10 research outputs found
The Status of Reading in Early Modern English Literature.
No full text"The Status of Reading in Early Modern English Literature" explores the social implications of print publication in England from the 1590s to the 1630s. Analyzing the fictional worlds of texts and their material forms, "The Status of Reading" pushes against a scholarly trend that emphasizes writers’ anxieties and fears about print publication. It claims instead that writers often invoked a popular reading public in opposition to the elite, rarefied world of aristocratic court circles. This reading public was tied to the needs and ideas of the writers who called it into being, and who used it strategically to explore their own cultural importance and the growing importance of people outside the ranks of the aristocracy as taste-makers. In invoking this reading public, writers developed new notions of status and claimed an alternate hierarchy of intellectual merit that existed in tension with the social hierarchy. Their works explore various ways people could achieve this new status: attaining an aristocratic title through proving one’s intelligence and wit; gaining cultural capital based on popularity; or asserting the unique value of cultural contributions made by people whose gender or social position were considered subordinate. The texts under consideration—Christopher Marlowe’s "Doctor Faustus;" William Shakespeare’s "Twelfth Night," "Macbeth," "Love’s Labour’s Lost," "As You Like It," and "Sonnets;" Aemilia Lanyer’s "Salve Deus Rex Judaeorum;" and Ben Jonson’s "The New Inn" and "Ode to Himself"—foreground multiple forms of publication to different readers. Each text stages fictional reading practices and the circulation of texts; moreover, its print manifestation addresses imagined readers to whom the text is marketed. Together, these texts challenge traditional hierarchical structures on two fronts: while exploring what it meant for readers to advance socially through reading well, they also suggest that a popular reading public, made of commoners, should be considered just as culturally valuable—or perhaps more culturally valuable—than smaller, socially elite communities of readers. In attending to the ways writers constructed and empowered a common reading public, "The Status of Reading" significantly expands our understanding of the social dynamics of reading in an age of increasing literacy and access to texts.PhDEnglish Language and LiteratureUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/113541/1/czukerma_1.pd
Scalable adaptive hierarchical clustering
No full textWe propose a new application-level clustering algorithm capable of building an overlay spanning tree among participants of large multicast sessions, without any specific help from the network routers. The algorithm and associated protocols are shown to exhibit scalable properties
Genetic programming and deductive-inductive learning: a multistrategy approach
No full textProceedings of: 15th International Conference on Machine Learning, Madison (Wisconsin, USA), July 24-27, 1998.Genetic Programming (GP) is a machine learning technique that was not conceived to use domain knowledge for generating new candidate solutions. It has been shown that GP can benefit from domain knowledge obtained by other machine learning methods with more powerful heuristics. However, it is not obvious that a combination of GP and a knowledge intensive machine learning method can work better than the knowledge intensive method alone. In this paper we present a multi-strategy approach where an analytical and inductive approach (hamlet) and an evolutionary technique based on GP (EvoCK) are combined for the task of learning control rules for problem solving in planning. Results show that both methods complement each other, supplying to the other method what the other method lacks and obtaining better results than using each method alone.Publicad
Effect of calcium-binding additives on ventricular fibrillation and repolarization changes during coronary angiography
No full textVentricular fibrillation during coronary angiography with Renografin-76 (meglumine sodium diatrizoate) has been attributed to the calcium-binding additives sodium citrate and sodium ethylenediaminetetraacetic acid (EDTA), which may produce repolarization changes manifested as prolongation of the QT interval. Angiovist-370 is a newer form of meglumine sodium diatrizoate that contains calcium EDTA as its additive and thus has a decreased calcium-binding effect. Eight hundred sixteen patients were prospectively randomized to receive either Renografin-76 or Angiovist-370. Ventricular fibrillation occurred in 10 of 410 patients receiving Renografin-76 and in 0 of 406 patients given Angiovist-370 (p < 0.0005).Clinical data were analyzed without knowledge of other data in the 10 patients treated with Renografin-76 who had ventricular fibrillation (Group I), 103 randomly selected patients who also received Renografin-76 but had no ventricular fibrillation (Group II) and 108 randomly selected patients given Angiovist-370 (Group III). Of several variables examined, only the QT interval differentiated patients receiving Renografin-76 and Angiovist-370. The mean corrected QT interval (QTcinterval) before coronary angiography was slightly but not significantly (p = 0.7) higher in Group I than in Groups II and III. Ten seconds after the first left coronary artery injection it was more prolonged in Groups I and II (0.552 and 0.561 second, respectively) than in Group III (0.448 second) (p < 0.00005). Similarly, 10 seconds after the first right coronary artery injection it was significantly longer in Groups I and II (0.545 and 0.544 second) than in Group III (0.477 second) (p < 0.00005). The mean QTC interval after coronary angiography was slightly more prolonged in Groups I and II (0.469 and 0.455 second) compared with Group III (0.439 second) (p = 0.06).Thus, the substitution of calcium EDTA in contrast agents significantly decreases the incidence of ventricular fibrillation during coronary angiography, perhaps by attenuating the repolarization changes (with resultant QT interval prolongation) induced by contrast agents
Investigating Performer Uniqueness: The Case of Jascha Heifetz
No full textThis thesis is based on the conviction that the greatest musical performers of history can and should be granted the same level of academic scrutiny and study as is so often received by the greatest composers. Composers had the early advantage of producing durable manuscripts, while performers prior to the age of recording were unable to leave more than impressions in the minds of those who heard them. With the recent successes of numerous investigations into performance and recordings, including the CHARM and CMPCP projects, such studies are becoming ever more viable and significant.
