8,275 research outputs found
Mary Ann Cox Index: Royal Society Collection
No full textBurton-Wood: in a series of letters, by a lady (Mrs. - Cox nee Wight), London (printed for the author by H.D.Steel) 1783, vol.11
(octovo vol, leather bound)
Enclosed: note The book Burtonwood was written by the mother of
Mary Ann Cox who ran the first coach from Hobart to Launceston.
It was passed on to me by her grand-daughter Miss Dora Clerk of Malahide.
I also am a grand-daughter of Mrs. Cox. Joan Harvey
(John Edward Cox m. Mary Ann Halls
V.D.L. 1821 J.E.C. started Hobart-Launceston coach) - (note - Mrs.
Harvey's identification of the author of the volume was based on family
tradition although not confirmed - no details are known of John Edward
Cox's parents)
Poems by C(harles) Best c 1847 - 1849
Includes poems to Miss Wilmot (Georgiana Wilmot, - Mrs. C. Butler)
and Mary Wilmot.
Enclosed: note by Joan Harvey
Article on Mrs. Mary Ann Cox 1950.
A pioneer career woman (on coach service between Hobart - Launceston)
from "Woman's Day" Aug. 21, 1950 (news clipping)
R.S. 14
Concentration in Knowledge Output: A case of Economics Journals
No full textThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
Trajetórias através de um prisma: Caribe, raça e consciência oposicional em C. L. R. James e Oliver C. Cox
No full textThis work has two main objectives. First, it launches an interpretation on the main routes that two black authors from the Caribbean took; Oliver C. Cox and C. L. R. James. For this task, a contrast is made between the initial life of the authors, whose period is marked by their birth in the British colony of Trinidad, in the Caribbean, in 1901 until the publication of their magnum opi; 1948 for Cox, and 1938 for James. The second objective is, by debating with sociological tendencies directed to the study of intellectual trajectories, to argue in defense of the utility of working with categories that place the displacements derived from racial experience – and their resulting dysfunctions – at the beginning of sociological explanation, and not at the end as residues or events. At last, is by taking this into consideration that the article looked for explanations about the disparity of social destinies in both authors, among the links between their social experiences and the kinds of interventions they proposed.Este trabajo tiene dos objetivos principales. Primero, lanza una interpretación sobre las rutas principales que tomaron dos autores negros del Caribe; Oliver C. Cox y C. L. R. James. Para esta tarea, se hace un contraste entre la vida inicial de los autores, cuyo período está marcado por su nacimiento en la colonia británica de Trinidad, en el Caribe, en 1901, hasta la publicación de sus magnum opi; 1948 para Cox, y 1938 para James. El segundo objetivo es, en debate con tendencias sociológicas dirigidas al estudio de las trayectorias intelectuales, argumentar en defensa de la utilidad de trabajar con categorías que sitúan los desplazamientos derivados de la experiencia racial – y sus disfunciones resultantes – al comienzo de la explicación sociológica, y no al final como residuos o eventos. Por último, es teniendo esto en cuenta que el artículo buscó, entre los vínculos de sus experiencias sociales con los tipos de intervenciones que propusieron, explicaciones sobre la disparidad de los destinos sociales de ambos autores.Cet article a deux objectifs principaux. Premièrement, il lance une interprétation sur les principales routes empruntées par deux auteurs noirs des Caraïbes; Oliver C. Cox et C. L. R. James. Pour cette tâche, un contraste est fait entre la vie initiale des auteurs, dont la période est marquée par leur naissance dans la colonie britannique de Trinidad, dans les Caraïbes, en 1901, jusqu’à la publication de leur magnum opi; 1948 pour Cox et 1938 pour James. Le deuxième objectif est, en discutant avec les tendances sociologiques orientées vers l’étude des trajectoires intellectuelles, de défendre l’utilité de travailler avec des catégories qui placent les déplacements issus de l’expérience raciale – et leurs dysfonctionnements – au début de l’explication sociologique, et pas à la fin comme des résidus ou des événements. Enfin, c’est en prenant cela en considération que l’article cherche, parmi les liens entre leurs expériences sociales et le type d’interventions proposées par eux, des explications sur la disparité q’on trouve entre les destines sociaux des deux auteurs.Este trabalho tem dois objetivos fundamentais. O primeiro é lançar uma interpretação sobre os diferentes rumos que tomam dois autores negros do Caribe, Oliver C. Cox e C. L. R. James. Para esta tarefa, realiza-se um contraste entre as trajetórias iniciais dos autores, cujo periodo é marcado pelo nascimento de ambos na colônia britânica de Trinidad, no Caribe, em 1901 até a publicação de suas magnum opi; 1948 para Cox e 1938 para James. O segundo objetivo é, em debate com tendências sociológicas voltadas ao estudo de trajetórias intelectuais, argumentar em pró da utilidade de se trabalhar com categorias que colocam os deslocamentos derivados da experiência racial – e as disfunções decorrentes – no princípio da explicação sociológica, e não ao final como resíduos ou eventos. Por fim, é levando isso em consideração que se buscou nos nexos entre as experiências sociais dos autores e os tipos de intervenções propostas por eles, explicações acerca da disparidade entre os destinos sociais de ambos
Isolamento di cloni di cDNA per le subunità VIa e VIIa della Citocromo c ossidasi umana (COX).
