594,120 research outputs found
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Lasioseius fujianensis Ma & Lin 2013
No full textLasioseius fujianensis Ma & Lin , 2013 Lasioseius fujianensis Ma & Lin, 2013: 34. TYPE DEPOSITORY: Institute of Plant Protection, Fujian Academy of Agricultural Science, Fuzhou, China. TYPE LOCALITY AND HABITAT: Zhangping, 25 ° 18 'N, 117 ° 24 'E, Fujian, China, on mandarin orange [Plantae: Rutaceae].Published as part of De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1) on page 169, DOI: 10.11646/zootaxa.4112.1.1, http://zenodo.org/record/39947
Lasioseius wuyishanensis Ma & Lin 2013
No full textLasioseius wuyishanensis (Ma & Lin , 2013) Neolaspina wuyishanensis Ma & Lin, 2013: 35 TYPE DEPOSITORY: Institute of Plant Protection, Fujian Academy of Agricultural Science, Fuzhou, China. TYPE LOCALITY AND HABITAT: Guangze (27 ° 33 ' N, 117 ° 20 ' E), Wuyishan Mountain, Fujian, China, in moss.Published as part of De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1) on page 191, DOI: 10.11646/zootaxa.4112.1.1, http://zenodo.org/record/39947
Letter from Carl Hayden to P. J Moran
No full textLetter from Carl T. Hayden to P. J. Moran concerning the alignment of the road to Bright Angel Trail
Asca hainanensis Ma & Lin 2008
No full text<p> <b> <i>Asca hainanensis</i> Ma & Lin</b> , <b>2008</b></p> <p> <i>Asca hainanensis</i> Ma & Lin, in Ma <i>et al</i>., 2008: 582. <i>Asca hainanensis</i>.— Ma & Lin, 2014: 21.</p> <p>TYPE DEPOSITORY: Entomology Gallery, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.</p> <p>TYPE LOCALITY AND HABITAT: Dongshanling, Wanning, Hainan, China, in leaf litter.</p>Published as part of <i>De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1)</i> on page 95, DOI: 10.11646/zootaxa.4112.1.1, <a href="http://zenodo.org/record/399477">http://zenodo.org/record/399477</a>
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