65,615 research outputs found
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Epanerchodus gangwonus Mikhaljova & Lim 2002
No full textEpanerchodus gangwonus Mikhaljova & Lim, 2002 Epanerchodus gangwonus Mikhaljova & Lim, 2002: 19 –21, 20: figs 1–8. Remarks. Originally described from Gangwon-do, South Korea (Mikhaljova & Lim, 2001), this species has since never been rediscovered. Distribution. South Korea.Published as part of M, E L E N A V., Va, I K H A L J O & Lim, Kil-Young, 2006, The millipede genus Epanerchodus Attems, 1901 in the Korean Peninsula, with a description of a new species (Diplopoda, Polydesmida, Polydesmidae), pp. 45-53 in Zootaxa 1350 on page 48, DOI: 10.5281/zenodo.17451
Goniozus koreanus Lim, sp. nov.
No full textGoniozus koreanus Lim, sp. nov. (Figs 17–24) Type material. Holotype, Ƥ. KOREA: CN: Mangilsa, Daesan, Daesan, Seosan, N 36 ° 56 ' 29.8 " E 126 ° 26 ' 85.1 ", Alt. 184 m, 20.v. 2006, S.W. Park leg. (SNU). Paratypes. KOREA: Seoul: Ƥ, Cheongyangri, Dongdaemun, MT, 25.vii– 1.viii. 2005, D.P. Lyu leg. (KFRI); Ƥ, ditto, 15–22.viii. 2005, D.P. Lyu leg. (KFRI); Ƥ, Mt. Surak, Sanggye, Nowon, MT, 18.vii– 24.viii. 2007, J. O. Lim leg. (SNU); Ƥ, Seoul National University campus, Daehak, Gwanak, 4.viii. 2008, J. O. Lim leg. (SNU); Ƥ, Mt. Bulam, Gongreung, Nowon, MT, 11–25.v. 2008, S.W. Park leg. (SNU). GG: Ƥ, Yongin, 21.v. 1989, S.B. Han leg. (SNU); Ƥ, Mt. Yeogi, Seodun, Gwonseon, Suwon, 16.iv. 1994, J. Y. Choi leg. (SNU); Ƥ, Mt. Cheonggae, Gwacheon, 22.ix. 2000, H. G. Kang leg. (SNU); Ƥ, Yeongjusa, Annyeong, Taean, Hwaseong, MT, 22–29.viii. 2005, Y.D. Kwon leg. (KFRI); 2 Ƥ, ditto, 5 – 2.ix. 2005, Y.D. Kwon leg. (KFRI); 2 Ƥ, ditto, 12–20.ix. 2005, Y.D. Kwon leg. (KFRI); Ƥ, Sihwado, Namyangju, MT, N 37 ° 40 ' 6 " E 127 ° 18 ' 39 ", Alt. 238 m, 27.v. 2007, S.W. Park leg. (SNU); Ƥ, Gwanak arboretum, Anyang, Manan, Anyang, MT, 26.vi– 4.vii. 2007, J. O. Lim leg. (SNU); Ƥ, ditto, MT, N 37 ° 25 ' 15.6 " E 126 ° 56 ' 44.3 ", Alt. 126 m, 18.iv– 2.v. 2008, J. O. Lim leg. (SNU); Ƥ, Suwon arboretum, Seodun, Gwonseon, Suwon, 1.vi. 2009, J. O. Lim leg. (SNU); Ƥ, Mt. Ungil, Songchon, Choam, Namyangju, MT, N 37 ° 34 ' 43.3 " E 127 ° 18 ' 37.5 ", Alt. 134 m, 18–31.iv. 2009, J. O. Lim leg. (SNU); Ƥ, ditto, MT, 1–26.v. 2009, J. O. Lim leg. (SNU); Ƥ, ditto, MT, 27.v– 10.vi. 2009, J. O. Lim leg. (SNU); Ƥ, Mt. Homyeong, Goseong, Cheongpyeong, Gapyeong, MT, N 37 ° 43 '15.0" E 127 ° 29 ' 18.9 ", Alt. 168 m, 18–31.iv. 2009, J. O. Lim leg. (SNU); 2 Ƥ, ditto, MT, 1–6.v. 2009, J. O. Lim leg. (SNU). GW: Ƥ, Jinae, Dong, Chuncheon, MT, 16–22.viii. 2005, S.J. Jang leg. (KFRI); Ƥ, ditto, MT, 31.vii– 7.viii. 2008, S.J. Jang leg. (KFRI); Ƥ, Jukheon, Gangreung, N 37 ° 46 ' 55 " E 128 ° 51 ' 35 ", Alt. 57 m, 29.v. 2009, S.W. Park leg. (SNU); Ƥ, Chundang, Cheongil, Hoengseong, N 37 ° 36 ' 36 " E 128 ° 8 ' 36 ", Alt. 249 m, 7.vi. 2009, S.W. Park leg. (SNU). CB: Ƥ, Mt. Wolak, Susan, Jecheon, MT, N 36 ° 52 ' 4 " E 128 ° 8 ' 57 ", 1.ix. 2006, J. C. Jeong leg. (SNU); Ƥ, Namdaemun, Hoenam, Boeun, N 36 ° 26 ' 27 " E 127 ° 34 ' 25 ", Alt. 104 m, 24.ix. 2009, S.W. Park leg. (SNU). CN: Ƥ, Donam, Banpo, Gongju, MT, 