2,198 research outputs found
Local Church Week Pastor Andre Mitchell
No full textPastor Andre Mitchell, Pastor, Author, CEO, Deliverance Temple/Andre Mitchell Ministries, Muncie, IN, speaks on how connecting with other believers is important to your faith for Local Church Week
Pearl Andre, Political Activist and Author from Bismarck
No full textAn undated photograph of Pearl Andre, an author and political activist from Bismarck. She wrote the book Women on the Move about the Nonpartisan League in North Dakota in 1975.https://commons.und.edu/nd-politics-photos/1254/thumbnail.jp
Andre Gide and the Negro, 1940
No full textBecause it is generally known that Andre Gide is one of France's most influential contemporary writers, there is no need to justify a study based on his works. Desirous of obtaining the opinion of an influential white author concerning Negroid people and learning his activities in their behalf, the writer of this thesis undertook the study, Andre Gide end the Negro. The value of such a study to the American Negro lies primarily in (1) a better acquaintance with and appreciation for one whose interest in darker people has resulted in a tangible contribution; (2) a knowledge of the condition of a people, who, though distant in territory, are kindred in race, and (3) a challenge for scholastic accomplishment. The method of procedure was a careful analysis of Voyage au Congo and Retour du Tchad supplemented by collateral readings. To secure information concerning Mr. Gide's official investigation in 1938 of the natives' educational facilities in Senegal, a letter was sent him. Despite the anxiety which must be his because of the present war in which his country is involved, the eminent author found time to respond. His reply is quoted on page thirty-one of this study. Grateful acknowledgment is hereby given both Mr. Gide for his amicable letter and Professor Cook, who made such a contact possible. The various factors for the evolution of Gide's interest in Negroid people are shown in Chapter I. Chapter II contains a discussion of the colonial abuses existing in French Equatorial Africa exposed by Gide and his efforts to eradicate these. Through Chapter III one learns the author's personal impression of the morale and intelligence of Negroid people. In Chapter IV an interpretation of Gide's literary art in Voyage au Gang and Retour du Tchad is presented. The results are summarized in the conclusion
Forholdet mellom fugler og vindmøller og andre lufthindringer. En litteraturoversikt
No full textNygård, T, Bevanger, K. & Reitan, O. 2008. Forholdet mellom fug-ler og vindmøller og andre lufthindringer. En litteraturoversikt. - NINA Rapport 413. 167 s.
Rapporten er en trykt versjon av en nettbasert referansedatabase om forholdet mellom fugl og flaggermus og vindmøller, kraftledninger, tårn, bygninger og andre lufthindringer. Den er en database som blir jevnilig oppdatert, og som er tilgjengelig over nettet via EndNote Web. Referansedatabasen inneholder i skrivende stund 1224 referanser til litteratur som omhandler denne problematikken. Databasen blir stadig utvidet etter hvert som ny litteratur blir tilgjengelig. Basen kan brukes som søkeverktøy mot andre litteraturdatabaser så som ISI Web of knowledge, Biosis og lignende, avhengig av brukertilgang. . I denne trykte utgaven er referansene sortert tematisk, deretter på trykkeår og forfatter. Basen har fått navnet ”Birdwind”. og oppdateres og administreres av NINA. Basen er ment som er verktøy som gjør det lettere å finne fram til relevant litteratur innenfor disse raskt voksende temaene. database, referanser, internett, EndNote web, fugl, flaggermus, vindmøller, vindkraft, kraftledninger, tårn, bygninger, gjerder, lufthindringer, radar, fugletrekk, kollisjoner, risiko, unnvikelse, økologiske effekter, avbøtende tiltak, litteratur, database, references, internet, EndNote Web, birds, bats, wind-farms, wind energy, turbines, utility structures, towers, buildings, fences, aerial obstacles, collisions, risk, radar, bird migration, avoidance, ecological effects, mitigation measures, literatureNygård, T., Bevanger, K. & Reitan, O. 2008. The relation between birds and wind turbines and other aerial obstacles. A literature survey. - NINA Report 413. 167 pp.
The report is a printed version of an internet-based reference database on the relation between birds and bats and aerial obstacles such as wind turbines, utility structures, towers and buildings. The database will be updated regularly, and is accessible via EndNote Web. At the date of printing it contains 1224 references on these topics. The database can also be used as a search engine for other databases such as ISI Web of knowledge, Biosis and others, depending on the access rights of the user.
