángeles Marcos, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena de la Mora, Nicole García-Pouton, Gerard Dueñas, Marta Hernández-Meneses, Alexy Inciarte, Genoveva Cuesta, Fernanda Meira, Sabina Herrera, Pedro Castro, Sergio Prieto-González, Jose Antonio Martínez, Gemma Sanjuan, Josep María Nicolás, Ana del Río, Jordi Vila and Felipe García have nothing to disclose. The Institutional Ethics Committee of Hospital Clinic of Barcelona approved the study and, due to the nature of the retrospective data review, waived the need for informed consent from individual patients (HCB/2020/0273). The study was performed in accordance with the Helsinki Declaration of 1964, and its later amendments. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.Peer reviewe
Isolated from a ‘single source of truth’: formats and sources of COVID-19 information utilised by linguistic minority communities in Aotearoa New Zealand
No full textThis paper explores the formats and sources of COVID-19 information that 85 linguistic minority participants in Christchurch, New Zealand, engaged with during the COVID-19 pandemic. Based on in-depth interviews conducted in 13 minority languages and English, our findings highlight varied information consumption patterns and the importance of both written and audio/audiovisual information formats. Local news, governmental sources, and personal networks played key roles, but, while intersectional factors shaped these practices, our analysis draws attention to the significance of language. Notably, inadequate multilingual information about the pandemic in New Zealand meant some participants with limited English and/or (digital) literacy were unable to access reliable local COVID-19 information. Thus isolated from a ‘single source of truth’, these participants instead had little choice but to rely on family or friends, social media and/or overseas news, often seeking to corroborate information across languages and sources. As such, our study emphasises the need for inclusive, targeted multilingual crisis communication strategies that address linguistic diversity. By highlighting the unique information consumption of linguistic minority communities, this paper contributes to current discussions about equitable access to public health information and the role of government in this endeavour as a matter of human rights for linguistic minorities
Process mining for healthcare: Characteristics and challenges
No full textProcess mining techniques can be used to analyse business processes using the data logged during their execution. These techniques are leveraged in a wide range of domains, including healthcare, where it focuses mainly on the analysis of diagnostic, treatment, and organisational processes. Despite the huge amount of data generated in hospitals by staff and machinery involved in healthcare processes, there is no evidence of a systematic uptake of process mining beyond targeted case studies in a research context. When developing and using process mining in healthcare, distinguishing characteristics of healthcare processes such as their variability and patient-centred focus require targeted attention. Against this background, the Process-Oriented Data Science in Healthcare Alliance has been established to propagate the research and application of techniques targeting the data-driven improvement of healthcare processes. This paper, an initiative of the alliance, presents the distinguishing characteristics of the healthcare domain that need to be considered to successfully use process mining, as well as open challenges that need to be addressed by the community in the future.This work is partially supported by ANID FONDECYT 1220202, Dirección de Investigación de la Vicerrectoría de Investigación de la Pontificia Universidad Católica de Chile - PUENTE [Grant No. 026/ 2021]; and Agencia Nacional de Investigación y Desarrollo [Grant Nos. ANID-PFCHA/Doctorado Nacional/2019–21190116, ANID-PFCHA/ Doctorado Nacional/2020–21201411]. With regard to the co-author Hilda Klasky, this manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/doe-public-accessplan).Peer ReviewedArticle signat per 55 autors/es:
Jorge Munoz-Gama (a)* , Niels Martin (b,c)* , Carlos Fernandez-Llatas (d,g)* , Owen A. Johnson (e)* , Marcos Sepúlveda (a)* , Emmanuel Helm (f)* , Victor Galvez-Yanjari (a)* , Eric Rojas (a) , Antonio Martinez-Millana (d) , Davide Aloini (k) , Ilaria Angela Amantea (l,q,r) , Robert Andrews (ab), Michael Arias (z) , Iris Beerepoot (o) , Elisabetta Benevento (k) , Andrea Burattin (ai), Daniel Capurro (j) , Josep Carmona (s) , Marco Comuzzi (w), Benjamin Dalmas (aj,ak), Rene de la Fuente (a) , Chiara Di Francescomarino (h) , Claudio Di Ciccio (i) , Roberto Gatta (ad,ae), Chiara Ghidini (h) , Fernanda Gonzalez-Lopez (a) , Gema Ibanez-Sanchez (d) , Hilda B. Klasky (p) , Angelina Prima Kurniati (al), Xixi Lu (o) , Felix Mannhardt (m), Ronny Mans (af), Mar Marcos (v) , Renata Medeiros de Carvalho (m), Marco Pegoraro (x) , Simon K. Poon (ag), Luise Pufahl (u) , Hajo A. Reijers (m,o) , Simon Remy (y) , Stefanie Rinderle-Ma (ah), Lucia Sacchi (t) , Fernando Seoane (g,am,an), Minseok Song (aa), Alessandro Stefanini (k) , Emilio Sulis (l) , Arthur H. M. ter Hofstede (ab), Pieter J. Toussaint (ac), Vicente Traver (d) , Zoe Valero-Ramon (d) , Inge van de Weerd (o) , Wil M.P. van der Aalst (x) , Rob Vanwersch (m), Mathias Weske (y) , Moe Thandar Wynn (ab), Francesca Zerbato (n) // (a) Pontificia Universidad Catolica de Chile, Chile; (b) Hasselt University, Belgium; (c) Research Foundation Flanders (FWO), Belgium; (d) Universitat Politècnica de València, Spain; (e) University of Leeds, United Kingdom; (f) University of Applied Sciences Upper Austria, Austria; (g) Karolinska Institutet, Sweden; (h) Fondazione Bruno Kessler, Italy; (i) Sapienza University of Rome, Italy; (j) University of Melbourne, Australia; (k) University of Pisa, Italy; (l) University of Turin, Italy; (m) Eindhoven University of Technology, The Netherlands; (n) University of St. Gallen, Switzerland; (o) Utrecht University, The Netherlands; (p) Oak Ridge National Laboratory, United States; (q) University of Bologna, Italy; (r) University of Luxembourg, Luxembourg; (s) Universitat Politècnica de Catalunya, Spain; (t) University of Pavia, Italy; (u) Technische Universitaet Berlin, Germany; (v) Universitat Jaume I, Spain; (w) Ulsan National Institute of Science and Technology (UNIST), Republic of Korea; (x) RWTH Aachen University, Germany; (y) University of Potsdam, Germany; (z) Universidad de Costa Rica, Costa Rica; (aa) Pohang University of Science and Technology, Republic of Korea; (ab) Queensland University of Technology, Australia; (ac) Norwegian University of Science and Technology, Norway; (ad) Universita degli Studi di Brescia, Italy; (ae) Lausanne University Hospital (CHUV), Switzerland; (af) Philips Research, the Netherlands; (ag) The University of Sydney, Australia; (ah) Technical University of Munich, Germany; (ai) Technical University of Denmark, Denmark; (aj) Mines Saint-Etienne, France; (ak) Université Clermont Auvergne, France; (al) Telkom University, Indonesia; (am) Karolinska University Hospital, Sweden; (an) University of Borås, SwedenPostprint (published version
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