9 research outputs found
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
No full textTo newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause
Recommended from our members
Author Correction: FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions
No full textAuthor Correction: FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions
No full textCorrection to: Naturehttps://doi.org/10.1038/s41586-024-07770-w Published online 31 July 2024 In the version of the article initially published, we omitted to include in the Methods section entitled “Electron microscopy and image processing” the method for the purification of untagged D2–I protein for cryoEM. The HTML and PDF versions of the article have now been updated
Epidemiology of Fungal Infections in Hematological Malignancies in Italy: SEIFEM-2004 Study ( Sorveglianza Epidemiologica Infezioni Fungine Nelle Emopatie Maligne)
No full textThe epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.
No full textBackground and Objectives. The aim of this study was to evaluate the incidence and
outcome of invasive fungal infections (IFI) in patients with hematologic malignancies.
Design and Methods. This was a retrospective cohort study of patients admitted
between 1999 and 2003 to 18 hematology wards in Italy. Each participating center
provided information on all patients with newly diagnosed hematologic malignancies
admitted during the survery period and on all episodes of IFI experienced by these
patients.
Results. The cohort was formed of 11,802 patients with hematologic malignacies:
acute leukemia (myeloid 3012, lymphoid 1173), chronic leukemia (myeloid 596, lymphoid
1104), lymphoma (Hodgkin’s 844, non-Hodgkin’s 3457), or multiple myeloma
(1616). There were 538 proven or probable IFI (4.6%); 373 (69%) occurred in
patients with acute myeloid leukemia. Over half (346/538) were caused by molds
(2.9%), in most cases Aspergillus spp. (310/346). The 192 yeast infections (1.6%)
included 175 cases of candidemia. Overall and IFI-attributable mortality rates were
2% (209/11802) and 39% (209/538), respectively. The highest IFI-attributable mortality
rates were associated with zygomycosis (64%) followed by fusariosis (53%),
aspergillosis (42%), and candidemia (33%).
Interpretation and Conclusions. Patients with hematologic malignancies are currently
at higher risk of IFI caused by molds than by yeasts, and the incidence of IFI is
highest among patients with acute myeloid leukemia. Aspergillus spp are still the
most common pathogens, followed by Candida spp. Other agents are rare. The attributable
mortality rate for aspergillosis has dropped from 60-70% to approximately
40%. Candidemia-related mortality remains within the 30-40% range reported in literature
although the incidence has decreased
Inflamação das vias aéreas e envolvimento pulmonar intersticial na esclerose sistêmica: associação com alterações esofágicas e microaspiração
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2012INTRODUCAO: O envolvimento pulmonar na Esclerose Sistemica (ES) tem sido associado com refluxo gastroesofagico (RGE) causado por dismotilidade esofagica e microaspiracao. Entretanto, a microaspiracao ainda nao foi objetivamente demonstrada. Nos objetivamos demonstrar, em pacientes com ES, a ocorrencia de microaspiracao e investigar sua associacao com o envolvimento intersticial pulmonar e das vias aereas e as anormalidades esofagicas. METODOS: Quarenta e sete pacientes com ES e 38 controles pareados por idade foram incluidos no estudo. Todos foram submetidos a inducao do escarro, espirometria e teste de broncoprovocacao com metacolina. Os pacientes tambem realizaram pletismografia e tomografia de torax de alta resolucao (TCAR), a qual foi analisada de acordo com um escore tomografico (Indice Tomografico, IT), monitoramento do pH esofagico de 24 horas e esofagomanometria. O indice lipidico de macrofagos (ILM) no escarro induzido foi usado como metodo para aferir a microaspiracao. RESULTADOS: O grupo dos pacientes constituiu-se de 91,5% de mulheres, com idade media (DP) de 49,3 (11,8) anos e media (DP) de duracao de doenca de 8,1(7,4) anos, 68,1% deles com a forma limitada da doenca. Anormalidades manometricas esofagicas foram encontradas em 78,7% dos pacientes e 70,2% deles tinha RGE patologico. Cinquenta e um por cento dos casos apresentava envolvimento pulmonar intersticial (IT . 3) e alteracoes a espirometria ocorreram em 48,9% deles (23,4% com defeito restritivo e 21,3% com defeito obstrutivo leve). Os niveis de DLCO (corrigidos pelo volume alveolar, DLCO/VA) estavam reduzidos em 44,6% dos casos. Microaspiracao (ILM . 7) foi encontrada em 93,6% dos pacientes, sendo que 42,6% deles tinham microaspiracao considerada significativa (ILM . 50). Os pacientes apresentaram contagem celular total (CT) (p=0,007), contagem de neutrofilos (pAbstract : INTRODUCTION: Pulmonary involvement has been associated with gastroesophageal reflux (GER) caused by esophageal dysmotility and probably microaspiration in patients with systemic sclerosis (SSc). However, microaspiration was not objectively demonstrated. We aimed to demonstrate the occurrence of microaspiration and to investigate its association with airways and pulmonary interstitial involvement and with esophageal abnormalities in SSc patients. METHODS: We enrolled 47 SSc patients and 38 controls matched by age. They performed sputum induction, spirometry and methacholine bronchial provocation test. Patients also performed plethysmography, chest high resolution computed tomography (HRCT), scored according to a tomographic index (TIx), esophageal 24 hour pH monitoring and esophageal manometry. Lipid laden alveolar macrophage index (LLAM) in induced sputum was used to measure microaspiration. RESULTS: Patients were 91,5% women, with mean (SD) age of 49,3 (11,8) years and mean disease duration of 8,1(7,4) years, 61,8% of them with limited disease subset. Esophageal manometry abnormalities were found in 78,7% of the patients and 70,2% of them had pathological GER. Fifty one percent of the cases presented with interstitial lesions on HRCT (TIx . 3) and 44,6% of them had spirometric abnormalities (23,4% with restrictive defect and 21,3% with mild obstructive defect). DLCO (corrected by alveolar volume, DLCO/VA) levels were reduced in 48,9 % of the patients. Microaspiration (LLAM . 7) was found in 93,6% of the patients and in 42,6% % of them it was considered severe (LLAM . 50). Patients had higher sputum total cell (TCC) (p=0,007), neutrophil (p< 0,001) and eosinophil counts (p=0,008) than controls. There was a positive correlation between LLAM and neutrophil count (r=0,30, p=0,04) and between LLAM and TCC (r=0,37, p=0,006). Mean DLCO/VA was was negatively correlated with LLAM (r=0,33, p=0,02) and tended to be lower in patients with manometry abnormalities and/or moderate to severe GER (severe esophageal involvement, p=0,05). Those patients with severe esophageal involvement had higher TIx (p=0,03). Neutrophils were higher in patients with HRCT lesions (p=0,04), but no association was found between LLAM and TIx. About one third (27,7%)of the patients had airway hyperresponsiveness, compared with none of the controls (p<0,0001), which was not associated with any other clinical or functional characteristics. CONCLUSION: In SSc patients, microaspiration and airways inflammation were both frequent and were associated with each other. Microaspiration was also associated with esophageal abnormalities and abnormal pulmonary function. Patients with HRCT lesions had more frequently an airways inflammatory pattern. These results demonstrate an association between microaspiration and lung involvement in SSc
Magrath Store News (April 24, 1969)
No full textAn archive of the Magrath Trading Store News.The University of Lethbridge Library received permission from the Wes Balderson to digitize and display this content.4
HiOJBS; OFFICE 758-3033 GROCERIES 758-3535 DRY GOODS 758-3252 HARDWARE 758-3065
STOxE HOURS:! ITWiY. TUESDaY, THURSDAY AND FRIDAY ...................... *......................8 A.M. to-6 P.M.
