3,277 research outputs found
Measurement of the B0–B0 oscillation frequency Δmd with the decays B0→D−π+ and B0→ J/ψK∗0
No full textThe B
0
–B
0
oscillation frequency Δmd is measured by the LHCb experiment using a dataset corresponding
to an integrated luminosity of 1.0 fb−1
of proton–proton collisions at √
s = 7 TeV, and is found to be
Δmd
=0.5156±0.0051 (stat.)±0.0033 (syst.) ps−1
. The measurement is based on results from analyses
of the decays B
0
→ D
−π
+ (D
−
→ K
+π
−π
−) and B
0
→ J/ψK
∗0
(J/ψ →μ
+μ
−,K
∗0
→ K
+π
−) and
their charge conjugated modes
Joel Glaser, MD: A Scholar\u27s Scholar
No full textJoel Glaser, MD is considered one of the great scholars of neuro-ophthalmology. His published contributions touch nearly every aspect of the field. The principal author of the highly respected textbook Neuro-Ophthalmology, he has trained over 50 fellows who occupy important academic positions across the planet.curriculum_fellow; IC-H1-history-of-neuro-ophthalmolog
Supplemental Data for A Phase II Study of Talazoparib Tosylate in Advanced Cancer Patients with Somatic and Germline (Not Breast or Ovarian Cancer) Alterations of BRCA1/2, Mutations/Deletions/Amplification in Other Homologous Recombination Repair Pathway Genes and PTEN or PTEN loss
No full textThe de-identified participant data and dataset generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Custom code that was used in the generation or analysis of the datasets is available upon reasonable request.
Corresponding Author: Sarina Piha-Paul,Department of Investigational Cancer Therapeutics (A Phase I Clinical Trials Program), University of Texas MD Anderson Cancer Center, Houston, TX. Phone: (713)-563-1055, Fax:(713)-792-3535, [email protected]://openworks.mdanderson.org/ict/1000/thumbnail.jp
A Multivariate Surface-Based Analysis of the Putamen in Premature Newborns: Regional Differences within the Ventral Striatum
No full textMany children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures have been documented in these subjects, but little is known about surface deformation in these structures. For the first time, here we found regional surface morphological differences in the preterm neonatal ventral striatum. We performed regional group comparisons of the surface anatomy of the striatum (putamen and globus pallidus) between 17 preterm and 19 term-born neonates at term-equivalent age. We reconstructed striatal surfaces from manually segmented brain magnetic resonance images and analyzed them using our in-house conformal mapping program. All surfaces were registered to a template with a new surface fluid registration method. Vertex-based statistical comparisons between the two groups were performed via four methods: univariate and multivariate tensor-based morphometry, the commonly used medial axis distance, and a combination of the last two statistics. We found statistically significant differences in regional morphology between the two groups that are consistent across statistics, but more extensive for multivariate measures. Differences were localized to the ventral aspect of the striatum. In particular, we found abnormalities in the preterm anterior/inferior putamen, which is interconnected with the medial orbital/prefrontal cortex and the midline thalamic nuclei including the medial dorsal nucleus and pulvinar. These findings support the hypothesis that the ventral striatum is vulnerable, within the cortico-stiato-thalamo-cortical neural circuitry, which may underlie the risk for long-term development of frontal executive dysfunction, attention deficit hyperactivity disorder and attention-related learning disabilities in preterm neonates. © 2013 Shi et al
When sexuality is in a research topic! The methodological\ud challenges in sexuality and street healing research in\ud Bangladesh
No full textThis paper is a bridge between two studies by the author: (i) completed MA research; and (ii) on-going PhD research, on male sexual health and the street healing system in Bangladesh. Street healing, a traditional healing system in Bangladesh, is at the centre of the studies. This is a popular form of folk healing in Bangladesh, where male impotency is a central issue. The author has been researching street healing to understand male sexual health-seeking behaviour in Bangladesh. In this paper, the author brings in experiences from his MA research to explore the challenges of studying sexuality and street healing in Bangladesh and concludes by describing his plan to address those issues in his on-going PhD research
An irreducible semigroup of non-negative square-zero operators
