46,477 research outputs found
Reply to comments on 'EPR study of He-implanted Si' by P. Pivac, B. Rakvin, R. Tonini, F. Corni, G. Ottaizani, Published in Mater. Sci. Eng. B73 (2000) 60-63 - Written by M. Kakazey, M. Vlasova, and J.G. Gonzalez-Rodriguez - Reply to discussion
No full textReply to comments on 'EPR study of He-implanted Si' by P. Pivac, B. Rakvin, R. Tonini, F. Corni, G. Ottaizani, Published in Mater. Sci. Eng. B73 (2000) 60-63 - Written by M. Kakazey, M. Vlasova, and J.G. Gonzalez-Rodriguez - Reply to discussio
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders
No full textThe sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg-/- mice show a premature expansion of polyclonal CD5+ B cells in the spleen and the peritoneal cavity. Here we studied the fate of B lymphocytes in Siglecg-/- mice over time. We demonstrate that in aging animals SIGLEC-G deficiency promotes progressive accumulation of monoclonal B lymphocytes and increases the susceptibility to develop B-cell lymphoproliferative disorders. Lymphoid tumors arising in aged Siglecg-/- mice are monoclonal and histologically heterogeneous as they include diffuse large B-cell lymphoma, follicular lymphoma, and medium-to-large B-cell monomorphic lymphoma but surprisingly not chronic lymphocytic leukemia. The tumors express high levels of BCL-2 and are transplantable. In keeping with these findings we have also observed a remarkable down-regulation of the human ortholog SIGLEC10 in human B-cell lymphoma and leukemia cell lines. Taken together, these observations indicate that the down-regulation of negative B-cell receptor regulators such as SIGLEC-G/SIGLEC10 may represent another mechanism relevant to the pathogenesis of B-cell lymphomas. © 2014 Ferrata Storti Foundation
Observations of Bºs→ψ(2S)η and Bº(s)→ψ(2S)π+π- decays
No full textFirst observations of the B0s
→ψ(2S)η, B0 →ψ(2S)π
+
π
− and B0s
→ψ(2S)π
+
π
− decays are made
using a dataset corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment in
proton–proton collisions at a centre-of-mass energy of
√
s = 7 TeV. The ratios of the branching fractions
of each of the ψ(2S) modes with respect to the corresponding J/ψ decays are
B(B0s
→ψ(2S)η)
÷
B(B0s
→J/ψη)
= 0.83± 0.14 (stat)±0.12 (syst) ±0.02 (B),
;
B(B0→ψ(2S)π
+
π
−
)
÷
B(B0→J/ψπ
+
π
−
)
= 0.56± 0.07 (stat)±0.05 (syst)± 0.01 (B),
;
B(B0s
→ψ(2S)π
+
π
−
)
÷
B(B0s
→J/ψπ
+
π
−
)
= 0.34± 0.04 (stat)±0.03 (syst)± 0.01 (B),
where the third uncertainty corresponds to the uncertainties of the dilepton branching fractions of the J/ψ
and ψ(2S) meson decays
Father Reyes Rodriguez, Hispanic Oral Histories, Accn 1369
No full textFather Rodriguez (b. 1934) talks about his family roots in Mexico, the marriage of his parents and their life in Layton, Utah, and his childhood. Other topics include home remedies, cooking, traditional hispanic family life, religion, his church service, entering the seminary at the age of 25, the psychological impact of his training, Catholicism, a memorable sermon, and life as a Catholic priest. Interviewed by Leslie Kelen, 117 pages
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders
No full textThe sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg-/- mice show a premature expansion of polyclonal CD5+ B cells in the spleen and the peritoneal cavity. Here we studied the fate of B lymphocytes in Siglecg-/- mice over time. We demonstrate that in aging animals SIGLEC-G deficiency promotes progressive accumulation of monoclonal B lymphocytes and increases the susceptibility to develop B-cell lymphoproliferative disorders. Lymphoid tumors arising in aged Siglecg-/- mice are monoclonal and histologically heterogeneous as they include diffuse large B-cell lymphoma, follicular lymphoma, and medium-to-large B-cell monomorphic lymphoma but surprisingly not chronic lymphocytic leukemia. The tumors express high levels of BCL-2 and are transplantable. In keeping with these findings we have also observed a remarkable down-regulation of the human ortholog SIGLEC10 in human B-cell lymphoma and leukemia cell lines. Taken together, these observations indicate that the down-regulation of negative B-cell receptor regulators such as SIGLEC-G/SIGLEC10 may represent another mechanism relevant to the pathogenesis of B-cell lymphomas
The clock diet: a practical nutritional guide to manage obesity through chrononutrition