u L/SD'iY ,[t.e„.8 A.M. to 1 P*M....................SATURDAY............. .8 A.M. to 7 P.M.
THURSDAY,, APRIL 2L+ h, 1%9 □........................................................... MAGRATH, ALBERTA.
FOaM
;
A good time to replenish your Bedding
Needs or purchase for coming Wedding«, et«.
Lovely new leathern•<!ike Mallow Plastic
Handbags in becoming new styles for Spring
Navy, Black, Bone,
White o.,,. r. - „ c,, „
PILLOWSLIPS
Attractively embroidered Pillow Slips,
nicely gift packed.
Per Pair ... 2^ & 3^
SHEETS
Tex-made and Wabasso Cotton Sheets inelud*
ing "Truprest" percale cotton- -
Full Size ........... 495 t. AyK)
o » c o n &
blLU
1 group cf Handbag,.'
REGULAR 5.95
"DISH.TOWE LS
limited quantity of Cotton
Dish Towels, Screen A _
prjjht desighs. or
............................ .
MAGRATH TRADING COMPANY LTD.
BABY DRESSES
and Dacrons,
and ribbon.
Pretty little Baby Dresses in Nylons, Terylenes
Beautifully trimmed with lace, embroidery, eyelet
White, Yellow, Blue, Pink, 325 to 495
PLAY OR SLEEP SETS; Wonderfully washable STRETCHY TERRY.
FANCI PANTS Nylon over plastic Panties in styles for both
boys and girls. Girls have ruffled back. Boys have little fly
front. Pink, White, Blue,
PRE FOLDED DIAPERS; Permanently folded. Saves work and time,
bLRTL..6Z5.'?????:..
TURTLE NECKS
Gold, White, short
sleeveSo So
Green, Blueo Stretch Nylon,
450^095
K___________________________ _________
Fine knits in Stripes- Long and short sleeves.
Navy, Coral, Loden, Brown, Tan, "yoo & C^00
PRET PULLOVERS
GIRLS
Fine Combed Cotton in long styles0 Assorted
stripesj Plain colored T shirts with crew or
turtle neck. Nice Spring Colors0 |98.
SWEAT SHIRTS
light fleece lining, long sleeves, raglan sleeve,
Assorted colors ■#£ Gold, Blue, White,,
SIZES; S. M. L, .......... ..
LADIES SIZES
Lovely Dresses,.,.;.Milrdy! s'
Spring and Summer Wardrobe
fiie ensembles in one and
two piece creations in
crimp knits, polyester and
fortrels that are washable
,Arnel printed Jerseys and
bonded knits, printed
s.’.lks, Styles that are
sure to please - colors
that are the latest
SIZES; 7 to
Misses and Children's White Shoes in
slings and flats, little heels - leathers
and patents.
Fashion's latest in Pants, Wranglers in
What* Denim and Navy Denim. New flare
leg that is so popular
MEET3S SIZES
MAGRATH TRADING COMR,NY LTD,
MEN'S-BOYS'WEAR
lIHUhllHIHIIIIIIHMtltlllillHIIliinilllllliniilb.
D
BOYS’ G,W.G. PaNTS INCLUDING JEANS IN ASSORTED COLORS, ALSO JEANS .
WITH "THE WELDED KNEE - UP TO 7 TIMES MORE WEAR"
SEES: 2 to 16 395 ^)95
| CORDUROYS ’
j Corduroy Slims in Gold, Loden and Tan* Leather
I reinforced pockets, SIZES: 6 017*
I REGULAR 7,95»
Western Straw Hats AT A BIG REDUCTION,
^951
I
I WORK I
I SOX I
f Nylon, Nylon & 1
f Wool, Cotton & 1
1 Nylon Work Sox !
179M1-5O
sJIH )1 HUH Hl H IfllHKHIIIIIUIltlU
White with klack grain,
REGULAR 3,95 ..................................
HUSH PUPPIES: Loafers, Slip-Ons and Ties in
smooth Black Leather, Grained Brown Leather I I
and Tan Suede, 1 I
BOYS SHOE SALE
Black Leather Slip-Ons & Ties, I / O P R I P'P
SIZES: 1 - 6i . 6.95-29,95 .......... ..
NEW ARRBVALS
ACRILON KNIT JACKETS
"Monsanto" Knit Jackets with full zipper front, 2 way 1
co] Jar, Attractive Sherbit Green shade«, Nice casual
Jacket for Spring and Summer wearing,
SIZES: 34 - 40 ...... | 5
SEE THE NEW JEaTHER-LIKE YINIL WESTERN FRINGED JACKETS
AND VESTS. 29o95.
MAGRATH TRADING COMP/-,NY LTD.
Patients in the ifegrath Municipal Hospital during the past week included Mr. Geo. Loxton, Mr. Joe Alston, Miss Rosa Entz, Patricia Bowen, Mr. George Henry* Mrs. Ethel Braithwaite, Mrs. Florence Fortner, Mrs* Geneva Wood, Karen Blumel, Melonie Fredricks Rhonda Rae Hicken, Mhrvin Striped Wolf, Mrs. Gean Wheeler, Mrs. Annie Johns, Mrs* Sue Chin and Mrs. Louisa Bird,
THE*INK’SPOTS’”
Yes! the fabulous "Ink Spbts" Will appear in person in the Magrath Elementary Gym Saturday, Miy 19th at 8 P.M.
The Mbgrath lions Club has booked the Ink Spots &. Co. to entertain the citizens of Magrath and Southern Alberta and they request you keep this date open. Entertainment of this calibre is most difficult to book and they solicit your support in buying advance tickets which are for the reserved section from any member of the Lions Club... Doug Mikado, Dee Leishman, Blair Sabey, Jay Hamilton, L. B. Tanner, J, A, Ririe, S. M. Ririe, Fred Strate, Frank Sabey, Ralph Thompson, Warren Sparks, Elden Christensen, Vai Kay, Hall Poulsen, Svend Jensen, Charlie Matkin, Ken Balderson, Ted Haynes, Cal Alston. Reserved Seats — 1.00. For further information contact President Doug Mikado,
J *C.A.
