57,691 research outputs found
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Restless legs syndrome: diagnosis, treatment and pathophysiology
No full textThis cumulative dissertation presents four articles focussing on diagnosis, treatment and pathophysiology of the restless legs syndrome:
1) Fulda S, Beitinger ME, Reppermund S, Winkelmann J, Wetter TC. Short-term attention and verbal fluency is decreased in restless legs syndrome patients. Movement Disorders 2010; 25: 2641-2648. DOI 10.1002/mds.23353
2) Fulda S, Wetter TC. Where dopamine meets opioids: a meta-analysis of the placebo effect in restless legs syndrome treatment studies. Brain 2008; 131: 902-917. DOI 10.1093/brain/awm244
3) Fulda S, Stalla GK, Wetter TC. Prevalence of the restless legs syndrome in transsexual patients: the hormonal hypothesis revisited. Journal of Neurology 2007; 254: 1748-1749. DOI 10.1007/100415-007-0624-6
4) Winkelmann J, Schormaier B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 2007; 39(8): 1000-1006. DOI 10.1038/ng209
Regulation of cell death in cancer - possible implications for immunotherapy
No full textSince most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future
Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
No full textSignaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers
Letter from Carl Hayden to P. J Moran
No full textLetter from Carl T. Hayden to P. J. Moran concerning the alignment of the road to Bright Angel Trail
Letter from P. J. Moran to Carl Hayden
No full textLetter from P. J. Moran to Carl T. Hayden inquiring when construction will begin on the approach road to Bright Angel Trail
Letter from P. J. Moran to Carl Hayden
No full textLetter from P. J. Moran to Carl T. Hayden inquiring when construction will begin on the approach road to Bright Angel Trai
Telegrams Between Carl Hayden to P. J. Moran, Democratic County Central Committee
No full textTelegram from Carl Hayden to P. J. Moran regarding the resignation of W. W. Crosby and his replacement J. R. Eakin
How to target apoptosis signaling pathways for the treatment of pediatric cancers
No full textApoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors. This implies that ineffective engagement of cell death programs can contribute to tumor formation as well as tumor progression. In addition, the majority of cytotoxic therapeutic principles rely on the activation of cell death signaling pathways in cancer cells. Blockade of signaling networks that lead to cell death can therefore confer treatment resistance. A variety of genetic and epigenetic events as well as dysfunctional regulation of signaling networks have been identified as underlying causes of cell death resistance in childhood malignancies. Apoptosis pathways can be therapeutically exploited by enhancing proapoptotic signals or by neutralizing antiapoptotic programs. The challenge in the coming years will be to successfully transfer this knowledge into the development of innovative treatment approaches for children with cancer
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