No full textChronobiology studies the biological rhythms or circadian cycles of living organisms and their adaptation to external changes. Biological rhythms can affect hormone production cycles such as sleep/wake, and nutrition/fasting, but these factors can also alter the circadian rhythm (CR). In recent years, numerous studies have highlighted how feeding times and frequency can influence biological rhythms. Additionally, individuals’ chronotype, working shifts, and food intake can make a deep impact on people’s tendency to develop obesity and metabolic diseases. In this context, a single food and a specific combination of these, can also affect the CR and fasting cycle and consequently body weight and viceversa. The purpose of the review is to propose practical nutritional recommendations to help in resynchronizing the circadian rhythm as a tool in weight control. (Cite this article as: Barrea L, Frias-Toral E, Aprano S, Castellucci B, Pugliese G, Rodriguez-Veintimilla D, et al. The clock diet: a practical nutritional guide to manage obesity through chrononutrition. Minerva Med 2022;113:172-88. DOI: 10.23736/ S0026-4806.21.07207-4
Complete 1H and 13C NMR assignments of clerodane diterpenoids of Salvia splendens
No full textUnambiguous and complete assignments of 1H and
13C NMR chemical shifts for five clerodane diterpenes,
four of them isolated from Salvia splendens
(salviarin, splendidin and splenolides A and B) and
one obtained by acetylation of splenolide A, are
presented. The assignments are based on 2D shiftcorrelated
[1H,1H–COSY, 1H,13C-gHSQC–1J(C,H) and
1H,13C-gHMBC-nJ(C,H) (n = 2 and 3)] and nuclear Overhauser
effect (NOE) experiments. The conformation of
the rings of these compounds is supported by the 3J(H,H)
values and NOE results. Copyright 2006 John Wiley &
Sons, Lt
Clerodane Diterpenoids from Salvia splendens
No full textFour new clerodane diterpenoids, salvisplendins A-D (1-4), have been isolated from an acetone extract of the flowers
of SalVia splendens, together with an artifact (5), arising from salvisplendin D (4) by addition of diazomethane, and the
already known clerodane olearin (6). The structures of the new compounds (1-5) were established mainly by 1D and
2D NMR spectroscopic studies and, in the case of salvisplendin A (1), by chemical correlation with splenolide B (7).
Complete 1H and 13C NMR assignments for olearin (6), not published hitherto, are also reported
Anonymization and Secrey in Supervision Processes – a Methodological, Ethical, Clinical and Legal Problem
No full textAus rechtlichen, ethischen und supervisionsmethodischen Gründen müssen PatientInnen/KlientInnen um Zustimmung gefragt werden, ob ihr Prozess in der Supervision thematisiert werden darf. Trotz eines obergerichtlichen Urteils in dieser Sache, wird – wie die Forschung bis in die neuste Zeit in bedauerlicher Weise zeigt – diese strafbewehrte Rechtsvorschrift von SupervisorInnen immer wieder verletzt (vgl. Petzold et al. 2017 Transparenzdilemma; Collenberg 2017). Dieser Text von 1996 – mehrfach aus gegebenen Anlässen wieder neu publiziert – wird mit seinen grundsätzlichen Argumentationen deshalb hier neu eingestellt. Zusammen mit anderen Arbeiten, die in dieser Zeitschrift zu „prekärer Supervision“ publiziert worden sind (z. B. 1, 2 und 7/2016; 5/2017; 4/2012), wird das für uns eine Thema der Qualitätssicherung in einem Bereich der Qualitätsdefizite und -schwächen von Supervision bleiben, dem unsere Aufmerksamkeit gilt (vgl. 2/2018, 3/2018).Because of legal grounds, ethical reasons and arguments from supervisory methodology patients/clients have to be asked for consent, that their process material can become a topic in supervision. Although there is a superior court decision concerning this issue, empirical research is showing to our regret that this punishable regulation is violated by supervisors again and again (vgl. Petzold et al. 2017 dilemma of transparency; Collenberg 2017). This text from 1996 – which has been published for good reasons several times anew – is posted here again with its fundamental arguments together with some more studies concerning precarious supervision. Together with other articles that have been published in this Journal concerning „precarious supervision“ (e.g. 1, 2 und 7/2016; 5/2017; 4/2012), this topic of quality assurance in an area of quality deficits and –weaknesses of supervision will stay a focus of our attention (cf. 2/2018, 3/2018).https://www.fpi-publikation.de/supervision/01-2018-petzold-h-g-rodriguez-petzold-f-1996-anonymisierung-schweigepflicht-ethisches/peerReviewedpublishedVersio
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