Friday, April 18th at the Magrath Elementary School Gym, the Magrath Lions Clkb held their annual Talent Night. Lion Jay Hamilton arranged and directed the evening’s performances which provided for all who attended a very enjoyable evening.
Talent from Magrath, Wei ling, Del Bonita Spring Coulee and Raymond was represented.
Thanks for the efforts of the teachers and parents who are so instrumental in guiding these youngsters, and thanks to all who attended to make the evening a success.
Magrath lions Club, Doug Mikado, Pres.
MAGRaTH PaRK THEATRE NEWS; Friday and Saturday, April 25th and 26th"DEVILS BRIGADE" — an ADULT movie in color starring William Holden, Vince Edwards, Cliff Robertson. Running Time — 140 minutes, Please Note: Children under 16 years of age must be accompanied by a parent to attend an Adult picture. Saturday matinee - April 26th at 1 P.M. "TOM THUMB" - a fawn 1y picture in color. All seats 500. Watch for T.V. advertising.
Mr. and Mrs, Darrell Passey and family of Calgary visited in Migrath recently with Mr. Glen Nate, Mr. and Mrs. Bill Ririe and Mr. and Mrs. Collin Fhssey,
NOTICE: The official installation of the new C.W»L. Executive will take place in the tfegrath Catholic Church Monday evening, April 28th at the 7s3O Ifess. The Sisters will show a film on Peru. Following the film there will be a social evening in the Lions Club Rooms. Lunch will be served.
WANTED; Boy - 16 years old and over preferred, to work after school, on Saturdays and during holidays. Hardware Dept.
FOR SALE: Rodney Seed Oats (2*4 lbs. per bushel) also Palliser Barley. Cy Card.
ALFALFA SEED - "Ladac" — 247.95 ......................
^IIUIII11 IltUlUtmillltl Hill It Hill III HI IHtll IU11 II I H(l UUtUHlI 111 in 11 lllil IIHBIUI11 til ll IHII11111
i AROUND THE WORLD WITH KELVIN-
| ATOR — Win a FREE trip for two
| to anywhere in the World that
: Air Canada flies0 Just fill in
j the coupon back and state your
1 wish® Deposit the coupon in
| the Kelvinator Contest Box.
LniHHimiinHUUUmtmUIHIinUHIIlUUlUIHUHHlIUinillllHIlUIHHUIIUlUIHHIIllHUUlll
SAVE 7000 REFRIGERATOR
Kelvinator "No Frost" 2 Door .REFRIGERATOR - FREEZER
with 102 lbe Freezer with flowing cold - stores fobd in
"zero zone’-1 temperatures. Flowing cold continually
circulates moist air at a constant temperature to keep .
food from drying out in Refrigerator. Deluxe steel wire
shelving with decorator trim. Easy*to-adjust temperature
control, Molded egg rack in door. Full width crisper with
lifetime porcelain finish.
REGULAR 399.95 ...................... ..
FLYER SPECIALS END THIS SATURDAY. DON'T MISSAN
OPPORTUNITY TO SAVE.
GARDEN TILLERS |
M.T.D. Garden Tillers with Briggs & Strat- I
ton motor. Extra heavy gear case, Forward, f
neutral and reverse. 16 heat treated, self 1
sharpening tines.
32 HePo no.......
LAWN MOWERS
1 ONLY Demonstrator Electric lawn Mower -
Ladies will love this model - no starter
to pull, no gas to pour, just plug it in
and switch it on. Swing-over handle. 18"
steel deck - 1£ h,pB 2450 r.p.m» motor.
Single blade. Will take grass catcher.
°® seecul 3888
LINK-TONE PAINTS FOR INSIDE =^OUT
EXTERIOR LATEX
5 hoPo ..........
13995
19995
EXTERIOR GLOSS - Regular 2.75 qt.
Regular 275 qU ¿q
Regular 8.95 gal» ß*0®
Reg. 7»95 gal.... 595
46374003081
LOOK FARMERS
11 piece COMBINATION WRENCH SET - box &
open end wrenches in plastic roll. Wrench
size 3/8" to 1". 1^88
MANY, MANY more worthwhile savings are
YOURS FOR THE SHOPPING.
Il l»HIJ111*11111 HI lllllll H IHltllBII IIIIIIH1IU1I11 IHltlllllll H1< H IHHIUlIl IIIIIIIH111 llllllHlllHUlll 11II Ull IIHIHIIIIHIHIHII
=1 FUN THINGS I
CASSETTE PORTABLE TAPE RECORDER - has i
sarrying i
388« f
remote control microphone with carrying
I strap, complete with batteries, '
| SAVE 49.95. ’------
I TRANSISTOR RADIO ShLE - Lloyds 8, in ' '
? leather case , . r......... o » •i
MAGRATH A, <ADING COMP/ .NY LTD.
PURSUE EXCELLENCE
"Most young people have strong-desires. They are not content to live a mere misceli.
lany, however pleasurable it may be. They dream beyond the actual and think beyond their
finger-tips. In doing so they are living up to the great Law of culture, that a man
should become all that he is created capable of being. •
Think of the example of Pablo Casals, the snail town boy who became world famous .
as a musician. At fouh he sang Gregorian chants in the parish church, at six he studied
the piano and the organ and wrote music, at seven he began to study the violin, at eleven
he took up the cello...«and so on, step by step, until at ninety, just a few months ago,
he conducted performances cf three major symphonies, the recordings of which are giving
world-wide pleasure,"' ; ...
The Magrath Lions Club held it's annual Talent Night in the Elementary School Gym
Friday evening. Telent was presented from Magrath, Del Bonita, Raymond, Welling and .
Spring Coulee, Lion Jay, Hamilton arranged and directed the evening which included the-following:
School Chorus - di rected by Jill Harker and accompanied by Inez Gibb - Grade
VI - "Merry Life"; Grade V - "Walking Song" and "Rabbit’s Duet"; Grade VI - "Happy Wand-- -
erer" and "Pop Com Popping". Dance Numbers were presented by Joanne Ririe, Loma Scott,
Cindy Rice and Nola Dahl;, Ireta Dahl; Janice Gurney; Vocal Trio’s - Brent Lowrey, Oliver-7
Bell and Barry Gorham; Carolyn Ririe, Nola Dahl and June Anderson7- Quartet Number - A t
Debbie and Mona Karren, D’Arcy Fletcher and Denise Hami ~lton, Instrumental Numbers — Rin«
Mucciarone --Accordian Solo; Byme Brewerton - Violin Solo, Piano Sclos by Roberta Bao*
rnn/cen,"Barcarolle"; Joanne Passey "The Curious Story";,"Rennaye Farries "Black Hawk
Waltz"; Shannon Farries rtCuckoo Waltz"; Linda Carter "Piano Waltz"; Carol Wheeler "Spark—'
lets". Vocal Solos: Vivian-Anderson "Whiskers"; Vicki -Bohnet "l^r Favorite Things”; Sharon
Sam - Medeley-’f roin "Mary Poppins",' Linda Carter accompanied by Melvin Mbh; Family .Group ■
Numbers were presented by the Dave Lowry family; The Ruby Fletcher Family and the. Tpe • ■ •
Keeler Family, Elocution Numbers - Carolyn Ririe "Skipping Song" and Denise Hamilton, — ’ - .
