15 research outputs found
Refined histopathological predictors of BRCA1 and BRCA2 mutation status:a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
No full textINTRODUCTION: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling.METHODS: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach.RESULTS: ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)).CONCLUSIONS: These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management.</p
Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
No full textMendelian randomization analysis of C-reactive protein on colorectal cancer risk
No full textBackground: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk, using a Mendelian randomization approach.Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 single nucleotide polymorphisms (SNPs) previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk.Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (P = 7.5 × 10-4, and P = 0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/l) was not associated with increased risk of CRC [odds ratio (OR) = 1.04; 95% confidence interval (CI): 0.97, 1.12; P = 0.256). No evidence of association was observed in subgroup analyses stratified by other risk factors.Conclusions: In spite of adequate statistical power to detect moderate association, we found genetically elevated CRP concentration was not associated with increased risk of CRC among individuals of European ancestry. Our findings suggested that circulating CRP is unlikely to be a causal factor in CRC development.</p
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia.
No full textThe distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling.Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach.ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)).These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
No full textIntroduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. Results: ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). Conclusions: These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management
Journeys Through Jackson 2014 Vol.24 No.01
No full textJourneys Through Jackson is the official journal of the Jackson County Genealogical Society, Inc. The journal began as a monthly publication in July 1991, was published bimonthly from 1994 to 2003, and continues today as a quarterly publication. The journal issues in this digital collection are presented as annual compilations.c
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J o u r n e y s
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T h e Official J o u r n a l of t h e J a c k s o n C o u n t y G e n e a l o g i c a l Society, Inc.
Vol. X X I V , No. I W i n t e r 2 0 14
JACKSON COUNTY GENEALOGICAL SOCIETY, INC.
2014 Officers
President Kenneth E. Nicholson
Vice Presidents Timothy Osment, William L. Crawford
Secretary Karen C. Nicholson
Treasurer Teresa Deitz Manring
Librarian KimberlyS. Shuler
Office Manager Ruth C. Shuler
Web Master. Deanne G. Roles
Computer Technician Jason N. Gregory
Chair, Publications (Editor) Sanji Talley Watson
Journeys Through Jackson is the official publication of the Jackson County Genealogical Society. Members and non-members are invited to
submit genealogical materials for publication, with the understanding that the editor reserves the right to edit these materials for genealogical
content, clarity, or taste. The Society assumes no responsibility for errors of fact that may be contained in submissions, and except where noted,
the opinions expressed are not those of the editor or of the Jackson County Genealogical Society. The Society accepts no advertising for this
publication except for notices from other non-profit groups.
From the Editor
Well, winter has made it to the mountains, everything from rain to sleet to snow has been seen
here lately. But, on the bright side, it has given everyone an unexpected opportunity to work on
genealogy.
The Society is thriving so far this year with members renewing their memberships, people
coming by the office to use the resources that we have and new mysteries coming to light all the time. If
you haven't been by the office lately, I encourage you to drop by and see all the new materials that we
have. I also encourage you to come to the monthly meetings on the second Thursday of every month.
The meetings are always informative and interesting.
This fall, in October will be our Semi-annual fund-raiser, so keep that in mind. We will be
sending out further information in a few months regarding the activities that we will be having.
Journey Through Jackson Winter 2014
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T a b l e o f C o n t e n t s
Table of Contents, Announcements and Expression of Sympathy 1
JCGS Photo Album 2-6
Webster School Catalogue 7-14
Descendants of John Thomas Tatham 15-18
Genetic Genealogy: The Basics of Using DNA for Genealogy 19-24
People Helping Their Neighbors 25-27
Library Acquisitions 27
Treasurer's Report 28
1880 Jackson County Census 29-32
Ruth Bryson Mysteries « 33-36
1931 Jackson County Death Certificates..., 37-40
Book Review: Green River Graves: Hooper and Related Families 41
2014 JCGS Meeting Schedule 42
WWI Draft Cards 43-46
Index 47-48
L ,
We offer our sincere sympathy and condolences to the family of JCGS member Eugene McGinnis. We
dedicate this issue of JTJ in his memory. We also offer our condolences to JCGS members Mary Jo
Hooper Cobb, Peggy Queen Mason , Barbara McCall Mathews, Lynn Allen Bryant and Elizabeth
Moss Wilson on the passing of their family members.
