11,504 research outputs found
Racial differences in androgen receptor protein expression in men with clinically localized prostate cancer
No full textPurpose: Black American men experience disproportionate mortality from prostate cancer (CaP) compared with white American men. Differences in outcome may stem from differences within the androgen axis. Since serum testosterone levels appear to be similar by race in men with CaP, we measured and compared androgen receptor (AR) protein expression in malignant and benign prostate tissue from black and white men who underwent radical prostatectomy for clinically localized CaP. Materials and Methods: Archived radical prostatectomy specimens obtained from 25 white and 25 black men had AR protein antigen retrieved and immunostained. AR protein expression from CaP and benign tissue was assessed by 2 methods. Automated digital color video image analysis was used to measure the percent area immunostained for AR protein and the intensity of expression (mean optical density). Visual scoring was performed to compare results with automated values. Results: In black compared with white men malignant nuclei were 27% more likely to immunostain for AR (p = 0.005) and in immunopositive nuclei AR protein expression was 81% greater (P = 0.002). Visual scoring of malignant nuclei revealed that AR immunostaining was significantly increased in black vs white men (171 +/- 40 vs 149 +/- 37, p = 0.048). In immunopositive benign nuclei AR protein expression was 22% greater in black than in white men (p = 0.027). Visual scoring of benign nuclei revealed 20% increased immunostaining in black vs white men, although this difference did not attain statistical significance (p = 0.065). Racial differences in AR protein expression were not explained by age, pathological grade or stage, although serum prostate specific antigen levels were higher in black men (9.7 +/- 7.5 vs 15.5 +/- 12.2 ng/ml, p = 0.049). Conclusions: AR protein expression was 22% higher in the benign prostate and 81% higher in the CaP of black African compared with white men. CaP may occur at a younger age and progress more rapidly in black than in white men due to racial differences in androgenic stimulation of the prostate
Partial Collapsing Degeneration of Floer Trajectories and Adiabatic Gluing
No full textIn the present paper, we study partial collapsing degeneration of Hamiltonian-perturbed Floer trajectories for an adiabatic ε-family and its reversal adiabatic gluing, as the prototype of the partial collapsing degeneration of 2-dimensional (perturbed) J-holomorphic maps to 1-dimensional gradient segments. We consider the case when the Floer equations are S 1-invariant on parts of their domains whose adiabatic limit has positive length as ε → 0, which we call thimble-flow-thimble configurations. The main gluing theorem we prove also applies to the case with Lagrangian boundaries such as in the problem of recovering holomorphic disks out of pearly configuration. In particular, our gluing theorem gives rise to a new direct proof of the chain isomorphism property between the Morse–Bott version of Lagrangian intersection Floer complex of L by Fukaya–Oh–Ohta–Ono and the pearly complex of L Lalonde and Biran–Cornea. It also provides another proof of the present authors’ earlier proof of the isomorphism property of the PSS map without involving the target rescaling and the scale-dependent gluing. © 2024, Springer-Verlag GmbH Germany & The Editorial Office of AMS.11Nscopu
Efeitos da administração sistêmica de 5-HT e 8-OH-DPAT sobre os estados de vigília e sono de pombos (Columba livia)
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em NeurociênciasInvestigar a participação dos mecanismos serotonérgicos sobre a regulação dos estados de sono e vigília em pombos por meio da caracterização comportamental e eletrográfica hipocampal dos estados de sono e vigília após administração sistêmica de 5-HT ou 8-OH-DPAT e quantificação dos efeitos da administração de 5-HT ou 8-OH-DPAT sobre a atividade eletrográfica hipocampal dos diferentes estados identificados
