42,891 research outputs found
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
A century of sea level data and the UK's 2013/14 storm surges: an assessment of extremes and clustering using the Newlyn tide gauge record
No full textFor the UK's longest and most complete sea level record (Newlyn), we assess extreme high waters and their temporal clustering; prompted by the 2013/2014 winter of storms and flooding. These are set into context against this almost 100-year record. We define annual periods for which storm activity and high sea levels can be compared on a year-by-year basis. Amongst the storms and high tides which affected Newlyn, the recent winter produced the largest recorded high water level (3 February 2014) and five other high water events above a 1 in 1-year return period. The large magnitude of tide and mean sea level, and the close inter-event spacings (of large return period high waters), suggests that the 2013/2014 extreme high water level "season" can be considered the most extreme on record. However, storm and sea level events may be classified in different ways. For example, in the context of sea level rise (which we calculate linearly as 1.81 ± 0.1 mm yr?1 from records between 1915 to 2014), a lower probability combination of surge and tide occurred on 29 January 1948, whilst the 1995/1996 storm surge season saw the most high waters of ? the 1 in 1-year return period. We provide a basic categorisation of the four types of extreme high water level cluster, ranging from consecutive tidal cycles to multiple years. The assessment is extended to other UK sites (with shorter sea level records and different tide-surge characteristics), which suggests 2013/2014 was particularly unusual. Further work will assess clustering mechanisms and flood system "memory"
Estimating extreme water level probabilities: A comparison of the direct methods and recommendations for best practise
No full textOver the past five decades, several approaches for estimating probabilities of extreme still water levels have been developed. Currently, different methods are applied not only on transnational, but also on national scales, resulting in a heterogeneous level of protection. Applying different statistical methods can yield significantly different estimates of return water levels, but even the use of the same technique can produce large discrepancies, because there is subjective parameter choice at several steps in the model setup. In this paper, we compare probabilities of extreme still water levels estimated using the main direct methods (i.e. the block maxima method and the peaks over threshold method) considering a wide range of strategies to create extreme value dataset and a range of different model setups. We primarily use tide gauge records from the German Bight but also consider data from sites around the UK and Australia for comparison. The focus is on testing the influence of the following three main factors, which can affect the estimates of extreme value statistics: (1) detrending the original data sets; (2) building samples of extreme values from the original data sets; and (3) the record lengths of the original data sets. We find that using different detrending techniques biases the results from extreme value statistics. Hence, we recommend using a 1-year moving average of high waters (or hourly records if these are available) to correct the original data sets for seasonal and long-term sea level changes. Our results highlight that the peaks over threshold method yields more reliable and more stable (i.e. using short records leads to the same results as when using long records) estimates of probabilities of extreme still water levels than the block maxima method. In analysing a variety of threshold selection methods we find that using the 99.7th percentile water level leads to the most stable return water level estimates along the German Bight. This is also valid for the international stations considered. Finally, to provide guidance for coastal engineers and operators, we recommend the peaks over threshold method and define an objective approach for setting up the model. If this is applied routinely around a country, it will help overcome the problem of heterogeneous levels of protection resulting from different methods and varying model setups
Inter-annual and long-term mean sea level changes along the North Sea coastline
No full textGlobally, mean sea levels are rising and there is concern that the rate of rise will accelerate throughout the 21st century significantly impacting growing coastal communities. Currently, most coastal management assessments are based on global mean sea level projections from the Intergovernmental Panel on Climate Change's Fourth Assessment Report. However, temporal and spatial variability of mean sea level change needs to be identified in order to establish an accurate projection of coastal management needs due to erosion and flooding associated with global sea level rise. This paper assesses historic changes in mean sea level from the beginning of the 19th century to present using 30 long and high quality tide gauge records located around the coastline of the North Sea. The North Sea coast is one of the most densely populated coastlines in the world. It contains a significant proportion of Europe's coastal flood risk as exemplified by London, Amsterdam and Hamburg, and the other extensive lowlands, and has a long history of significant coastal flooding. Previous analyses of mean sea level changes along Europe's coastlines have tended to be conducted at a national level, using a variety of different methods and sea level records of different quality and length. This study has three main objectives: (1) to examine the inter-annual variations observed in mean sea level across the North Sea region; (2) to examine linear and non-linear longer-term trends in relative and absolute mean sea level from the beginning of the 19th century to present; and (3) to assess whether 19 years of altimetry data provide valuable information on the spatial patterns of sea level trends and inter-annual variability in the North Se
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
J. T. Wiswall papers, W.0011
No full textAbstract: Two notebooks, containing mathematical equations and scientific essays, as well as the handwritten manuscripts of J. T. Wiswall's works "The African" and "Iliad of the Family," neither of which were ever published.Scope and Content Note: The collection contains two small, leather notebooks. One contains the handwritten manuscript "The African" and includes a bookplate identifying Caldwell Delaney as the owner. The other contains the handwritten manuscript "Iliad of the Family," as well as mathematical equations and scientific essays.Biographical/Historical Note: A Mobile, Alabama, author, J. T. Wiswall published two books,
The Last Crusader in 1861 and
Mr. Christopher Katydid (of Casconia) in 1864 (under the pseudonym Mark Heywood). The two handwritten manuscripts in this collection, "The African" and "Iliad of the Family," were never published, although they were listed in Robert E. Bell's
Bibliography of Mobile, which noted that Mobile historian Caldwell Delaney held the manuscripts in his private collection
Letter from J. R. Eakin to Carl Hayden
No full textLetter from J. R. Eakin to Carl T. Hayden concerning access to Rowe Well and the canyon
Letter from J. R. Eakin to Stephen Mather
No full textLetter from J. R. Eakin to Stephen T. Mather about expenses and reconstruction of the Kaibab Trail
Letter from Carl Hayden to J. B. Rickel
No full textLetter from Carl T. Hayden to J. B. Rickel concerning proposed changes to Grand Canyon National Park boundaries
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