In the Holiday issue of JTJ, the address for Jean Hayes Cook was incorrect: The correct address is: 165
Grady Wiggins Drive, Otto, NC 27863.
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A w a r d W i n n e rs
In December at the annual meeting of JCGS the following awards were presented:
The Daniel Washington Deitz Award as presented'to William L. "Bill" Crawford.
The Robert Lee and Drusilla Holden Award was presented to Irene Bishop Hooper.
The Patron Award was presented to James and Jean Scott.
Plaques were presented to Dorris Dills Beck and Lawrence "Larry" Morton for their many years of
service and contributions to JCGS.
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m W
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Fowler House and Cottages, Glenville, N. C
Altitude 3.500 ft. Modern Conveniences. Golf, Tennis, Swimming, Fishing, Hiking.
Not a Hotel, but a Home for Summer Quests.
Jean Scott bought this postcard on e-bay, and granted use of it for JTJ. According to Joann
Davis Suddreth, the Fowler House was on the point behind the old Glenville School that sat on
the lake shore. She remembers that it was still operating in 1965 when she was a senior at the
school. The picture below of Robert Lee Gunter and wife Martha Avaline "Mattie" Green
and their son Willie Clarence Gunter was also provided by Jean Scott.
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The above picture is of the David Mitchell and Caroline Owen Shelton family. Mitchell
Shelton is the tall young man in the middle and the girl in the back row with him is Abia
Shelton (never married). The young boy in the front is J. O. "Bud" Shelton and the young
girl is Elsie Shelton Phillips. This picture belongs to Carmaletta Gates and she granted
permission for it to be used in JTJ.
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m Kj
The following pictures belonged to the late Gwen McCall Ashe.
allowed us to use them in this issue of JTJ.
Her daughter, Kim Ashe graciously
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The gentleman to the above right is John
Harlin Mathis (21 Jan 1842 - 28 Nov
1901). The lady above is his wife Sarah
Haseltine Cathey (19 Oct 1848 - 15 Jun
1930).
The picture to the left is their daughter Dovie
Elizabeth Mathis (16 Apr 1868 - 28 May
1937) and her husband, James Milford
Owen (13 Jan 1865 - 4 Apr 1947).
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Journey Through Jackson Winter 2014
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J C G S P h o t o A l b u m
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The picture above left is a son of John H.
and Sarah H. Cathey Mathis. Weston
Ulysses Mathis (22 Jun 1869 - 23 Feb
1939) and his wife, Martha Jane Owen
(25 Oct 1 8 7 3 - 6 May 1959).
The man above is Andrew Jackson
Owen (3 May 1831 - 18 Sep 1905). The
lady to the left is his wife Mary Ann
McCall (9 Jan 1832-20Mar 1915).
Journey Through Jackson Winter 2014
J C G S P h o t o A l b u m v _ y
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The picture above is of Andrew Jackson Wood
(6 Dec 1816 - 1 Jan 1908) and his wife, Jane
Henderson (1819-1915).
The picture to the upper right is of Melissa M.
Luker (26 Mar 1899 - 22 Nov 1918), the
daughter of Charles Benjamin Luker and
Sarah Ann McCall, and her husband Shelvin
Owen.
The couple to the right is John Lee Shook (27
Mar 1884 - 20 Aug 1965), and his wife, Mary
Elizabeth Galloway (14 Feb 1883 - 3 Jan 1964)
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Journey Through Jackson Winter 2014
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W e b s t e r S c h o o l C a t a l o g u e
The catalogue below was sent to the Society by Gary W. Hines of Louisville, KY. The catalogue predates a gift of
the 1916 catalogue shared by Betty Raby Rowland.
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Journey Through Jackson Winter 2014
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D e s c e n d a n t s o f J o h n T h o m a s T a t h am
ED: This was submitted by JCGS member, Mary Buchanan Smith. It will continue in following issues.
MACON AND JACKSON COUNTY LAND RECORDS:
Bk. A., Page 382,1836 ... '180 acres for 10.00 per 100 acres on waters of Savannah Creek.
Bk. A. Page 512, 3 Dec 1845. William Tatham to Warren Barker, for 300.00 pd by Wm. Tatham to Richard Wilson (Hs father-in-law) in year
1840 a parcel of land on Savannah Creek. 85 acres.
