240,037 research outputs found
Cangshanaltica fuanensis Ruan, Konstantinov and Damaska 2022
No full textCangshanaltica fuanensis Ruan, Konstantinov and Damaška, 2022 Fig. 8B Cangshanaltica fuanensis Ruan, Konstantinov and Damaška, 2022: 29 Type locality: China, Fujian, Fuan. Type series: Holotype — IZAS; paratypes: IZAS, SZPT, ADPC. Remarks: The species was described originally by Ruan et al. (2020), however, the description did not comply with the ICZN, and the name has been considered as nomen nudum. Therefore, it has been described correctly by Ruan et al. (2022). The species is known only from the type series (30 specimens). It is very similar to the C. castanea species complex (from which it can be separated by using the key below) in having brown, ellipticalrounded body. However, Damaška et al. (2021) revealed that C. fuanensis is more closely related to the Taiwanese Cangshanaltica species complex, rather than to the C. castanea s. lat. from Zhejiang to which it is most similar.Published as part of Damaška, Albert František, Ruan, Yongying & Fikáček, Martin, 2022, The genus Cangshanaltica (Coleoptera: Chrysomelidae: Alticinae): overview, new species, and notes on species complexes, pp. 49-64 in Zootaxa 5219 (1) on page 54, DOI: 10.11646/zootaxa.5219.1.2, http://zenodo.org/record/740814
Composition of water-soluble polysaccharides and molecular characteristics of galactan from Anoectochilus formosanus Hayata.
No full textNocardiopsis halophila Al-Tai and Ruan 1994
No full textEMENDED DESCRIPTION OF THE NOCARDIOPSIS HALOPHILA AL-TAI AND RUAN 1994 The description is based on Al-Tai and Ruan [9], Li et al. [3] and Nouioui et al. [10]. Utilization of inositol, raffinose and xylose are variable. Urea hydrolysis is variable. The major phospholipids may contain phosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol, phosphatidylinositolmannoside or phosphatidylmethylethanolamine, besides diphosphotidylglycerol and phosphotidylcholine. May tolerate temperature as high as 50 Ǫ C. The type strain of Nocardiopsis halophila is IQ-H3 T (=CGMCC 4.1195 T = DSM 44494 T =JCM 9892 T). The former type strain of Nocardiopsis baichengensis YIM 90130 T (=CCTCC AA 2040016 T = DSM 44845 T =KCTC 19009 T) is another strain of Nocardiopsis halophila. The G +C content of the type strain is 73.6 mol%.Published as part of Zhang, Xiao-Tong, Salam, Nimaichand, Xiao, Min, Asem, Mipeshwaree Devi & Li, Wen-Jun, 2020, Genome analysis reveals that Nocardiopsis baichengensis Li et al. 2006 is a later heterotypic synonym of Nocardiopsis halophila Al-Tai and Ruan 1994, pp. 89-92 in International Journal of Systematic and Evolutionary Microbiology 70 (1) on page 92, DOI: 10.1099/ijsem.0.003721, http://zenodo.org/record/604867
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
Full text linkThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Fabrication of low-loss nanodiamond doped tellurite fibres
No full textEbendorff Heidepriem, H.; Ruan, Y.; Ji, H.; Gibson, B. C.; Monro, T. M.http://www.aomevents.com/ACMMICON
Un vase protohistorique à Pont-de-Ruan (I.-et-L)
No full textYvard J.-C. Un vase protohistorique à Pont-de-Ruan (I.-et-L). In: Bulletin de la Société préhistorique française. Comptes rendus des séances mensuelles, tome 63, n°7, 1966. pp. 234-235
Letter from Carl T. Hayden to C. H. Gensler, Havasupai Reservation
No full textLetter from Carl T. Hayden to C. H. Gensler, Havasupai Indian Reservation, regarding Hualapai and Cataract Canyons geography
Chaetocnema (Udorpes) midimpunctata Ruan & Yang & Konstantinov & Prathapan & Zhang 2019, New Species
No full text71. Chaetocnema (Udorpes) midimpunctata Ruan, Konstantinov & Yang, New Species (Figs. 98, 99) Etymology: This species is named after the pronotum with a narrow longitudinal impunctate area in middle. Specific epithet is a noun in apposition. Diagnosis: This species is close to C. concinnicollis, C. modiglianii and C. ingenua. It can be easily differentiated from these three species by the punctation of the peri-scutellar area (four confused rows of punctures) and the shape of aedeagus. It also resembles C. westwoodi and can be differentiated by the shorter antennae and smaller body size. Distribution: China, Vietnam, Thailand, India, Sri Lanka. Host plants: Unknown. Description: Body length 2.00– 2.30 mm, body width 1.10–1.23 mm. Ratio of elytron length (along suture) to width (maximum): 2.45–2.50. Ratio of pronotum width (at base) to length: 1.70–1.75. Ratio of length of elytron to length of pronotum (along middle): 3.00–3.05. Ratio of width of elytra at base to width of pronotum at base (in middle of humeral calli): 1.15–1.20. Ratio of maximum width of elytra to maximum width of pronotum: 