67,344 research outputs found
Response to Tomoyuki Kawada, MD: Smoking, Systolic Blood Pressure, Fasting Plasma Glucose and Progression of Carotid Atherosclerosis.
No full textResponse to: Kawada T. Smoking, Systolic Blood Pressure, Fasting Plasma Glucose and Progression of Carotid Atherosclerosis. Nicotine Tob Res. 2016 Jul;18(7):1680. doi: 10.1093/ntr/ntw020. Epub 2016 Jan 17. PMID: 26783295. (which was a comment on: Zingg S, Collet TH, Locatelli I, Nanchen D, Depairon M, Bovet P, Cornuz J, Rodondi N. Associations Between Cardiovascular Risk Factors, Inflammation, and Progression of Carotid Atherosclerosis Among Smokers. Nicotine Tob Res. 2016 Jun;18(6):1533-8. doi: 10.1093/ntr/ntv255. Epub 2015 Nov 16. PMID: 26574552. https://archive-ouverte.unige.ch/unige:165183)</p
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Effects of vitamin E on extracellular matrix components of the vascular wall: Non-antioxidant roles in the prevention of cardiovascular diseases.
No full textOxidized LDLs as Signaling Molecules
No full textLevels of oxidized low-density lipoproteins (oxLDLs) are usually low in vivo but can increase whenever the balance between formation and scavenging of free radicals is impaired. Under normal conditions, uptake and degradation represent the physiological cellular response to oxLDL exposure. The uptake of oxLDLs is mediated by cell surface scavenger receptors that may also act as signaling molecules. Under conditions of atherosclerosis, monocytes/macrophages and vascular smooth muscle cells highly exposed to oxLDLs tend to convert to foam cells due to the intracellular accumulation of lipids. Moreover, the atherogenic process is accelerated by the increased expression of the scavenger receptors CD36, SR-BI, LOX-1, and SRA in response to high levels of oxLDL and oxidized lipids. In some respects, the effects of oxLDLs, involving cell proliferation, inflammation, apoptosis, adhesion, migration, senescence, and gene expression, can be seen as an adaptive response to the rise of free radicals in the vascular system. Unlike highly reactive radicals, circulating oxLDLs may signal to cells at more distant sites and possibly trigger a systemic antioxidant defense, thus elevating the role of oxLDLs to that of signaling molecules with physiological relevance
Letter from Carl Hayden to M. J. Riordan
No full textLetter from Carl Hayden to M. J. Riordan expressing his support for Coconino County in turning over the Bright Angel Trail to the federal government
α-Tocopherol binding to human serum albumin
No full textGiven the ability of human serum albumin (HSA) to bind hydrophobic ligands, the binding mode of α-tocopherol, the most representative member of the vitamin E family, is reported. α-Tocopherol binds to HSA with K = (7.0 ± 3.0) × 10-6 M (pH 7.2, 25.0°C). Competitive and allosteric modulation of α-tocopherol binding to full-length and truncated (Asp1-Glu382) HSA by endogenous and exogenous ligands suggests that it accommodates preferentially in the FA3-FA4 site. As HSA is taken up into cells, colocalizes with the α-tocopherol transfer protein, and contributes to ligand secretion via ABCA1, it might participate in the distribution of α-tocopherol between plasma, cells, and tissues
Palaeobotanical and geochronological evidence for the Alpine age of the metamorphism in the Sesia-Zone
No full textDas Alter der letzten Metamorphose der Sesia-Zone wurde lange Zeit für herzynisch oder älter gehalten. Als Argument dienten Grundgebirgseinschlüsse in den Trachyandesiten bis Andesiten der Sesia-Zone. Diese Vulkanite hielt man in Analogie zu den permischen Vulkaniten der Südalpen für permisch. In jüngster Zeit wurden in Tuffiten der Sesia-Vulkanite Pflanzenreste gefunden, die als oberkarbonisch beschrieben wurden. Diese Schlüsse standen in Diskrepanz zu strukturgeologischen Beobachtungen und zu den zahlreichen radiometrischen Altersbestimmungen in der Sesia-Zone und zwangen zur nochmaligen überprüfung der paläobotanischen Evidenzen. Die von uns gefundene Flora weist sehr moderne Züge auf und läßt sich mit Sicherheit ins Tertiär einstufen. Kein einziges paläozoisches Fossil wurde gefunden. Das durch die Pflanzenreste bestätigte tertiäre Alter der Vulkanite konnte mit radiometrischen K-Ar-Gesamtgesteinsaltern auf 29–33 m.y. präzisiert werden. Die letzte Hochdruck-Metamorphose in der Sesia-Zone fand nach K-Ar-Altersbestimmungen an Glimmern zwischen 60 und 90 m. y. statt. Vor ca. 38 m. y. wurden die alpeneinwärts liegenden Partien der Sesia-Zone von der lepontinischen Kristallisationsphase in Grünschieferfazies überprägt.For a long time the age of the last metamorphism of the Sesia-zone was considered to be Hercynian or older. Basement inclusions in basic volcanics were the main argument for this interpretation. The Trachyandesites — Andesites of the Sesia-zone were regarded as Permian, analogoues to the widespread Permian volcanics of the Southern Alps. Recently, plant remnants have been found in tuffitic interlayers of the Sesia volcanics. These fossils have been described as palaeozoic plants, in contradiction to structual observations and to the numerous radiometric data acquired in the region. To check the age of the fossils a detailed palaeobotanical study was carried out. Our samples contained a very modern flora of definitely Tertiary age. Not one palaeozoic fossil was detected. The Tertiary age found on palaeobotanical evidence proved to be between 29 and 33 m. y. on the basis of total rock K-Ar ages. The last high pressure metamorphism of the Sesia-zone occurred between 90 and 60 m. y. as has been shown by radiometric ages on micas. The external part of the zone was overprinted by the Lepontine phase of metamorphism in greenschist facies 38 m. y. ago
Letter from M. J. Riordan, Arizona Lumber and Timber Company, to Carl Hayden
No full textLetter from M. J. Riordan to Carl Hayden expressing his opposition to the federal government's takeover of Bright Angel Trail
7-(2'-Deoxy-?-D-ribofuranosyl)hypoxanthine
No full textThe [alpha]-configured N7 analogue of 2'-deoxyinosine [7-(2'-deoxy-[alpha]-D-ribofuranosyl)hypoxanthine, C10H12N4O4] shows the following structural characteristics: (i) the furanose part of the molecule adopts the 2'-endo conformation [pseudorotation phase angle 166.4 (2)°]; (ii) the torsion angle [chi] (O4'-C1'-N7-C5) is syn [70.9 (1)°] with the base substituent pointing away from the sugar unit; (iii) the nucleobases are not hydrogen bonded to each other; only sugar-base hydrogen bonds between adjacent molecules were detected
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