23–30.viii. 2005, J.H. Han leg. (KFRI); 2 Ƥ, Gahak, Songak, Dangjin, N 36 ° 55 ' 17.5 " E 126 ° 42 ' 33 ", Alt. 34 m, 19.v. 2006, S.W. Park leg. (SNU); Ƥ, Baekja, Susin, Cheonan, 6.vi. 2008, S.W. Park leg. (SNU); 2 Ƥ, Annyeong, Tancheon, Gongju, 24.v. 2009, S.W. Park leg. (SNU); Ƥ, Hwaam, Cheongra, Boryeong, 14.vi. 2009, S.W. Park leg. (SNU); Ƥ, Hanseo Univ., Daegok, Haemi, Seosan, MT, N 36 ° 41 ' 30 " E 126 ° 34 ' 50 ", 11.vi– 8.vii. 2009, J.W. Lee leg. (YNU); Ƥ, Masan, Seocheon, 12.vi. 2010, S.W. Park leg. (SNU). Daejeon: 3 Ƥ, Wolpyeong, Seo, MT, 20.vi– 10.vii. 2008, J.W. Lee leg. (YNU). JB: Ƥ, Majeong, Bug, Jeongeub, MT, 19–26.vii. 2005, J.W. Park leg. (KFRI); Ƥ, ditto, 2–9.viii. 2005, J.W. Park leg. (KFRI); Ƥ, ditto, 30.viii– 6.ix. 2005, J.W. Park leg. (KFRI); Ƥ, Majeong, Bug, Jeongeub, MT, 19.iv– 8.v. 2007, J.W. Park leg. (KFRI); [JN] Ƥ, Pungsan, Dado, Naju, MT, 25.vii– 8.viii. 2005, S.B. Yu leg. (KFRI); Ƥ, ditto, 9–30.ix. 2005, S.B. Yu leg. (KFRI); 2 Ƥ, Pungsan, Dado, Naju, MT, 27.iv– 17.v. 2007, S.B. Yu leg. (KFRI); 2 Ƥ, ditto, 17.v– 7.vi. 2007, S.B. Yu leg. (KFRI); Ƥ, Mt. Naejang, Ssangung, Bukha, Jangseong, MT, N 35 ° 25 ' 31.6 " E 126 ° 51 ' 46.9 ", 13.v. 2007, J.W. Lee leg. (YNU); 2 Ƥ, Pungsan, Dado, Naju, MT, 26.v– 2.vi. 2008, S.B. Yu leg. (KFRI); Ƥ, Mt. Naejang, Sinseong, Bukha, Jangseong, N 35 ° 27 ' 17.9 " E 126 ° 50 ' 38.8 ", Alt. 161 m, 3.vii. 2009, J. O. Lim leg. (SNU). GB: Ƥ, Yeungnam Univ., Dae, Gyeongsan, MT, 30.iv– 7.v. 2007, J.W. Lee leg. (YNU); Ƥ, Namsa, Hyeongok, Kyeongju, MT, 30.vi– 14.vii. 2005, J.T. Mun leg. (KFRI); 2 Ƥ, Namsan, Gakbuk, Cheongdo, MT, N 35 ° 41 ' E 128 ° 35 ', 9–19.viii. 2007, J.W. Lee leg. (YNU); Ƥ, ditto, 15.x– 4.xi. 2007, J.W. Lee leg. (YNU); Ƥ, Yeongnam Univ., Dae, Gyeongsan, MT, 30.iv– 7.v. 2007, J.W. Lee leg. (YNU); Ƥ, ditto, MT, N 35 ° 58 ' E 128 ° 47 ', 12–21.vii. 2007, J.W. Lee leg. (YNU); Ƥ, Namsan, Gakbuk, Cheongdo, N 35 ° 41 ' E 128 ° 35 ' 23 ", 5.x– 2.xi. 2008, J. O. Lim leg. (SNU); Ƥ, Mt. Unmun, Cheongdo, MT, N 35 ° 38 ' 45 " E 128 ° 57 ' 33 ", 23.v. 2008, J.W. Lee leg. (YNU); Ƥ, ditto, MT, N 35 ° 38 ' 19 " E 128 ° 57 ' 40 ", 30.v– 16.vi. 2009, C. J. Kim leg. (YNU); Ƥ, Sangju campus, Gyeongbuk Univ., Gajang, Sangju, MT, 28.v– 4.vi. 2009, S.W. Park leg. (SNU). GN: Ƥ, Dapcheon, Ibanseong, Jinju, MT, 1–9.viii. 2005, B.G. Ahn leg. (KFRI). Busan: Ƥ, Daemadeung, Nakdonghagu, Myeongji, Gangseo, 22.viii. 2006, T. H. Kim leg. (SNU). JJ: Ƥ, Donggye, Jeju, MT, 27.vi– 18.vii. 2007, C. H. Shin leg. (KFRI). Diagnosis. This species is mostly similar to Goniozus japonicus Ashmead, 1904 by having mandible yellow; by fore wing without areolet; by flagellomere 3–5 longer than wide respectively; by propodeal disc with complete transverse carina; by ratio of head and propodeal disc. However, this species can be distinguished from G. japonicus by short antennal segments, by pedicel to flagellomere 2 less than 1.5 × as long as wide, by flagellomere 11 1.5 × as long as wide (long antennal segments, pedicel to flagellomere 2 longer than 2.0 × as long as wide, flagellomere 11 2.0 × as long as wide in G. japonicus); by median and submedian cell of fore wing with