2,302 research outputs found
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
Viajantes ex-cêntricas nas histórias de Ana Miranda
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Literatura.No conjunto das narrativas ficcionais da escritora brasileira Ana Miranda, a temática da viagem # considerada uma das mais férteis da literatura ocidental de todos os tempos # ocupa um espaço de centralidade, podendo até mesmo ser vista como o mais importante eixo de estruturação de suas obras. O estudo realizado pela presente tese tem por objetivo analisar o tratamento dado ao tema da viagem nos romances Desmundo, O retrato do rei, Dias & Dias e Amrik, evidenciando que por intermédio das narradora-viajantes # Oribela, Mariana, Feliciana e Amina # a autora promove um diálogo entre diferentes culturas, gêneros, etnias e gerações, ao mesmo tempo em que estabelece um profícuo diálogo com o passado em sua invariante problematização concernente aos limites e cruzamentos entre o discurso ficcional e os discursos narrativos extraliterários que o cercam, sobretudo o histórico e o biográfico. In the whole of Brazilian writer Ana Miranda#s fictional narrative, the travel thematic # considered one of the most fertile themes of the western literature of all times # occupies a central space, and can even been seen as the most important structuring axis of Miranda#s works. The aim of the present thesis is to analyze the treatment given to the travel subject in the novels Desmundo, O retrato do rei, Dias & Dias and Amrik, emphasizing that, through the traveling narrators, Oribela, Mariana, Feliciana and Amina, the author promotes a connection between different cultures, genders, ethnics and generations, at the same time that establishes a profitable dialogue with the past in her invariant problematization concerning the limits and crossings between the fictional and the extra-literary narrative discourses that surrounds it, mainly the historical and the biographic ones
A comparative analysis of intonational patterns in Ana Maria Matute and Juan Goytisolo : a study of two different contemporary styles
No full textThis study of the intonational patterns in selections of Ana María Matute and Juan Goytisolo was undertaken to see what the results would be. As the analysis progressed, it became more and more evident that these patterns were distinctive for each author and reflected two different temperaments, backgrounds and styles. One work of each author has been examined (Doce historias de la Artámila from Matute and Duelo en el Paraíso from Goytisolo) by studying three of the Doce historias de la Artámila and the first, middle, and last ten pages of the Duelo en el Paraíso, thus giving a representative sample of the total text. The procedure has been a quantitative linguistic approach in which the occurrences of intonational patterns have been counted and tabulated in terms of raw totals, then converted into percentages. The results indicate a consistency between intonational patterns and the thought and emotions of the authors. In this case, Ana María Matute and Juan Goytisolo show contrasting tendencies
Produção/reprodução e transformação do comportamento alcoolista nos contextos culturais da família e do trabalho /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.A presente dissertação de mestrado trata de uma investigação realizada a partir dos resultados obtidos na Prática Assistencial, quando foi oferecida, a três famílias de servidores alcoolistas, uma modalidade de assistência de enfermagem pautada na Teoria Sistêmica de Família e na Teoria de Leininger. Buscando ampliar e complementar os dados obtidos, foi elaborado um projeto que deu origem a este estudo, o qual tem por objetivos: analisar as influências do contexto do trabalho na produção/reprodução e transformação do comportamento alcoolista; analisar os nexos entre a produção/reprodução e transformação do comportamento alcoolista no contexto do trabalho e da família e propor alternativas para a transformação do comportamento alcoolista no trabalho, mediante as potencialidades identificadas na família e no trabalho. Este é um estudo exploratório, qualitativo, realizado com três funcionários alcoolistas da UFSM (Universidade Federal de Santa Maria) vinculados às famílias anteriormente pesquisadas. A metodologia constitui-se na análise de fichas funcionais, observação participante no ambiente de trabalho e entrevista com chefias, quando necessário. Após a etapa de coleta de dados, foi possível analisar os nexos entre o comportamento alcoolista na família e o comportamento alcoolista no trabalho. Identificar a produção/reprodução do comportamento alcoolista no contexto do trabalho viabilizou a sinalização de uma proposta de transformação, para a qual aponto indicadores de mudanças; e também reconheço a necessidade de espaços para desenvolver um trabalho integrado entre os serviços que tratam o alcoolismo, principalmente ao nível institucional, no qual me incluo, na tentativa de buscar outras maneiras de investir em mudanças gradativas do comportamento alcoolista
ANA LUÍSA DE AZEVEDO CASTRO: A INDYGENA DO YPIRANGA
No full textResumo: O presente trabalho destaca a vida e a obra da escritora catarinense Ana Luísa de Azevedo Castro, que usava o pseudônimo de Indygena do Ipiranga. O intuito é resgatar uma autora do século XIX que foi importante para a sua época, mas que foi apagada pela crítica e pela história da literatura. Serão abordados dois de seus textos, pois é o que se tem publicado: um poema intitulado “O Pranto do Poeta” e um romance, D. Narcisa de Villlar.