Bk. C , pg'1354, 27 Feb 1841. Jacob Sims of 1st part and John Wilson, (Brother-in-law) and William
Tatham of the second part for 10.00 sold unto Isaac Ashe a parcel of land on Savannah
Creek beginning at the mouth of the Hollow below the Ridge, by estimation 40 acres or more . . .
Bk. D., pg 1724 10 June 1844. James M. Tatham for sum of 30.00 on the waters of Savannah Creek, 100 acres with the exception of 10 acres marked off and
granted for the purpose 6f a mill site.
25 Jul 1848. Between William Tatham and George Bumgarner for the sum of fifty dollars a tract of
land on Savannah Creek in County of Macon containing 50 acres.
Bk. 1, pg 32, 1853. William Tatham - Methodist Church (By trans.) 10 Mar 1853 between William
Tatham, Isaac Ashe, Amos Ashe, Christenbury Webb, George Bumgarner and William Tatham,
Trustees for Church grounds and building and appurtenances there on known as the Weslannah Church or
Savannah Church for the use and benefit of the members and minitsers of the Methodist Epispocal
Church and their successors in office as they may be appt. by proper authorities of the Church as
inheritance forever... on waters of Savannah Creek on the North side of Tatham's Mill Race.
William Tatham and R. V. Welch
File 431, Grant 407, Entry 136, Bk 162, pg 293, 3 May 1853, 384 acres Savannah Creek
File 209, Grant 287, Entry 135, Bk 160, pg 559, 3 May 1853, 640 acres Savannah Creek near the head of
Sang Branch.
File 522", Grant 498, Entry 133, Bk 162, pg 572, 3 May 1853, 350 acres on Savannah Creek at J. L.
Tatham's Corner.
File 523, Grant 499, Entry 141, Bk 162, pg 573, 2 May 1853, 640 acres on Savannah Creek. (Tatham and
Welch) marker in Wilson's line . . . Hall's line . . . Wilson's Corner . . . Quilliams line . . . passing
Green's line.
File 524, Grant 500, Entry 134, Bk 162, pg 573, 3 May 1853, 640 acres on Savannah Creek.
File 525, Grant 501, Entry 142, Bk 162, pg 573, 3 May 1853, 640 acres on Savannah Creek.
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File 538, Grant 504, Entry 143, Bk 162, pg 575, 3 May 1853, 640 acres on Savannah Creek.
Bk. 1, pg 109, 1854. William Tatham sold to William H. Higdon, land on Savannah Creek for 2.00.
Bk. 1, pg 109, 1854. 18 Mar 1856. William Tatham, 1st part and Wm. F. Passmore 2nd part. William
Tatham for consideration of 12.00 to him in hand by the said Wm. F. Passmore, Jr. his interest in a
piece of land lying in Jackson County consisting of 1/3 of one undivided interest in same, which lands are
lying on the waters of Chattooga River. Certified 8 Apr 1856.
Pg 533, 24 Apr 1856. Whereas William Tatham has heretofore by entry obtained an interest in Entries
#862, 640 acres; #103, 350 acres; #134, 640 acres; #136, 384 acres; #137, 640 acres; #141, 640 acres;
#142, 640 acres; and #143, 640 acres lying in the County of Jackson for consideration of the sum of two
hundred dollars to William Tatham in hand paid has contracted and sold to James Tatham and F. Leach
off the County of Cherokee on the sixth of said entries on condition that they pay the said Tathm the sum
often cents per acre for one sixth part of the afore said entries and costs of surveying and contingent fees
there and then and the case Tatham obligtes (sic) himself to convey to John Tatham and Leach on
undivided sixth part of said entries.
Bk. 1, pg 494, 18 Mar 1856. William Tatham of State of NC and County of Macon for 30.00 paid by
Warren Barker a piece of land on the east side of Savannah Creek, in Dist. #8 being said Tatham's
interest in the land with John Wilson and Company. Entered 2 May 1836. Estimated 100 acres.
Bk. 2, pg 6, 12 Sep 1856. Between M. Francis, Wm. Tatham, N. Woodfin of Is' part and Wm. Passmore
Jamison of 2nd part for 85.00 paid in full. Sum paid above will be more or less than 10 cents per acre.
