6,809 research outputs found
Encoding the states of interacting proteins to facilitate biological pathways reconstruction
No full textAbstract Background In a systems biology perspective, protein-protein interactions (PPI) are encoded in machine-readable formats to avoid issues encountered in their retrieval for the reconstruction of comprehensive interaction maps and biological pathways. However, the information stored in electronic formats currently used doesn't allow a valid automatic reconstruction of biological pathways. Results We propose a logical model of PPI that takes into account the "state" of proteins before and after the interaction. This information is necessary for proper reconstruction of the pathway. Conclusions The adoption of the proposed model, which can be easily integrated into existing machine-readable formats used to store the PPI data, would facilitate the automatic or semi-automated reconstruction of biological pathways. Reviewers This article was reviewed by Dr. Wen-Yu Chung (nominated by Kateryna Makova), Dr. Carl Herrmann (nominated by Dr. Purificación López-García) and Dr. Arcady Mushegian.</p
[Poesia] Três poemas de Alberto Secama
No full textThree poems by Alberto Secama. About the author: Alberto Secama is an Angolan poet who has poems published on many websites and on facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secamaTres poemas de Alberto Secama. Sobre el autor: Alberto Secama es un poeta angoleño que tiene poemas publicados en varios sitios y en el facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secamaTrês poemas de Alberto Secama. Sobre o autor: Alberto Secama é um poeta angolano que possui poemas publicados em vários sites e no facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secam
Orizzonti mantovani. Spunti e dinamiche paesaggistiche ne L'Illustrissimo di Alberto Cantoni
No full textIn the literary production of Alberto Cantoni, short story writer and novelist between the nineteenth and twentieth centuries, the novel L'Illustrissimo is highly important both because it is the last publication of the author, from Pomponesco, a small town a few kilometers south of Mantua, both because it summarizes in a single text the different nuances and different directions that his writing has taken over the course of his literary career, also due to a writing and processing time that embraces the entire span of years of his career itself. In the foreground, in addition to the numerous and brilliant characters, one of the protagonists is the Mantuan landscape which, not a simple background, becomes a true literary parameter which in different and significant ways affects the purposes and mechanisms of the novel
Plenary Session: Luis Alberto Urrea
No full texta) Plenary Session: Luis Alberto Urrea, Mexican American Chicago Writer
Luis Alberto Urrea is a 2005 Pulitzer Prize finalist for non-fiction and member of the Latino Literature Hall of Fame. He is a prolific and acclaimed writer who has used his dual-culture life border experiences to explore the complex and interconnected Mexican-US American reality. The critically acclaimed and best-selling Mexican-born author of 13 books, Urrea has won numerous awards for his poetry, fiction and essays.
Moderator: Dr. Héctor García, Loyola University Chicag
O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em LiteraturaA pretensão desta dissertação intitulada O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes é investigar a relação entre o sentir e o puro pensar, usando como referência a poesia O Guardador de Rebanhos, de Alberto Caeiro, que apresenta de forma evidente o tema; e como este assunto é tratado nas Meditações Metafísicas de René Descartes, também de forma claramente visível. Podemos perceber em ambos os autores, uma diplopia, uma espécie de duplo olhar sobre a relação sentir e puro pensar. No primeiro capítulo vou falar sobre a tese do duplo olhar de Descartes, a respeito da relação sentir e puro pensar na leitura de Merleau-Ponty, salientando a visão de natureza. No segundo capítulo, parto da leitura das três primeiras Meditações Metafísicas para caracterizar a tensão que se pode verificar entre Descartes e Alberto Caeiro quando se referem ao puro pensar. O foco principal de Descartes, nas três primeiras Meditações, é o pensar puro, e neste ponto Alberto Caeiro critica o pensar puro. No terceiro capítulo, analisando as três últimas Meditações, percebe-se que há uma virada no pensamento de Descartes, no qual o autor inverte seu ponto de vista, aproximando-se da idéia de Alberto Caeiro. No quarto capítulo, mostrarei a leitura que outros autores fazem acerca do sentir e do pensar na obra de Alberto Caeiro, mostrando que assim como Descartes, este também ostenta uma diplopia, não do sentir, mas do pensar. The pretension of this work entitled O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes is to investigate the relationship between the feeling and the pure thinking, using as reference the poetry O Guardador de Rebanhos, by Alberto Caeiro, that presents in an evident way this theme; and as this subject is treated in René Descartes' Metaphysical Meditations, also in a clearly visible way. It is possible to