No full textDescriviamo la caratterizzazione di cDNA per le isoforme epatica e muscolare della subunità VIa e per l'isoformadella subunità VIIa della citocromo c ossidasi umana (COX). I due cDNA della subunità VIa costituiscono la prima coppia di geni per isoforma tessuto-specifica della COX ad essere identificata nell'uomo e rivestono un'importanza primaria per l'analisi dei difetti di COX che si manifestano con selettivo coinvolgimento muscolare
Simultaneous Golgi-Cox and immunofluorescence using confocal microscopy
No full textVisualization of neuronal elements is of fundamental
importance in modern neuroscience. Golgi-Cox
impregnation is a widely employed method that provides
detailed information about morphological characteristics of
neurons, but none regarding their neurochemical features.
Immunocytochemical procedures, on the other hand, can
provide a high degree of biochemical specificity but poorer
morphological details, in particular if compared to Golgi-
Cox impregnation. Hence, the combined use of these two
approaches is highly desirable, especially for confocal
microscopy that can exploit the advantages of both methods
simultaneously. Here we show an innovative procedure
of perfusion and fixation of brain tissue, that allows, by
applying Golgi-Cox impregnation and immunofluorescence
in the same histological section, to obtain high-quality histological material, with a very simple and inexpensive
method. This procedure is based on three simple fixation
steps: (1) a paraformaldehyde perfusion followed by a standard post-fixation to stabilize the subsequent immunofluorescence reaction; (2) the classical Golgi-Cox impregnation and (3) an immunofluorescence reaction in previously impregnated material. This combination allows simultaneous visualization of (a) the structural details (Golgi-Cox impregnated neurons), (b) the antigens’ characterization, (c) the anatomical interactions between discrete neuronal elements and (d) the 3D reconstruction and modeling. The method is easy to perform and can be reproducibly applied by small laboratories and expanded through the use of different antibodies. Overall, the method presented in this study offers an innovative and powerful approach to study the nervous system, especially by using confocal microscopy
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
No full textPMCID: PMC3711559This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Avaliação da atividade do valeril salicilato, um inibidor da ciclooxigenase-1, em modelos de edema em camundongos
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O presente trabalho procurou avaliar a participação da ciclooxigenase-1 (COX-1) nos modelos de edema d e pata e edema de orelha em camundongos, utilizando o Valeril salicilato, um inibidor da COX-1, como ferramenta farmacológica. De acordo com os resultados obtidos, a inibição da COX-1, promove uma redução no edema de pata formado na primeira fase do edema (nas primeiras 4 horas após a injeção de carragenina), bem como outros inibidores, indometacina e o inibidor seletivo para a COX-2, celecoxib. Entretanto, em 48 horas após a injeção de carragenina, apenas os animais tratados com o valeril salicilato, apresentaram um aumento significante do edema formado. Os resultados demonstram que, para que este evento ocorra, além da inibição da COX-1, há a participação da via da lipooxigenase e do óxido nítrico
Critical role of COX-1 in prostacyclin production by human endothelial cells under modification of hydroperoxide tone
No full textWe aimed at evaluating the relative contribution of cyclooxygenase (COX) -1 and COX-2 to the synthesis of prostacyclin in endothelial cells under static conditions in the presence or absence of exogenous arachidonic acid and/or altered intracellular redox balance. Selective inhibitors of either COX-1 (SC560 and FR122047) or COX-2 (SC236) concentration dependently (1-300 nM) reduced basal and interleukin (IL) -1beta-induced prostacyclin production in human umbilical vein endothelial cells by 70% or more; compound selectivity was confirmed using a whole-blood assay (IC(50) COX-1/COX-2: 13 nM/930 nM for SC-560; 9 microM/457 nM for SC-236). The observed concomitant formation of isoprostane appeared to be associated with COX enzyme activity, while formation of COX-1/COX-2 heterodimers was detected by immunoprecipitation. In the presence of arachidonic acid and 12-hydroperoxy-eicosatetraenoic acid, either exogenous or provided by platelet activation, or after glutathione depletion, COX-1 inhibition but not COX-2 inhibition concentration dependently decreased prostacyclin production. Both isoforms appear to contribute to basal prostacyclin production by endothelial cells, with COX-2 providing the hydroperoxide tone required for COX-1 activity. Conversely, in the case of intracellular glutathione depletion or enhanced availability of arachidonic acid and hydroperoxides, selective COX-2 inhibition did not significantly affect the production of endothelial prostacyclin. These findings contribute to a better understanding of the effects of cyclooxygenase inhibitors on prostacyclin production
Virginia Cox Guerra holding infant daughter Elizabeth Guerra
No full textPhotograph shows Virginia Cox Guerra, resident of Roma, Texas, seated in studio, with infant daughter Elizabeth seated on her lap.Photographer's name on mount:''"Jose R. Mendez, / Artista Fotografo, / Matamoros, Mexico.'' Inscription on mount:""Dedico el presente a mis queridos hermanos Jacobo Cox Guerra y Maria Isabel Cox de Guerra en pureba delo verdadero...Virginia C. de Guerra / Roma [Texas] / Deciembre 29 de 1886.
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