In this printed version, the references are sorted by theme, thereafter by year of printing and author. The database is named “Birdwind”, and is administered and updated by NINA. The database is meant to be a tool that will make it easier to find relevant literature within these rapidly growing topics
Andre Gide: a study of the relationship between the author and his characters
No full textAndre Paul Guillame Gide was a controversial French writer. Some critics claimed he never wrote about anyone but himself; others denied that he used himself as a model for any but his first works. This paper is the result of a study to determine to what extent the characters of Andre Gide are autobiographical. The novel and novelle of Gide were chosen as a basis for this study because their characters are definite and their situations relatively clear. Each major character in these works was analyzed and his characteristics and actions noted in detail. Then a study was made of the author by reading his own autobiographical works and many biographies and studies of Gide. The characteristics and actions of Andre Gide were analyzed and noted. With the personalities of the author and his characters broken down into habits, characteristics and actions and organized, each character was again observed and his traits and attitudes matched with those of the author whenever this was possible. To avoid a confused jumble of characters, one book with its characters was studied at a time. [...]English, Department o
Functional and genetic approaches to decipher novel roles of Src homology region 2 domain-containing phosphatase-1 (SHP1) in physiology and metabolism
No full textInsulin resistance coupled with obesity is a condition that promotes metabolic disorders such as type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Alterations in lipid and glucose homeostasis, as well as low-grade chronic inflammation are the hallmarks of T2D and NAFLD. SHP-1 (encoded by the gene Protein Tyrosine Phosphatase Non-Receptor Type 6, PTPN6) is a tyrosine phosphatase with two SH2 domains and is known to act as a modulator of glucose and lipid metabolism. In addition, SHP-1 also regulates cytokine signaling and inflammatory gene expression. Besides being localized in the cytoplasm, SHP-1 is also found in the nucleus of epithelial cells. The function of this nuclear SHP-1 remains elusive. Here, we investigated tyrosine phosphatase dependent and independent functions of SHP-1 in controlling metabolic pathways.Previous findings from our laboratory established a link between SHP-1 and peroxisome proliferator-activated receptor 2 (PPAR2) activity. PPAR2 is a ligand-activated transcription factor that controls lipid metabolism. In chapter II, we found that SHP-1 interacts with PPAR2 mainly via its N-terminal SH2 domain and can dephosphorylate PPAR2 in vitro. Our data suggest that PPAR2 is tyrosine phosphorylated mainly on tyrosine residue 78 (Y78) and SHP-1-mediated dephosphorylation of PPAR2 is associated with its stability. The knockdown of SHP-1 in PPAR2 expressing cells resulted in enhanced expression of the classical PPAR2 targets FABP4 and CD36 coupled with increased adipogenesis. These effects were blunted in cells expressing mutant PPAR2 where tyrosine 78 has been replaced with the non-phosphorylatable phenylalanine (Y78F). Collectively, phosphatase activity of SHP-1 controls the stability of PPAR2 thereby affecting lipid metabolism. SHP-1 is a modulator of insulin signaling. Hepatocyte-specific SHP-1 KO mice compared to their wild type control littermates exhibited lower fasting glucose and vmarkedly decreased hepatic glucose production suggesting the existence of an additional insulin-independent effect of SHP-1 on glucose homeostasis. In Chapter III, we found that SHP-1 acts as a co-activator for controlling the transcription of the phosphoenolpyruvate carboxykinase 1 (PCK1) gene thereby regulating gluconeogenesis. SHP-1 is recruited to the regulatory region of the PCK1 gene, the potential site where it interacts with RNA polymerase II (RNAPII). The recruitment of SHP-1 to the chromatin was mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Depletion of STAT5 as well as SHP-1 resulted in a decrease in PCK1 transcript levels and blunted gluconeogenesis. Taken together, we discovered a novel function of SHP-1 whereby it acts as a key transcriptional co-regulator of the PCK1 gene and exerts control over gluconeogenesis. Collectively, findings from these studies provide novel functions of SHP-1 in controlling lipid and glucose metabolismLa résistance à l'insuline associée à l’obésité est une condition qui favorise les troubles métaboliques tels que le diabète de type 2 (T2D) et la stéatose hépatique non alcoolique (NAFLD). Des altérations de l'homéostasie des lipides et du glucose, ainsi qu'une inflammation chronique de bas grade