1,720,952 research outputs found
The art of peer review and author response in music therapy publications: A workshop with the NJMT team
No full textPeer review is a widely accepted format for evaluating a manuscript’s quality and suitability for publication. The Nordic Journal of Music Therapy (NJMT), published with Taylor & Francis, is required to have every manuscript undergo independent peer review. The process begins with the Editorial team, and expands by inviting two or more independent colleagues with relevant experience to provide feedback to the author/s. The NJMT has opted to keep the identity of both the peer reviewers and the authors concealed. Keeping these identities anonymous is believed to promote a more open exchange of opinions free from various power dynamics and conflicts. When it works well, peer review is an opportunity for rich dialogue that supports the author/s to better articulate their findings and perspectives. Publisher surveys have found that authors consistently report that their final version is better quality than the one they originally submitted. However, our Editorial team wishes to explore the experience of the peer review journey, and not just the authors’ satisfaction with the end result.
This workshop will be led by members of the NJMT Editorial Team who will share and analyse deidentified examples of reviewing practices, responses from authors to reviewers, and other Editor perspectives. Workshop attendees will have the opportunity to further develop collegiate reviewing practices that also uphold high standards of research reporting. We will share plans for further resources to support reviewers and authors, and invite workshop attendees to provide feedback on these resources and share their own tips and experiences
Fictionality and Literature: Core Concepts Revisited
No full textAuthor / Henrik Zetterberg-Nielsen -- Narrator / Sylvie Patron -- Plot / Wendy Veronica Xin -- Character / H. Porter Abbott -- Consciousness / Maria Mäkelä -- Metaphor / Greta Olson -- Paratext / Louise Brix Jacobsen -- Intertextuality / Rikke Andersen Kraglund -- Metafiction and metalepsis / Richard Walsh -- The novel / Catherine Gallagher and Simona Zetterberg-Nielsen -- Poetry / Lasse R. Gammelgaard -- Literary nonfiction / James Phelan -- Ethics / Jakob Lothe -- Social justice / Susan S. Lanser.Item embargoed for five year
Author response
Get PDFMethylation of cytosines (5 me C) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here, we use Saccharomyces cerevisiae as a system lacking DNA methylation to define the chromatin features influencing the activity of the murine DNMT3B. Our data demonstrate that DNMT3B and H3K4 methylation are mutually exclusive and that DNMT3B is co-localized with H3K36 methylated regions. In support of this observation, DNA methylation analysis in yeast strains without Set1 and Set2 shows an increase of relative 5 me C levels at the transcription start site and a decrease in the gene-body, respectively. We extend our observation to the murine male germline, where H3K4me3 is strongly anti-correlated while H3K36me3 correlates with accelerated DNA methylation. These results show the importance of H3K36 methylation for gene-body DNA methylation in vivo
Obliteração pulpar em incisivo decíduo traumatizado
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia.Este estudo descritivo retrospectivo em incisivos centrais superiores decíduos traumatizados teve por objetivo, verificar a ocorrência de obliteração pulpar, o tempo decorrido entre o trauma e o desenvolvimento desta seqüela, a presença de alteração de cor da coroa bem como a freqüência de necrose pulpar secundária nos dentes obliterados, além de avaliar a existência de associação entre a obliteração e o sexo, a idade do paciente no momento do trauma dental, o tipo e a reincidência de trauma. Para isto, realizou-se uma pesquisa desenvolvida a partir dos dados clínicos e radiográficos dos prontuários de pacientes participantes do Programa de Atendimento ao Paciente Traumatizado da Universidade Federal de Santa Catarina, entre agosto de 1998 e agosto de 2007. Seguindo os critérios de elegibilidade, foram incluídos 112 dentes de 82 crianças. Destes, 60 (53,6%) apresentavam obliteração pulpar, sendo que em 58,3% dos casos esta foi diagnosticada em até 12 meses após o trauma. A associação entre alteração de cor da coroa e obliteração pulpar foi confirmada (p<0,001), e não houve casos de necrose pulpar secundária. Não se observou associação estatística entre as variáveis sexo e idade dos pacientes, bem como tipo e recorrência de trauma em relação a obliteração pulpar. Os resultados deste estudo permitem concluir que a ocorrência de obliteração pulpar em dentes decíduos traumatizados é alta e a proservação clínica e radiográfica periódica é a melhor conduta para esta seqüela
Mechanistic Investigations into the Palladium-Catalyzed Decarboxylative Allylic Alkylation of Ketone Enolates Using the PHOX Ligand Architecture
Get PDFPalladium-catalyzed asymmetric allylic alkylation has become a large and important field for chemical synthesis. Many methodologies in this field offer mild conditions under which challenging and important molecular features can be reliably synthesized, including chiral all-carbon quaternary stereocenters. As a result, palladium- catalyzed asymmetric allylic alkylation has found significant use in total synthesis, and growing use in industry. While the general process of palladium-catalyzed asymmetric allylic alkylation has been studied for decades, there have been a number of recent modifications and developments, such as asymmetric versions of decarboxylative allylic alkylation procedures that are not yet well understood. The development of future implementations and improvements to palladium-catalyzed asymmetric allylic alkylation and related methodologies is expected to be facilitated by a better understanding of these more recent developments, and thus further mechanistic investigation is warranted.
