7 research outputs found
Analisi preliminare dei fattori demografici ed eziopatogenetici in pazienti affetti da carcinoma vescicale a medio rischio di recidiva
No full textEMBANKMENT OF CHARTERED TOWN ŻYCHLIN
No full textPrawna lokacja miasta Żychlina nastąpiła prawdopodobnie w latach 1340-1348, a jego kształt przestrzenny
powstał w drugiej połowie XIV wieku. Obszar miasta o powierzchni około 7,5 morgi (4,1 ha)
tworzył owal otoczony obwałowaniami. Centralną częścią miasta był rynek o wymiarach 13x20 prętów
(około 56x86 m) otoczony blokami zabudowy mieszkalnej. Obwałowania miasta lokacyjnego, potwierdzone
w dokumentach historycznych, miały długość około 800 m oraz 4 bramy wjazdowe. Brak jest informacji
o wielkości nasypów ziemnych. Autor hipotetycznie przyjął, że ich kubatura mogła wynieść ponad
11 tys. m3 ziemi, piasku i żwiru. Tak duża objętość materiałów kopalnych użytych do usypania wałów zostawiła
ślad – wyrobisko w najbliższej okolicy miasta lokacyjnego tj. przy dawnej ul. Żabiej, obecnej Kościuszki,
na terenie współcześnie urządzonego Parku Miejskiego. Wały miejskie istniały prawdopodobnie
do połowy XVII wieku, tj. do czasu kiedy podjęto decyzję o powiększeniu rynku i budowy frontem do niego
murowanego kościoła p.w. św. Piotra i Pawła oraz wytyczeniu nowej ul. Łowickiej (ob. Narutowicza).Legal location of town Żychlin had taken place probably in years 1340 – 1348. It’s dimensional shape was
established in second half of XIV century. City area was about 7,5 acres (4,1 ha) and it created oval, surrounded
by embankment. Central city part was marketplace size of 13x20 poles (around 56x86 m) surrounded
by blocks of residential buildings. Embankment of chartered town, reassured in historical documents, had
length of approximately 800m and 4 entrance gates. There is no information about the size of earthen banks.
Author hypothetically assumed that its cubature was over 11 thousand cubic meters of earth, sand and gravel.
Such big volume of dug materials used to build the embankment left remnant – excavation in the nearest
surroundings of chartered town, beside Żabia street currently Kościuszki street, on territory of modern decorated
Town Park. Town embankment had existed probably until half of XVII century when the decision was
made to increase the marketplace size, building brick church dedicated to saint Peter and Paul and to demarcate
new Łowicka street (now Narutowicza)
Noise from scattered light in Virgo's second science run data
No full textVirgo is one of the large, ground-based interferometers aimed at detecting gravitational waves. One of the technical problems limiting its sensitivity is caused by light in the output beams which is backscattered by seismically excited surfaces and couples back into the main beam of the interferometer. The resulting noise was thoroughly studied, measured and mitigated before Virgo's second science run (VSR2). The residual noise during VSR2, which increases in periods with a large microseism activity, is accurately predicted by the theoretical model. The scattered light has been associated with transient events in the gravitational-wave signal of the interferometer
Virgo calibration and reconstruction of the gravitational wave strain during VSR1
No full textVirgo is a kilometer-length interferometer for gravitational waves detection located near Pisa. Its first science run, VSR1, occured from May to October 2007. The aims of the calibration are to measure the detector sensitivity and to reconstruct the time series of the gravitational wave strain h(t). The absolute length calibration is based on an original non-linear reconstruction of the differential arm length variations in free swinging Michelson configurations. It uses the laser wavelength as length standard. This method is used to calibrate the frequency dependent response of the Virgo mirror actuators and derive the detector in-loop response and sensitivity within ~5%. The principle of the strain reconstruction is highlighted and the h(t) systematic errors are estimated. A photon calibrator is used to check the sign of h(t). The reconstructed h(t) during VSR1 is valid from 10 Hz up to 10 kHz with systematic errors estimated to 6% in amplitude. The phase error is estimated to be 70 mrad below 1.9 kHz and 6 micro-seconds above
Hemodynamic regulation of metalloendopeptidases EC3.4; 24.15 and EC3.4; 24.16: expression and function in the vascular endothelium