"The Ballad of Dennis McCinty". The Big Band performed for the first time, members of , „ ■
which are — Debbie Karren (Alto Sax), Burns Alston (Clarinet), Donald Hamilton (Tenor Sax),
Allan Dahl (Trumpet), Devar Dahl (Trombone), Christine Harker (Piano), and Kirn Taylor
(Drums). . ' . , . . ..
S-'u-lenl.-. performing in the various'events were instructed by’the following teachers:
Elocution - Mrs. Ifery 1, Hohm; Vocal - Mrs, G, Andersen, Mrs. Jill Harker, Mrs, Owen Dell,
Mrs. Anne Campbell/ Dance - Miss Janice Gurney, Mrs. M. Jnl 1 i ffe, Piano - Mrs.: M, Thomson
Miss Carol Wheeler, Mrs. Carol Lowry, Mrs. Charlotte Fletcher and Mrs. Swansdun, "
A'former^Magrath resident, Mrs. Emma. Bertha Arndt, wife of the late William Arndt,
passed away Sunday, April 20th-at the age of 97 years. '
Born in the United States, the late Mrs. Arndt came to Magrath in 1908 .where she
resided until'a number of years ago when she took up residence in Lethbridge-, .
Predeceased by a son Ralph in January of this year, she is survived by .three sons
Harrey of Olds, Turo of Cardston, Hugo cf Mirror; two daughters Mrs. Edna AlloWay of '.
Edmonton, Mrs. norothy B'ennett of Lethbridge; sixteen grandchildren and forty great grandchildren;
one sister'Mrs. Clara Hall of South Dakota and one brother Hugo Hillmer of
Raymond. '? .
Funeral serviced were'held Thursday afternoon in the St _ John,’s. Lutheran Church,
Magrath with Rev. L. -Dressier officiating. Interment followed in the family plot of the
Nhgrath cemetery, .
A lively April' Wedding took place in Cardston: when Alice Woodruff, daughter of ^r,
and Mrs, Lloyd D. Woodruff'of ’ Grassy’Lake became the bride of Martin Clemens, son of Mr,
and Mrs. W. Clemens ¿'f• Seattle, . ’
Between the wedding and reception, the bridal party attended a buffet dinner at the
home of Mr. and Mrs. Dan Atwood in Mhgrath. Mrs. Atwood was assisted by her sisters Mrs,
Douglas Bly and’Mrs. Robert Rasmussen with other family -members helping with kitchen
preparations, -About ¿0 guests were served by cousins of the bride — Roberta Rasmussen,
Deedan Atwood, Sherylin Atwood and Lorna Scott. . . .......
Alice Woodruff is the grand-daughter of Mr. and Mrs. J. Rasmussen.
• ■
In a crowded cemetery beside the cathedral in Dromo-re, -Northern Ireland, is a monument
to Bishop Jeremy Taylor, author of Holy Living, one of the- great.churchmen in history.
He was.imprisoned half'A’dozen, times and persecuted often. He'wrote, full of
experience,' "No man is more miserable than he that hath'no adversity.......... Softness is for
slaves and beqsts, for minstrels and useless persons. • •
MAGRATH TRADING COMR .NY LTD.
LOST; Man’s dark green Jacket with spot of
light green paint on back. Lost between
home and town. Finder please contact
Ed Clifton.
NOTICE; The Del Bonita Brownies and ffuides
will conduct a Bottle and Rag Drive in the
Del Bonita area Saturday afternoon, Nhy 5th.
Please give the girls your support in this
endeavour.
NOTICE: Wi 1 ~l the person who borrowed a Log
Chain from my shed without asking, return
it. Frank W. Brown
NOTICE; The Women's Hospital Auxiliary will
hold it's annual Florence Nightingale Tea
and Bake Sale Saturday, May 10th. Contributions
for the event, to be held in the Lions
Hall, will be ranch appreciated.
NOTICE; The United Church Ladies Aid will
hold it’s regular meeting Tuesday, April
29th at 2:30 P.M. at the home of Mrs. Dan
Mai.
TO GIVE AiaiaY; One white male kitten, 5
weeks old. Brian -^arick. Ph. 758-3152.
FREE FOR THE DIGGING: Beautiful Van Houttei
Spirea (Bridal Wreath). One large bush will
make several small ones.
Bill & Myrtle Passey.
FOR SALE: Small Ford Compact. Fair shape.
Ph. 758-3203
FARMERS - ATTENTION: All Risk Crop Insurance
contracts must be signed by April 30th. In
Magrath on Fridays er phone 328-6821.
Alan Rains.
NOTICE: Anyone wanting Saturday help please
phone 758-6646*
NOTICE: All married women interested in
playing soft ball please contact Marge Arndt
phone 758-3121* A meeting will be held at
the Arndt home Monday evening April 28th at
8 P.M. for all those interested,
BROWNIE & GUIDE COOKIE SALE — the annual
Brownie and Guide Cookie Sale will be held
Saturday, May 3rd. Spring Coulee residents
wishing cookies please contact Arlene
Gruninger - 758-66J2,- Helen Long 758-6644
or Mfery Bevers 758-6636.
THANK YOU: We are very grateful to everyone
who donated food to our pantry sale and
patronized our Spring Tea on April 5th.
Sincerely. The Del Bonita United Church
Ladies Aid - Helen M, Newton, Secretary.
THANK YOU; I would like to express my
sincere thanks to the Doctors, Nurse» and
Staff vf the Magrath Hospital for the
wonderful care I received while I was a
patient. Also thanks to my many friends who
so. kindly came to visit me, -cent flowers,
cards and gifts* Mitsi Takahashi.
Anyone can condemn sin, but someone must
forgive the sinner, as did He.
MAGRATH ÌADING COMP, .NY LTD.
s
I W V?.
| B IIbR 1 K JmL /À
PINEAPPLE JUICE
DOLES • o o a • o z « 2/790 :
I POTATO CHIPS
:
NALLEYS TRI PACK
TOOTH PASTE
CREST Family Size 9901
D
GRAPEFRUIT JUICE I
YORK .,,.48 oz 4901
WAX BEANS
aYLMER 14 ftz 4/890)
I 12 oz»
- BURNS ,12 oz.
