28,120 research outputs found
Letter from Carl Hayden to Henry F. Ashurst
No full textLetter describing three enclosures, a letter from F. M. Gold, Carl T. Hayden's reply to Gold's letter, and a copy of a bill introduced by Cameron
Letter from A. F. Potter to Carl Hayden
No full textLetter from A. F. Potter to Carl T. Hayden describing John H. Page's request to build a railway for the Canyon Copper Company as "impractical"
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Elaboration on Kwapien's theorem: Representing bounded mean zero functions f as coboundary f = g ◦ T − g
No full textIn [8] Kwapien proved that every mean zero function f ∈ L∞[0, 1] we can write as f = g ◦ T − g for some g ∈ L∞[0, 1] and some measure preserving transformation T of [0, 1]. However, as was discovered in [4] there is a gap in the proof for the case that f is not continuous. The aim of this bachelor thesis is filling in that gap in the proof. We first extend Kwapien’s proof for continuous functions to certain other measure spaces. Thereafter, we use the method of proof suggested by Kwapien, to proof the theorem for mean zero function f ∈ L∞[0, 1] for which λ(f−1({x})) = 0 for all x ∈ R. Using this result we then proof that every mean zero function f ∈ L∞[0, 1] can be written as a sum f =(g1 ◦ T1 − g1) + (g2 ◦ T2 − g2) where g1, g2 ∈ L∞[0, 1] and where T1, T2 are measure preserving transformations of [0, 1]. We finish this thesis with an application of Kwapien’s theorem in the study to singular traces Applied Mathematic
f(G,T) and its Cosmological Implications
No full textA coupled formulation of the Gauss-Bonnet invariant term G and the
energy momentum trace T term provide a modified f(G,T) gravity,
has been analyzed in this study. The functional form for the
f(G,T) gravity has been taken as f(G,T)=αT+ βGThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Bianchi type-I universe in f(R, T) modified gravity with quark matter and Λ
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this study, we investigate homogeneous and anisotropic Bianchi type I universe in the presence of quark matter source in f (R, T) gravity (Harko et al. in Phys. Rev. D 84:024020, 2011) with cosmological constant A (where R is the Ricci scalar and T is the trace of the energy momentum tensor). For this aim we have used the anisotropy feature of Bianchi type I universe and equation of states (EoS) of quark matter. We explore the exact solution f(R, T)=R + 2f(T) model for Bianchi type I universe model. When t -> infinity, we get very small cosmological constant value, this result agrees with recent observations.Turkish Phys So
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
On Kasner solution in Bianchi I f(T) cosmology
No full text© 2018, The Author(s). Recently the cosmological dynamics of an anisotropic Universe in f(T) gravity became an area of intense investigations. Some earlier papers devoted to this issue contain contradictory claims about the nature and propertied of vacuum solutions in this theory. The goal of the present paper is to clarify this situation. We compare properties of f(T) and f(R) vacuum solutions and outline differences between them. The Kasner solution appears to be an exact solution for the T= 0 branch, and an asymptotic solution for the T≠ 0 branch. It is shown that the Kasner solution is a past attractor if T 0 branch
On Kasner solution in Bianchi I f(T) cosmology
No full text© 2018, The Author(s). Recently the cosmological dynamics of an anisotropic Universe in f(T) gravity became an area of intense investigations. Some earlier papers devoted to this issue contain contradictory claims about the nature and propertied of vacuum solutions in this theory. The goal of the present paper is to clarify this situation. We compare properties of f(T) and f(R) vacuum solutions and outline differences between them. The Kasner solution appears to be an exact solution for the T= 0 branch, and an asymptotic solution for the T≠ 0 branch. It is shown that the Kasner solution is a past attractor if T 0 branch
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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