No full textHemodynamic forces, namely shear stress and cyclic strain, have been well characterised as modulators of vascular endothelial function, and have been assigned an important role in the maintainence of vascular tone, haemostasis, and regulation of vascular growth and health. They exert their influence in part by effecting changes in the production and release of vasoactive compounds by the endothelium, and by effecting changes in the levels and activity of various enzymes. Thimet oligopeptidase (EC3.4.24.15, EP24.15) and neurolysin (EC3.4.24.16, EP24.15) are closely related zinc metalloendopeptidases that have been shown to be expressed and active in the vascular endothelium. Their substrates include the vasoactive peptides bradykinin and angiotensin I, which have been identified as important regulators of both blood pressure and angiogenic processes. Other related peptidases, namely endothelin converting enzyme (ECE) and angiotensin converting enzyme (ACE), have been shown to be regulated by hemodynamic forces in the vascular endothelium. As such EP24.15 and EP24.16 are likely candidates for regulation by hemodynamic forces.
In this regard we have investigated the effect of cyclic strain on the expression and activty of EP24.15 and EP24.16 in cultured bovine aortic endothelial cells (BAECs). We have shown that exposure to cyclic strain significantly increases the mRNA expression as well as both the cellular and secreted activity of both enzymes. We have demonstrated that up-regulation of both enzymes is dependent on Gi-protein mediated signalling, although with varying Gia/G(3y subunit specificity for either enzyme. Using immunocytochemistry, we have also demonstrated a strain-dependent increase in EP24.15 protein expression within the nucleus and cytoplasm in parallel with an increase in membrane associated EP 24.15
The effects of strain on the ability of BAECs in culture to cleave both Ang I, and BK in an EC24.15/EC24.16 specific manner was also studied. We observed that exposure to cyclic strain induces a significant increase in the EP24.15 specific hydrolysis of both exogenously added BK and Ang I.
The potential of the observed effects of cyclic strain on EP24.15 to effect changes in endothelial cell function were also examined. Use of the dual EP24.15/EP24.16 inhibitor, cFP-AAF-pAB, and the EP24.15 specific antisense, FLIP, was seen to significantly attenuate cyclic strain-induced endothelial cell tubule formation and migration. We also found that the effects of FLIP transfection on cyclic strain-induced endothelial cell tubule formation could be largely reversed by addition of exogenous Ang-(l-7). Taken together these results suggest that strain-induced endothelial cell angiogenesis and migration putatively involves EP24.15 cleavage of vasoactive peptide substrates
Status and perspectives of the Virgo gravitational wave detector
No full textInternational audienceVirgo is designed to detect gravitational waves of both astrophysical and cosmological origin in the frequency range from a few Hz to a few kHz. After the end of the first science run, partially overlapped with the LIGO fifth science run, the detector underwent several upgrades to improve its sensitivity. The second Virgo science run started at the beginning of July 2009 in coincidence with LIGO. A further upgrade is planned at beginning of 2010 with the installation of new suspensions for the test masses and of new mirrors. This will lead to a considerable improvement in the sensitivity and represents an intermediate step toward the development of the advanced detectors
Tools for noise characterization in Virgo
No full textInternational audienceSeveral software tools were used to perform on-line and of-line noise analysis as a support to commissioning activities, to monitor the rate of glitches, the occurrence of non stationary noise, the presence of environmental contamination, the behavior of narrow spectral features and the coherence with auxiliary channels. We report about the use of these tools to study the main sources of identified noise: broadband, spectral lines and glitches. Plans for the upgrade of the tools will be presented, for example for lines identification purpose to let the scientists in control room do noise characterization in an easier way
