8,469 research outputs found
Social trauma and the mu-opioid system in depression
No full textThe overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to long term dysregulation in key related circuitries and neuroanatomical structures
Personality and attention bias in adults with a history of childhood trauma, and attenuating effects of mu-opioid agonist buprenorphine on attention bias
No full textThe current study compared personality characteristics and cognitive functioning (specifically, attentional bias) in a sample of adults who had experienced childhood trauma (the Trauma group) and a matched healthy control group. The study also examined the possible effects of the mu-opioid agonist buprenorphine on attentional bias in the Trauma group
Phase Diagram at Finite Chemical Potentials in the Nambu-Jona-Lasinio Model
No full textWe study the phase diagram of two flavor dense QCD at finite isospin and baryon chemical potentials in the framework of Nambu-Jona-Lasinio model. The system undergoes a crossover from a Bose-Einstein condensate of charged pions to a BCS superfluid with condensed quark-antiquark Cooper pairs when mu(I) increases at mu(B) = 0, and a nonzero baryon chemical potential serves as a mismatch between the pairing species. We observe a gapless pion condensation phase near the quadruple point (mu(I), mu(B)) = (m(pi), M-N-1.5m(pi)) where m(pi), M-N are the vacuum masses of pions and nucleons, respectively. At very large isospin chemical potential, mu(I) > 6.36m(pi), an inhomogeneous LOFF superfluid phase appears in a window of mu(B). Between the gapless and the LOFF phases, the pion superfluid phase and the normal quark matter phase are connected by a first order phase transition.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000302957500023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Atomic, Molecular & ChemicalCPCI-S(ISTP)
Mu-Beta event-related (de)synchronization and EEG classification of left-right foot dorsiflexion kinaesthetic motor imagery for BCI
No full textThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The left and right foot representation area is located within the interhemispheric fissure of the sensorimotor cortex and share spatial proximity. This makes it difficult to visualize the cortical lateralization of event-related (de)synchronization (ERD/ERS) during left and right foot motor imageries. The aim of this study is to investigate the possibility of using ERD/ERS in the mu, low beta, and high beta bandwidth, during left and right foot dorsiflexion kinaesthetic motor imageries (KMI), as unilateral control commands for a brain-computer interface (BCI). EEG was recorded from nine healthy participants during cue-based left-right foot dorsiflexion KMI tasks. The features were analysed for common average and bipolar references. With each reference, mu and beta band-power features were analysed using time-frequency (TF) maps, scalp topographies, and average time course for ERD/ERS. The cortical lateralization of ERD/ERS, during left and right foot KMI, was confirmed. Statistically significant features were classified using LDA, SVM, and KNN model, and evaluated using the area under ROC curves. An increase in high beta power following the end of KMI for both tasks was recorded, from right and left hemispheres, respectively, at the vertex. The single trial analysis and classification models resulted in high discrimination accuracies, i.e. maximum 83.4% for beta ERS, 79.1% for beta ERD, and 74.0% for mu ERD. With each model the features performed above the statistical chance level of 2-class discrimination for a BCI. Our findings indicate these features can evoke left-right differences in single EEG trials. This suggests that any BCI employing unilateral foot KMI can attain classification accuracy suitable for pra
First observation of the rare decay at the NA62 experiment
No full textThe first observation of the rare decay using data collected by the NA62 Experiment in 2017 and 2018 is presented in this thesis. The branching ratio is measured using the process as a normalisation channel. The number of observed data candidates is , with a background contamination of . The analysis yields , including a complete treatment of relevant systematic effects. The complete software package for the ANTI-0 detector, added to the NA62 setup in 2021, was developed by the author within the NA62 software framework and is described in detail. The software tools allowing for short and long-term verification of ANTI-0 data quality are presented, with their output used to summarise the commissioning and performance of the detector in the 2021, 2022 and 2023 NA62 data-taking campaigns