Reported herein is a set of investigations into the palladium-catalyzed decarboxylative asymmetric allylic alkylation of ketone enolates using the PHOX ligand architecture. By monitoring the reaction via 31P NMR, a series of previously unidentified key intermediates is discovered. Two representatives of these key intermediates are isolated and characterized. The solution behavior of these species under reaction-like conditions is studied along with a few novel and related complexes. The role of these intermediates and their impact on the behavior of the reaction and product formation is discussed. Previously confounding experimentally observed behavior for this methodology is rationalized via the properties elucidated for these discovered intermediates.</p
Numerical investigation of nearshore wave transformation and surf zone hydrodynamics
No full textRapid climate change and the corresponding estimated sea level rise can affect the performance of the coastal defense structures such as breakwaters, seawalls, and dikes. In order to improve these coastal defenses, a detailed understanding of the processes which contribute to wave run-up and overtopping over the coastal defenses needs to be established. Following the exponential growth of computing capacity around 1970’s, a wide variety of computational models were developed to study fluid flow. Traditionally, three computational paradigms have existed in order to study wave transformation and surf zone hydrodynamics: phase averaged models, phase resolving models, and Computational Fluid Dynamics (CFD) models. Limitations posed by the underlying linear wave theory in phase averaged and other simplifications in the phase resolving models, may not provide sufficient detail in wave breaking, wave energy dissipation, wave run-up, wave overtopping, and potentially other detailed hydrodynamic processes. This lack of resolution in depth averaged models for wave-breaking, wave run-up, and wave overtopping processes motivates a detailed investigation using CFD based models, which can correctly mimic wave-breaking and other hydrodynamic processes.The recent growth in available computational capacity has greatly improved the applicability of CFD based models for large scale transient flows such as waves near a coast. Additionally, the developments in wave generation and wave absorption boundary conditions by Jacobsen et al. [2012] in the open-source CFD toolbox OpenFOAM, have facilitated the use of OpenFOAM in coastal engineering applications. This encourages investigating the coastal environment using relatively complex models, thus providing insights into fundamental processes which contribute to coastal safety. To that end, this thesis focuses on investigating wave overtopping and the underlying processes which contribute to the aforementioned hydrodynamic aspects.Overtopping demands accurate capture of the free surface (interface between water and air). The waveFoam solver suffers from numerical diffusion of the interface, consequently requiring a different approach to mimic the sharp interface. In order to cater to this deficiency, a new solver which combines the capabilities of waveFoam [Jacobsen et al., 2012] and isoAdvection [Røenby et al., 2016] which has the ability to capture sharp interfaces by means of a sub-grid approach has been integrated (waveFlow) and used in this study. In addition to the new solver, a new set of Reynolds Averaged Navier-Stokes (RANS) closures developed by Larsen and Fuhrman [2018] for wave modeling applications have been employed to correctly capture turbulence levels under breaking waves. The preliminary steps include calibrating and assessment of the newly integrated waveFlow solver. Using a relatively simple conceptual test case, a comparison of the free surface behavior and overtopping discharge was carried out. This calibration test was followed by a comparison of numerical results with the experimental investigations carried out by Ting and Kirby [1994]. Following this benchmarking study, experimental studies carried out by Flanders Hydraulics investigating wave overtopping over dikes in shallow foreshore environments was validated. A comparison of waveFlow and waveFoam was made to assess the qualitative and quantitative differences between the two interface capture methods on overtopping. Using this new solver, OpenFOAM was able to reproduce the surface elevation and significant improvement in the overtopping results were obtained for identical model setup in comparison to the waveFoam solver. A coupled approach using a potential flow solver named OceanWave3D aided simulation of large domain wave propagation and helped to cut down the computational time.Civil Engineering | Hydraulic Engineerin
Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions
No full textabstract: Osteosarcoma is the most common bone cancer in children and adolescents. Although 70% of patients with localized disease are cured with chemotherapy and surgical resection, patients with metastatic osteosarcoma are typically refractory to treatment. Numerous lines of evidence suggest that cytotoxic T lymphocytes (CTLs) limit the development of metastatic osteosarcoma. We have investigated the role of PD-1, an inhibitory TNFR family protein expressed on CTLs, in limiting the efficacy of immune-mediated control of metastatic osteosarcoma. We show that human metastatic, but not primary, osteosarcoma tumors express a ligand for PD-1 (PD-L1) and that tumor-infiltrating CTLs express PD-1, suggesting this pathway may limit CTLs control of metastatic osteosarcoma in patients. PD-L1 is also expressed on the K7M2 osteosarcoma tumor cell line that establishes metastases in mice, and PD-1 is expressed on tumor-infiltrating CTLs during disease progression. Blockade of PD-1/PD-L1 interactions dramatically improves the function of osteosarcoma-reactive CTLs in vitro and in vivo, and results in decreased tumor burden and increased survival in the K7M2 mouse model of metastatic osteosarcoma. Our results suggest that blockade of PD-1/PD-L1 interactions in patients with metastatic osteosarcoma should be pursued as a therapeutic strategy.This is a non-final version of an article published in final form as Lussier, Danielle M., O'Neill, Lauren, Nieves, Lizbeth M., McAfee, Megan S., Holechek, Susan A., Collins, Andrea W., Dickman, Paul, Jacobsen, Jeffrey, Hingorani, Pooja, & Blattman, Joseph N. (2015). Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions. JOURNAL OF IMMUNOTHERAPY, 38(3), 96-106. http://dx.doi.org/10.1097/CJI.000000000000006
Perov5
No full textPlease consider citing the following two papers:
```
@article{castelli2012new,
title={New cubic perovskites for one-and two-photon water splitting using the computational materials repository},
author={Castelli, Ivano E and Landis, David D and Thygesen, Kristian S and Dahl, S{\o}ren and Chorkendorff, Ib and Jaramillo, Thomas F and Jacobsen, Karsten W},
journal={Energy \& Environmental Science},
volume={5},
number={10},
pages={9034--9043},
year={2012},
publisher={Royal Society of Chemistry}
}
```
```
@article{castelli2012computational,
title={Computational screening of perovskite metal oxides for optimal solar light capture},
author={Castelli, Ivano E and Olsen, Thomas and Datta, Soumendu and Landis, David D and Dahl, S{\o}ren and Thygesen, Kristian S and Jacobsen, Karsten W},
journal={Energy \& Environmental Science},
volume={5},
number={2},
pages={5814--5819},
year={2012},
publisher={Royal Society of Chemistry}
}
```</p
An evaluation of the ice melting during concrete-ice abrasion experiment
No full textThe process of ice melting during abrasive interactions with concrete is essential in a variety of contact phenomena. In this paper, we refer to abrasive tests for different samples of concrete with roughness in the range of 9–35 μm. The experimental conditions were: 1 MPa ice pressure, ambient temperature −10 °C, average sliding velocity 0–0.16 m/s. Using the experimental logs, we balance the heat transfer in the ice-concrete contact zone to compute the amount of molten ice. The average melting of ice varies from 3 to 29% of total ice consumption. The highest melting rate of ice corresponded to the lowest ice consumption and lower average abrasion of concrete. The theoretical calculations are validated against benchmarked commercial software with an in-house melting model.Concrete Structure
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