22 research outputs found
HYDROXYCARBAMINE: FROM AN OLD DRUG USED IN MALIGNANT HEMOPATHIES TO A CURRENT STANDARD IN SICKLE CELL DISEASE
No full textWhile hydroxycarbamine (hydroxyurea, HU) has less and less indications in malignant hemopathies, it represents the only widely used drug which modifies sickle cell disease pathogenesis. Clinical experience with HU for patients with sickle cell disease has been accumulated over the past 25 years in Western countries. The review of the literature provides increasing support of safety and efficacy in both children and adults for reducing acute vaso-occlusive events including pain episodes and acute chest syndrome. HU has become the standard-of-care for sickle cell anemia, but remains underused. Barriers to its use should be identified and overcome
The usefulness of OMALIZUMAB in low response to corticosteroids DRESS syndrome: a case series.
No full textInternational audienc
Developments in Heat and Water Balance Coupling for Micro-Climate Modelling of Urban Squares under the Influence of Greening - A Review and Case Study
No full textUrban areas are prone to extremely high temperatures as a result of climate change and the urban heat island effect. Urban micro-climate modelling has become an important tool to evaluate the effect of heat mitigating measures and develop climate-sensitive urban designs. However, many models lack the accurate fine scale simulation of evapotranspiration influence and soil moisture conditions to predict human thermal comfort (HTC).This works objective is to better understand the coupling of the heat and water balance for micro-climate predictions of urban squares and its influence on the HTC, especially under the influence of greening. Therefore, a literature review on recent model developments was conducted. Additionally, a case study was performed for the Heat Square in the Green Village using the model VTUF-3D, chosen based on the literature review. Five urban micro-climate models work on the fine scale water balance representation, namely ENVI-met, i-Tree Hydro+, Solene-Microclimat, ST, and VTUF-3D. ENVI-met offers comprehensive analysis options of greening solutions and user-friendliness, while VTUF-3D excels in detailing soil and plant characteristics. Given the detailed water balance simulation and the accurate trend prediction for the latent heat flux, it is expected that greening effects on the urban micro-climate of the Heat Square can be predicted accurately with VTUF-3D, if not for spatial and human thermal comfort assessment.The reviewed models require further model development towards a comprehensive water balance representation and related greening analysis options. Additionally, further efforts towards model applicability are needed, including validation and user-friendliness. VTUF-3D requires improvement of spatial variability representation and HTC prediction.Note, the literature review is no holistic assessment and does not provide a conclusion on the overall performance of the models. The case study was limited in model feature configuration.Water Management | Urban Water Engineerin
Prevalence of bone complications in young patients with sickle cell disease presenting low bone mineral density
No full textInternational audiencePurpose: Bone fragility in sickle cell disease (SCD) has been previously reported even in young patients, but the clinical consequences and specific management remain unclear. The objective of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.Methods: We conducted a single-center cross-sectional study. Bone mineral densitometry (BMD) at the lumbar spine and the hip, Vertebral Fracture Assessment (VFA) and biological measurements were performed in patients aged between 20 and 40 years.Results: One hundred and thirty-eight patients with sickle cell disease were included between June 2020 and December 2021. One hundred and one patients (73.2 %) were from Sub-Saharan Africa, 13 from North Africa (9.4 %), 11 from the Caribbean (7.9 %), 6 from the Indian Ocean. A Z-score < -2 was found in 43 patients (31.2 %) at the lumbar spine, in 4 patients (3 %) at the total hip, and in 5 patients (3.7 %) at the femoral neck. 59 patients (46.8 %) had vertebral deformities. Fragility fractures were recorded in 9 patients (10.8 %). Patients with low BMD had lower BMI (21.3 (19.0, 24.0) versus 24.0 (20.7, 26.1) Kg/m2, p = 0.003), lower osteonecrosis history (7 % versus 25.3 %, p = 0.011) and lower hemoglobin levels (9.0 (8.0, 10.0) versus 10.0 (9.0, 11.0) g/dL, p < 0.01). No association was found between history of fracture and low BMD.Conclusion: Young patients with SCD commonly have low BMD at the lumbar spine, but the prevalence of fragility fracture was low. Low BMD - specifically at the spine - may not be tantamount to bone fragility
Independência, legalidade e imparcialidade da procuradoria europeia – contributo para garantia e densificação dos direitos processuais de suspeitos e arguidos
No full textThe author analyses “the independency, the legality and the impartiality” as a decisive attribute within the concrete role of the EPPO. The legal proclamation is not sufficient. In other way, that attribute should be a guarantee in favor of the promotion of the procedural rights of the suspects. Both the individual members (and their status of independency) and the central structure of the EPPO are asked to do a reinforced role for the promotion of those procedural rights.No artigo, o autor aborda o tema da “ independência, legalidade e imparcialidade” como atributo imprescindível no exercício funcional e concreto da Procuradoria Europeia, não bastando uma mera proclamação solene na lei. Esse atributo deverá constituir uma garantia em prol da defesa e densificação dos direitos processuais de suspeitos e arguidos. Nesse sentido os membros da PE (e respectivo estatuto de independência) e a sua estrutura central são chamados a desempenhar um papel reforçado que leve a uma praxis na promoção de tais direitos
The Internationalization of Higher Education: from people’s mobility to curriculum internationalization