- YORK
- 1# pkg
- STRaWBERRY & RHUBARB 48 oz
SCOPE
9901
17 oz
ea
A
(C
Presh Produce
LETTUCE .Grispheads... c lb. 270
ORANGES - 7# bags o 990
TOMATOES - Ripe o lb. 290
PARSN I PS - O 3 ft ft ft ft o ft n o lb. 29
Magrath Store News (May 6, 1955)
No full textAn archive of the Magrath Trading Store News.The University of Lethbridge Library received permission from the Wes Balderson to digitize and display this content.PHONES-OFFICE 21-HARDWARE 34-DRY GOODS 124
Groceries 4
Friday May 6th./55
98d
Nylons
"MOTHER'S DAY MAY
Purses
Cosmeti cs
honor MOM with some
are some worthwhile
DACRON SLIP* - laee trim,
34 & 42................... 3.98
"SUNDAY MAY STH".‘IS MOTHER'S
DAY...the day on which you will
appreciative little gift. Above
GIFT SUGGESTIONS-Gloves
NYLON. GLOVES IN ASSORTED COLORS............................. 1.19
KID GLOVES IN Brown, Black & Navy........................ 3.95
WASHABLE SUEDED MATEZA GLOVES.......................................... 95^
Scarves
SILK CHIFFON •• Turquoise with painted designs.
NYLON SCARVES - Plain colors
NYWN SCARVES — Printed.
Hankies
BY THE BOX....................................
SEPERATE AND EMBROIDERED
QUILTED PLASTIC TABLE COVE
Red, Green or Blue NYLONS ~ Real dressy.
Neutral shade. Can be
worn with any col»r.3.49
*<•**•••■*■
HAVE A NICE ASSORTIMENT
OF PURSES IN PLAST:
AND LEATHER
NYLON FANCI STRETCHIE
PANTS...........................1.55
PINK MIST COLOGNE
with atomizer..1.35
CASHMERE BOQUET PERFUME
................. SOtf
EVENING IN PARIS PERFUME
................65^
1
■ " ------ --* -
Pearl (Ehlert) Irving of Salt Lake
City is 7isiting her parents, Mr. & Mrs.
Emil Ehlert. When home Pearl is employed
at the Hotel Utah. Cashier and Food Checker
Pearl worked at the Trading Co. Lunch
counter for six months."It
This is the year the
Men à Boy's are in
the Pi nk.__________
was all new to me then.I
could manage it now",she
Shirts says
"BRILL” DRESS SHIRTS
Pink & Charcoal..4.95
"LAMPRON PLAIN PINK
BROADCLOTH.....,3.50
RAYON WESTERN- Pink &
Charcoal................03.50
Ti es
Students home from the
University for the summei
are; Campbell Spencer,
Ann Toomer, Claire Nortor
Jolayne Thomson,Shirley
Gorham,Evelyn Loose and
Maureen Brown.
SOME ONE LEFT SOME
STAMPS ON THE LUNCH
COUNTER ON TUESDAY NIGHT.
WE HAVE .a GOOD ASSORTMEA
OF CHURCH BOOKS NOW IN
STOCK.
I PINK & CHARCOAL TIES
................... 1.50 BIG BEN WORK SHIRTS
..............11.95
DON’T FORGET THE REGULAR SATURDAY NIGHT
DANCE. ORCHESTRA.
Caff Links
FORSYTH PINK AND CHARCOAL CUFF LINKS..............4.50
WATCH FOR FURTHER ANNOUNCEMENTS ABOUT
THE BALLET DEMONSTRATION IN THE STORE ON
MAY 28TH.
a e 'i o o c o - ■* i e e
OoOaoeo'iOotfO
You rive your thoughts so be careful
what they are. • » O > » •
• • • * ■ • • • •
SHOP AT HOME AND SAVE.
Mr. 2. Mrs. Don Bennett of Edmonton
have returned home for the summer.
WE WILL HAVE A SUPPLY OF FLOWERS AND
PLANTS FOR "MOTHER’S DAY".
Seeks
PINK STRETCHIE SOX
................... 1.50
AT THE PARK THEATRE —
"THE AMERICANO" with Glen Ford.
May 6th. & 7th.
Fri. & Satl.
"CITY THAT NEVER SLEEPS" Mon. & Tues. May
9th. & 10th.
"ARENA" with Gig Young and Jean Hagen.Also
"COUNT THE HOURS. Wed. I Thurs.May 11th.&
12th.
Mrs. Lamar Ashton of New Brunswick is
visiting Jaer parents Nr. 1 Mrs.
I Teacher: "With the
single stroke of his brush, the painter
could change a smiling face to a frow nin ?
one."
Small Boy:°That’s nothing - so can my
mother.
Mr. & Mrs. Jim Sabey of Milk River
visited relatives in town this week.
KIDDIES RUBBER BOOTS
SIZES 8 to 11 ........................................4.50
SEE OUR DRESS SHOES FOR MEN. OXFORDS AND
SPORT STYLES.
I:::::::::::
FLOWERS FOR MOTHER’S DAY -------
WILL THE PERSON WHO TOOK THE JACK FROM UNDER MY LEVELLER PLEASE RETURN AND AVOID FURTHER TROUBLE, - Rulon Harker
The funeral of the late Myr^n Harker was held on Monday May 2nd. in the second Ward Chapel with Bishop Emerson Blumel officiating.
The opening prayer was given by Elder Bert Gibb. Selections by the choir were,- "Oh My Father11 with L.B.Tanner as soloist, "Sometime, Somewhere" with Mrs. Maude Ririe as organist and Orson Bridge as conductor. A duet by Mrs. Nonna Alctcn and Orson Bridg "The Old Rugged Cross". Three of Mr.Harkers nieces from Hillspring sang "King of Glory" Mr. Joe McClean of Raymond accompanied by Mrs. Emma Dahl rendered "Going Home". The closing prayer was by Elder George Thomson and the grave was dedicated by Eld.Clyde Spencer.
Pallbearers were nephews of the deceased j- Blaine, Douglas, Lee and Ted Harker and Kenneth and Clifford Miller.
Flowers were under the direction of the Relief Society. Interment was in the Magrath Cemetery.
THE HOSPITAL AUXILIARY MEETING WILL BE HELD IN THE HOSPITAL ON FRIDAY NIGHT AT 8 P.M.
The Newspapers report that the Eddingtoi Canning Co. of Springville, Utah, have contracted for 500 acres of corn at Medicine Hat. A factory later.
At Magrath only four men in the district have contracted for peas with the Alberta Canning Co.- Mike Schneyder,Louis Triscli, Frank Hufnagel.and Werner Meyers.