sont les caractéristiques du T2D et de la NAFLD. SHP-1 (codé par le gène PTPN6) est une tyrosine phosphatase avec deux domaines SH2 et est connu pour agir comme modulateur du métabolisme du glucose et des lipides. SHP-1 régule également la signalisation des cytokines et l'expression des gènes inflammatoires. En plus d'être localisé dans le cytoplasme, SHP-1 se trouve également dans le noyau des cellules épithéliales. La fonction de ce SHP-1 nucléaire reste inconnue. Ici, nous avons étudié les fonctions dépendantes et indépendantes de la tyrosine phosphatase de SHP-1 dans le contrôle des voies métaboliques. Des découvertes antérieures de notre laboratoire ont établi un lien entre SHP-1 et l’activité du récepteur activé par les proliférateurs de peroxysomes 2 (PPAR2). PPAR2 est un facteur de transcription activé par des ligands et contrôle le métabolisme des lipides. Dans le chapitre II, nous avons constaté que SHP-1 interagit avec PPAR2 principalement via son domaine SH2 en N-terminal et peut déphosphoryler PPAR2 in vitro. Nos données suggèrent que PPAR2 est phosphorylé sur le résidu tyrosine 78 (Y78) et que la déphosphorylation catalysée par SHP-1 est associée à la stabilité de PPAR2. L’invalidation génétique de SHP1 dans des cellules exprimant PPAR2 augmente l’expression des cibles transcriptionnelles de PPAR2 telles que FABP4 et CD36 en plus d’augmenter l’adipogenèse. Ces effets étaient atténués dans des cellules exprimant une forme mutée de PPAR2 où la tyrosine 78 avait été remplacée par une phénylalanine ne pouvant être phosphorylée (Y78F). Collectivement, ces résultats indiquent que l’activité phosphatase de SHP-1 contrôle la stabilité de PPAR2 et donc affecte l’adipogenèse. iiiSHP-1 est un modulateur de la signalisation de l’insuline. L’invalidation génétique de SHP-1 spécifiquement dans les hépatocytes chez la souris (SHP-1 KO) est associée à une glycémie à jeun plus basse que celle de leurs congénères non transgéniques. Les souris SHP-1 KO présentaient également une diminution importante de la production hépatique de glucose, suggérant donc l’existence d’uneautre fonction de SHP-1 sur l’homéostasie du glucose, possiblement indépendante de l’insuline. Dans le chapitre III, nous avons découvert que SHP-1 agit comme coactivateur pour contrôler la transcription du gène phosphoénolpyruvate carboxykinase 1 (PCK1) et donc régule la gluconéogenèse. SHP-1 est recruté à la région régulatrice du gène PCK1, le cite potentiel où il interagit avec l’ARN polymérase II (RNAPII). Le recrutement de SHP-1 à la chromatine est dépendant du facteur de transcription transducteur de signal et activateur de transcription 5 (STAT5). L’épuisement de STAT5 ainsi que SHP-1 résulte en une diminution du niveau de transcrit de PCK1 et une réduction de la gluconéogenèse. Ensemble, ces résultats indiquent que nous avons découvert une nouvelle fonction de SHP-1 où la phosphatase agit comme un co-régulateur transcriptionnel clef du gène PCK1 et exerce un contrôle sur la gluconéogenèse
Andre P. Brink Collection index
No full textThis index describes the Andre P. Brink collection and contains letters by André P. Brink, Afrikaans author as well as newspaper clippings. The collection is compiled as 4 items in a pamphlet box
Development, Implementation, and Industry Reception of a Novel Multi-source, Data-driven Building Energy Management Toolkit
No full textInefficient and uninformed operations negatively impact building energy performance, leading to wide disparities between predicted and actual energy use in commercial and institutional buildings. Though ample research in data-driven building operations analytics has derived various methodologies for extracting energy-saving insights that can inform best practices, these approaches have traditionally remained disparate, and are mostly inaccessible to operations personnel who can benefit from these approaches in augmenting their duties and optimizing building energy efficiency. This research explores the development, implementation, and industry reception of a novel multi-source, data-driven building energy management toolkit as a synthesis of established data-driven approaches in the literature. Energy-saving insights identified from over five separate case study buildings demonstrated the toolkit's multifaceted application to identify operational deficiencies, and interviews with building operators and facility managers regarding the toolkit's outputs were conducted to identify possible barriers which may inhibit operations professionals from effectively deriving and utilizing data-driven insights
Critical properties of measurement interleaved quantum circuits
No full textauthor: Andre GladbachMasterarbeit Universität Innsbruck 202
Critical properties of measurement interleaved quantum circuits
No full textauthor: Andre GladbachMasterarbeit Universität Innsbruck 202
- …