No full textO presente ensaio constituiu a Oração de Sapiência proferida na cerimónia de Abertura Solene do Ano Lectivo 2019/2020 no ISMT a 6 de Novembro de 2019. Nele, a autora reflecte sobre a internacionalização das instituições do ensino superior, dando destaque à passagem de uma ênfase na mobilidade internacional de
estudantes, enquanto modalidade por excelência de internacionalização do ensino, para uma ênfase na própria internacionalização dos cursos e das instituições. Para esse efeito, o ensaio percorre conceitos teóricos centrais nesta questão – internacionalização do ensino superior, internacionalização em casa e internacionalização do currículo –, salientando algumas das dinâmicas institucionais e pedagógicas que lhes estão associadas. Na parte final do ensaio, nota-se a necessidade de equilibrar os requisitos de quantificação e estandardização dos indicadores de internacionalização com uma atenção às especificidades das áreas disciplinares, argumentando-se que estas devem ter um papel crucial nas dinâmicas institucionais de internacionalização do currículo. / This essay was the Lecture at the Solemn Opening Ceremony of the Academic Year 2019/2020 at the Miguel Torga Institute of Higher Education, on the 6th November 2019. In it, the author reflects on the internationalization of higher education institutions, highlighting a shift from an emphasis in the international mobility of students as the main form of the internationalization of education to an
emphasis on the very internationalization of the degrees and institutions. To this purpose, the essay reviews core theoretical concepts about this issue - internationalization of higher education, internationalization at home and internationalization of the curriculum - referring some of the institutional and pedagogical dynamics associated with them. At the end of the essay, the author notes the need to balance the requirements of quantification and standardization of the internationalization indicators with an attention to the specificities of the disciplinary areas, and argues that these should play a crucial role in the institutional dynamics of the internationalization of the curriculum
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France
No full textInternational audience© 2023, The Author(s).Background: Proton pump inhibitors (PPIs) are largely used in older adults and data are needed in off-label indications, such as the prevention of upper gastrointestinal bleeding (UGIB) in patients receiving oral anticoagulants (OACs). This study aimed to assess whether PPIs reduce the risk of UGIB in patients initiating oral anticoagulation. Methods: We conducted a longitudinal study based on the French national health database. The study population included 109,693 patients aged 75u2013110 years with a diagnosis of atrial fibrillation who initiated OACs [vitamin K antagonist (VKA) or direct OAC (DOAC)] between 2012 and 2016. We used multivariable Cox models weighted by inverse of probability of treatment to estimate the adjusted hazard ratio (aHR) of UGIB between PPI users and nonusers over a 6- and 12-month follow-up. Results: PPI users represented 23% of the study population (28% among VKA initiators and 17% among DOAC initiators). The mean age (83 ± 5.3 years) and proportion of women (near 60%) were similar between groups. The risk of UGIB in the first 6 months after initiation of OAC decreased by 20% in PPI users compared with PPI nonusers [aHR6 months = 0.80, 95% confidence interval (CI) 0.65u20130.98], but was not significantly modified when the follow-up was extended to 12 months (aHR12 months = 0.90, 95% CI 0.76u20131.07), with a stronger effect among patients treated with vitamin K antagonists (aHR6 months = 0.73, 95% CI 0.58u20130.93; aHR12 months = 0.81, 95% CI 0.67u20130.99). Conclusions: This study suggests that PPIs were associated with reduced risk of gastrointestinal bleeding after initiation of oral anticoagulation in older patients with atrial fibrillation, particularly within 6 months after initiation of an antivitamin K antagonist
''The World at Their Feet'': Logo-Iconic Representations of the Four Continents in the Celebrations of the Iberian Princes' Double Marriage (1729).
No full textAssinalando a aliança entre João V de Portugal
e Filipe V de Espanha, a troca das princesas,
em 1729, implicou um pomposo espetáculo solene, com o intuito de mostrar a força política
das duas coroas ibéricas através de grandiosas
festas. Comparando as fontes informativas sobre
as celebrações realizadas em Sevilha, Lisboa e
Bahia, pretende-se refletir sobre as funções dos
relatos impressos, analisando diferentes parâmetros tais como o autor, a tipologia textual e as características editoriais. Elegendo a representação logo-icónica dos quatro continentes como um dos motivos mais repetidos nos programas festivos de 1729, mostra-se como estes componentes expressam o aplauso universal aos casamentos ibéricos, colocando em diálogo as representações simbólicas do Velho e do Novo Mundo. Apresenta-se, asssim, um exemplo expressivo
da globalização artística e cultural do Barroco Iberoamericano.Strengthening the political alliance between John
V of Portugal and Philip V of Spain, the ceremony
of the exchange of the princesses in 1729 gave
rise to an impressive spectacle that demonstrated the power of the two Iberian kings, according to Baroque festival procedures. By comparing reports of the ceremonies held in Seville, Lisbon, and Bahia, this study proposes a reflection on the role played by printed festival accounts, taking different aspects into account including the author, textual typology, and editorial features. The logo-iconic representation
of the four continents is a meaningful motif, since it is displayed in all the iconographic programs of the ceremonies. Here we discuss how these elements express the universal acceptance of
the double Iberian marriage, suggesting a complex dialogue between the traditional allegories and the symbolic representations of the New and the Old Worlds. In this way, we outline a significant example of the artistic and cultural globalization of the Iberoamerican Baroque.Área de Historia del Arte, UPO.Postprin
Red blood cell senescence and vascular function in patients with hereditary spherocytosis with and without splenectomy
No full textInternational audienc
