169,946 research outputs found
Molecular structure of highly excited resonant states in Mg-24 and the corresponding Be-8+O-16 and C-12+C-12 decays
No full textExotic Be-8 and C-12 decays from high-lying resonances in Mg-24 are analyzed in terms of a cluster model. The calculated quantities agree well with the corresponding experimental data. It is found that the calculated decay widths are very sensitive to the angular momentum carried by the outgoing cluster. It is shown that this property makes cluster decay a powerful tool to determine the spin as well as the molecular structures of the resonances.Physics, NuclearSCI(E)7ARTICLE5null8
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
B -> eta K-c(eta ' K-c) decays in QCD factorization
No full textWe study the exclusive decays of the B meson into pseudoscalar charmonium states eta(c) and eta(c)' within the QCD factorization approach and find that the non-factorizable corrections to naive factorization are infrared safe at leading-twist order. The spectator interactions arising from the kaon twist-3 effects are formally power suppressed but chirally and logarithmically enhanced. An important improvement by including the O(alpha(s)) corrections is the cancellation of the renormalization scale mu dependence of the decay amplitude. However, the calculated decay rates are too small to accommodate the experimental data. On the other hand, we compare the theoretical calculations for B meson decays to J/psi, psi', eta(c) and eta'(c), and find that the predicted relative decay rates of these four states are approximately compatible with the experimental data.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000223097800007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Particles & FieldsSCI(E)17ARTICLE3365-3703
History sketch 157th Engineer (C) Bn.
No full textThis is a historical description of the 157th Engineer (C) Battalion written from memory by author. Notes are not attached as described on last page of document
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Identification of screening biomarkers for chromosomal anomalies and pregnancy-related disorder using quantitative plasma proteomics
No full textDue to the risk associated with invasive procedures, a large research effort has been expended to the development of risk free alternatives. Current results indicate that we may be approaching the long sought goal of Non-Invasive Prenatal Diagnosis (NIPD), whereby it will be possible to identify hereditary single gene disorders or a chromosomal abnormality in the growing fetus.
One of the routes explored for NIPD was via the enrichment of fetal cells, specifically erythroblasts, from maternal blood. After the enrichment, the putative fetal cells were examined by FISH analysis for the presence of a chromosomal anomaly. In the large a multi-centre NIFTY study it was concluded that although promising, the sensitivity and specificity was below the required clinical application.
Proteomics is defined as the analysis of whole protein component of a tissue (e.g. brain), cell (e.g. yeast) or a body fluid (blood or urine). More precisely it involves the determination of identity of the protein present in the mixture and its relative and absolute quantity. Recently it is also used to identify protein modifications (e.g. phosphorylation, glycosylation). Applications of proteomics are very wide, with the major application in clinical research being applied for the better understanding of biological processes and disease state. Examples are, to find and validate new biomarkers (diagnostic and prognostic) or to understand the pharmacodynamics and pharmacokinetics of a drug compound.
A specific proteome is very dynamic and can provide lot of information on the expression pattern on normal vs. disease or control vs. treated. To study the proteome in its complexity, advanced tool are required, and in this context mass spectroscopy has emerged as a powerful technique for proteomic analysis.
A typical mass spectroscopy based proteomics workflow involves the digestion of protein in-gel or in liquid. Online or off-line fractionation of the peptides is performed by liquid chromatography (LC) and followed by ionization. The peptides are converted into ions and mass analysis is done on these ions, following which the mass to charge ratio is recorded. The resulting fragment masses are used to search of large protein databases search, resulting in the identification of the peptide and protein.
Plasma is an attractive entity for the proteomics studies. It contains different proteins from the various organs in high or low abundance. Many pathology or disease associated proteins are often present in plasma. Due to there low abundance, a number of different strategies have been developed to detect these in the plasma proteome, of which a few are discussed below.
In traditional 2D gel electrophoresis the most preferred staining method is by Coomassie Brilliant Blue (CBB) or sliver stains. After staining intensity of the protein spot is used for relative quantitation when compare with the gel which is run in parallel. But CBB has poor detection sensitivity, where as sliver stain is not compatible with the down stream mass spectroscopy analysis. To over come this problem the proteins were label with fluorescent cyanine dye (cy2, cy3 and cy5) before the 2D separation. This method in know as 2-D differential gel electrophoresis (2D DIGE) to avoid the gel to gel variation. In same gel one can run control and experimental sample as well the internal standard. Internal standard is made by mixing equal amount of control and experimental sample and is used for the relative quantitation. After the run the gel is scanned with the special Typhoon variable mode imager and DeCyder software is used for the differential analysis.