No full textWe construct an irreducible multiplicative semigroup of non-negative square-zero operators acting on L-P[0, 1), for 1 less than or equal to p < infinity.PT: J; CR: CHOI MD, 1993, INDIANA U MATH J, V42, P15 DRNOVSEK R, IN PRESS OPERATOR TH DRNOVSEK R, 2000, P EDINBURGH MATH S 1, V43, P43 HADWIN D, 1986, INTEGR EQUAT OPER TH, V9, P739 HALMOS PR, 1950, MEASURE THEORY RADJAVI H, 2000, SIMULTANEOUS TRIANGU RUDIN W, 1986, REAL COMPLEX ANAL TUROVSKII YV, 1999, J FUNCT ANAL, V162, P313 ZHONG Y, 1995, T AM MATH SOC, V347, P3093; NR: 9; TC: 1; J9: INTEGRAL EQUATION OPER THEORY; PG: 12; GA: 533RTSource type: Electronic(1
Episodic encoding is more than the sum of its parts: An fMRI investigation of multifeatural contextual encoding
No full textEpisodic memories are characterized by their contextual richness, yet little is known about how the various features comprising an episode are brought together in memory. Here we employed fMRI and a multidimensional source memory procedure to investigate processes supporting the mnemonic binding of item and contextual information. Volunteers were scanned while encoding items for which the contextual features (color and location) varied independently, allowing activity elicited at the time of study to be segregated according to whether both, one, or neither feature was successfully retrieved on a later memory test. Activity uniquely associated with successful encoding of both features was identified in the intra-parietal sulcus, a region strongly implicated in the support of attentionally mediated perceptual binding. The findings suggest that the encoding of disparate features of an episode into a common memory representation requires that the features be conjoined in a common perceptual representation when the episode is initially experienced
Selective Saccadic Palsy
No full textHead-free gaze shifts; Slow/absent saccades; Normal smooth pursuit; Absent optokinetic quick phases of nystagmus; Normal oculocephalics; Absent torsional quick phases of nystagmusSelective Saccadic Palsy: https://collections.lib.utah.edu/details?id=2174235Difficulty redirecting gazeThis case is published courtesy of Scott D.Z. Eggers, M.D., Department of Neurology, Mayo Clinic College of Medicine (1). The patient is a healthy 50 year old woman who underwent otherwise uncomplicated aortic valve replacement for an incidentally discovered ascending aortic aneurysm. Upon awakening from anesthesia she noted difficulties directing her gaze and began using head movements to facilitate gaze shifts. She had no dysarthria, dysphagia or gait instability. She was discharged and had no problems other than her visual complaints for three months at which time she developed complex partial seizures that responded to levetiracetam. On examination ten months post-operatively, a general neurological exam was notable only for diffuse hyporeflexia. Visual acuity, pupils, visual fields and fundoscopic examination were normal. Examination of the eye movements showed: 1. Straight ahead fixation was steady and no spontaneous saccades, square wave jerks or nystagmus was seen ophthalmoscopically. 2. She made no fast volutional or reflexive saccades in any direction, but instead made extremely slow eye movements to eventually reach a target, except for slightly faster downward saccades. 3. Pursuit was smooth and of full range horizontally and vertically, even with high frequencies. 4. With a horizontal optokinetic drum the eyes can fix laterally in the orbits without any corrective quick phases, but she made a few downbeats of nystagmus with upward optokinetic (OKN) drum. 5. Vestibular slow phases, with slow oculocephalics and with rapid head impulse testing were normal. 6. Torsional head rolling produced excellent counter-rolling, but without any torsional quick phases. 7. Fixation suppression of the vestibule-ocular reflex was intact. 8. With head-free gaze shifts, she made exaggerated head turns associated with blinks, with contraversive vestibular slow phase eye movements that place the eyes in the corner of the orbits until the head was maximally rotated, and then the eyes would continue to slowly drift toward the target as can be seen in congenital ocular motor apraxia. Eye movements were recorded with video oculography. Figure A shows video oculography recordings of the patient. Horizontal saccades were absent during random saccade paradigm (top) but sinusoidal smooth pursuit was normal across all frequencies (bottom). Vertical eye movements demonstrated the same findings. Additionally rotary chair sinusoidal vestibular and optokinetic testing demonstrated normal vestibular slow phases and optokinetic ocular following reflex, but absent vestibular or OKN quick phases of nystagmus (not shown). Investigations: Figure B MRI of the brain showing a focus of increased FLAIR signal (an increased T2 signal, not shown) in the right dorsomedial pons (arrow) ten months after surgery. Comment: Two additional cases have been