1,305 research outputs found
NCAM1, TACR1 and NOS Genes and Temperament: A Study on Suicide Attempters and Controls
No full textSuicide, one of the leading causes of death among young adults, seems to be plausibly modulated by both genetic and personality factors. The aim of this study was to dissect the potential association between genetics and temperament in a sample of 111 suicide attempters and 289 healthy controls. We focused on 4 genes previously investigated in association with suicide on the same sample: the nitric oxide synthase 1 and 3 (NOS1 and NOS3), the neuronal cell adhesion molecule 1 (NCAM1), and the tachykinin receptor 1 (TACR1) genes. In particular, we investigated whether a set of genetic variants in these genes (NOS1 : rs2682826, rs1353939, rs693534; NOS3 : rs2070744, rs1799983, rs891512; NCAM1 : rs2301228, rs1884, rs1245113, rs1369816, rs2196456, rs584427; TACR1 : rs3771810, rs3771825, rs726506, rs1477157) were associated with temperamental traits at the Temperament and Character Inventory (TCI). No strong evidence was found for the association between TCI personality traits and the polymorphisms considered in the 4 genes, with the exception of an association between reward dependence trait and the rs2682826 SNP in NOS1 in the healthy sample. However, this result could be plausibly interpreted as a false-positive finding. In conclusion, our study did not support the thesis of a direct modulation of these genes on temperament; however, further studies on larger samples are clearly required in order to confirm our preliminary findings and to exclude any possible minor influence. Copyright (C) 2011 S. Karger AG, Base
Personality and attempted suicide. Analysis of anger, aggression and impulsivity
No full textSuicide is one of the leading causes of death worldwide, mortality from suicide being approximately 2%. Attempted suicide appears to be a major risk factor for suicide completion. Anger, aggression and impulsivity are personality traits associated with suicide attempt. In this study we analysed a part of a previously reported sample in order to test anger, impulsivity and temperament/character scales as predictors of aggression and self-aggression in suicide attempters and to compare anger- and aggression-related traits between impulsive and premeditated suicide attempts as well as between violent and non-violent suicide methods. One-hundred-eleven consecutively admitted inpatients with a lifetime history of attempted suicide were assessed for anger (State-Trait Anger Expression Inventory, STAXI), aggression (Questionnaire for Measuring Factors of Aggression, FAF) and temperament/character (Temperament and Character Inventory, TCI). Higher aggression scores, as measured by FAF, were predicted by being male, meeting criteria for borderline personality disorder and having higher angry temperament scores as assessed by STAXI; low cooperativeness was also associated with aggression but not after controlling for STAXI scales. TCI dimensions associated with self-aggression were high harm avoidance, high impulsivity and low self-directedness; state anger, inwardly directed anger and inhibition of aggression were also predictors of self-aggression. In conclusion, impulsivity and harm avoidance have emerged as temperament dimensions independently associated with self-aggressive tendencies in personality. Such interactions could explain the correlation between temperament and suicidality but further research is needed. Anger and self-directedness appear to have some effects on suicide attempt. © 2009 Elsevier Ltd. All rights reserved
Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study
No full textSerotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and B (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls. Among males, MAOA rs909525 A allele was associated with higher Reward Dependence in suicide attempters. Multivariate analyses controlling for age and educational level mainly confirmed results. Case-control analyses in this subsample do not differ from our previously reported one. Despite of the small sample size, a possible involvement of these genes in the modulation of personality traits closely related to suicidal behaviour cannot be excluded
The birth and early years of INA, the International Neurotoxicology Association
No full textAbstractThe International Neurotoxicology Association (INA) is a scientific society whose members have interest and expertise in the discipline of neurotoxicology. The idea of forming INA was born in 1984, as a follow-up to a NATO-sponsored meeting on Toxicology of the Nervous System. INA held its first meeting in the Netherlands in 1987 and has had continuous meetings every other year since then. INA is registered as a scientific society in the Netherlands, and is an affiliated society of IUTOX. This paper presents a personal account of the events that led to the birth of INA, and of the first fifteen years of this association
Koło się zamyka
No full textIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Pioneering Doktormutter Remembering Ina-Maria Greverus
No full textThe author reconsiders German scholar Ina-Maria Greverus as a committed feminist supporter of female doctoral students and early career academics. Greverus acted as an innovator especially in the realms of anthropology and aesthetics, and initiated a new international dialogue forum with the Anthropological Journal or European Cultures, which she founded in 1990 together with Christian Giordano.</p
The Circle Closes
No full textIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Chronicles of Oklahoma
No full textArticle discusses the life of the author and her family after homesteading in Logan County, Oklahoma Territory. Ina Robinson discusses the difficulties faced on the frontier, the people they encountered there, education available, and social life
La Cañada Drive, River Road to Ina Road
No full texttableOfContents: The Pima County Department of Transportation proposes to widen approximately 2.7 miles of La Cañada Drive from a two-lane arterial road into a four-lane arterial road between River Road and Ina Road. The project also includes the installation of a closed stormwater collection and conveyance system, installation of culverts to create an all-weather roadway, and addition of curbs, sidewalks, bike lanes, and a public use trail
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