EKRANISASI NOVEL PERBURUAN KARYA PRAMOEDYA ANANTA TOER KE FILM PERBURUAN KARYA SUTRADARA RICHARD OH
No full textAdapun tujuan dalam penelitian ini adalah pendeskripsian proses ekranisasi novel Perburuan karya Pramoedya Ananta Toer ke film Perburuan karya sutradara Richard Oh yang meliputi penciutan, penambahan, dan perubahan variasi, serta implementasi hasil penelitian terhadap pembelajaran Bahasa Indonesia di sekolah. Metode yang digunakan dalam penelitian ini adalah metode deskriptif, dengan pendekatan penelitian yakni pendekatan objektif. Sumber data dalam penelitian ini adalah novel Perburuan karya Pramoedya Ananta Toer dan film Perburuan karya sutradara Richard Oh. Data dalam penelitian ini berupa kata-kata, frasa, klausa, kalimat dan kutipan yang terdapat di dalam novel Perburuan karya Pramoedya Ananta Toer dan dialog yang terdapat dalam film Perburuan karya sutradara Richard Oh. Teknik pengumpulan data yang digunakan adalah studi dokumentasi, teknik baca dan catat, serta teknik transkripsi. Teknik analisis data yang digunakan adalah Analysis Interactive Model dari Miles dan Huberman yang dilakukan dengan langkah reduksi data, penyajian data, dan kesimpulan/verifikasi. Pengecekan keabsahan data dilakukan dengan menggunakan empat cara yaitu ketekunan pengamatan, kecukupan referensi, tringulasi, dan pemeriksaan sejawat melalui diskusi. Berdasarkan hasil penelitian, data yang diperoleh adalah penciutan sebanyak 196 data, penambahan 102 data, dan perubahan variasi 52 data. Hasil penelitian selanjutnya diimplementasikan pada pembelajaran Bahasa Indonesia (peminatan) jenjang Sekolah Menengah Atas (SMA) kelas XII semester ganjil pada kompetensi dasar KD 3.3 “Menganalisis hasil alih wahana (konversi) dalam karya satra baik dari novel ke film maupun sebaliknya” dan KD 4.3 “Mengevaluasi hasil analisis alih wahana (konversi) novel ke film maupun sebaliknya”
OH produced from o-nitrophenol photolysis: A combined experimental and theoretical investigation
No full textPhotodissociation dynamics of o-nitrophenol in the gas phase at different photolysis wavelengths (361-390 nm) is investigated, and the nascent OH radical is observed by the single-photon laser-induced fluorescence technique. At all the photolysis wavelengths, the OH radicals are formed in vibrationally cold state (upsilon"=0) and have similar rotational state distributions. The average rotational temperature for all the photolysis wavelengths is approximately 970 +/- 120 K, corresponding to a rotational energy of 1.9 +/- 0.2 kcal mol(-1). The spin orbit and Lambda-doublet states of the OH fragments formed in the dissociation are measured to have nonstatistical distributions. To get an insight into the dissociative mechanism leading to OH formation in the photolysis of o-nitrophenol, the potential energy surfaces of the OH-forming channels are mapped by ab initio theoretical calculations. According to both experimental and theoretical results, a possible mechanism for OH formation is proposed
Pengaruh Doping Zn pada MgF1,985(OH)0,015 terhadap Difraktogram Mg1 xZnxF1,985(OH)0,015
No full textPada penelitian ini dilakukan sintesis padatan Mg1‑xZnxF1,985(OH)0,015 dengan variasi doping sebesar x=0; 0,025; 0,05; 0,075; 0,1 dan 0,15 mol. Sintesis padatan dilakukan dengan metode sol-gel. Struktur padatan dikarakterisasi dengan difraksi sinar-X. Difraktogram hasil sintesis menunjukkan bahwa padatan Mg1‑xZnxF1,985(OH)0,015 memiliki struktur kristal yang sama dengan MgF2 standar yang merupakan tetragonal. Difraktogram katalis Mg1‑xZnxF1,985(OH)0,015 menunjukkan adanya pengaruh doping Zn terhadap MgF1,985(OH)0,015 yang ditandai dengan bergesernya 2θ pada puncak yang sama dengan padatan MgF1,985(OH)0,015. Ditemukan doping Zn berpengaruh dari 2q puncak padatan Mg1‑xZnxF1,985(OH)0,015. Semakin banyak Zn yang didoping, 2q semakin bergeser ke nilai yang lebih besar