The Canadian Sugar Factory warned the Magrath Beet Growers that low crop yields of beets are not wanted. A 10 ton crop is required to pay expenses.
Smith Ackroyd trucked alfalfa hay
from Diamond City for his sheep (now lambing) Very little hay is grown in the district , At one time Magrath was known as the Garden City. To-day practically all our vegetables! are grown outside the district.
It looks like "Something rotten in Denmark."
WE HAVE EVERYTHING YOU NEED FOR THE BaBY. ROMPERS, NYLON DRESSES, BONNETS, BLANKETS, NYLON PANTEES, NAPKINS, PETTICOATS ETC.
IF YOU ARE PLANNING HOLIDAYS THIS YEAR aND DON’T KNOW WHAT TO DO WITH THE LITTLE TOTS|. GET IN TOUCH WITH MYRTLE PASSEY tlND TALK . THINGS OVER.
SEE THE DISPLAY OF FLOWERS FOR MOTHER’S I DAY. GET YOURS NOW WHILE THE SELECTION IS GOOD.
"My garden was such a success this year boasted a gentleman farmer,"that my neighbors chickens took first price at the poultry show.
WANTED TO BUY— 1 used International Crow foot packer for repairs.
Chas. Harker.
»a ooQ-JOOOaoOOoO
FOR SALE — Household articles including Kitchen table and four chairs, one large upholstered chair, home made book case & end table . Contact Mrs. Frank Cook.
OUND—Pocket knife found by Garry Hamilton. Owner may have it by calling up stairs.
o»0Baoaoaa<ia00a
o a b o b oooooaoece
FOR SALE— Blue Budgie Bird, stand and cagij
Friendly. 1.00 per bus.Home •after 6 p.m. - Waldon Gurney.
FOUND - A high school ring. See Ted in the Hardware department.
FOR SALE - 1939 Dodge. Motor completely 'overhauled. Will trade for grain.
Karl Keeler.
• flO000oao«>OOO0
FOR SALE— 1 pair charcoal colored suede casuals. Size Never been worn. Price 4.00 . Emma Lou Pricer Phone 248
aoaaooooaaaooo
WANTED — Some one to put a garden in my lot. Land is worked and ready to plant. No share basis. Just some one to put it in and keep the lot clean. Irene Strang.
LOST—Magrath 1st. Ward F’_lmary (LaRK
MkNUa.1’ Yellow. In Plastic bag. Return to Ruth Johnson.
TO RENT— Small home ideal for elderly couple
in Magrath. Phone R 309-Inez Benneti
♦ •»•♦•••••••J
of lela, ’Hanker on L’oôrz
honoring ll’.cd (Âwbæ
Tomlinson. Effie Bennett and
-.i -ne heme evening' w. th Merjorio Jean Sabey as hostesses. Those prosent were:June Harker,
Ina Blaxall, Shirley Karren, Margaret Sabey Dorothy Hamilton, Belle Harker, Hattie Harker, Lamar Ashton,Gwen Harker, Winnie Elhert, Elva Harker, Lillian Naylor,Esther Toomer, Melva Christensen, Karma Harker, Eva Marie Harker,Helen Perverziff, Doreen Alston, Iola Harker, Lillian Sabey,Gladys Sheer, Theta Sabey, Gen Sabey and Sheila Sabey. An enjoyable evening was spent and s a delicious lunch served by the hostesses.
1 Weather - Warmer. Strong wind blowing.I
I
Week' End Specials Fri-& Sat.May 6 &
Beef Roasts (SHOULDER) lb.420
Rolled Beef Roasts (MEATY).. .... lb. 590
Lamb leg Roasts
(LEAN & TASTY).. lb..590
I
Lamb Stew .
(LEAN RIBS).... lb.190
Pork Sausage-Meat
(SEASONED).... lb. 350
iI
I
Smoked Cod Fillet
.......lb.450
I
• ••••••• « « • •
A calling shower was held at the
home of Mrs. Mike Schneyder on Wednesday
afternoon in honor of her daughter Irene,
whose marriage to Mr. Alex Ponomarew takes
place this month.
Mrs. Shirley Neilson assisted in receiving
the guests and Miss Ruth Steele was
in charge of the guest book. Mrs. Sue Mikad<
arranged the gifts and Mrs. John Schneyder
and Mrs. Mike Schneyder Jr. were in charge
of refreshments. Irene received many lovely
gifts.
! BE SURE AND ATTEND THE FLC FENCE NIGHTINGALE
TEA BEING HELD AT THE HOSPITAL ON
.THURSDAY MAY 12 TH. AT 2 P.M. SILVER COLLECTION.
A nurse in a mental hospital noticed
a patient with his ear close to the wall,
listening intently. The patient held up a
finger as a warning to be quiet. Then he
beckoned the nurse over and said,"Listen
here.”
The nurse listened for some time and
then said,"I can’t hear anything."
"No," said the patient," and it's been
like that all day."
PANTRY SALE
DON’T FORGET THE PANTRY SALE BEING HELD
IN SHERBA’S CAFE ON SAT. MAY 5TH. AT 3
P.M.SHARP. BOXED CANDY FOR POTHER’S DAY,
MEAT PIES, SPUDNUTS, POPCORN, ANGEL FOOD
CAKES ETC.
This is for the benefit of the 1st.
Ward Relief Societies’ New Room.
TO-DAYS RECIPE— This may be a repeat but
it is so good that I’m sure you won't mind
trying it again.
SNOW WHITE CHOCOLATE ROLL
5 eggs_6 tbsp.cocoa6 tbsps. cake flour
£ teaspoon b. powder- 1 tsp. vanilla
y teasp.salt -j cup sugar
The egg whites are to be stiffly beaten &
the yolks until they ar thick and lemon
colored. Sift flour once and measure. Add
cocoa, Baking powder and salt and sift three
times. Fold 6Ugar in to, og^ ’b '.ies, a
small amount at-altime. Add egg yolks.Then
fold flour in gradually. Bake in paper lins I
pan on 4001 oven for ten minutes. Turn
out on cloth sprinkled with powdered sugar
Whip pint of cream. Spread on cake and
roll like jelly roll. Serve with chocolate
sauce or syrup.
11
FIG MRS LB. 290 MARTINS RAISINS 2 LB. PKG..390
I APPLE AND STRAWBERRY JAM.....670 CLOVER LEAF PILCHARDS 270
CREAM CORN o., 15 oz. tins. 3 for 470 DELTA RICE .... Short grain.2#pkg.370
JELL-O ». Assorted flavors- 4 pkgs.390 HEINZ BABY FOODS 4 tins 390
WHITE SUGAR ... 10 LB. PAPER BAG..1.02 PURITAN POTTED MEAT..3 tins 390
POWDERED MILK 5 LBS 890 SHREDDED WHEAT 2 pkgs 370
ROBIN HOOD CAKE MIX & 1 BROWNIE MIX.510
(White)
FRESH CAKES , BUNS AND PASTRIES EVERY
WEEK END.
