481 research outputs found
Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs.
No full textThere are two types of interactions between drugs, pharmacokinetic and pharmacodynamic. For antiepileptic drugs (AEDs), pharmacokinetic interactions are the most notable type, but pharmacodynamic interactions involving reciprocal potentiation of pharmacological effects at the site of action are also important. By far the most important pharmacokinetic interactions are those involving cytochrome P450 isoenzymes in hepatic metabolism. Among old generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone induce the activity of several enzymes involved in drug metabolism, leading to decreased plasma concentration and reduced pharmacological effect of drugs, which are substrates of the same enzymes (eg, tiagabine, valproic acid, lamotrigine, and topiramate). In contrast, the new AEDs gabapentin, lamotrigine, levetiracetam, tiagabine, topiramate, vigabatrin, and zonisamide do not induce the metabolism of other AEDs. Interactions involving enzyme inhibition include the increase in plasma concentrations of lamotrigine and phenobarbital caused by valproic acid. Among AEDs, the least potential interaction is associated with gabapentin and levetiracetam
Clinically important drug interactions in epilepsy: Interactions between antiepileptic drugs and other drugs.
No full textAntiepileptic drugs (AEDs) are commonly prescribed for long periods, up to a lifetime, and many patients will require treatment with other agents for the management of concomitant or intercurrent conditions. When two or more drugs are prescribed together, clinically important interactions can occur. Among old-generation AEDs, carbamazepine, phenytoin, phenobarbital, and primidone are potent inducers of hepatic enzymes, and decrease the plasma concentration of many psychotropic, immunosuppressant, antineoplastic, antimicrobial, and cardiovascular drugs, as well as oral contraceptive steroids. Most new generation AEDs do not have clinically important enzyme inducing effects. Other drugs can affect the pharmacokinetics of AEDs; examples include the stimulation of lamotrigine metabolism by oral contraceptive steroids and the inhibition of carbamazepine metabolism by certain macrolide antibiotics, antifungals, verapamil, diltiazem, and isoniazid. Careful monitoring of clinical response is recommended whenever a drug is added or removed from a patient's AED regimen
Criminal anthropology of mariticide in Russia. Foreword to the article by P.N. Tarnovskaya “Female criminality in connection with early marriages”
No full textObjective: to provide a general overview of the content of P.N. Tarnovskaya’s article “Female criminality in connection with early marriages”, to determine its place in its author’s heritage and its scientific value for modern criminology.Methods: the general scientific method of dialectical cognition, comparison, as well as the formal logical method (deduction, induction, definition and division of concepts).Results: having analyzed the content of P.N. Tarnovskaya’s article, the author determined its significance as the initial stage of forming her anthropological concept in the study of female murderers. The author specified the sections of P.N. Tarnovskaya’s monograph “Women-murderers” (1902), which use the results of the research described in the article under study. The author refuted the opinion, previously prevailing in Russian criminology, that anthropological research by P.N. Tarnovskaya was supposed to use biological means to prevent crime. On the contrary, in this work Tarnovskaya recommended changing the social environment to curb female criminality (mariticide), namely, abandoning the widespread early marriages of adolescent women before the end of puberty.Scientific novelty: for the first time, the author gives a criminological assessment of P.N. Tarnovskaya’s article “Female criminality in connection with early marriages” and indicates its links with her subsequent works.Practical significance: the results obtained make it possible to change the perception of research by P.N. Tarnovskaya’s as one of the founders of world criminological science. In her concept of crime prevention, the impact on general social factors on female criminality was considered fundamental for the prevention of women’s deviant behavior
First observation of Bs → J/ψf0(980) decays
No full textUsing data collected with the LHCb detector in proton–proton collisions at a centre-of-mass energy of 7 TeV, the hadronic decay is observed. This CP eigenstate mode could be used to measure mixing-induced CP violation in the system. Using a fit to the π+π− mass spectrum with interfering resonances gives . In the interval ±90 MeV around 980 MeV, corresponding to approximately two full f0 widths we also find , where in both cases the uncertainties are statistical and systematic, respectively
Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays
No full textThis Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within
expectations from the Standard Model
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
No full textThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
Relation Between the Plant Size and Occurrence of Fasciated Flower Stalk in Japanese Ever-Season Radish
No full text1.本試驗自民國五十三年一月一日開始至五十四年六月底止結東,自五十三年一月一日至十二月一日每月初播種一次,共分十二次播種,試驗地點在海拔2250公尺,年平均溫度12.5。C之福壽山農場進行。
2.在年平均溫度12.5。C之福壽山農塲,十月一日至十二月一日,一月一日至三月一日播種者,苗體發育不大,平均直徑最小2.6分,最大6.76公分,至抽苔季節,花序正常,分枝整齊,結籽良好。
3.自四月一日至九月一日播種者,苗體直徑平均在7.5公分以上,雖能抽苔,花序呰成畸形,畸形花序之頂端,略現花朶,均花而不實,無種孒可收。
4.花序正常之植株,單株種孒收量,以早播者較晚播者為多,種子形粒大小,亦以早播者較晚播者大。
5.在年平均溫18。C以上之地區,歷年試驗,不論大苗,小苗,均難抽苔開花。
1. In this experiment the author studied the relation between the Plant sue and occurrence of fasciated flower sta1k in connection With the seed production of Jpanese ever-season radish.
2. As the seed production of Japanese ever-season radish was
impossible in the area Where the annual mean temperature exceeds 18。C, the experiment was carried out at the Fu Show-Shan Farm ( 2,250 meter altitude, annual mean temperature 12.5。 C ), Taichung
prefecture during the period of January 1964 to June 1965. The radish seeds were sown on the first day of each month in 1964. The plants which were sown in January, February, and March bolted and flowered in the same year, others bolted and flowered in the next year.
3. It is note worthy that the occurrence of fasciated flower stalk were closely related with plant size, other words, the plants which were sown from April to September had large plant size at flowering season, and all of these plants bolted fasciated flower stalks. No seed was obtained from these plants. On the other hand the plants which were sown in January' February' March, October November, and December bolted flowered, and produced seeds normally in spite Of they were small in plant Size. The author also observed that early seeding resulted in higher production of seeds
The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluid
No full textSummaryPurposeData on the blood pharmacokinetics of vigabatrin, an antiepileptic drug with a unique and novel mechanism of action, in the rat are sparse. Additionally, little is known of the kinetics of vigabatrin in the central cerebrospinal fluid (CSF) compartment. We therefore investigated the rate of penetration into and the inter-relationship between serum and CSF compartments following systemic administration of vigabatrin in the rat.MethodsSprague–Dawley rats were implanted with a jugular vein catheter and a cisterna magna catheter for blood and CSF sampling, respectively. Vigabatrin was administered by intraperitonial injection at three different doses (250, 500 and 1000mg/kg) and blood and CSF collected at timed intervals up to 8h. Vigabatrin concentrations in sera and CSF were determined by high performance liquid chromatography.ResultsVigabatrin concentrations in blood and CSF rose linearly and dose-dependently and the time to maximum concentration (Tmax) was 0.4 and 1.0h, respectively. Vigabatrin is not protein bound in serum and its elimination from serum (mean t1/2 values, 1.1–1.4h) is rapid and dose-independent. The efflux of vigabatrin from CSF was significantly slower than that seen for serum (mean t1/2 values, 2.2–3.3h).ConclusionsThe kinetics of vigabatrin are linear with rapid entry into CSF. However, although vigabatrin CSF kinetics parallel that seen in serum, CSF vigabatrin concentrations represent only 2% of concentrations seen in serum and do not reflect free drug concentrations in serum
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