7,215 research outputs found
E. Harold Shryock, MD
No full textA teacher of the ages, administrator, author, lecturer, ambidextrous artist, trick cyclist, Chair of the Department of Anatomy, and Dean of the School of Medicine of Loma Linda University.All descriptions are taken verbatim from: Portraits of Honored Faculty by S. Wesley Kime, MD. Editor Raymond Herber, MD. (Loma Linda, Calif.: Alumni Association of School of Medicine of Loma Linda University, 2005) and are thus not up-to-date as to positions held or contributions made to Loma Linda University Health
Failure to launch: The self-regulating Md -MYB10R6 gene from apple is active in flowers but not leaves of Petunia
No full textColoured foliage due to anthocyanin pigments (bronze/red/black) is an attractive trait that is often lacking in many bedding, ornamental and horticultural plants. Apples (Malus × domestica) containing an allelic variant of the anthocyanin regulator, Md-MYB10R6, are highly pigmented throughout the plant, due to autoregulation by MYB10 upon its own promoter. We investigated whether Md-MYB10R6 from apple is capable of functioning within the heterologous host Petunia hybrida to generate plants with novel pigmentation patterns. The Md-MYB10R6 transgene (MYB10–R6pro:MYB10:MYB10term) activated anthocyanin synthesis when transiently expressed in Antirrhinumroseadorsea petals and petunia leaf discs. Stable transgenic petunias containing Md-MYB10R6 lacked foliar pigmentation but had coloured flowers, complementing the an2 phenotype of ‘Mitchell’ petunia. The absence of foliar pigmentation was due to the failure of the Md-MYB10R6 gene to self-activate in vegetative tissues, suggesting that additional protein partners are required for Md-MYB10 to activate target genes in this heterologous system. In petunia flowers, where endogenous components including MYB-bHLH-WDR (MBW) proteins were present, expression of the Md-MYB10R6 promoter was initiated, allowing auto-regulation to occur and activating anthocyanin production. Md-MYB10 is capable of operating within the petunia MBW gene regulation network that controls the expression of the anthocyanin biosynthesis genes, AN1 (bHLH) and MYBx (R3-MYB repressor) in petals
Measurement of the B0–B0 oscillation frequency Δmd with the decays B0→D−π+ and B0→ J/ψK∗0
No full textThe B
0
–B
0
oscillation frequency Δmd is measured by the LHCb experiment using a dataset corresponding
to an integrated luminosity of 1.0 fb−1
of proton–proton collisions at √
s = 7 TeV, and is found to be
Δmd
=0.5156±0.0051 (stat.)±0.0033 (syst.) ps−1
. The measurement is based on results from analyses
of the decays B
0
→ D
−π
+ (D
−
→ K
+π
−π
−) and B
0
→ J/ψK
∗0
(J/ψ →μ
+μ
−,K
∗0
→ K
+π
−) and
their charge conjugated modes
Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A.
No full textSynthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differentiation primary response protein) branch of the bifurcated TLR4 (Toll-like receptor 4) signaling pathway, in contrast to diphosphoryl lipid A (sDLA), which is a strong activator of both branches of TLR4. sMLA's weak MyD88 signaling activity is apparent downstream of TLR4/MyD88 signaling as we show that sMLA, unlike sDLA, is unable to efficiently recruit the TNF receptor-associated factor 6 (TRAF6) to the Interleukin-1 receptor-associated kinase 1 (IRAK1). This reduced recruitment of TRAF6 explains MLA's lower MAPK (Mitogen Activated Protein Kinase) and NF-κB activity. As further tests of sMLA's ability to activate TLR4/Myeloid differentiation factor 2 (MD-2), we used the antibody MTS510 as an indicator for TLR4/MD-2 heterotetramer formation. Staining patterns with this antibody indicated that sMLA does not effectively drive heterotetramerization of TLR4/MD-2 when compared to sDLA. However, a F126A mutant of MD-2, which allows lipid A binding but interferes with TLR4/MD-2 heterotetramerization, revealed that while sMLA is unable to efficiently form TLR4/MD-2 heterotetramers, it still needs heterotetramer formation for the full extent of signaling it is able to achieve. Monophosphoryl lipid A's weak ability to form TLR4/MD-2 heterotetramers was not restricted to synthetic E. coli type because cells exposed to a biological preparation of S. minnesota monophosphoryl lipid A (MPLA) also showed reduced TLR4/MD-2 heterotetramer formation. The low potency with which sMLA and MPLA drive heterotetramerization of TLR4/MD-2 contributes to their weak MyD88 signaling activities
Perspectives an Analysis of "Vērtne MD" Ltd.