DANISH BLUE CHEESE
CASINO GOUDA CHEESE
270
500
NEILSONS - POT-O-GOLD—1 LB..3.25 DAIRY
O-HENRY PETIT 550 WELLA PACK 490
BOX—1 LB. 2.65
TRAUBEN SWISS CHEESE -12 portions
.490
........ 980
I
Fresh Produce .
Aspargus (green & tender)... Lb.35^
Green Onions & Radish
........ 2 bunches 25
Lettuce (large head> 2/0 Cabbage ow)...2L .. 23^!
I
I
r > ,\ VZ%-.
I remember a multitude of maternal kindnesses
which I have received from my Mother and which have
endeared her memory to me beyond expression.
William Cooper,
Dresses
Blouses
in
in
DACRON, PONGEE, TAFFETa'S ETC.
DACRON, NYLON, PONGEE AND COTTON.
Housecoats in WHITE QUILTED COTTON WITH
’ COLORED COLI«R AND CUFFS. FANCY STITCHED.
SATIN WITH FaNCY STITCHED COLLAR & CUFFS.
PRINTED COTTONS IN SHORTIE STYLE.
Si.TIN
Coat Sets Ballerinas
EABT GIRL'S COAT SETS IN Gsbxrdine,
Corduroy and Velvet. All with hats to
match. Blv.e, Rose ,-uid Yellow.. .¿A..95 up.
HOSPITAL PATIENTS THIS WEEK; Mesdames
Julia Ririe, Laura Anderson, Sadie Rice,
Jehzell Merkley, Christie Harker, Eliza
Rich, Grace Clifton and Douglas Anderson.
Blouses
I EROCADED WHITE S..TIN BALLERINAS SUITABLE
TO WEAR WITH FORMMLS MID SEMI-FOHMaLS.
Get yours for graduation................3.95
« a » . * •< 4 * * *
Mr. & 14rs. Charles Harker entertained
the following couples recently at a social
evening: Mr. A Mrs. Nephi Harker, Jack
Bridge,Joe Alston, Richard Bradshaw, Qrsen
Bridge, Clyde Bennett, Smith Ackroyd,Elmer
Ririe and Mrs. Irene Strang. A delicious
lunoh was served by the hostess.
GIRL'S BLOUSES 0? "DuN RIVER" WRINKLESEED
COTTON. - Colorful plaids, short
sleeves and pocket trim. Fast colors.
8-10-12-14 yrs.......................................2.45
Word has been received of the death in
Calgary on April 23rd. of John M. Pharis,
brother of Leslie B. Pharis.
Mr. <1 Mrs. Wagunot and
children of Burmis were recens
visitors at the home of Mr. &
Mrs. Dan Mai.
INFANTS DRESSES OF HEAT-SET
SHRUNK NYLON . Fancy trim
with nylon ruffles. 12 mo's,
size................................ 3.98
MAGRkTH
ÏÏIGH SCH00L - SPRING DANCE
"Le Paris Au Printemps"
FRIDAY MAY 6TH. 9
RAYMOND ORCHESTRA
75ç Oouple -2.98
SUMMERWEIG. T COTTON
PYJaM&S. 2 Piece.
Blue una Pink-
3 yrs../-.1.98
O-CLOCK
1.00 Men - 50<£ Ladies.
■ «04A0»« • «
Children need Models more than they
need Critics.
I
¡
t
Di shes
COOKIE JARS
PLATE floral design
- Cat, Bear, Pig, Owl and Kitten Designs
03.95
.6.20 to 4.25
FANCY CUT GLASS SALT & PEPPER SHAKERS...pr...1.35
cups and saucers in fruit designs..................O1.65
PYREX BEVERAGE CONTAINER with heating candle in
wrought iron. To keep beverages warm at table.5.95
Miss Marjorie Harker of Salt Lake
City whose wedding is scheduled for next
week is at home now.
Mrs. Pearl Irvine of Salt Lake Citp
is visiting at the home of her parents,
Mr. & Mrs. Emil Ehlert.
f ►S
WE WISH TO MAKE A CORRECTION IN THE
PRICE OF MERGAMA C AND LEYTOSAN G91.
THEY ARE BOTH 3.00 PER POUND.
Mr. & Mrs. Wm. Harker and sons of
Claresholm were week end visitors at the
home of his mother? Mrs. Christie Harker.
BOXED STATIONERY— 650
SUNBEAM STEAM AND DRY IRON. 2f LBS.Has
seperate water container and stand.
23.95
DRY IRON.
18.95
2.75
ELECTRIC FRYING :
Lid extra
GENERAL ELECTRIC STEAM AND '
i-
PAN.
..........................
I • . to $2.00
Little Janet Dudley, daughter of Mr. <
Gee.T.Dudley entertained a few friends .
her farm home on Friday in honor ef her
WE HAVE A NEW SHIPMENT OF PLANTERS-VASES-
ALUMINUM TUMBLERS - CUPS AND
SAUCERS, TEA POTS - WATER SETS ETC.
f•> C0 • • • * • 0 O • • 4
WILL HAVE FLOWERS AND PLANTS FOR
MOTHER’S DAY.
Mr^.
at
’ birthday.
&
I
Children will tend to
adopt the beliefs of
those whom they instinctively
recognize as
happy, and ne »thers<!
:::::::::::
ONION PLANTS
Bunch............. 200
ONION SETS
per lb. 300 & 400
UNITED CHURCH NEWS Smocks
WoG.BLue denim
Reg..... ">6.25
Men's G
smocks.
Week End Special
S3.75
• ••ocaoooo
a
'j. j.
ON SUNDAY MAY 8TH. THERE WILL BE NO
EVENING SERVICE. EVERYONE WILL MEET WITH
THE SUNDAY SCHOOL AT 11 A.M.
FROM NOW THROUGHOUT THE SUMMER THE HOUR
FOR CHURCH SERVICE WILL BE 11 A.M.
WE
RACK
SOME
a
FLORENCE NIGHTINGALE TEA
under the auspices of the Hospital Auxiliary
TO BE HELD IN THE BASEMENT OF THE HOSPITAL
ON THURSDAY, MaY 12TH. STARTING AT 2.30 P.M.
SILVER COLLECTION.
HAVE SEVERAL NEW ITEMS
OF REDUCED DRESSES Al©
REALLY GOOD BUYS.
( UP STAIRS )
ADDED TO THE
BLOUSES.
o
THE CHEST OF SILVER BEING RAFFLED WILL ALSO
BE DRAWN FOR .AT THE TEA.
Scott has been oalled East to be
who is quite ill, at Georgetown.