The thesis focuses on the violinist Jascha Heifetz (1901-1987) and primarily his performances of the Bach solo violin works (BWV 1001-1006). While there have been studies of individual pieces, of particular performers, and of multiple recordings of the same piece, a study focussing on specific repertoire played by a specific performer is something that has been somewhat overlooked in the literature. The thesis draws on numerous methods to distil what is distinctive and unique about Heifetz. This includes an examination of what and how the performer played, why the performer played that way, and how that way of playing compares to other performers. The study concludes with a discussion of Heifetz’s unique performer profile in the context of violin performance history.
Focussing on one of the most famous and successful performing musicians of the twentieth century along with some of the most frequently played pieces, this case study will suggest research methods and approaches transferable to related studies. The thesis draws on original interviews with former Heifetz students, friends, and colleagues, and on over thirteen months of archival research in the Jascha Heifetz Collection held by the Library of Congress. This array of previously untapped material aided the analytical and empirical investigations into Heifetz’s uniqueness
Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry
No full textThe 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1–3) and 1 (IQR 0–2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21–2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641–0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377
Global COVID-19 lockdown highlights humans as both threats and custodians of the environment
No full textThe global lockdown to mitigate COVID-19 pandemic health risks has altered human interactions with nature. Here, we report immediate impacts of changes in human activities on wildlife and environmental threats during the early lockdown months of 2020, based on 877 qualitative reports and 332 quantitative assessments from 89 different studies. Hundreds of reports of unusual species observations from around the world suggest that animals quickly responded to the reductions in human presence. However, negative effects of lockdown on conservation also emerged, as confinement resulted in some park officials being unable to perform conservation, restoration and enforcement tasks, resulting in local increases in illegal activities such as hunting. Overall, there is a complex mixture of positive and negative effects of the pandemic lockdown on nature, all of which have the potential to lead to cascading responses which in turn impact wildlife and nature conservation. While the net effect of the lockdown will need to be assessed over years as data becomes available and persistent effects emerge, immediate responses were detected across the world. Thus initial qualitative and quantitative data arising from this serendipitous global quasi-experimental perturbation highlights the dual role that humans play in threatening and protecting species and ecosystems. Pathways to favorably tilt this delicate balance include reducing impacts and increasing conservation effectiveness
Validating the predictive ability of the 2MACE score for major adverse cardiovascular events in patients with atrial fibrillation: results from phase II/III of the GLORIA-AF registry
No full textThe 2MACE score was specifically developed as a risk-stratification tool in atrial fibrillation (AF) to predict cardiovascular outcomes. We evaluated the predictive ability of the 2MACE score in the GLORIA-AF registry. All eligible patients from phase II/III of the prospective global GLORIA-AF registry were included. Major adverse cardiac events (MACEs) were defined as the composite outcome of stroke, myocardial infarction and cardiovascular death. Cox proportional hazards were used to examine the relationship between the 2MACE score and study outcomes. Predictive capability of the 2MACE score was investigated using receiver-operating characteristic curves. A total of 25,696 patients were included (mean age 71 years, female 44.9%). Over 3 years, 1583 MACEs were recorded. Patients who had MACE were older, with more cardiovascular risk factors and were less likely to be managed using a rhythm-control strategy. The median 2MACE score in the MACE and non-MACE groups were 2 (IQR 1-3) and 1 (IQR 0-2), respectively (p < 0.001). The 2MACE score was positively associated with an increase in the risk of MACE, with a score of ≥ 2 providing the best combination of sensitivity (69.6%) and specificity (51.6%), HR 2.47 (95% CI, 2.21-2.77). The 2MACE score had modest predictive performance for MACE in patients with AF (AUC 0.655 (95% CI, 0.641-0.669)). Our analysis in this prospective global registry demonstrates that the 2MACE score can adequately predict the risk of MACE (defined as myocardial infarction, CV death and stroke) in patients with AF. Clinical trial registration: http://www.clinicaltrials.gov . Unique identifiers: NCT01468701, NCT01671007 and NCT01937377
The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
No full textBackground GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Global COVID-19 lockdown highlights humans as both threats and custodians of the environment
No full textGlobal COVID-19 lockdown highlights humans as both threats and custodians of the environmen