Palavras-chave: Ana Castro; Indygena do Ipiranga; D. Narcisa de Villar; Escritoras brasileiras; Literatura brasileira.
Abstract: This work highlights the life and work of the Santa Catarina writer Ana Luísa de Azevedo Castro, who used the pseudonym Indygena do Ipiranga. The goal is to rescue a 19th century author who was important for her time, but who was erased by criticism and the history of literature. Two of her texts will be discussed: a poem entitled “O Pranto do Poeta” and the novel D. Narcisa de Villlar.
Keywords: Ana Castro; Indygena do Ipiranga; D. Narcisa de Villar; Brazilian writers; Brazilian literature
ANA LUÍSA DE AZEVEDO CASTRO: A INDYGENA DO YPIRANGA
No full textResumo: O presente trabalho destaca a vida e a obra da escritora catarinense Ana Luísa de Azevedo Castro, que usava o pseudônimo de Indygena do Ipiranga. O intuito é resgatar uma autora do século XIX que foi importante para a sua época, mas que foi apagada pela crítica e pela história da literatura. Serão abordados dois de seus textos, pois é o que se tem publicado: um poema intitulado “O Pranto do Poeta” e um romance, D. Narcisa de Villlar.
Palavras-chave: Ana Castro; Indygena do Ipiranga; D. Narcisa de Villar; Escritoras brasileiras; Literatura brasileira.
Abstract: This work highlights the life and work of the Santa Catarina writer Ana Luísa de Azevedo Castro, who used the pseudonym Indygena do Ipiranga. The goal is to rescue a 19th century author who was important for her time, but who was erased by criticism and the history of literature. Two of her texts will be discussed: a poem entitled “O Pranto do Poeta” and the novel D. Narcisa de Villlar.
Keywords: Ana Castro; Indygena do Ipiranga; D. Narcisa de Villar; Brazilian writers; Brazilian literature
José Augusto França interviewed by Ana Tostões
No full textOn April 2016, Ana Tostões interviewed Professor José-Augusto França, the Portuguese modern art researcher of reference on the contemporary era, in order to discuss the key modern structure that made the shift towards a Modern Lisbon.
José-Augusto França (b. 1922, Tomar) is historian, sociologist and critic of art. He has a graduation in Historical and Philosophical Sciences (1944, Faculty of Letters, University of Lisbon), a PhD in History (1962, Paris-Sorbonne University, Une Ville des Lumères: la Lisbonne de Pombal), a diploma on Sociology of the Art (1963, L'Art et la Société Portugaise au XXè siècle) and a PhD in Letters (1969, Paris-Sorbonne University, Le Romantisme au Portugal). He is professor emeritus of the Nova University of Lisbon, where he created the first Art History masters of the country (1976). He was Director of the Portuguese Cultural Center of the Calouste Gulbenkian Foundation in Paris (1983), President of the National Academy of Fine Arts (1985) and member of the UNESCO Comité du Patrimoine Mondial. He is a reference author in the field of visual and cultural arts in Portugal, being the first one identifying and presenting modern architecture in Portugal in his Arte em Portugal no Século XX (1974). Among his works stand out studies on art in Portugal in the 19th and 20th centuries, as several volumes of essays on historical, sociological and aesthetic reflection on contemporary art issues. He has received the Medal of Honor of the City of Lisbon (1992), the Grand Officer (1991) and the Grand Cross (2006) of the Infante D. Henrique Order and the Grand Cross of the Order of Public Instruction (1992)
The Personality of Ana Ozores
No full textHOUDKOVÁ, Sandra: Osobnost Any Ozores [Bakal愃Ā爃ఀsk愃Ā pr愃Āce]. - Univerzita Karlova. Filozofick愃Ā fakulta; 唃Āstav rom愃Ānsk礃Āch studi椃Ā. Hispanistika. - vedouc椃Ā pr愃Āce: doc. Juan Antonio Sánchez Fernández, Ph.D. La Regenta je mistrovsk礃Ām d椃Ālem španělského autora Leopolda Alase a p爃ఀedmětem zkoum愃Ān椃Ā této bakal愃Ā爃ఀské pr愃Āce. V prvn椃Ā č愃Āsti se zamě爃ఀ椃Ām na autora tohoto d椃Āla, zasad椃Ām d椃Ālo do historického kontextu, objasn椃Ām ž愃Ānr a p爃ఀibl椃Āž椃Ām roli ženy v 19. stolet椃Ā, abych p爃ఀibl椃Āžila postaven椃Ā protagonistky d椃Āla, Any Ozores, které se věnuje anal礃Āza druhé č愃Āsti této pr愃Āce. Anal礃Āza se nejd爃ఀ椃Āve zamě爃ఀ椃Ā na postavu samotnou a poté bude zkoumat č愃Āsti jej椃Āho života a lidi, které ji ovlivnili. P爃ఀesněji se soust爃ఀed椃Ā na jej椃Ā dětstv椃Ā, romantick礃Ā život, v椃Āru a společnost města, ve kterém Ana žije. Kl椃Āčové slova v češtině: La Regenta, Clarín, naturalismus, realismus, osobnost Any Ozores, psychologieHOUDKOV䄃Ā, Sandra: Osobnost Any Ozores [Bakal愃Ā爃ఀsk愃Ā pr愃Āce]. - Univerzita Karlova. Filozofick愃Ā fakulta; 唃Āstav rom愃Ānsk礃Āch studi椃Ā. Hispanistika. - vedouc椃Ā pr愃Āce: doc. Juan Antonio S愃Ānchez Fern愃Āndez, Ph.D. La Regenta is the masterpiece of