37,024 research outputs found
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Recommended from our members
Identifying idiolect in forensic authorship attribution: an n-gram textbite approach
No full textForensic authorship attribution is concerned with identifying authors of disputed or anonymous documents, which are potentially evidential in legal cases, through the analysis of linguistic clues left behind by writers. The forensic linguist “approaches this problem of questioned authorship from the theoretical position that every native speaker has their own distinct and individual version of the language [. . . ], their own idiolect” (Coulthard, 2004: 31). However, given the diXculty in empirically substantiating a theory of idiolect, there is growing concern in the Veld that it remains too abstract to be of practical use (Kredens, 2002; Grant, 2010; Turell, 2010). Stylistic, corpus, and computational approaches to text, however, are able to identify repeated collocational patterns, or n-grams, two to six word chunks of language, similar to the popular notion of soundbites: small segments of no more than a few seconds of speech that journalists are able to recognise as having news value and which characterise the important moments of talk. The soundbite oUers an intriguing parallel for authorship attribution studies, with the following question arising: looking at any set of texts by any author, is it possible to identify ‘n-gram textbites’, small textual segments that characterise that author’s writing, providing DNA-like chunks of identifying material
Human immunodeficiency virus type 1 drug resistance among patients failing second-line antiretroviral treatment in Butha-Buthe and Mokhotlong, Lesotho
No full textThesis (Master: Health Sciences (Biomedical Technology))--Central University of TechnologyBackground: To date, there is no cure for HIV. However, antiretroviral treatment (ART) is used to control the replication of HIV and many people living with HIV take ART. Unfortunately, over time, some patients develop drug resistance which is becoming a major public threat limiting future treatment options for people living with HIV. HIV-1 drug resistance is defined as the ability of HIV-1 to mutate and reproduce itself in the presence of ARV drugs. This occurs as a result of: (a) poor adherence to treatment; (b) inadequate potency of ARVs; (c) suboptimal drug levels and (d) pre-existing resistance. There are two types of resistance-associated mutations (RAMs) namely acquired and transmitted. When an individual is infected with HIV-1 resistant strain, it may become the dominant strain for further transmission leading to increasing number of antiretroviral-naive patients and reducing their therapeutic effectiveness. HIV drug resistance testing is a test used to detect the presence of RAMs to HIV type 1 (HIV-1). Currently patients are switched empirically in the country. Therefore, it is crucially important to understand the HIV drug resistance pattern in order to find ways how to limit the occurrence. This will helpful in the clinical decision making and selection of regimens upon treatment failure. Objective: The objective of the study was to access the prevalence and patterns of HIV resistance-associated mutations in patients with an unsuppressed viral load when taking second-line ART in Butha-Buthe and Mokhotlong districts, Lesotho. Methods: In a retrospective study, we used convenience sampling and sequenced all eligible (patients on second line ART with a viral load ≥ 1000 copies/mL) stored leftover plasma samples taken between January 2016 and October 2020. The study was conducted at Seboche Hospital Laboratory which served all health facilities (hospitals and clinics) in the northern region of Lesotho. During testing, RNA extraction was done manually using the Purelink Viral/DNA kit. PCR amplification and sequencing of the protease (PR) and reverse transcriptase (RT) region was done using the Amplification and Sequencing module kits developed by Thermo Fisher Scientific. Consensus sequences were derived, aligned, and analysed using the web-based Recall software. The Stanford HIV Drug Resistance Database was used to interpret the presence or absence of drug resistant mutants. Results and discussion: Out of 55 patients’ samples, 30 samples were successfully amplified and sequenced. The median age was 41 years (IQR: 30 to 49) and the majority (62%) of participants were female. The median duration on a second-line regimen at the time of phlebotomy was 1.9 years (IQR: 0.5 to 3.0). The majority of patients (94%) were taking ritonavir-boosted lopinavir-based ART. Major RAMs were observed in 62% of participants; one patient had major RAMs in the PR while 18 had RAMs in the RT region. All participants had HIV-1 subtype C. The most frequent mutations conferring resistance to nucleoside reverse transcriptase