29 research outputs found
Use of the virtual medical record data model for communication among components of a distributed decision-support system
No full textMobiGuide is a distributed decision-support system (DSS) that provides decision support for patients and physicians. Patients receive support using a light-weight Smartphone DSS linked to data arriving from wearable monitoring devices and physicians receive support via a web interface connected to a backend DSS that has access to an integrated personal health record (PHR) that stores hospital EMR data, monitoring data, and recommendations provided for the patient by the DSSs. The patient data model used by the PHR and by all the system components that interact in a service-oriented architecture is based on HL7's virtual medical record (vMR) model. We describe how we used and extended the vMR model to support communication between the system components for the complex workflow needed to support guidance of patients any time everywhere
Designing Enterprise Resources Planning Application for Integrating Main Activities in a Simulator Model of SCM Network Distribution
No full textCollaborative supply chain is a specific topic in supply chain management and studied by
industrial engineering students in supply chain management course. Unfortunately, conventional
learning media cannot explain the phenomenon of collaborative supply chain to the students. This study
aimed to design a dynamic learning media so that inter-company collaboration and information sharing
on the activities of Supply Chain entities can be explained effectively to the students. The problem was
solved using 3 (three) steps. First, the distribution network was described using mock up. It consists of
miniature trucks, miniature network and miniature of the manufacturer-distributor-retailer embedded
with tag and reader of RFID. Second, the Enterprise Resources Planning application was developed for
supporting business activities. Third, we developed the integrator consists of monitor’s user interface
and practice modules. The result of the research - an SCM-Simulator – will be able to improve learning
skills of industrial engineering graduates, especially abilities to identify, formulate, and solve the
activities of tactical plan & operational routines of Supply Chain entities. However, distribution module
designed is for limited scale laboratory study of simple objects.
Keywords: Distribution Network, Enterprise Resource Planning, Industrial Engineering Education,
SCM Simulator,and Learning Media
Developing weighted criteria to evaluate lean reverse logistics through analytical network process
No full textOs caminhos da ruptura do autoritarismo pedagogico : a ruptura das relações autoritarias para a construção coletiva do conhecimento
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciencias da EducaçãoO principal objetivo desta pesquisa foi o de analisar as ações pedagógicas desenvolvidas por uma "escola alternativa", tendo em vista suas possíveis aproximações com os pressupostos da pedagogia libertária. Para tanto, teremos como referencial os princípios libertários presentes nas experiências pedagógicas desenvolvidas em vários países, desde o final do século passado até os nossos dias. O confronto das análises nos permite pontuar onde as ações pedagógicas da "escola alternativa" aproximaram-se ou distanciaram-se de uma prática libertária, no sentido de desenvolver a autonomia/independência/solidariedade, em contraposição a heteronomia/dependência/individualismo
Signaling and technological marketing tools for exporters
No full textBesides superior productivity, what other firm characteristics are associated with export success? This empirical study identifies the effects of signaling tools (foreign technical license, International Standards Organization certification, and review of financial statements) and Internet tools (email and website) on export frequency and intensity of firms in developing countries. Using data from the World Bank’s Enterprise Survey, the author finds that productivity, size, foreign ownership, International Standards Organization certification, and the use of Internet tools have positive effects on the probability of exporting and on the intensive margin of trade. International Standards Organization certified firms are 22 percent more likely to be exporters, whereas firms that use their own website to communicate with clients and suppliers increase the likelihood they export by 11 percent. Among exporting firms, those that are International Standards Organization certified sell 41 percent more abroad than firms that are not certified. Firms that use email sell 31 percent more in foreign markets than exporting firms that do not.Economic Theory&Research,E-Business,Microfinance,Labor Policies,Markets and Market Access
Functional and in silico assessment of MAX variants of unknown significance.