notice in both authors, the diplopy, a sort of double look about the relationship between feeling and pure thinking. The thesis about Descartes'double look regarding the relation of feeling and pure thinking, in Merleau-Ponty reading, pointing out the nature vision, will be treated in the first chapter. In the second chapter, I start from the reading of the first three Metaphysical Meditations to characterize the tension that can be verified between Descartes and Alberto Caeiro when they refer to the pure thinking. Descartes' main focus in the first three Meditations is pure thinking and, in this point, Alberto Caeiro criticizes pure thinking. In the third chapter, analyzing the last three Meditations, it is possible to notice that there is an alteration in Descartes' thought, in which the author inverts his point of view, approaching of Alberto Caeiro's idea. In the fourth chapter, I will show the reading that other authors do concerning feeling and thinking in Alberto Caeiro's work, showing that as well as Descartes, this also shows a diplopy, not of feeling, but of thinking
Lobbying for change as a new theory and practice of active citizenship: author interview with Alberto Alemanno
No full textDo you believe that lobbying is a vehicle for representing the interests of some rather than all, meaning its actors can never be a force for good? Alberto Alemanno, author of Lobbying for Change: Find Your Voice to Create a Better Society, might convince you of the contrary. This interview with Barbara Aubin, LSE Public Affairs, reflects on the importance of engaging with our political representatives, holding them accountable and lobbying for the causes we deeply care about as fundamental elements of a healthy democracy
Bibliografia di Umberto Romagnoli
No full textA complete bibliography of Umberto Romagnoli writings, introduced by a few lines by editors of the Journal and completed by an essay by Alberto Mattei dealing with some technical aspects of the collection of the
bibliography interwoven with some scholarly life moments of the author
Fray Alberto arquitecto (1575 – 1635): José Luis García Martínez y José Miguel Muñoz Jiménez
No full textMuch of the baroque architecture was the work of religious men of the we do not know, perhaps for being humility one of his necessary virtues. However, this ignorance is surprising in the case of the Carmelite Fray Alberto de la Madre de Dios, given his enormous stature and work, ignorance that has even sometimes turned into denial on the part of some uninformed author. And the thing is that he, of whom Chueca Goitia said that he had been the initiator of the Baroque in Castile, is the proven author of nearly eighty works and supposedly of as many others, as is more than accredited in the book reviewed here.Gran parte de la arquitectura barroca fue obra de religiosos de los que no sabemos su nombre, por ser quizá la humildad una de sus virtudes necesarias. Sorprende sin embargo esta ignorancia en el caso del carmelita Fray Alberto de la Madre de Dios, dada su enorme talla y obra, ignorancia que incluso en ocasiones se ha convertido en negación por parte de algún autor desinformado. Y es que aquel, de quien dijo Chueca Goitia que había sido el iniciador del Barroco en Castilla, es autor demostrado de cerca de ochenta obras y supuesto de otras tantas, como queda más que acreditado en el libro aquí reseñado
Fray Alberto arquitecto (1575 – 1635): José Luis García Martínez y José Miguel Muñoz Jiménez
No full textMuch of the baroque architecture was the work of religious men of the we do not know, perhaps for being humility one of his necessary virtues. However, this ignorance is surprising in the case of the Carmelite Fray Alberto de la Madre de Dios, given his enormous stature and work, ignorance that has even sometimes turned into denial on the part of some uninformed author. And the thing is that he, of whom Chueca Goitia said that he had been the initiator of the Baroque in Castile, is the proven author of nearly eighty works and supposedly of as many others, as is more than accredited in the book reviewed here.Gran parte de la arquitectura barroca fue obra de religiosos de los que no sabemos su nombre, por ser quizá la humildad una de sus virtudes necesarias. Sorprende sin embargo esta ignorancia en el caso del carmelita Fray Alberto de la Madre de Dios, dada su enorme talla y obra, ignorancia que incluso en ocasiones se ha convertido en negación por parte de algún autor desinformado. Y es que aquel, de quien dijo Chueca Goitia que había sido el iniciador del Barroco en Castilla, es autor demostrado de cerca de ochenta obras y supuesto de otras tantas, como queda más que acreditado en el libro aquí reseñado
Charting the NF-κB pathway interactome map.
No full textInflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-κB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-κB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-κB activation system. Such a reconstruction shows that the NF-κB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-κB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development, refinement and analysis
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