inhibitors were M184V (31%) and K70R/E (16%), while the most frequent mutations conferring resistance to non-nucleoside reverse transcriptase inhibitors were K103N (38%), P225H (19%) and G190A (19%). The observed PR mutations from one sample were M46I, I54L and V82L. Only 10 (31%) patients had RAMs which conferred resistance to their second-line regimen. Though RAMs were detected, the majority of patients had three active drugs in their second-line regimen and many observed mutations likely conferred resistance to their previous regimens. Conclusion: Though 62% of patients had RAMs, only 31% had RAMs conferring resistance to their second-line regimen during the first 2 years after switch to second-line ART, indicating that adherence plays a major role in second-line treatment failure. These RAMs reflect the reality of HIV care in resource-limited settings such as Lesotho. Adherence should be strengthened among people with treatment failure while taking second-line ART in order to avoid development of resistance mutations
Gaps in intervals of N-expansions
No full textFor N ∈ N≥2 and α ∈ R such that 0 < α ≤ N − 1, the continued fraction map Tα: [α, α+1] → [α, α+1) is defined as Tα (x):= N/x−d(x), where d: [α, α+1] → N is defined by d(x):= ⌊N/x − α⌋. A maximal open interval (a, b) ⊂ Iα is called a gap of Iα if for almost every x ∈ Iα there is an n0 (x) ∈ N such that xn /∈ (a, b) for all n ≥ n0 . In this paper, all conditions are given in which Iα is gapless. For α =√N − 1 it is shown that the number of gaps is a finite, monotonically non-decreasing and unbounded function of N.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Applied Probabilit
Challenge in R&D Management : Tata Steel A Case Study
No full textThe purpose of R&D management is to promote innovation as
well as wealth creation. The paper traces the history of R&D managementhow it has changed from the first generation when only innovation was the main objective to the fifth generation where IT plays an important role. It is now necessary to understand the needs of market for conducting worthwhile research. The author shares his experience of R&D management at Tata Steel. The experience shows that by adopting judicious R&D strategy it is possible to face the challenges of reconciling innovation with wealth
creation is possible by a judicious R&D strategy
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
No full textThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
Covariantly constant curvature tensors and D=3, N=4, 5, 8 Chern-Simons matter theories
No full textWe construct some examples of D = 3, N = 4 GW theory and N = 5 superconformal Chern-Simons matter theory by using the covariantly constant curvature of a quaternionic-Kahler manifold to construct the symplectic 3-algebra in the theories. Comparing with the previous theories, the N = 4, 5 theories constructed in this way possess a local Sp(2n) symmetry and a diffeomorphism symmetry associated with the quaternionic-Kahler manifold. We also construct a generalized N = 8 BLG theory by utilizing the dual curvature operator of a maximally symmetric space of dimension 4 to construct the Nambu 3-algebra. Comparing with the previous N = 8 BLG theory, the theory has a diffeomorphism invariance and a local SO(4) invariance associated with the symmetric space.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000301843500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Astronomy & AstrophysicsPhysics, Particles & FieldsSCI(E)2ARTICLE6null8
A 121.4dB DR, -109.8dB THD+N Capacitively-Coupled Chopper Class-D Audio Amplifier
No full textClass-D amplifiers (CDAs) are often used in audio applications due to their superior power efficiency. Due to the sensitivity of the human ear, a large dynamic range (DR) is desired, and audio DACs with up to 130dB DR are commercially available [1]. However, the DR of the CDAs they drive is typically much lower [2]-[4], mainly due to the thermal noise introduced by the input resistors of their resistive feedback networks. Reducing this resistance is difficult, as it reduces the CDA's input impedance and increases the required loop-filter capacitance. Alternatively, the CDA could be configured as a capacitively coupled chopper amplifier (CCCA), whose capacitive feedback network could then achieve low noise without reducing input impedance. However, the large PWM component present at its output would then saturate its input stage. By exploiting the inherent PWM filtering present in a feedback-after-LC architecture, this paper presents a capacitively coupled chopper CDA, resulting in significantly improved DR and THD+N. The prototype achieves 8V_RMS of integrated output noise (A-weighted), a 121.4dB DR, and -1 09.8dB THD+N while delivering a maximum of 15/26W into an 8/4Omega load with 93%/88% efficiency.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
- …