Over a decade MS has evolved as a powerful technique. This has lead to the development of shotgun proteomics, which is a useful tool as it bank ready quantification using special reagent and technique. Lately there are different techniques available for the labeling which enables the quantification of the protein like stable isotope labeling of amino acid in cell cultures (SILAC), isotopic-coded affinity tags (ICAT) and isobaric tags for relative and absolute quantitation (iTRAQ).
iTRAQ is an isobaric chemical labeling approach currently the only technique capable of multiplexing up to eight different samples for relative quantification. 8-plex chemically identical iTRAQ reagents are available, named 114, 115, 116, 117, 118, 119, and 121 which have the same overall mass. Each label is composed of a peptide reactive group (NHS ester) and an isobaric tag of 145 Da that consists of a balancer group (carbonyl) and a reporter group (based on N-methyl piperazine), between the balancer and the reporter group is a fragmentation site. The peptide reactive group attaches specifically to free primary amino groups – N-termini and ε-amino groups of lysine residues.
Each sample to be analyzed is tryptic digested and labeled with the single iTRAQ label after which sample are pooled for tandem mass analysis. The peptide product ion spectra is then used for the identification of the proteins and relative quantitation is derived from the peak intensities of the 8-plex iTRAQ reporter ions detected in the 114-121 m/z region of the fragmented ion spectra. Data acquired is always compared to a reference sample, and the quantity of each peptide is expressed as a ratio relative to the reference sample. As the field of shotgun proteomics is evolving rapidly, it is likely to play a role in the detection of biomarkers. iTRAQ has been shown to permit very reliable quantitation of proteins in complex mixture such as plasma, serum or urine. As such it has been suggested to be a useful tool for the detection of biomarkers. Hence, it is likely to play a key role in this field.
Selected Reaction Monitoring (SRM) is very rapidly developing tool for the MS based quantitation. It exploits the unique future of the triple quadrupole. The first and third quadrupole act as a filter to select the ion of defined m/z and the second quadrupole is a collision cell. The research carried out in this thesis does however demonstrate that it is possible to mine the maternal plasma proteome for new biomarkers. Their verification will however need to be carried out in much larger studies, and using more convenient techniques
Microscopic mechanism of charged-particle radioactivity and generalization of the Geiger-Nuttall law
No full textA linear relation for charged-particle emissions is presented starting from the microscopic mechanism of the radioactive decay. It relates the logarithms of the decay half-lives with two variables, called. chi' and. rho', which depend upon the Q values of the outgoing clusters as well as the masses and charges of the nuclei involved in the decay. This relation explains well all known cluster decays. It is found to be a generalization of the Geiger-Nuttall law in a radioactivity, and therefore we call it the universal decay law. Predictions of the most likely emissions of various clusters are presented by applying the law over the whole nuclear chart. It is seen that the decays of heavier clusters with nonequal proton and neutron numbers are mostly located in the trans-lead region. The emissions of clusters with equal protons and neutrons, like (12)C and (16)O, are possible in some neutron-deficient nuclei with Z >= 54.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271352900039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, NuclearSCI(E)51ARTICLE4null8
O. A. C. Review Volume XLVI Issue 5, February 1934
No full textThe focus of this issue is the preparation for College Royal and recognizing its tenth anniversary. This month's agricultural article is a report from the Dominion Parasite Laboratory on the biological control of pests. Other articles provide an account of the activities of a stage manager and the development of the field of home economics at Macdonald College in Quebec. Campus news addresses the success of the 1934 Conversazione, the commemorating of the sixtieth anniversary of the founding of O. A. C., the attendance at the Canadian Author Lecture, and the successful productions of "The Apple Cart" and "Iolanthe". The Macdonald Institute column comments on the Conversat and women's athletics activities in basketball and the rifle club. The Alumni Record supplies alumni updates.EditorialTen Years of the RoyalRamblings on the RoyalBlame it on the stage managerBiological control of insect pests in CanadaNot for girls onlyCollege lifeLiterary sectionO. A. C. sportsfolioAlumni recordMacdonald newsLetters to the editoradvertisin
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
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