0 • :::::::
OF A CITY OR THE REFUGEES OF A DESOLATION.
INTUITION, FOR SHE HAS THE SENSE OF FUTURE
COURAGE, FOR SHE IS BRAVER THAN THE BRAVEST OF
Ass * to of prints at 49£
per yd.
Prints
FLORENCE NIGHTINGALE DAY is nation wide Tootai Fabric
at all hospitals in remembrance of the "Lady
with the Lamp". This is an annual affair and
we would like all the Ladies' of the Town &
District to come out and spend a sociable
afternoon.
PROCEEDS IN AID OF THE HOSPITAL.
Ralph Nishoforo, the Shoemaker has
closed his shop and Hans Pfeffel at the
Tailor Shop is agent for Fred's Shoe Repair
in Cardston. Leave your shoes with him for
repairs.
viA ” 1
"MOTHER’S DAY" MAY STH.
Mrs. S.
with her mother
Ontario
SUNDAY IS MOTHER'S DAY. OF THE THOUSANDS UPON THOUSANDS
OF WORDS THAT HAVE BEEN WRITTEN FOR THIS AND OTHER SUCH
DAYS,NONE SURPASS IN MEANING OR BEAUTY THE FOLLOWING, WRITTEN
YEARS AGO BY AN AUTHOR WHOSE IDENTITY HaS BEEN LOST:
’’MOTHER IS THE NAME OF WOMAN, WHETHER SHE BEARS AND
MOTHERS HER OWN CHILDREN OR MOTHERS THE CHILDREN OF ANOTHER,
OR THE WAIFS
CALL HER
EVENTS.
CALL HER
• THE BRAVE.
CALL HER COMFORT, FOR EVEN GOD COULD FIND NO RICHER
FIGURE—AS ONE WHOM HIS MOTHER COMFORTETH, SO I WILL
i COMFORT YOU.
CALL HER SACRIFICE, FOR SHE GIVES HER AIL-BODY,MIND &
SPIRIT; GIVES aLL GLADLY ANO WEEPING ONLY THAT, HAVING
GIVEN ALL, SHE HAS NOTHING LEFT TO GIVE.
CALL HER FORGIVENESS, FOR SHE IS THE SANE YESTERDAY,
Te-DAY AND FOREVER.
AND FAITH-CALL HER FAITH TO THE LAST- FAITH WHEN ALL
EISE FallS AND ALL OTHERS FLEE.
THESE aRE THE SIX PERFECT PARTS OF MOTHER LOVE, WHICH
NEXT TO THE LOVE OF CHRIST IS MOST SUBLIME
Clinical and microbiological characterization of bloodstream infections in cancer patients in a health care institution in Barranquilla (Colombia), 2023
No full textIntroducción: Las infecciones del torrente sanguíneo (IS) son una importante causa de enfermedad y muerte en pacientes oncológicos. Los principales factores de riesgo para desarrollar infección del torrente sanguíneo en este tipo de pacientes son la neutropenia, quimioterapia y uso de catéter intravascular. Se adquieren con mayor frecuencia en el ámbito intrahospitalario y en la mayoría no se logra determinar un foco primario de la infección. Los pacientes oncológicos cursan con un riesgo de aproximadamente 20%, de ser colonizados por gérmenes multirresistentes.
Objetivo: Describir las características clínicas y microbiológicas de pacientes con cáncer e infecciones del torrente sanguíneo hospitalizados en unidad de cuidados intensivos de una institución de salud de Barranquilla (Colombia), durante el período 2023.
Métodos: Estudio descriptivo, de corte transversal. Se evaluó la normalidad de los datos a través de la prueba de Kolmogórov-Smirnov. Se utilizaron frecuencias absolutas y relativas para describir las variables categóricas. Para el análisis de las variables categóricas, se utilizó la prueba de Chi-cuadrado o el test exacto de Fisher. Se utilizó un modelo de regresión logística multivariado con el fin de identificar posibles factores de riesgo y factores protectores asociados a mortalidad. Se consideró un valor p <0.05 para significancia estadística. El software estadístico utilizado fue R-CRAN versión 4.3.0.
Resultados: Se observó una mayor prevalencia de Klebsiella spp. en IS primarias y de microorganismos resistentes en IS secundarias. En IS secundarias, se observó una mayor prevalencia de microorganismos potencialmente productores de carbapenemasas (33%) en comparación con IS primarias (17%). El mecanismo de resistencia AMPc y los microorganismos meticilino resistentes fueron más frecuentes en IS secundarias (19% vs 2.4%) y (15% vs 7.3%), respectivamente. Se encontró que factores como la estancia en UCI de menos de 15 días, la neutropenia y la presencia de mieloma múltiple se asociaron con un mayor riesgo de mortalidad.
Conclusión: En la población con cáncer e IS analizada existe mayor aislamiento por microorganismos resistentes, principalmente Klebsiella spp., la neutropenia y el mieloma múltiple se asociaron a mayor riesgo de mortalidad.Universidad Libre Seccional Barranquilla -- Facultad de Ciencias de la Salud y Exactas y Naturales -- Especialización en Medicina InternaIntroduction: Blood stream infections (BSI) are a major cause of illness and death in cancer patients. The main risk factors for developing bloodstream infection in this type of patient are neutropenia, chemotherapy, and intravascular catheter use. They are most often acquired in the hospital and in most cases the primary focus of infection cannot be determined. Oncological patients are at approximately 20% risk of being colonized by multi-resistant germs.
Objective: Describe the clinical and microbiological characteristics of patients with cancer and bloodstream infections hospitalized in an intensive care unit of a health institution in Barranquilla, Colombia, during the period 2023.
Methods: Descriptive study, cross-cutting. The normality of the data was evaluated using the Kolmogorov-Smirnov test. Absolute and relative frequencies were used to describe categorical variables. For the analysis of the categorical variables, the Chi- square test or the exact Fisher test was used. A multivariate logistic regression model was used to identify possible risk factors and protective factors associated with Mortality. A p value <0.05 was considered for statistical significance. The statistical software used was R-CRAN version 4.3.0
Results: An increased prevalence of Klebsiella spp. was observed in primary BSI and of resistant microorganisms in secondary BSI. In secondary BSI, a higher prevalence of potentially carbapenemase-producing microorganisms (33%) compared to primary BSI (17%) was observed. The AMPc resistance mechanism, and methicillin-resistant microorganisms were more common in secondary BSIs (19% vs. 2.4%) and (15% vs. 7.3%), respectively. Factors such as UCI stay of less than 15 days, neutropenia, and the presence of multiple myeloma were found to be associated with an increased risk of mortality.
Conclusion: In the population with cancer and IS analyzed, there is a greater isolation of resistant microorganisms, mainly Klebsiella spp., neutropenia and multiple myeloma were associated with a higher risk of mortality
