50,445 research outputs found
The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer
Get PDFYakovtcova I. I., Tkachenko P. V., Ivakhno I. V. The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer. Journal of Education, Health and Sport. 2017;7(8):415-422. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.852570
http://ojs.ukw.edu.pl/index.php/johs/article/view/4754
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Authors 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 01.08.2017. Revised: 27.08.2017. Accepted: 30.08.2017.
The significance of angiogenesis in tumorigenesis and prognosis of prostate cancer
I. I. Yakovtcova, P. V. Tkachenko, I. V. Ivakhno
Kharkiv medical academy of postgraduate education
Abstract
Angiogenesis is a key factor in tumor growth, invasion, and metastasis. The aim of the present study is to investigate the diagnostic and predictive value of prostatic cancer (PC) angiogenesis by immunohistochemically examination of CD34, VEGF and Ki-67 in 40 cases of PC, 8 cases of nodular hyperplasia and 8 cases of intraepithelial neoplasia. It was found that the density of microvessels and intensity data of stroma but not epithelium VEGF staining in PC more than in benign pathology, and increased with risk of recurrence and as the differentiation of cancer was reduced. Results indicate that the vascularization is a sign of growth and progression of PC and may be used as predictor of the disease.
Key words: prostatic cancer, angiogenesis, vascular endothelial growth factor, microvessel density
Nondiscrete P-Groups can be reflexive
Get PDFWe present a series of examples of nondiscrete reflexive P-groups (i.e.,
groups in which all G -sets are open) as well as noncompact reflexive !-bounded groups
(in which the closure of every countable set is compact). Our main result implies that every
product of feathered (equivalently, almost metrizable) Abelian groups equipped with
the P-modified topology is a reflexive group. In particular, every compact Abelian group
with the P-modified topology is reflexive. This answers a question posed by S. Hern´andez
and P. Nickolas and solves a problem raised by Ardanza-Trevijano, Chasco, Dom´ınguez,
and Tkachenko
Observation of Tkachenko Oscillations in Rapidly Rotating Bose-Einstein Condensates
Get PDFPhys.Rev.Lett.91:100402,2003 We directly image Tkachenko waves in a vortex lattice in a dilute-gas
Bose-Einstein condensate. The low (sub-Hz) resonant frequencies are a
consequence of the small but nonvanishing elastic shear modulus of the
vortex-filled superfluid. The frequencies are measured for rotation rates as
high as 98% of the centrifugal limit for the harmonically confined gas.
Agreement with a hydrodynamic theory worsens with increasing rotation rate,
perhaps due to the increasing fraction of the volume displaced by the vortex
cores. We also observe two low-lying m=0 longitudinal modes at about 20 times
higher frequency
Subgroups and products of -factorizable -groups
No full textsummary:We show that {\it every\/} subgroup of an -factorizable abelian -group is topologically isomorphic to a {\it closed\/} subgroup of another -factorizable abelian -group. This implies that closed subgroups of -factorizable -groups are not necessarily -factorizable. We also prove that if a Hausdorff space of countable pseudocharacter is a continuous image of a product of -spaces and the space is pseudo--compact, then . In particular, direct products of -factorizable -groups are -factorizable and -stable
AdNDP 2.0 code.
No full text<p>AdNDP 2.0 code associated with the publication: <br>
Tkachenko N.V. and Boldyrev A.I. Chemical bonding analysis of excited states using the Adaptive Natural Density Partitioning method, <em>Phys. Chem. Chem. Phys.</em>, <strong>2019</strong>, <em>21</em>, 9590-9596..</p>
<p>version 2: https://zenodo.org/record/3252298#.XQ3Fra_QhPY</p>User's manual is available through the following links: http://ion.chem.usu.edu/~boldyrev/, and http://ion.chem.usu.edu/~boldyrev/nikolay.html
Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
Get PDFTkachenko P. V., Yakovtcova I. I., Dolgaya O. V., Ivakhno I. V. Expression of vimentin, E-cadherin and TGF-β as markers of epithelial-mesenchymal transformation and criteria for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer. Journal of Education, Health and Sport. 2017;7(7):764-775. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.843519
http://ojs.ukw.edu.pl/index.php/johs/article/view/4700
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Authors 2017;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 01.07.2017. Revised: 02.07.2017. Accepted: 31.07.2017.
Expression of vimentin, E-cadherin and TGF-β as markers
of epithelial-mesenchymal transformation and criteria
for the prognosis of the diseaseby epithelium in benign pathology and prostate gland cancer
P. V. Tkachenko, I. I. Yakovtcova, O. V. Dolgaya, I. V. Ivakhno
Kharkiv medical academy of postgraduate education
Abstract
Epithelial-mesenchymal transformation in prostate gland cancer is a criterion of aggressive biological behavior of the tumor, but the clinical material is not sufficiently studied. The objective of the research was to study epithelial-mesenchymal transformation and its prognostic significance in benign pathology and prostate gland cancer. The absence of vimentin expression and the evident reaction of E-cadherin in the epithelium in benign pathology of the prostate glandwere revealed. The change in the expression of these markers in prostate gland canceroccur at the expense of low-differentiated forms and is characteristic of the high-risk group (p <0.05 and p <0.01, respectively). An inverse dependence between the reaction of vimentin and E-cadherin (p <0.05) and their correlation withTGFβ (p <0.05) was detected. Conclusion: community of the molecular-biological manifestations of the epithelial-mesenchymal transformation in prostate gland cancer and involvement of TGFβ into its process has been proved. Epithelial-mesenchymal transformation maybe a prognostic criterionof the disease.