reported by Eggers et al (1). Patient #2 a 53 year old man and patient #3 a 57 year old man who underwent aortic valve-aneurysm and aortic dissection repair and upon awakening both had lost all saccadic eye movements including optokinetic and vestibular quick phases of nystagmus. As with the 50 year old woman (described above) all other eye movement classes were preserved. Both men had gait ataxia and the 53 year old man also had dysarthria and limb dysmetria. Patient #3, the 57 year old man developed complex partial seizures. The MRI in Patient #2 showed left mesial temporal sclerosis and hippocampal atrophy. The MRI in Patient #3 showed patchy subcortical white matter small vessel changes. The patients were examined 6 to 22 months after surgery with no improvement in the eye movement findings. They all remain unable to read or drive.The eye movements in this patient with selective saccadic palsy show: With head free gaze shifts, exaggerated head turns associated with blinks and controversive vestibular slow phase eye movements that place the eyes in the corner of the orbits until the head is maximally rotated. Then the eyes continue to slowly drift towards the target as can be seen in congenital ocular motor apraxia. With head fixed, the eyes make small slow hypometric saccades. Intact smooth pursuit eye movements both horizontally and vertically. With horizontal OKN, the eyes pursue the lines and fix laterally in the orbits without any corrective quick phases. Torsional head rolling produced excellent counter-rolling, but without any torsional quick phases.MRI showed a focus of increased FLAIR signal in the right dorsomedial pons.The functional classes of eye movements (saccades, pursuit, vestibular, optokinetic, vergence) have different anatomic substrates. Premotor (excitatory) burst neurons (PBN) reside in the pons for horizontal saccades and the midbrain for vertical saccades. Omnipause neurons (OPN) in the paramedian pontine raphe interpositus (RIP) transiently cease inhibiting the PBN to allow saccade initiation. Long lead burst neurons (LLBN) in the brainstem receive and combine various cortical and collicular saccade commands and project to PBN and the cerebellum, potentially directing target identification and providing a trigger signal for saccade initiation. Whether a single lesion could cause selective slowing of all saccades but spare other eye movements has been unclear. Perhaps counterintuitively, tiny neurotoxic lesions in the RIP have produced slowing of horizontal and vertical saccades (2), and clinical lesions of the paramedian pons, presumably affecting the OPN, have also caused similar horizontal and vertical saccade slowing in post-cardiac surgery cases. (3, 4). An elegant brainstem neural network model of saccade generation has recently been proposed, explaining how OPN lesions could slow saccades by eliminating the normal post-inhibitory rebound in premotor burst neurons (via membrane channel properties(5), leaving the remaining trigger signal from LLBN insufficient to generate a normal velocity saccade (6). Additional findings, ataxia, seizures, PSP-like syndrome in some of our and others\u27 cases suggests more widespread injury (7-9). Sub-MRI-threshold bihemispheric frontoparietal eye field lesions seem unlikely to explain selective saccadic palsy given the preserved pursuit and impaired reflexive saccades and quick phases.The mechanism of injury remains unclear, but an ischemic cause seems likely given the immediacy after surgery and the ischemic-appearing pontine lesion in our patient 1 and in the single autopsy case (3). While embolic phenomena are possible, susceptibility of specific vulnerable neuronal populations to hypoxic/ischemic injury in the setting of cardiopulmonary bypass and hypothermic circulatory arrest is another potential mechanism (8). These cases occurred despite the fact that the surgeries were otherwise uncomplicated, with normal circulatory arrest and total operative time and without hypotension.Brainstem hypoxic/ischemic injury Hypotension or possibly intraoperative hypothermia may contribute to the development of this syndrome.None available. Patients remain visually disabled. View Selective Saccadic Palsy (data Solomon D et al (7) to see figures and tables.1. Eggers SD, Moster ML, Cranmer K. Selective saccadic palsy following cardiac surgery. Neurology 2008;70:318-320. http://www.ncbi.nlm.nih.gov/pubmed/18057315 2. Kaneko CR. Effect of ibotenic acid lesions of the omnipause neurons on saccadic eye movements in rhesus macaques. J Neurophysiol 1996;75(6):2229-2242. http://www.ncbi.nlm.nih.gov/pubmed/8793737 3. Hanson MR, Hamid MA, Tomsak RL, Chou SS, Leigh RJ. Selective saccadic palsy caused by pontine lesions: clinical, physiological, and pathological correlations. Ann