William Tatham died in 1858 without a will. His estate had to be settled in federal court in Morganton,
Burke County, NC.
Jackson County Register of Deeds
This indenture made this the 10* day of May in the year of our Lord, 1860, between E. D. Davis Esq.
High Sheriff of the County of Jackson and State of NC of the one part and John Wilson of Jackson Co.
NC of the other, part witnessed by virtue of two executions issuing from the county Court of Jackson
against Joseph Keener and William Tatham for the sum of 263.58 to satisfy the said Execution
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with the cost thereon and the said E. D. Davis Sheriff did seize and take into his hands and custody no
goods nor chatties to be found a certain piece or parcel of land in the County of Jackson bounded as
follows beginning on a Black Oak N. E. corner of No. 158 and runs North seventy Five West 105 pole to
a Black Walnut thence south Twelve west sixty three poles to a White Oak thence South forty poles to a
stake on Savannah Creek at Bumgarner's N. W. Corner thence down the meanders of Savannah Creek
ninety five poles to a Beach Bumgarner's N. E. Corner thence south Twenty five west twenty one poles to
a dogwood thence east twenty five poles to a Hickory thence South forty poles to a Chestnut thence East
fifty eight poles to a Red Oak thence North seventy poles to a Hickory thence seventy eight poles to a
Black Oak thence North five East one hundred poles to a Lynn (sic) at the Stillhouse Branch thence West
down said Branch fifty poles to a Maple on bank of Savannah Creek then North west eighteen poles to a
Stake at a Bridge on the State Road adjoining the Wilson old tract then south seventy two sixteen poles to
stake thence N. fifty five w e s t . . . containing one hundred and seventy nine acres the lands on which the
Widow Tatham now lives and the sheriff after due advertisement according tq,law did cause the piece of
land with all appurtenances be put up at public sale to the highest bidder on the 20th day of March in 1860
at which time John Wilson (Brother to Isabella Tatham) became the last and highest bidder at the sum
of twenty dollars for the lands with appurtenances belonging to William Tatham deed.
Isabella Wilson is the daughter of Richard Wilson and Racheal Strain. She was born on 1 Jun 1802 in
Buncombe Co., NC. She died on 3 Oct 1889, in Jackson Co., NC. Burial in Wesleyanna Cemetery,
Jackson Co., NC.
Notes for Isabella Wilson
1860 Census, Jackson County, North Carolina
I. Tatham
J . L .
T.N.
J.M.
D.J.
55
22
20
18
18
female Farmer
male
male
male
male
William Henry Tatham .and Isabella Wilson were married on 12 Jan 1826, (Ref. Bible of John & Ann
Tatham.)
15. i. Elizabeth Araline Tatham. She was born on 2 Apr 1827 in Haywood Co., NC. She
married George Bumgarner on 27 Feb 1847 in Macon Co., NC. She died on 24 Aug 1903 in Jackson
Co., NC. Burial in Fairyiew Memorial Gardens, Jackson Co., NC.
16. ii. Lucinda Tatham. She was bprn on 1 Aug 1828 in Savannah Jackson Co., NC. She died
5 Jul 1892 in Savannah, Jackson Co., NC. Burial in Weslyanna Methodist Church Cemetery, Jackson
Co., NC.
17. iii. Clarinda Tatham. She was born on 16 Feb 1830. She married Robert A. Phillips on
13 Oct 1853 in Jackson Co., NC. She died on 3 Oct 1920 in Macon Co., NC.
iv. Alpheus L. Tatham. He was born 22 Nov 1832 in Macon Co., NC. He died in 1854.
Notes for Alpheus L. Tatham
Macon County Land Records
Grant 1144, 23 Dec 1843, Issued 11 Feb 1853, District 11, Section 158 (Jackson County,
NC) on Tatham's Creek, on the waters of Savannah Creek, adjoining William Tatham.
Grant 1145, 12 May 1847, Issued 11 Feb 1853, 100 acres on Savannah Creek (probably
same as Bk. G, pg 52.)
17
Journey Through Jackson Winter 2014
Bk. G, pg 52, 1853. Altheous Tatham, 100 acres on the waters of Savannah Creek v-^->'
beginning at a popular (sic) tree . . . runs by Luke Wilson's corner.