1.50–1.55. Color of dorsum variable, commonly bronzy to bronzy brown. Antennae obviously short, just reaching humeral callus. Antennomere 1 yellow, 2–5 partially brown, 6–11 brown, distal antennomeres progressively darkened towards apex. Color of leg slightly variable; generally, anterior and middle legs light brown to pale yellow, metafemora brown to pale yellow. Head hypognathous. Frontal ridge narrow and flat, with numerous closely placed punctures. Frontolateral sulcus absent. Suprafrontal sulcus present, shallow. Ratio of width of frontal ridge to width of antennal socket (counting surrounding ridges): 1.90–2.00. Frons evenly covered with large, closely placed punctures. Vertex flat, situated on same level as orbit. Surface of vertex densely and evenly covered with punctures (about more than 200 punctures), some specimens (e.g. those from Ceylon) with a narrow longitudinal impunctate area in middle. Base of pronotum without short longitudinal impressions. Deep row of large punctures at base of pronotum absent. Pronotal base only slightly convex. Area adjacent to mid basal margin of pronotum covered with punctures. Pronotum without shallow antebasal transverse impression. Lateral margins of pronotum convex, strongly converging forward. Anterolateral prothoracic callosity poorly developed, truncate, facing anterolaterally. Posterolateral prothoracic callosity poorly developed. Diameter of pronotal punctures slightly larger than distance between them. An impunctate area present in middle of pronotum. Elytra with convex lateral sides. Elytral punctures in peri-scutellar area arranged in 4 confused rows. Remaining rows of elytral punctures regular. Humeral callus well developed. First male protarsomeres as large as those in females. Large lateral denticle on metatibia obtuse. Metatibial serration absent. Apex of aedeagus in ventral view narrowing abruptly. Ventral longitudinal groove wide in apical half, narrowing towards basal opening. Apical denticle of aedeagus in ventral view well differentiated, short, apex truncate. Apical denticle of aedeagus in lateral view straight. Minute transverse wrinkles on basal part of ventral side of aedeagus absent. Aedeagus in lateral view evenly and strongly curved. Spermatheca wih pump much shorter than receptacle, with apex flattened. Spermathecal receptacle sinuate. Maximum width of receptacle situated at apex. Apex of vaginal palpus rounded. Vaginal palpus more or less parallel-sided. Anterior sclerotization of vaginal palpus slightly narrowed anteriorly. Posterior sclerotization longer than wide. Posterior sclerotization wider than anterior. Variability. Color vary from bronzy, bronzy blue, coppery to bronzy brown. Several specimens from Hainan Is., China are with pale yellow appendages and extremely weakly sclerotized aedeagus. Types: Holotype: ♀ (USNM), labels: 1) Ceylon, Anu. Dist. Padaviya, 180m, 2–8.XI.1970, O. S. Flint; 2) Chaetocnema (Chaetocnema) singala det. G. Scherer, 1978; 3) Holotype C haetocnema midimpunctata sp. nov. des. Ruan, Konstantinov & Yang, 2016. Paratypes: 1 (IZCAS): 1) China, Hainan, Jian–feng–ling, 750m IZCAS; 2) 1980.III.28 under lamp, Leg. Shuyong Wang; 3) Chaetocnema concinnicollis det. Shuyong Wang; 4) Paratype; 5) paratypes C haetocnema midimpunctata sp. nov. des. Ruan et al., 2017. 11 (IZCAS): 1) China, Hianan, South China Tropical Agricultural University, 150m, 19.50°N, 109.47°E, 2007.V.16 Deyan Ge, IZCAS; 2) PARATYPE; 3) paratypes C haetocnema midimpunctata sp. nov. des. Ruan et al., 2017. 1♀ 1♂ (IZCAS): 1) Vietnam, Tonkin Hoa–bin, leg. A. de cooman; 2) Paratype; 3) Chaetocnema concinnicollis scutellaris sp. nov. Chen; 4) Paratype; 5) paratypes C haetocnema midimpunctata sp. nov. des. Ruan et al., 2017. 1♀ (USNM), Thailand, Khon Kaen, Im Zoo, ad lucem, 26.I.1978, Sunanta Aumphansirl leg.; 2) Paratype; 3) C haetocnema midimpunctata sp. nov. des. Ruan, Konstantinov & Yang, 2016. 1♂ (BMNH) labels: 1) India, Mungpha?? Alkinn... Coll. 92–3; 2) Paratype; 3) C haetocnema midimpunctata sp. nov. des. Ruan, Konstantinov & Yang. 1♂ (USNM), labels: 1) Ceylon, Anu. Dist. Padaviya, 180m, 2–8.XI.1970, O. S. Flint; 2) Chaetocnema (Chaetocnema) singala det. G. Scherer, 1978; 3) Paratype; 4) C haetocnema midimpunctata sp. nov. des. Ruan, Konstantinov & Yang, 2016.Published as part of Ruan, Yongying, Yang, Xingke, Konstantinov, Alexander S., Prathapan, Kaniyarikkal D. & Zhang, Mengna, 2019, Revision of the Oriental Chaetocnema species (Coleoptera, Chrysomelidae, Galerucinae, Alticini), pp. 1-206 in Zootaxa 4699 (1) on pages 170-172, DOI: 10.11646/zootaxa.4699.1.1, http://zenodo.org/record/354303
Paradoxical effect of mexiletine treatment in lqt3: In vitro and in silico analysis.
