62 research outputs found
An experience of using Laennec in patients at high risk of a cytokine storm with COVID-19 and hyperferritinemia
No full textThe probability of formation of the so-called “cytokine storm” accompanied by an avalanche-like growth of inflammatory markers - interleukins (IL)-1β, -6, interferon-γ, tumor necrosis factor-α, C-reactive protein (CRP), ferritin, etc. is high at a heavy current of COVID-19. In the absence of adequate treatment in the development of “cytokine storm” increases the risk of death, especially against the background of comorbid pathology. Methods. In April-May 2020, patients (n = 28: 12 men, 16 women; age 39 - 86 years) with long, chronic COVID-19 course were under observation, hospitalized on critical days of the disease. All patients reported anosmia, cough with poor sputum, signs of conjunctivitis. The patients had chronic diseases (n = 22: coronary heart disease, diabetes mellitus type 2, scleroderma). All patients were given standard therapy; half (n = 14) were additionally prescribed Laennec for 3 - 10 days (6 ml per 350 ml of 0.9% NaCl solution, intravenous infusion for the first 3 days, from day 4 - 6 ml per 250 ml of 0.9% NaCl solution) until stable remission is achieved. Results. The majority state (n = 25) stabilized; several patients died in the control group (n = 3; p = 0.067). In spite of the state stabilization, no reliable positive dynamics was noted in the control group for the tested parameters. Initially, liver dysfunction (level of alanine aminotransferase (ALT) - 113 ± 121, aspartate aminotransferase (AST) - 90.8 ± 87) was registered in 71% of patients, 8 units/l) and high risk of “cytokine storm” development (ferritin levels in men - 480 - 1 072 µg/l, in women - 274.7 - 493 µg/l, C-reactive protein - 5.0 - 52.6 mg/l, lymphocytes - < 25%). Positive clinical dynamics, a decrease in the level of ferritin (-282 µg/l - in men, -80 µg/l - in women; p = 0.039), an increase in blood oxygenation to normal values (p = 0.0029), a decrease in the area of lung injury according to CT data (on average - 10%); p = 0.0027), increase in relative lymphocyte content (+8%; p = 0.04), normalization of markers of liver dysfunction (AST, ALT), creatinine and systolic blood pressure (p < 0.05) were observed on prescription of Laennec. All patients who received Laennec recovered within 3 - 15 days from the start of the drug and were discharged with a negative test for SARS-CoV-2. Conclusion. Health condition is significantly improved, a wide range of hepatoprotective, immunomodulatory and regenerative effects are observed when the polypeptide Laennec is included in the complex therapy in patients with severe COVID-19. Laennec should be used primarily in patients with liver pathology, diabetes mellitus type 2, coronary heart disease, including high ferritin levels
To the 110th anniversary of the birth of the outstanding scientist A. L. Mikhnov
No full textСтаттю присвячено видатному українському вченому-терапевту, доктору
медичних наук, професору, заслуженому діячу науки Української РСР А. Л. Міхньову.The article is dedicated to Anatoly Mikhnov, an outstanding Ukrainian scientist-therapist,
doctor of medical sciences, professor, Honored Scientist of the Ukrainian SSR, who was born on
July 1, 1909 in a large family in the sloboda of Radul, Lyubetska parish of Horodnya district
of Chernihiv province (now - settlement of Radul, Ripkinsky district of Chernihiv region).
Remaining an orphan in childhood, Anatoly began his labor activity at the age of 13 as a
worker, then a raftsman Radulsky rafting section of the trust «Ukrainforest». From 1929 to
1933 he studied at the Kiev Medical Institute. Since 1939 - Associate Professor of this institute.
From 1941 to 1943 he worked as a leading therapist, deputy chief of the medical unit at a
military evacuation hospital. In 1949, he received a doctor’s degree and became the Deputy
Director for Scientific Research of the Ukrainian Research Institute of Clinical Medicine
named after Academician M. D. Strazhesko (now - the National Scientific Center “Institute
of Cardiology named after Academician M. D. Strazhesko” of the National Academy of Medical
Sciences of Ukraine»). From 1952 to 1970 - Director of this institute. He is the author of
more than 200 scientific works, including 8 monographs. Under his guidance, 15 doctoral and
22 candidate’s theses were performed. His disciples were academician L. A. Pirig, professors
B. M. Bezborodko, V. P. Bezugly, I. M. Ganja, N. A. Gvatou and others. Died A. L. Mikhnev
October 03, 1970 in Kiev at the 62nd year of life. Buried at Baykovo Cemetery
Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study
No full textThe effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified “risky clusters” of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management
Characteristics of healthy vascular ageing in pooled population-based cohort studies : the global Metabolic syndrome and Artery REsearch Consortium
No full textOBJECTIVE: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.METHODS: In all, 18 490 participants from the global MARE Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension.RESULTS: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P < 0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years.CONCLUSION: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors
Markers of arterial health could serve as accurate non-invasive predictors of human biological and chronological age
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Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.
No full textChronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV)
Decelerated Epigenetic Aging in Long Livers
No full textEpigenetic aging is a hot topic in the field of aging research. The present study estimated epigenetic age in long-lived individuals, who are currently actively being studied worldwide as an example of successful aging due to their longevity. We used Bekaert’s blood-based age prediction model to estimate the epigenetic age of 50 conditionally “healthy” and 45 frail long-livers over 90 years old. Frailty assessment in long-livers was conducted using the Frailty Index. The control group was composed of 32 healthy individuals aged 20–60 years. The DNA methylation status of 4 CpG sites (ASPA CpG1, PDE4C CpG1, ELOVL2 CpG6, and EDARADD CpG1) included in the epigenetic clock was assessed through pyrosequencing. According to the model calculations, the epigenetic age of long-livers was significantly lower than their chronological age (on average by 21 years) compared with data from the group of people aged 20 to 60 years. This suggests a slowing of epigenetic and potentially biological aging in long livers. At the same time, the obtained results showed no statistically significant differences in delta age (difference between the predicted and chronological age) between “healthy” long livers and long livers with frailty. We also failed to detect sex differences in epigenetic age either in the group of long livers or in the control group. It is possible that the predictive power of epigenetic clocks based on a small number of CpG sites is insufficient to detect such differences. Nevertheless, this study underscores the need for further research on the epigenetic status of centenarians to gain a deeper understanding of the factors contributing to delayed aging in this population
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