25,962 research outputs found
Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma
No full textEpi-reevesioside F, a new cardiac glycoside isolated from the root of Reevesia formosana, displayed potent activity against glioblastoma cells. Epi-reevesioside F was more potent than ouabain with IC50 values of 27.3 +/- 1.7 vs. 48.7 +/- 1.8 nM (P < 0.001) and 45.0 +/- 3.4 vs. 81.3 +/- 4.3 nM (P < 0.001) in glioblastoma T98 and U87 cells, respectively. However, both Epi-reevesioside F and ouabain were ineffective in A172 cells, a glioblastoma cell line with low Na+/K+-ATPase alpha 3 subunit expression. Epi-reevesioside F induced cell cycle arrest at S and G2 phases and apoptosis. It also induced an increase of intracellular concentration of Na+ but not Ca2+, cleavage and exposure of N-terminus of Bak, loss of mitochondrial membrane potential, inhibition of Akt activity and induction of caspase cascades. Potassium supplements significantly inhibited Epi-reevesioside F-induced effects. Notably, Epi-reevesioside F caused cytosolic acidification that was highly correlated with the anti-proliferative activity. In summary, the data suggest that Epi-reevesioside F inhibits Na+/K+-ATPase, leading to overload of intracellular Na+ and cytosolic acidification, Bak activation and loss of mitochondrial membrane potential. The PI3-kinase/Akt pathway is inhibited and caspase-dependent apoptosis is ultimately triggered in Epi-reevesioside F-treated glioblastoma cells
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
DSM of Newton type for solving operator equations F(u) = f with minimal smoothness assumptions on F.
No full textThis paper is a review of the authors’ results on the DSM (Dynamical Systems Method) for solving operator equation (*) F(u) = f. It is assumed that (*) is solvable. The novel feature of the results is the minimal assumption on the smoothness of F. It is assumed that F is continuously
Fr´echet differentiable, but no smoothness assumptions on F0(u) are imposed. The DSM for solving equation (*) is developed. Under weak assumptions global existence of the solution u(t) is proved, the existence
of u(1) is established, and the relation F(u(1)) = f is obtained. The DSM is developed for a stable solution of equation (*) when noisy data
f are given, kf − f k
K. F. C. Rose, The date and author of the Satyricon, with an introduction by J. P. Sullivan, 1971
No full textRastier Françoise. K. F. C. Rose, The date and author of the Satyricon, with an introduction by J. P. Sullivan, 1971. In: Revue des Études Anciennes. Tome 74, 1972, n°1-4. pp. 300-303
K. F. C. Rose, The Date and Author of the Satyricon. With an Introduction by J. P. Sullivan
No full textVerdière Raoul. K. F. C. Rose, The Date and Author of the Satyricon. With an Introduction by J. P. Sullivan. In: L'antiquité classique, Tome 42, fasc. 1, 1973. pp. 279-280
K. F. C. Rose, The date and author of the Satyricon, with an introduction by J. P. Sullivan, 1971
No full textRastier Françoise. K. F. C. Rose, The date and author of the Satyricon, with an introduction by J. P. Sullivan, 1971. In: Revue des Études Anciennes. Tome 74, 1972, n°1-4. pp. 300-303
Quality Assurance Policies and Indicators for Long-Term Care in the European Union, Country Report: Austria. ENEPRI Research Report No. 105, February 2012
No full textIn Austria, the responsibilities for long-term care mainly lie with the provinces, although federal and organisational-level initiative has grown. Quality assurance policies focus overwhelmingly on the health system and are only slowly appearing in the realm of long-term care (LTC). Although the Austrian LTC system is still very fragmented owing to the division of competencies, there are enhanced efforts underway to harmonise LTC provision, standards and quality nationwide. Currently, quality assurance remains mostly at the stage of setting general frameworks or launching small-scale projects, with some notable exceptions. Additional efforts are needed for concerted reforms and for furthering implementation activities
K-theory for group C*-algebras
No full textThese notes are based on a lecture course given by the first author in the Sedano Winter School on K-theory held in Sedano, Spain, on January 22-27th of 2007. They aim at introducing K-theory of C*-algebras, equivariant K-homology and KK-theory in the context of the Baum-Connes conjectur
MILNOR K-THEORY, F-ISOCRYSTALS AND SYNTOMIC REGULATORS
No full textWe introduce a category of filtered F-isocrystals and construct a symbol map from Milnor K-theory to the group of 1-extensions of filtered F-isocrystals. We show that our symbol map is compatible with the syntomic symbol map to the log syntomic cohomology by Kato and Tsuji. These are fundamental materials in our computations of syntomic regulators which we work in other papers
Spatial and Individual Influence on Commuting Behaviour in Germany
No full textIn regional planning literature it is often argued that regional deconcentration process and urban sprawl tend to increase the amount and distance of commuting (Vandersmissen et al. 2003). Supported by improved traffic infrastructure and falling transport costs the spatial division of labour and housing location extends the travel-to-work areas and allows to compensate for locational disadvantages of local labour markets (Moss et al. 2004). On the other hand, the contrary hypothesis is postulated, too. Since both working and living places are deconcentrating shorter commuting distances may happen because centre-orientated connections are substituted by intra-peripheral commuting patterns (Gordon; Richardson 1991: 419). The intention of the paper is to analyse the influence of spatial structure on commuting behaviour of employees: e.g. does commuting behaviour differ between type of regions and what are the reasons for these differences? There are several ways how the locational conditions of the living area may influence the commuting behaviour. Firstly, the more jobs are available, the less is c.p. the necessity for long-distance commuting. Thus, the lower the regional density of jobs the more frequent and longer commuting should be expected. In addition, the variety of local jobs should have an influence on the commuting behaviour. As in rural regions less varied jobs are available, there should be a pressure on the local residents to increase their job opportunities by extending their commuting distance. However, apart from regional influences, individual characteristics may effect commuting behaviour, too. For example, highly qualified employees are expected to commute to longer distances since they could be more interested in realizing their investment in human capital. Conversely, long-distance commuting should be c.p. less attractive for part-time employees because of the less favourable relation between work and commuting time. The empirical analysis consists of two parts: Firstly, regional differences in commuting behaviour are analyzed. The focus of investigation lies on regions and the relationship between the regional characteristics of living places and the regional amount of commuting. The second part includes individual influences. As they can only observed at the level of individuals, the focus of investigation changes from regions to individuals: In addition to regional effects the commuting behaviour of individuals is explained by individual characteristics such as education or occupation. The data base is given by the social security statistics. It covers all employees in the social security system and contains information about each individual. As data on both the living and the working places are available, the statistics allows a much greater regional differentiation than the frequently used surveys. The other information relate to some personal characteristics (like sex or education) as well as to the occupation such as full-/part-time or the sector of employment.
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