No full textPARADOXICAL EFFECT OF MEXILETINE TREATMENT IN LQT3:
IN VITRO AND IN SILICO ANALYSIS
INTRODUCTION
Sodium channel blockers are used as gene-specific treatment in Long-QT syndrome type 3 (LQT3) that is caused by mutations in the sodium channel gene (SCN5A). Response to treatment varies based on mutation characters. The aim of this study is to investigate the unexpected deleterious effect of the sodium channel blocker mexiletine observed in a LQT3 patient with F1473S mutation: after the treatment, corrected QT interval increased and the patient experienced more torsade de points.
METHODS
Genetic analysis of the patient was performed [1]. The SCN5A mutation F1473S was expressed in human embryonic kidney (HEK293) cells [2] and membrane currents were measured using whole-cell patch clamp procedures at room temperature. The effect of 48 h incubation with 10 μM mexiletine were tested.
Consequences of the biophysical properties of the mutation on action potential were investigated in silico. A Markovian model of the Na+ channel (see [3] for details) was implemented. Parameters defining transition rates, which are functions of the membrane potential (Vm), were identified in order to fit data from experimental registrations. This Markovian description replaced the sodium current Hodgin-Huxley formulation in an action potential model of human ventricular myocyte [4, 5], in which all the membrane currents are described by ordinary differential equations. The effects of mutation and of mexiletine treatment were analyzed.
RESULTS AND DISCUSSION
In comparison with wild-type (WT), mutation expressed in HEK293 cells presented rightward shift of steady-state inactivation, enlarged window current and huge sustained sodium current. Unexpectedly, however, it also reduced the peak sodium current by 80%: immunostaining showed that clusters of Na+ channel were retained in the cytoplasm. Incubation with 10 μM mexiletine rescued the trafficking defect of F1473S, causing a significant increase in peak current, as rescue effect overwhelmed the block effect.
On the contrary, sustained current was unchanged since rescued trafficking simply offset the block effect. Simulation results showed that exposure of F1473S to mexiletine increases action potential duration (APD) over a wide range of pacing frequencies. At fast rates adaptation of APD is impaired resulting in capture failure. In silico analysis pointed out that the detrimental effect of mexiletine is mainly due to the window current, which is very large in mutant channels and further increased by the drug.
Sodium channel blockers may be deleterious in selected SCN5A mutations. Clinical phenotype is not enough for predicting mutation character and response to sodium channel blockers, in vitro and in silico analysis may help to choose the proper treatment.
REFERENCES
[1] Napolitano C. et al., JAMA 2005; 294:2975-2980.
[2] Ruan Y. et al., Circulation 2007; 116:1137-1144.
[3] Grandi E. et al., Biophys J 2007; 93:3835-3847.
[4] Ten Tusscher K. H. et al., Am J Physiol Heart Circ Physiol 2006; 291(3):H1088-H1100.
[5] Severi S. et al., Phil Trans 2009; 367:2203-2223
Singular symplectic flops and Ruan cohomology
No full textAbstractIn this paper, we study the symplectic geometry of singular conifolds of the finite group quotient Wr={(x,y,z,t)∣xy−z2r+t2=0}/μr(a,−a,1,0),r≥1, which we call orbi-conifolds. The related orbifold symplectic conifold transition and orbifold symplectic flops are constructed. Let X and Y be two symplectic orbifolds connected by such a flop. We study orbifold Gromov–Witten invariants of exceptional classes on X and Y and show that they have isomorphic Ruan cohomologies. Hence, we verify a conjecture of Ruan
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