Key words: prostate gland cancer, vimentin, E-cadherin, TGFβ, epithelial-mesenchymal transformation
Energy indicators of operation the heat pumping system heating of the energy efficient house
No full textEnergy indicators of operation the heat pumping system heating of the energy efficient house / B. I. Basok, O. M. Nedbailo, I. K. Bozhko, M. V. Tkachenko // Актуальні проблеми енергетики та екології : зб. наук. пр. за матеріалами XVIII Всеукр. наук.-техн. онлайн-конф., Одеса, 29-30 верес. 2020 р. / Одес. нац. акад. харч. технологій ; ред. О. С. Тітлов. – Одеса : Бондаренко М. О., 2020. – P. 4–5. – Ref.: 2 tit
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Static and dynamic structure factors with account of the ion structure for high-temperature alkali and alkaline earth plasmas
Get PDFThe electron-electron, electron-ion, ion-ion and charge-charge static structure factors are calculated for alkali (at T = 30 000 K, 60 000 K, n (e) = 0.7 x 10(21) A center dot 1.1 x 10(22) cm(-3)) and Be2+ (at T = 20 eV, n (e) = 2.5 x 10(23) cm(-3)) plasmas using the method described by Gregori et al. The dynamic structure factors for alkali plasmas are calculated at T = 30 000 K, n (e) = 1.74 x 10(20), 1.11 x 10(22) cm(-3) using the method of moments developed by Adamjan et al. In both methods the screened Hellmann-Gurskii-Krasko potential, obtained on the basis of Bogolyubov's method, has been used taking into account not only the quantum-mechanical effects but also the repulsion due to the Pauli exclusion principle. The repulsive part of the Hellmann-Gurskii-Krasko (HGK) potential reflects important features of the ion structure. Our results on the static structure factors for Be2+ plasma deviate from the data obtained by Gregori et al., while our dynamic structure factors are in a reasonable agreement with those of Adamyan et al.: at higher values of k and with increasing k the curves damp down while at lower values of k, and especially at higher electron coupling, we observe sharp peaks also reported in the mentioned work. For lower electron coupling the dynamic structure factors of Li+, Na+, K+, Rb+ and Cs+ do not differ while at higher electron coupling these curves split. As the number of shell electrons increases from Li+ to Cs+ the curves shift in the direction of low absolute value of omega and their heights diminish. We conclude that the short range forces, which we take into account by means of the HGK model potential, which deviates from the Coulomb and Deutsch ones, influence the static and dynamic structure factors significantly.The work has been realised at the Humboldt University at Berlin (Germany). One of the authors (S. P. Sadykova) would like to express sincere thanks to the Erasmus Mundus Program of the EU for the financial support and especially to Mr. M. Parske for his aid, to the Institute of Physics, Humboldt University at Berlin, for the support which made her participation at some scientific Conferences possible; I. M. T. acknowledges the financial support of the Spanish Ministerio de Educacion y Ciencia Project No. ENE2007-67406-C02-02/FTN and valuable discussions with Dr. D. Gericke.Sadykova, SP.; Ebeling, W.; Tkachenko Gorski, IM. (2011). Static and dynamic structure factors with account of the ion structure for high-temperature alkali and alkaline earth plasmas. 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Optical properties of kelbg-pseudopotential-modelled plasmas
No full textSimulation data on hydrogen-like plasmas, modelled with the Kelbg pseudopotential, are treated within the
classical theory of moments. The possibility is analyzed for the model inverse dielectric function to satisfy
five convergent sum rules and other exact relations. The sum rules are the power frequency moments of the
loss function and the latter are calculated using the hypernetted chain approximation with the Kelbg interaction
potential. An approach to the reconstruction of the Nevanlinna parameter function is proposed and successfully
tested against the simulation data. Conclusions on the applicability of the Kelbg potential are drawn and a