relatively denser hairs (very sparse hairs in G. japonicus). Description. FEMALE (holotype). Body length 4.1 mm. LFW 2.5 mm. Color. Head: mandible yellow, antenna yellow, from flagellomeres 6–11 pale castaenous. Mesosoma black; fore wing subhyaline, veins pale castaenous; legs yellow except coxa and femora dark castaenous, tarsal claw dark castaenous. Metasoma black except distal margin of terga 4–7 pale castaenous. Head (Figs 18–20): 1.0 × as long as wide, coriaceous; lateral margin convex, posterior margin straight, postero-lateral corner forming round angle in dorsal view; lateral surface smooth and polished. Mandible with four acute teeth. Clypeus well-developed, frontal angle right; fronto-clypeal median longitudinal carina developed, exceeding antennal socket. First antennal segment in ratio of 2.3: 1.0: 1.0: 1.1: 1.2 in length; from scape to flagellomere 3 and 11 2.0, 1.3, 1.2, 1.2, 1.3 and 1.6 × as long as wide, respectively. Frons and vertex coriaceous with sub-erect hairs and sparse moderate punctures, aparted from each other 2.0–3.0 × as wide as their maximum diameter. WF 1.1 × LE, WF 0.6 × WH. Compound eye 0.37 mm long without hairs. LE 1.8 × OOL, WF 1.7 × WOT. Frontal angle of ocellar triangle obtuse, POL 2.1 × AOL, OOL 0.8 × WOT. Vertex coriaceous without conspicuous long hairs. Mesosoma (Figs 21–23): Pronotum coriaceous, 0.4 × as long as wide with sparse hairs, antero-lateral corner obtuse. Mesoscutum coriaceous; notauli absent; parapsidal furrows thin and anteriorly divergent. Scutellum polish and coriaceous with sparse small punctures; scutellar pit elliptical, oblique and connected by 3.9 × as wide as their maximum diameter. Propodeal disc 0.6 × as long as wide, lateral and transverse carina complete; medial basal triangle smooth and polished, extending mid-length of disc, connected to transverse carina with thin longitudinal carina in areolate surface. Disc areolate-rugose; declivity coriaceous with complete marginal carina; lateral surface coriaceous. Fore wing without closed areolate; median and submedian cell with two rows of hairs; radial vein curved outward at apex with obtuse angle; pterostigma 0.29 mm long; metacarpo absent. Metasoma (Fig. 24): Tergite 1 smooth and polished without fine puncture and microreticulation. Terga 2–4 smooth and micoreticulation on anterior half with some hairs on dorso-lateral surface. Terga 5–7 microreticulate with sparse hairs on distal surface. MALE. Unknown. Distribution. Korea (Busan, CB, CN, Daejeon, GB, GG, GN, GW, JB, JJ, JN, Seoul).Published as part of Lim, Jongok & Lee, Seunghwan, 2012, Review of Goniozus Förster, 1856 (Hymenoptera: Bethylidae) of Korea, with descriptions of two new species, pp. 43-57 in Zootaxa 3414 on pages 49-51, DOI: 10.5281/zenodo.21079
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Solar Power in the Garden State
