162,351 research outputs found
Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability
No full textKampf J, Gerwig J, Kruse K, et al. Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability. mBio. 2018;9(5): e01464-18
Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
No full textThis work characterizes the protective effects of ANP preconditioning in ischemia-reperfusion
injury of the isolated perfused rat liver. It was of particular interest to evaluate
the influence of ANP on the mode of cell death occurring during cold ischemia and
reperfusion and to elucidate the involved signal transduction pathways.
Apoptotic cell death was mainly seen after cold liver storage, whereas necrosis was
predominant in the reperfusion period.
It could be demonstrated for the first time that preconditioning with ANP was able to
reduce both apoptotic as well as necrotic cell death. After cold ischemia, in particular
hepatocytes were protected against apoptosis. After reperfusion, protection against
necrosis comprised hepatocytes and sinusendothelial cells predominantly in the periportal
liver areas.
As target molecules for ANP action, the cGMP-dependent protein kinases did not seem to
be responsible for the conferred cytoprotection. In the liver, no expression of these
kinases could be detected and a functional connection could not be derived. In contrast,
the cAMP-dependent protein kinases were identified to promote survival. This was further
supported by the ability of ANP to directly activate cAMP-dependent protein kinases in
livers and hepatocytes.
An early transcriptional induction of HO-1 by ANP independent of cGMP could be
demonstrated. The induction of heme oxygenase-1 by ANP might not be responsible for
the observed hepatoprotection, since inhibition of HO-1 activity did not abrogate the ANP
effect. Interestingly, cell-type specific evaluation detected that induction of HO-1 in livers
by ANP is exclusively restricted to Kupffer cells.
In summary, this thesis gives new insights into the actions of the cardiovascular hormone
ANP in IRI of the rat liver. This data helps to understand the mechanisms of how ANP
mediates cytoprotection by illuminating effects and potential pathways, an important
prerequisite for a rational application in therapy.
This work was supported by the Deutsche Forschungsgemeinschaft (DFG: Ge 576/14-2
and FOR 440/1, TP2)
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
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