model is put forward to define the Coulomb dielectric function with the space dispersion taken into account.This work was partially supported by the Spanish Ministerio de Ciencia e Innovacion under Grant No. ENE2010-21116-C02-02 and by the Sciences Committee of the Ministry of Education and Sciences of the Republic of Kazakhstan under Grants No. 1128/GF, 1129/GF and 1099/GF. The authors acknowledge the financial support of KazNU and are thankful to I. V. Morozov for providing the numerical data; I. M. T. is grateful to the UPV for the granted sabbatical leave and to the KazNU for its hospitality.Arkhipov, YV.; Ashikbayeva, AB.; Askaruly, A.; Davletov, AE.; Tkachenko Gorski, IM. (2013). Optical properties of kelbg-pseudopotential-modelled plasmas. Contributions to Plasma Physics. 53(4-5):375-384. https://doi.org/10.1002/ctpp.201200113S375384534-5Ballester, D., & Tkachenko, I. M. (2005). Two-moment modelling of the dynamic longitudinal conductivity of strongly coupled Coulomb systems. Contributions to Plasma Physics, 45(3-4), 293-299. doi:10.1002/ctpp.200510033Tkachenko, I. M., & Ballester, D. (2005). Reconstruction of internal longitudinal conductivity of non-ideal plasmas by exact relations and sum rules. Journal of Physics: Conference Series, 11, 82-88. doi:10.1088/1742-6596/11/1/008Arkhipov, Y. V., Askaruly, A., Ballester, D., Davletov, A. E., Meirkanova, G. M., & Tkachenko, I. M. (2007). Collective and static properties of model two-component plasmas. Physical Review E, 76(2). doi:10.1103/physreve.76.026403Arkhipov, Y. V., Askaruly, A., Davletov, A. E., & Tkachenko, I. M. (2010). Dynamic Properties of One-Component Moderately Coupled Plasmas: The Mixed Löwner-Nevanlinna-Pick Approach. Contributions to Plasma Physics, 50(1), 69-76. doi:10.1002/ctpp.201010015Arkhipov, Y. V., Askaruly, A., Baimbetov, F. B., Ballester, D., Davletov, A. E., Meirkanova, G. M., & Tkachenko, I. M. (2010). Optical Properties of Model Moderately Coupled Plasmas. Contributions to Plasma Physics, 50(2), 165-176. doi:10.1002/ctpp.201010031Arkhipov, Y. V., Askaruly, A., Ballester, D., Davletov, A. E., Tkachenko, I. M., & Zwicknagel, G. (2010). Dynamic properties of one-component strongly coupled plasmas: The sum-rule approach. Physical Review E, 81(2). doi:10.1103/physreve.81.026402Filippov, A. V., Starostin, A. N., Tkachenko, I. M., & Fortov, V. E. (2011). Dust acoustic waves in complex plasmas at elevated pressure. Physics Letters A, 376(1), 31-38. doi:10.1016/j.physleta.2011.10.030M. G. Krein A. A. Nudel'man “The Markov moment problem and extremal problems”, Trans. of Math. Monographs, 50, Amer. Math. Soc., Providence, R. I.,1977.N. I. Akhiezer “The Classical Moment Problem”, Hafner Publishing Company, N. Y., 1965.Adamyan, V., Alcober, J., & Tkachenko, I. (2003). Applied Mathematics Research eXpress, 2003(2), 33. doi:10.1155/s1687120003212028J. Alcober I. M. Tkachenko M. Urrea In: “Integral Methods in Science and Engineering”, Ed. C. Constanda, Eugenia Pérez, Ch. 2 , 11-20, 2009, Birkhäuser Verlag, Basel, Switzerland.Reinholz, H., Morozov, I., Röpke, G., & Millat, T. (2004). Internal versus external conductivity of a dense plasma: Many-particle theory and simulations. Physical Review E, 69(6). doi:10.1103/physreve.69.066412Morozov, I., Reinholz, H., Röpke, G., Wierling, A., & Zwicknagel, G. (2005). Molecular dynamics simulations of optical conductivity of dense plasmas. Physical Review E, 71(6). doi:10.1103/physreve.71.066408S. Ichimaru “Statistical Plasma Physics”, Addison-Wesley, New York, 1991, Vol. 1; S. Ichimaru, “Statistical Plasma Physics: Condensed Plasmas” Addison-Wesley, New York, 1994, Vol. 2.I. M. Tkachenko Yu. V. Arkhipov A. Askaruly “The Method of Moments and its Applications in Plasma Physics”, LAMBERT Academic Publishing, Saarbrucken, Germany, 2012.Maksimov, E. G., Dolgov, O. V., & Dolgov, O. V. (2007). Physics-Uspekhi, 50(9), 933. doi:10.1070/pu2007v050n09abeh006213D. Pines P. Nozièrs “The Theory of Quantum Liquids”, Benjamin, NY, 1966.M. J. Corbatón I. M. Tkachenko International Conference on Strongly Coupled Coulomb Systems, Camerino, Italy, 2008, Book of Abstracts, p. 90.Kugler, A. A. (1975). Theory of the local field correction in an electron gas. Journal of Statistical Physics, 12(1), 35-87. doi:10.1007/bf01024183Baus, M., Hansen, J.-P., & Sjögren, L. (1981). Electrical conductivity of a strongly coupled hydrogen plasma. Physics Letters A, 82(4), 180-182. doi:10.1016/0375-9601(81)90115-8Reinholz, H. (2005). Dielectric and optical properties of dense plasmas. Annales de Physique, 30(4-5), 1-187. doi:10.1051/anphys:2006004D. N. Zubarev V. Morozov G. Röpke “Relaxation and HydrodynamicProcesses”, Vol. 2 of Statistical Mechanics of Nonequilibrium Processes, Akademie Verlag/Wiley, Berlin, 1997.Röpke, G. (1998). Dielectric function and electrical dc conductivity of nonideal plasmas. 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