Narni oh pardi
No full textGarapan tariini berjudul nani oh pardi dengan tema percekcokan suami istri yang berakibat buruk terhadap diri mereka sendiri yang divisualisasikan secara simbolis representasional ke dalam sebuah garapan seni tari dengan 3 penari dan di iringi musik ilustrasi
EKRANISASI NOVEL “PERBURUAN KARYA PRAMOEDYA ANANTA TOER” KE DALAM FILM “PERBURUAN KARYA SUTRADARA RICHARD OH”
No full textPerburuan merupakan salah satu novel yang diekranisasikan, namun dalam ekranisasinya Perburuan mendapatkan banyak kritik. Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan proses ekranisasi pada unsur alur, tokoh, dan latar dalam ekranisasi novel Perburuan karya Pramoedya Ananta Toer ke dalam film Perburuan karya Sutradara Richard Oh. Metode penelitian yang digunakan adalah metode penelitian sastra. Sumber data penelitian ini adalah novel Perburuan karya Pramoedya Ananta Toer dan film Perburuan karya sutradara Richard Oh. Data penelitian diperoleh dengan teknik membaca, melihat, dan mencatat. Hasil penelitian ini menunjukkan bahwa ditemukan sebanyak 59 proses ekranisasi pada unsur alur, yang terdiri dari 24 proses penciutan, 21 penambahan, dan 14 perubahan bervariasi. Ditemukan sebanyak 14 proses ekranisasi pada unsur tokoh, yang terdiri dari 3 proses penciutan, 7 penambahan, dan 4 perubahan bervariasi. Ditemukan sebanyak 12 proses ekranisasi pada unsur latar, yang terdiri dari 1 proses penciutan, 9 penambahan, dan 2 perubahan bervariasi. Proses penciutan terjadi pada unsur-unsur yang dirasa tidak terlalu penting. Proses penambahan yang terjadi menambah esensi film sehingga penonton akan terbawa masuk dalam alur cerita. Adapun untuk perubahan bervariasi yang dilakukan dalam visualisasinya ke bentuk film secara keseluruhan tidak jauh melenceng dari penggambaran yang ada dalam novel. Secara keseluruhan proses ekranisasi yang terjadi, baik itu penciutan, penambahan, dan perubahan bervariasi masih relevan dengan cerita yang ada dalam novel
Dielectric relaxation of dilute aqueous NaOH, NaAl(OH)4 and NaB(OH)4
No full textThe complex dielectric permittivity of aqueous NaOH (c ≤ 2 M) and of dilute (≤0.6 M) NaAl(OH)4 and NaB(OH)4 solutions in NaOH ([Na] = 1 M) at 25°C has been determined in the frequency range 0.2 ≤ v/GHz ≤ 20. All spectra could be represented by a single Cole-Cole relaxation time distribution attributed to the cooperative relaxation of the solvent. The concentration dependence of the effective hydration number of OH- has been determined. For aluminate and borate solutions the deduced parameters: effective conductivity Ke, static permittivity ε, relaxation time τ, and distribution parameter a suggest a 1:1 replacement of hydroxide by aluminate and borate, accompanied by a release of bound water. The lack of an ion-pair relaxation process despite notable ion association suggests that rapid proton exchange is important not only for the dynamics of OH- but also for Al(OH)4- and B(OH)4-
OH fragment from benzoic acid monomer photolysis: Threshold and product state distribution
No full textPhotodissociation dynamics of benzoic acid monomer (BAM) at different ultraviolet excitation wavelengths (280-295 nm) has been investigated. The nascent OH product state distributions were measured using the laser-induced fluorescence (LIF) technique. The rotational state distributions, the A-doublet-state ratio, and spin-orbit state distributions of the OH fragment were also measured at 280-294 nm. The OH fragments are vibrationally cold, and their rotational state distributions are peaked at J '' = 3.5 at each photolysis wavelength. No LIF signal of OH fragments was observed at 295 rim. The photodissociation threshold is determined to be 102.5-103.9 kcal/mol for OH channel. The dissociative state and mechanism have been discussed for OH produced from the photodissociation of BAM
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