No full textBakalaura darba „SIA „Vērtne MD” saimnieciskās darbības analīze un perspektīvas” tiek pētīts kokrūpniecības nozares uzņēmums SIA „Vērtne MD”, tā saimniecisko darbība, kā arī uzņēmuma, darbinieki un darba vide kopumā.
Bakalaura darba mērķis ir analizēt uzņēmuma SIA „Vērtne MD” saimniecisko darbību, parādot analīzes metožu pielietojumu, tādējādi nosakot darbības nepilnības un problēmas.
Pirmajā daļā daba autors apraksta no teorijas aspektiem saimnieciskās darbības metodes.
Otrā daļā darba autors analīze un apraksta Latvijas kokapstrādes attīstību par pēdējiem gadiem.
Trešajā daļā, pielietojot pirmajā daļā aprakstītas teorijas aspektus, veica uzņēmuma SIA „Vērtne MD” saimnieciskās darbības analīze.
Darba noslēgumā autors veica secinājumus un priekšlikumus
Atslēgvārdi: Saimnieciskā darbība, SVID analīze, finanšu analīze, kokrūpniecība.Bachelor's Work "Perspectives an analysis of "Vertne MD" Ltd."an economic analysis and perspectives" are being analyzed timber industry company "Vērtne MD" its business activities, as well as employees and the environment as a whole.
In the first part the author describes the nature of the theory aspects of of economic activity methods
In the second part the author describes the analysis and development of Latvian woodworking for the past years.
In the third part, using the first part describes the theory aspects, performed company "Vērtne MD" an economic analysis.
In the final phase the author performed the conclusions and proposions..
Keywords: Economic activity, SWOT analysis, financial analysis, the timber industry
A Tribute to the Incomparable John S. Najarian, MD (1927-2020)
No full textIn this article, author Mary E. Knatterud, PhD, pays tribute to her incomparable longtime boss, transplant surgeon-scientist John S. Najarian, MD, who died at the age of 92 on August 31, 2020. The two worked together for several decades in the University of Minnesota Department of Surgery, which he chaired from July 1967 until February 1993. With deep affection and abiding respect, Knatterud describes his stellar academic background, internationally renowned career, and high-achieving yet genial style. She also showcases a cross-section of heartfelt comments (gathered by her, via email and/or phone, the sad week of his death) from colleagues in the workplace he built: Mary Jane Towle; Mary Dodds; Rainer W.G. Gruessner, MD; Barbara Elick, RN, BSN, MA; Henry Buchwald, MD, PhD; Catherine Statz, RN, MPH; and David A. Rothenberger, MD.Knatterud, Mary E. (2021). A Tribute to the Incomparable John S. Najarian, MD (1927-2020). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/219611
Open Access for the Medical Librarian
No full textThe most important aspects of open access for the medical librarian are presented. Reasons for open access include access to research information, access to taxpayer-funded research, facilitation of evidence-based medicine, equity of access, promotion of author control, and controlling library costs. The two primary approaches to open access, via author self-archiving and open access publishing, are presented. Key open access policy developments are highlighted. Many of the major policy initiatives of the moment are from the research funders. From the researcher funders' point of view, open access means more research impact, more real-world impact when professionals can access the literature, and value is illustrated to the taxpayer, building support for further research funding. The world's largest medical research funders, including the U.S. National Institute of Health and the Wellcome Trust, have public access policies, and many more policies are in development. For example, two weeks ago the Federal Research Public Access Act was introduced in the U.S. Senate. One of the essential elements of open access policy is ensuring that researchers are required, not requested, to deposit works. In Canada, the Canadian Institutes of Health Research has a policy in development called Access to Products of Research; public comments are due May 15, 2006. The dramatic growth of open access - over 2,220 journals in DOAJ, over 7.3 million items in an OAIster search - is discussed, as is the idea of new roles for librarians in an open access environment
