56,683 research outputs found
P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?
No full textThe discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine. The periaqueductal gray (PAG) region of the brainstem modulates craniovascular nociception and, through its role in the descending pain modulation system, may contribute to migraine pathophysiology. In this study we sought to investigate the possible link between the genetic mutations found in migraineurs and the PAG as a modulator of craniovascular nociception. We microinjected the P/Q-type calcium-channel blocker omega-agatoxin IVA into the rat ventrolateral PAG (vlPAG). We examined its effect on the nociceptive transmission of second-order neurons recorded in the trigeminal nucleus caudalis and activated by stimulation of the parietal dura mater. After injection of agatoxin into the vlPAG (n = 20) responses to dural stimulation were facilitated by 143% (p < 0.0001) for Adelta-fiber activity and 180% for C-fiber activity (p < 0.05). Similarly, spontaneous background activity increased by 163% (p < 0.0001). These results demonstrate that P/Q-type calcium channels in the PAG play a role in modulating trigeminal nociception and suggest a role for dysfunctional P/Q-type calcium channels in migraine pathophysiology.<br/
Author response: Gray matter volume modifications in migraine: A cross-sectional and longitudinal study
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Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Supplemental material for Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial
No full textSupplemental Material for Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial by David W Dodick, Richard B Lipton, Stephen Silberstein, Peter J Goadsby, David Biondi, Joe Hirman, Roger Cady and Jeff Smith in Cephalalgia</p
Letter from Carl Hayden to P. J Moran
No full textLetter from Carl T. Hayden to P. J. Moran concerning the alignment of the road to Bright Angel Trail
Letter from P. J. Moran to Carl Hayden
No full textLetter from P. J. Moran to Carl T. Hayden inquiring when construction will begin on the approach road to Bright Angel Trail
Letter from P. J. Moran to Carl Hayden
No full textLetter from P. J. Moran to Carl T. Hayden inquiring when construction will begin on the approach road to Bright Angel Trai
sj-pdf-1-cep-10.1177_03331024221110111 - Supplemental material for Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine
No full textSupplemental material, sj-pdf-1-cep-10.1177_03331024221110111 for Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine by Margarida Martins-Oliveira, Simon Akerman, Philip R Holland, Isaura Tavares and Peter J Goadsby in Cephalalgia</p
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