Jackson County Minute Docket - March Term 1856
Invoice of Estate of A. L. Tatham by William Tatham, Administrator.
Trivit (?) on Stephen Munday, 53.00
2 Watches 108.00
1 bolts refroster (?) 30.00
John B. Allison debt for 150.00
William E. Enloe 50.00
Benjamin Allison 10.00
J. B. Love
1 shot gun
140 acres of land
William Tatham, Administer - Certified by D. Rogers, Clk.
"Family History" said that Lee Tatham was arrested for forcibly taking mail from letter
carrier between Dillsboro and Franklin because he was expecting a letter from a woman.
He was arrested and jailed in Macon County, NC Jail and there died of the "Bloody
Flux". (Told by Mattie Buchanan Cabe, daughter of Lillie Tatham Buchanan.)
18. v. Racheal Minerva Tatham. She was born on 24 Jul 1834 in Macon Co., NC. She
married Jesse Jones in 1856. She died before 1875 in Jackson Co., NC
19. vi. James Lafayette Tatham. He was born on 18 Jul 1837 in Macon Co. NC. He married •^^J
Catherine Boyd on 9 Jun 1861 in Jackson Co., NC. He died on 14 Mar 1919 in Jackson Co., NC. Burial
in Wesleyanna Methodist Church Cemetery, Jackson Co., NC.
20. vii. Thomas Nathaniel Tatham. He was born on 4 Jun 1839 in Jackson Co., NC. He
married Artie Mae Bryson on 15 Feb 1865 in Jackson Co., NC. He died Sep 1919 in Young Harris,
Georgia. Military Service: CSA, CO. A. Infantry Regiment, Thomas Legion. He is buried in Young
Harris, Gerogia.
21. viii. David Jasper Tatham. He was born 15 Apr 1842 in Jackson Co., NC. He married
Mary Collins Pilky on 22 Mar 1866 in Jackson Co., NC. He died 17 Oct 1891 in Jackson Co., NC.
Burial in Wesleyanna Methodist Cemetery, Jackson Co., NC.
22. ix. John M. Tatham. He was bom
Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types
No full textBreast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis but this has
not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses
combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421
controls of European ancestry, all together and in pairs, identified at P < 10-8 seven new cross-cancer loci:
three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11;
rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci
(rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci
(rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions
previously associated with only one cancer also showed clear association with a second cancer type.
Cell-type specific expression quantitative trait locus and enhancer-gene interaction annotations suggested
target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant
enrichment of death receptor signaling genes near loci with P < 10-5 in the three-cancer meta-analysis.
Significance
We demonstrate that combining large-scale genome-wide association meta-analysis findings across
cancer types can identify completely new risk loci in common to breast, ovarian, and prostate cancer. We
show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared
biology underlying these hormone-related cancers
Recommended from our members
Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
No full textThe distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management
The BRCA2 c.68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity.
No full textAlthough the spliceogenic nature of the BRCA2 c.68-7T > A variant has been demonstrated, its association with cancer risk remains controversial. In this study, we accurately quantified by real-time PCR and digital PCR (dPCR), the BRCA2 isoforms retaining or missing exon 3. In addition, the combined odds ratio for causality of the variant was estimated using genetic and clinical data, and its associated cancer risk was estimated by case-control analysis in 83,636 individuals. Co-occurrence in trans with pathogenic BRCA2 variants was assessed in 5,382 families. Exon 3 exclusion rate was 4.5-fold higher in variant carriers (13%) than controls (3%), indicating an exclusion rate for the c.68-7T > A allele of approximately 20%. The posterior probability of pathogenicity was 7.44 × 10-115 . There was neither evidence for increased risk of breast cancer (OR 1.03; 95% CI 0.86-1.24) nor for a deleterious effect of the variant when co-occurring with pathogenic variants. Our data provide for the first time robust evidence of the nonpathogenicity of the BRCA2 c.68-7T > A. Genetic and quantitative transcript analyses together inform the threshold for the ratio between functional and altered BRCA2 isoforms compatible with normal cell function. These findings might be exploited to assess the relevance for cancer risk of other BRCA2 spliceogenic variants
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia
No full textIntroduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. Results: ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). Conclusions: These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management