the Spanish author Leopoldo Alas and the subject of this bachelor thesis. In the first part, I will focus on the author of this work, place the work in its historical context, explain the genre, and introduce the role of women in the 19th century in order to bring into focus the position of the protagonist of the work, Ana Ozores, who is the focus of the analysis of the second part of this thesis. The analysis will first focus on the character herself and then examine parts of her life and the people who influenced her. More specifically, it will focus on her childhood, romantic life, faith, and the society of the city in which Ana lives. Keywords in English: La Regenta, Clarín, naturalism, realism, personality Any Ozores, psychologyInstitute of Romance StudiesÚstav románských studiíFilozofická fakultaFaculty of Art
Tagging of Biomedical Articles on CiteULike: A Comparison of User, Author and Professional Indexing
No full textThis paper examines the context of online indexing from the viewpoint of three different groups: users, authors, and professional indexers. User tags, author keywords and descriptors were collected from academic journal articles, which were both indexed in Pubmed and tagged on CiteULike, and analysed. Descriptive statistics, informetric measures, and thesaural term comparison shows that there are important differences in the use of keywords between the three groups in addition to similarities which can be used to enhance support for search and browse. While tags and author keywords were found that matched descriptors exactly, other terms which did not match but provided important expansion to the indexing lexicon were found. These additional terms could be used to enhance support for searching and browsing in article databases as well as to provide invaluable data for entry vocabulary and emergent terminology for regular updates to indexing systems. Additionally, the study suggests that tags support organisation by association to task, projects and subject while making important connections to traditional systems which classify into subject categories
HUMAN CAPITAL ASSESSMENT INDICATORS AS INFLUENTIAL DETERMINANTS PERTAINING TO THE ADMISSION CRITERIA UTILIZED BY PRE-LICENSURE PROGRAMS FOR NURSING EDUCATION
No full textThe attainment of educational credentials contributes to the acquisition of human capital. Academic preparedness is a component therein that allows for the attainment of increased levels of education. Most institutions of higher education utilize measures of academic preparedness, such as grade point averages or standardized tests. Requirements for the levels of academic preparedness are based upon many factors. The requirements most relevant to this study are the selectivity of the institution and the academic preparedness of potential candidates of pre-licensure programs for nursing education.
The pre-licensure education of nurses is enigmatic when compared to other professional disciplines. Pre-licensure education for registered nurses exists in three distinct and differently classified programs: a hospital-based diploma program, an associate degree program, or a baccalaureate program. (There is an additional baccalaureate program, known as accelerated second degree programs, for students possessing a baccalaureate degree in another discipline. These accelerated programs are not included in this discussion.) The National Center for Education Statistics classifies each of the three programs, making clear that the differing program levels of post-secondary education are neither equivalent nor interchangeable.
According to the literature, the academic preparedness of individuals and the level of selectivity of higher education institutions vary greatly depending upon the particular classification of nursing program. What then, is the level of programmatic selectivity, given that all three pre-licensure programs produce candidates for the identical occupational certification while attracting candidates known to have varying levels of academic preparedness? This study aimed to determine the levels of selectivity of the three pre-licensure nursing education programs types so as identify trends and patterns within and across pre-licensure program types. In order to determine these trends and patterns, the author examined the admissions requirements that are transparent to the public on schools’ websites in which these programs are housed, employing the methodology of document analysis. The determination for the level of selectivity was based upon Barron’s Measure of Selectivity (Barron’s Educational Series, 2011)
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