8,024 research outputs found
Resilience in pediatric oncology. Family risk and resilience factors and child behavioral adjustment
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183420.pdf (Publisher’s version ) (Open Access)Radboud University, 21 maart 2018Promotores : Prins, J.B., Grootenhuis, M.A., Hoogerbrugge, P.M. Co-promotor : Verhaak, C.M
Psychological distress in lung cancer. Mindfulness-based stress reduction for patients and partners
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176913.pdf (Publisher’s version ) (Open Access)Radboud University, 05 oktober 2017Promotores : Speckens, A.E.M., Prins, J.B. Co-promotor : Drift, M.A. van de
Expression and Functional Studies on the Noncoding RNA, PRINS.
Get PDFPRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated variable expressions in different human tissues and a consistent staining pattern in epidermal keratinocytes and in vitro cultured keratinocytes. To identify the cellular function(s) of PRINS, we searched for a direct interacting partner(s) of this stress-induced molecule. In HaCaT and NHEK cell lysates, the protein proved to be nucleophosmin (NPM) protein as a potential physical interactor with PRINS. Immunohistochemical experiments revealed an elevated expression of NPM in the dividing cells of the basal layers of psoriatic involved skin samples as compared with healthy and psoriatic uninvolved samples. Others have previously shown that NPM is a ubiquitously expressed nucleolar phosphoprotein which shuttles to the nucleoplasm after UV-B irradiation in fibroblasts and cancer cells. We detected a similar translocation of NPM in UV-B-irradiated cultured keratinocytes. The gene-specific silencing of PRINS resulted in the retention of NPM in the nucleolus of UV-B-irradiated keratinocytes; suggesting that PRINS may play a role in the NPM-mediated cellular stress response in the skin
Asian Eden : large herbivore ecology in India
No full textThe study of large mammalian herbivore ecology has a strong allometric tradition. The majority of studies that have helped better understand how body mass affects large herbivore ecology in the tropics, from a biological, functional, and ecological perspective, are from Africa. India’s large herbivore assemblage—the richest outside of Africa and with a body mass range similar to Africa’s—is a poorly understood assemblage that has never been studied from the perspective of body mass theory. The goal of this study was to bridge this gap. I tested hypotheses of large herbivore biology and ecology in India based on body mass theory across different spatial, temporal and organizational scales. Data collection and analyses included: a 20 month field study the provided data of forage availability, the seasonal variation in diet, habitat preference and overlap, the timing of parturition, and the life history traits of different body mass large herbivore species in South India; a year long treatment based exclosure field experiment that provided a better understanding of the seasonal variation in graminoid biomass and quality in South India; a country level analysis of the distribution of the large herbivore assemblage with respect to environmental covariates; and a modelling approach to determine the impact of body mass on reproductive biology. Results showed that body mass based principles offered explanations for some, but not all, of what I observed and predicted. This study for the first time proposes that the impact of body mass might explain why some smaller herbivore species show seasonality in annual parturition while some large herbivores species do not. Also, as predicted and similar to Africa, large herbivore species richness in India is highest in areas with high soil nutrients and intermediate moisture levels. Beyond this study, important questions that still remain are “Which environmental and ecological conditions shaped species richness in Africa to be four times higher than what is found in India?” As India remains the last stronghold—Asia’s Eden—for most of Asia’s large herbivores, there is a need for further studies of the biology and ecology of large herbivore species in India. <br/
Unravelling Drivers of Morphological Change: A Case Study on the Prins Hendrik Sand Dike
No full textFlood defense will have to be strengthened all over the world as sea level rise poses great challenges for the safety of coastal settlements. Strengthening traditional hard flood defenses is becoming increasingly more difficult due to limited space in the coastal zone and large costs inflicted with renovation. Adaptive ‘soft solutions’ pose an alternative as they make use of natural processes that are able to adapt to changing boundary conditions. The Prins Hendrik Sand Dike is a pilot project of such a soft solution placed in front of an existing hard sea dike. The Prins Hendrik Sand Dike is the subject of this research.This research strives to identify the role of waves, currents, and water levels on morphological development of the Prins Hendrik Sand Dike. Which requires an identification of the morphological development during the 3.5 years of service lifetime. This is followed by a characterization of the forcing climate based on measured on-site data. This knowledge is used to hindcast the full forcing climate during the PHSD lifetime and calculate morphological development. Lastly, a comparison of calculated and observed morphological development reveals suitability of engineering formulae on low-energy beaches.Results indicate the spit head develops at a faster rate than predicted in model studies. In addition, constant erosion in the form of coastline retreat is observed in a section that serves as primary sea defense. These findings hamper successful development of habitat and possibly decrease the longevity of the sea defense if maintenance is not performed. Furthermore, waves have been determined to be the dominant forcing mechanism resulting in sediment transport and morphological development. In addition, systematic water level changes that occur under specific wave conditions are identified causing increased Northeastward transport of sediment. These findings likely explain discrepancies between the previously modelled and observed morphological development. Implications of this research contribute to an understanding of the interconnected nature of forcing scenarios at low-energy beaches and can be used to improve modelling efforts of low-energy beaches. Furthermore, it provides a basis for Hoogheemraadschap Noorderkwartier to make decisions on maintenance activities.Prins Hendrik Sand DikeCivil Engineering | Structural Engineering | Hydraulic Structure
Rapid oceanographic changes associated with last glacial ice-rafting events: Observations from the past and present northern North Atlantic
Get PDFWeering, T.C.E. van [Promotor]Brummer, G.J.A. [Copromotor]Prins, M.A. [Copromotor
Climate and Tectonic Influence on Alluvial Dynamics in the Weihe Basin, Central China
Get PDFBalen, R.T. van [Promotor]Zheng, H. [Promotor]Prins, M.A. [Copromotor]Beets, C.J. [Copromotor
Highstand vs. lowstand turbidite system growth in the Makran active margin: Imprints of high-frequency external controls on sediment delivery mechanisms to deep water systems
No full textJ. Bourget, S. Zaragosi, S. Ellouz-Zimmermann, E. Ducassou, M.A. Prins, T. Garlan, V. Lanfumey, J.-L. Schneider, P. Rouillard, J. Giraudea
Understanding and managing fear of cancer recurrence
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173266.pdf (Publisher’s version ) (Open Access)Radboud University, 12 juni 2017Promotores : Prins, J.B., Speckens, A.E.M. Co-promotores : Thewes, B., Gielissen, M.F.M
Controls on terrigenous sediment supply to the Arabian Sea during the late Quaternary: the Indus Fan
No full textA previous study on the basis of long-range side-scan sonar data (Kenyon et al., 1995. Geometry of the younger sediment bodies of the Indus Fan. In: Pickering, K.T., Hiscott, R.N., Kenyon, N.H., Ricci Lucchi, F., Smith, R.D.A. (Eds.), Atlas of deep water environments: architectural style in turbidite systems. Chapman and Hall, London, pp. 89-93.) revealed a distributary complex of large channel-levee systems radiating from the mouth of the Indus Canyon and lower-order distributary complexes, each consisting of several smaller channel-levee systems, on the middle Indus Fan. Sediment cores from the Indus Canyon and the middle Indus Fan are analysed in this study in order to reconstruct the timing of turbidite sedimentation on the fan. Sediment cores from the middle fan show that turbidite sedimentation of the last but one switched to the last and youngest channel-levee system at the transition from oxygen-isotope stage 3 to 2 (≃24.
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