Search for D+(s) to pi+ mu+ mu- and D+(s) to pi- mu+ mu+ decays
No full textA search for non-resonant D+(s) to pi+mu+mu- and D+(s) to pi-mu+mu+ decays is performed using proton-proton collision data, corresponding to an integrated luminosity of 1.0 fb-1, at sqrt(s) = 7 TeV recorded by the LHCb experiment in 2011. No signals are observed and the 90% (95%) confidence level (CL) limits on the branching fractions are B(D+ to pi+mu+mu-) < 7.3 (8.3) x 10-8, B(Ds+ to pi+mu+mu-) < 4.1 (4.8) x 10-7, B(D+ to pi-mu+mu+) < 2.2 (2.5) x 10-8, B(Ds+ to pi-mu+mu+) < 1.2 (1.4) x 10-7. These limits are the most stringent to date
Visiting author Dr. Arthur Schlesinger, Jr. at MU
No full textVisiting author Dr. Arthur Schlesinger, Jr. at MU , b&w. Schlesinger wrote a book on disuniting America.https://mds.marshall.edu/parthenon_photo_morgue/1756/thumbnail.jp
Visiting author Dr. Arthur Schlesinger, Jr. being interviewed at MU
No full textVisiting author Dr. Arthur Schlesinger, Jr. being interviewed at MU , b&w. Schlesinger wrote a book on disuniting America.https://mds.marshall.edu/parthenon_photo_morgue/1757/thumbnail.jp
Sponge-associated fungi and their bioactive compounds - the Suberites case
No full textSpecimens of Suberites domuncula that had been cultured in aquaria for 4 weeks were analyzed for their associated fungi. A total of 81 fungal strains belonging to 20 different genera was isolated and identified by morphological and molecular methods. The most frequently isolated taxa were Cladosporium spp., Penicillium spp., Petriella sp., Phialophora spp. and Engyodontium album. Based on chromatographic and mass spectrometric analysis of fungal extracts, as well as on bioassay results, Aspergillus ustus, Penicillium sp., Petriella sp. and Scopulariopsis sp. were selected for in-depth analysis of their natural products. A total of 19 different fungal metabolites, including three new natural products, was isolated and structurally identified. A. ustus yielded two sesquiterpenes, a drimane derivative and deoxyuvidin, as well as a sesterterpene ophiobolin H. The drimane derivative had an ED50 value against L5178Y cells of 1.9 mu g ml(-1) in vitro. The crude extract of Petriella sp. was also strongly cytotoxic against the L5178Y cell line. The cyclic tetrapeptide WF-3161 was primarily responsible for the activity; the ED50 value was <0.1 mu g ml(-1). It was identical to the known compound WF-3161 and had been previously isolated from Petriella guttulata. In addition to WF-3161, three further natural products were obtained and unequivocally identified as new derivatives of infectopyrone by one-and two-dimensional NMR spectroscopy and by mass spectroscopy. Of the new compounds, only dihydroinfectopyrone was active against L5178Y cells; the ED50 value was 0.2 mu g ml(-1). Penicillium sp. yielded the largest number of metabolites. Viridicatin, viridicatol, cyclopenin and cyclopenol suppressed larval growth of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet at an arbitrarily chosen concentration of 237 ppm. Viridicatol was the most active compound and had an ED50 value of ca. 50 ppm. Scopulariopsis sp. yielded three metabolites, including the known acetylcholinesterase inhibitors quinolactacin A1 and A2
Improved measurement of the absolute branching fraction of D+ -> (K)over-bar(0)mu(+)nu(mu)
No full textKolcu, Onur Buğra (Arel Author)By analyzing 2.93 fb(-1) of data collected at root s = 3.773 GeV with the BESIII detector, we measure the absolute branching fraction B(D+ -> (K) over bar (0) (+)(mu)nu(mu)) = (8.72 +/- 0.07(stat). +/- 0.18(sys).) %, which is consistent with previous measurements within uncertainties but with significantly improved precision. Combining the Particle Data Group values of B(D-0 -> K- mu(+)nu(mu)), B(D+-> (K) over bar (0)e(+)nu(e)), and the lifetimes of the D-0 and D+ mesons with the value of B(D+ -> (K) over bar (0)mu(+)nu(mu)) measured in this work, we determine the following ratios of partial widths: Gamma (D-0 -> (K) over bar (-)mu(+)nu(mu))/Gamma (D+ -> (K) over bar (0)mu+nu(mu)) = 0.963 +/- 0.044 and Gamma (D+ -> (K) over bar (0) mu+nu(mu))/Gamma(D+ -> (K) over bar (0)e+nu(e)) = 0.988 +/- 0.033
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