No full textThis work was supported in part by the Fondo de Investigaciones Sanitarias (projects PI12/00236 and PI11/01359 to A.C. and M.R., respectively), the Fundacion Mutua Madrilena (project AP2775/2008 to M.R.), and a grant from the European Community's Seventh Framework Programme (ENS@T-CANCER; HEALTH-F2-2010-259735). Aguirre A. de Cubas and Veronika Mancikova are pre-doctoral fellows in "la Caixa"/CNIO International PhD Programme. Lucia Inglada-Perez and Inaki Comino-Mendez are predoctoral fellows with the CIBERER and the Fundacion Ferrer, respectively.The presence of germline mutations affecting the MYC-associated protein X (MAX) gene has recently been identified as one of the now 11 major genetic predisposition factors for the development of hereditary pheochromocytoma and/or paraganglioma. Little is known regarding how missense variants of unknown significance (VUS) in MAX affect its pivotal role in the regulation of the MYC/MAX/MXD axis. In the present study, we propose a consensus computational prediction based on five "state-of-the-art" algorithms. We also describe a PC12-based functional assay to assess the effects that 12 MAX VUS may have on MYC's E-box transcriptional activation. For all but two of these 12 VUS, the functional assay and the consensus computational prediction gave consistent results; we classified seven variants as pathogenic and three as nonpathogenic. The introduction of wild-type MAX cDNA into PC12 cells significantly decreased MYC's ability to bind to canonical E-boxes, while pathogenic MAX proteins were not able to fully repress MYC activity. Further clinical and molecular evaluation of variant carriers corroborated the results obtained with our functional assessment. In the absence of clear heritability, clinical information, and molecular data, consensus computational predictions and functional models are able to correctly classify VUS affecting MAX.A functional assay assesses the effects of MAX VUS over MYC transcriptional activity. A consensus computational prediction and the functional assay show high concordance. Variant carriers' clinical and molecular data support the functional assessment.N
Effect of antimony on the eutectic reaction of heavy section spheroidal graphite castings
No full textThere is a strong demand for heavy section castings made of spheroidal graphite with a fully ferritic matrix, e.g. for manufacturing hubs for windmills. Such castings with slow solidification process are prone to graphite degeneration that leads to a dramatic decrease of the mechanical properties of the cast parts. Chunky graphite is certainly the most difficult case of graphite degeneracy, though it has long been known that the limited and controlled addition of antimony may help eliminate it. The drawback of this remedy is that too large Sb additions lead to other forms of degenerate graphite, and also that antimony is a pearlite promoter. As part of an investigation aimed at mastering low level additions to cast iron melts before casting, solidification of large blocks with or without Sb added was followed by thermal analysis. Comparison of the cooling curves and of the microstructures of these different castings gives suggestions to understand the controlling nucleation and growth mechanisms for chunky graphite cells
Reliability of lumped hydrological modeling in a semi-arid mountainous catchment facing water-use changes
No full textThis paper explores the reliability of a hydrological modeling framework in a
mesoscale (1515 km2) catchment of the dry Andes (30° S) where
irrigation water use and snow sublimation represent a significant part of the
annual water balance. To this end, a 20-year simulation period encompassing a
wide range of climate and water-use conditions was selected to evaluate three
types of integrated models referred to as A, B and C. These models share the
same runoff generation and routing module but differ in their approach to
snowmelt modeling and irrigation water use. Model A relies on a simple
degree-day approach to estimate snowmelt rates and assumes that irrigation
impacts can be neglected at the catchment scale. Model B ignores irrigation
impacts just as Model A but uses an enhanced degree-day approach to account
for the effects of net radiation and sublimation on melt rates. Model C
relies on the same snowmelt routine as Model B but incorporates irrigation
impacts on natural streamflow using a conceptual irrigation module. Overall,
the reliability of probabilistic streamflow predictions was greatly improved
with Model C, resulting in narrow uncertainty bands and reduced structural
errors, notably during dry years. This model-based analysis also stressed the
importance of considering sublimation in empirical snowmelt models used in
the subtropics, and provided evidence that water abstractions from the
unregulated river are impacting on the hydrological response of the system.
This work also highlighted areas requiring additional research, including the
need for a better conceptualization of runoff generation processes in the dry
Andes
Thermal Analysis of the Formation of Chunky Graphite during Solidification of Heavy-section Spheroidal Graphite Iron Parts
No full textAnalysis of cooling curves recorded at the centre of large blocks cast with near-eutectic spheroidal graphite cast irons prone to give chunky graphite has been checked against microstructure observations. It has been observed that solidification proceeds totally at temperatures lower than the stable eutectic temperature and the following solidification sequence could be proposed: 1) nucleation of primary graphite in the liquid; 2) initial eutectic reaction processing by growth of austenite-like dendrites encapsulating the primary nodules; 3) bulk eutectic reaction related to nucleation and then growth of CHG cells and of secondary nodules, these latter giving spheroidal graphite eutectic cells. It was found that the maximum recalescence during the eutectic reaction first increases with the volume of the block affected by chunky graphite, and then decreases when most of the material is affected. Interestingly enough, a relationship between the volume of the blocks affected by CHG and the recalescence measured on TA cups has been observed
Effect of mould inoculation on formation of chunky graphite in heavy section spheroidal graphite cast iron parts
No full textThe manufacturing process of heavy section ductile iron castings is strongly influenced by the risk of graphite degeneration under slow cooling rates. Appearance of this kind of defect is commonly linked to significant reductions in the mechanical properties of large castings. Studies on the effect of inoculation on chunky graphite formation in heavy sections have led to contradictory results in the literature and this triggered the present work. New experimental data are presented on the effect of mould inoculation on chunky graphite appearance during solidification of nodular irons which clearly demonstrate that mould inoculation increases the risk of chunky graphite formation in heavy sections. This is in agreement with some previous works which are reviewed, and it is suggested that the contradiction with other results could relate to the fact that these latter works dealt with chill casting