Episodic encoding is more than the sum of its parts: An fMRI investigation of multifeatural contextual encoding
No full textEpisodic memories are characterized by their contextual richness, yet little is known about how the various features comprising an episode are brought together in memory. Here we employed fMRI and a multidimensional source memory procedure to investigate processes supporting the mnemonic binding of item and contextual information. Volunteers were scanned while encoding items for which the contextual features (color and location) varied independently, allowing activity elicited at the time of study to be segregated according to whether both, one, or neither feature was successfully retrieved on a later memory test. Activity uniquely associated with successful encoding of both features was identified in the intra-parietal sulcus, a region strongly implicated in the support of attentionally mediated perceptual binding. The findings suggest that the encoding of disparate features of an episode into a common memory representation requires that the features be conjoined in a common perceptual representation when the episode is initially experienced
Jefferson Medical College, of Philadelphia. Session 1858-9 Admit Mr. John E Logan of NC to the Lectures on Materia Medica and General Therapeutics, By Tho.s D. Mitchell MD Prof
No full textSession 1858-1859https://jdc.jefferson.edu/lecturetickets/1949/thumbnail.jp
sMLA is further reduced in signaling if heterotetramerization of TLR4/MD-2 is prevented.
No full text<p>HEK 293 cells were engineered to express either mouse MD-2 and CD14 or mouse F126A MD-2 and CD14 and transfected with a mouse TLR4 construct and a reporter plasmid that expresses SEAP upon activation of NF-κB. A) Fold-increase in SEAP activity was calculated by dividing the SEAP activity of the agonist by the SEAP activity from the vehicle control for that cell line. The graph shows the mean +/− SEM from 3 experiments in which the TLR4 transfection efficiencies of WT and F126A MD-2 cells were within 10% of each other. B) Histograms and dot blots are of live cells. Two wild type clones (WT) and two F126A MD-2 (MU) clones were stained for the presence of CD14 top panel. Bottom panel staining: HEK293 cells transfected with mouse TLR4 and thy 1.1 expressing construct or TLR4 and a MD-2/thy1.1 expressing construct stained with MTS510. Also shown are the WT1, WT2, MU1, and MU2 clones stained with MTS510 as an indication of surface expression of TLR4 and MD-2. C-E) EC50 measurement. The maximum SEAP values per clone was used to calculate 100% of maximum and a nonlinear curve fit, variable slope with 4 parameters was used to calculate the EC50 of each curve. C) Representative curve fits from one experiment for WT1 and MU2 clones showing the mean +/− SEM. A comparison of fits on Log EC50 using the Extra sum-of squares F test, was performed on the curves. D) Mean values +/− SEM of the log EC50 of three experiments with two clones for WT and MU. E) The difference in the log EC50 for sMLA and sDLA for WT and MU MD-2 as indicated at the bottom of the graph. The experiment in C–E was performed 3 times with triplicate samples for each dose of agonist. Asterisks represent the significant difference between agonist and vehicle control for A, and a significant difference between WT and MU for D and E, with *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, respectively. A paired two tailed T test was performed for Log EC50 difference, and a two-way ANOVA with Tukey’s multiple comparison test or Sidak’s multiple comparisons were performed A and D, respectively.</p
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