No full textThis special issue on energy and solar power in New Jersey was made possible because of the extensive portfolio of research centers and institutes at the Edward J. Bloustein School of Planning and Public Policy. Dr. Frank A. Felder, an Associate Research Professor, has been director of the School’s Center for Energy, Economic & Environmental Policy (CEEEP) since 2006. Frank is a nuclear engineer with a PhD degree from MIT, and he, along with his CEEEP colleague, Shankar N. Chandramowli, coauthored the main article in this issue of the Advance & Rutgers Report. CEEEP has worked extensively with the New Jersey Board of Public Utilities on projects, including New Jersey’s current Energy Master Plan.Shining Brightly: Bloustein's Centers of Excellence / by James W. Hughes and Joseph S. Seneca -- Solar Power in the Garden States / by Shankar N. Chandramowli and Frank A. Felder.Guest contributors include Shankar N. Chandramowli and Frank A. Felder, PhD, Director—Center for Energy, Economic and Environmental Policy at the Edward J. Bloustein School of Planning and Public PolicyReports published as Issue Paper Number 5, May 2011, in Advance & Rutgers Report, Special Issue
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
University of Białystok Lim-Inf Convergence 1
No full textand [13] provide the notation and terminology for this paper. One can prove the following propositions: (1) For every complete lattice L and for every net N in L holds inf N � lim inf N. (2) Let L be a complete lattice, N be a net in L, and x be an element of L. Suppose that for every subnet M of N holds x = lim inf M. Then x = lim inf N and for every subnet M of N holds x � inf M. (3) Let L be a complete lattice, N be a net in L, and x be an element of L. Suppose N ∈ NetUniv(L). Suppose that for every subnet M of N such that M ∈ NetUniv(L) holds x = lim inf M. Then x = lim inf N and for every subnet M of N such that M ∈ NetUniv(L) holds x � inf M. Let N be a non empty relational structure and let f be a map from N into N. We say that f is greater or equal to id if and only if: (Def. 1) For every element j of the carrier of N holds j � f(j). We now state three propositions: (4) For every reflexive non empty relational structure N holds idN is greater or equal to id. (5) Let N be a directed non empty relational structure and x, y be elements of N. Then there exists an element z of N such that x � z and y � z. (6) For every directed non empty relational structure N holds there exists a map from N into N which is greater or equal to id
A note on the connectedness locus of the families of polynomials Pc(z)=z n - cz n-j
No full textLet j be a positive integer. For each integer n > j we consider the connectedness locus Mn of the family of polynomials Pc(z) = z n - cz n-j, where c is a complex parameter. We prove that lim n→∞ Mn = D in the Hausdorff topology, where D is the unitary closed disk {c;|c|Seja j um inteiro positivo. Para cada inteiro n > j, consideramos o locus conexo Mn da família de polinômios Pc(z) = z n - cz n-j, onde c é um parâmetro complexo. Provamos que lim n→∞ Mn = D na topologia de Hausdorff; onde D é o disco unitário {c;|c|<1}
Drug effects on triiodothyronine uptake by rat anterior pituitary cells in vitro
No full textC.-F. Lim, N. M. Loidl, J. A. Kennedy, D. J. Topliss, J. R. Stockig
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
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