Neurol 1986;20(2):209-217. http://www.ncbi.nlm.nih.gov/pubmed/3752965 4. Tomsak RL, Volpe BT, Stahl JS, Leigh RJ. Saccadic palsy after cardiac surgery: visual disability and rehabilitation. Ann N Y Acad Sci 2002;956:430-433. http://www.ncbi.nlm.nih.gov/pubmed/11960832 5. Miura K, Optican LM. Membrane channel properties of premotor excitatory burst neurons may underlie saccade slowing after lesions of omnipause neurons. J Comput Neurosci 2006;20(1):25-41. http://www.ncbi.nlm.nih.gov/pubmed/16511656 6. Ramat S, Leigh RJ, Zee DS, Optican LM. What clinical disorders tell us about the neural control of saccadic eye movements. Brain 2007;130(Pt 1):10-35. http://www.ncbi.nlm.nih.gov/pubmed/17121745 7. Solomon, D, Ramat S, Tomsak RL, Reich SG, Shin RK. Zee DS, Leigh RJ. Saccadic Palsy following Cardiac Surgery: Characteristics and Pathogenesis. Ann of Neurol 2007;62:1-11. http://www.ncbi.nlm.nih.gov/pubmed/17696176 8. Mokri B, Ahlskog JE, Fulgham JR, Matsumoto JY. Syndrome resembling PSP after surgical repair of ascending aorta dissection or aneurysm. Neurology 2004;62(6):971-973. http://www.ncbi.nlm.nih.gov/pubmed/15037703 9. Bernat JL, Lukovits TG. Syndrome resembling PSP after surgical repair of ascending aorta dissection or aneurysm. Neurology 2004;63(6):1141-1142; author reply 1141-1142. http://www.ncbi.nlm.nih.gov/pubmed/15452329curriculum_fello
HUMAN CAPITAL ASSESSMENT INDICATORS AS INFLUENTIAL DETERMINANTS PERTAINING TO THE ADMISSION CRITERIA UTILIZED BY PRE-LICENSURE PROGRAMS FOR NURSING EDUCATION
No full textThe attainment of educational credentials contributes to the acquisition of human capital. Academic preparedness is a component therein that allows for the attainment of increased levels of education. Most institutions of higher education utilize measures of academic preparedness, such as grade point averages or standardized tests. Requirements for the levels of academic preparedness are based upon many factors. The requirements most relevant to this study are the selectivity of the institution and the academic preparedness of potential candidates of pre-licensure programs for nursing education.
The pre-licensure education of nurses is enigmatic when compared to other professional disciplines. Pre-licensure education for registered nurses exists in three distinct and differently classified programs: a hospital-based diploma program, an associate degree program, or a baccalaureate program. (There is an additional baccalaureate program, known as accelerated second degree programs, for students possessing a baccalaureate degree in another discipline. These accelerated programs are not included in this discussion.) The National Center for Education Statistics classifies each of the three programs, making clear that the differing program levels of post-secondary education are neither equivalent nor interchangeable.
According to the literature, the academic preparedness of individuals and the level of selectivity of higher education institutions vary greatly depending upon the particular classification of nursing program. What then, is the level of programmatic selectivity, given that all three pre-licensure programs produce candidates for the identical occupational certification while attracting candidates known to have varying levels of academic preparedness? This study aimed to determine the levels of selectivity of the three pre-licensure nursing education programs types so as identify trends and patterns within and across pre-licensure program types. In order to determine these trends and patterns, the author examined the admissions requirements that are transparent to the public on schools’ websites in which these programs are housed, employing the methodology of document analysis. The determination for the level of selectivity was based upon Barron’s Measure of Selectivity (Barron’s Educational Series, 2011)
Hydrogen bonding in alcohols: its effect on the carbene insertion reaction
No full textPT: J; CR: NRCC20486 PUBL BETHELL D, 1970, CHEM COMMUN, P792 CLOSS GL, 1976, J AM CHEM SOC, V98, P8190 COGGESHALL ND, 1951, J AM CHEM SOC, V73, P5414 EISENTHAL KB, 1980, J AM CHEM SOC, V102, P6563 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 GRILLER D, UNPUB JOESTEN MD, 1974, HYDROGEN BONDING, CH5 JONES M, 1973, CARBENES KERR JA, 1967, J CHEM SOC A, P897 KIRMSE W, 1964, CARBENE CHEM LANDECK H, 1977, J PHYS CHEM-US, V81, P718 LIU MTH, 1972, CAN J CHEM, V50, P3009 SCAIANO JC, 1980, J AM CHEM SOC, V102, P7747 SENTHILNATHAN VP, 1980, J AM CHEM SOC, V102, P7637 TURRO NJ, 1980, J AM CHEM SOC, V102, P7576 VALERO J, 1980, J CHIM PHYS PHYS CHI, V77, P65 WILSON GM, 1964, J AM CHEM SOC, V86, P127; NR: 18; TC: 95; J9: J AMER CHEM SOC; PG: 3; GA: PJ911Source type: Electronic(1
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