45 research outputs found
BMP1 5'UTR+104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease
No full textAkadam Teker, Aysegul Basak/0000-0003-3618-0560; Ozturk, Oguz/0000-0002-2439-9269WOS: 000444752900058PubMed: 30062502Apolipoprotein A1 (Apo A1), the major protein of HDL, is secreted as a proprotein and then is cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP1). BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variations of BMP1 gene may affect serum ApoA1 and HDL levels. We aimed to investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease (CHD) in this study. The BMP1 5'UTR + 104 (T/C) (rs143383) variation was determined in 131 male patients with CHD and 51 male controls by real-time polymerase chain reaction technique. ApoA1 levels were measured by immunoturbidimetry. The serum Apo-A1 levels were found higher in controls with the BMP1-CC genotype than those with the T-allele (p < 0.001). Our findings show the association of this variation with serum ApoA1 and HDL-C levels which increase in the order of CT < TT < CC in the controls. No effect was found on ApoA1 and HDL-C levels in CHD patients, as it was observed in the controls. However, the BMP1-TT genotype was associated with higher triglyceride (TG) levels as compared to C-allele (p = 0.009). These discrepancies could be due to statin therapy which has dominant effects on lowering cholesterol levels comparing to TG levels. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of CHD.Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [11304]The present study was supported by a grant from the Scientific Research Projects Coordination Unit of Istanbul University (Project No: 11304)
Effects of the Variants of Activin Receptor-like Kinase-1 and 2 on the Lipid Profile of Patients with Coronary Heart Disease
No full textIntroduction: Coronary heart disease (CHD) due to atherosclerosis is a multifactorial disease with high morbidity caused by interaction of various genetic and environmental factors. Hyperlipidemia which is accepted as the most important risk factor for atherosclerosis; characterized by high concentration of low density lipoprotein (LDL)-cholesterol (LDL-C) and low concentration of high density lipoprotein (HDL)-cholesterol (HDL-C). Epidemiological studies prove the inverse relationship between HDL-C levels and CHD. Apolipoprotein A1, the major protein of HDL, is secreted as proprotein and then cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP-1). Reporting of the role of BMP receptors in lipoprotein metabolism indicates that variations in these genes may be important. However, there are no studies in the literature about the variations in type I receptors for activin receptor-like kinase (ALK) 1 and ALK2 and its effects on lipid profile. In this study, it was aimed to determine the role of the gene variants of ALK1 (Q292P ve S333G) and ALK2 (R206H) receptors in the development of CHD and their effects on serum lipoprotein levels.
Methods: This study was carried out using a sample of 131 patients with CHD and 51 controls. ALK1 and ALK2 genotypes were determined by real-time polymerase chain reaction and technique.
Results: Genotype distributions of ALK1 and ALK2 were the same between the study groups (p>0.05). Mutations in ALK1 and ALK2 were observed only in the patient group. ALK1 Q292P mutation and ALK2 R206H mutation exerted positive effects on the serum lipid profile.
Conclusion: The findings of our study suggested that mutations of ALK1 and ALK2 genes may contribute to antiatherogenic lipid profile and may protect against the development of CHD.Supported by Istanbul University Scientific Research Projects Unit (no: 11304)
Glycoprotein Ib alpha Kozak polymorphism in patients presenting with early-onset acute coronary syndrome
No full texthancer, veysel sabri/0000-0003-2994-1077WOS: 000436361500011PubMed: 30013602Introduction: Glycoprotein Ib alpha (GPIb alpha) receptor is the chief molecule responsible for initial platelet adhesion to the subendothelium. A thymidine to cytosine single nucleotide substitution at position -5 from the ATG start codon characterizes the Kozak sequence polymorphism. The Kozak sequence polymorphism may increase the surface expression of GPIb alpha and contribute to thrombogenesis. We evaluated the allele frequencies of GPIb alpha Kozak sequence polymorphism in the Turkish population and examined the relationship between GPIb alpha Kozak sequence polymorphism and early-onset acute coronary syndrome (ACS). Material and methods: This study enrolled 200 patients (122 male, 78 female, mean age: 39 +/- 5 years) and 200 healthy control subjects (110 male, 90 female, 41 +/- 4 years). The patient group was composed of patients admitted to our coronary care unit with early-onset ACS and patients who attended to our cardiology outpatient clinic after hospital discharge with a diagnosis of early-onset ACS. Results: Kozak polymorphism frequencies in patients and control subjects did not differ significantly (23% versus 22.5%, p = 0.812, respectively). In patients who presented with non-ST elevation myocardial infarction (NSTEMI), the frequency of GPIb alpha Kozak polymorphism was borderline significantly higher when compared with patients who presented with ST elevation myocardial infarction (STEMI) (35% vs. 20%, p = 0.05, respectively). Allele frequencies of T and C were calculated to be 0.873 and 0.128. Conclusions: Although the frequency of GPIb alpha Kozak polymorphism did not differ significantly in early-onset ACS patients versus control subjects, Kozak polymorphism frequency was borderline significantly higher in patients who presented with NSTEMI when compared to patients with STEMI
Association between the interferon gamma 874 T/A polymorphism and the severity of valvular damage in patients with rheumatic heart disease
No full textOzturk, Oguz/0000-0002-2439-9269WOS: 000433521500005PubMed: 29332266Interferon gamma (IFN-gamma) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-gamma +874 T/A polymorphism and the severity of valvular damage in the Turkish population. The IFN-gamma genotypes were determined in 152 RHD patients and 151 healthy controls by ARMS-PCR. Differences in genotype distribution between patients with RHD and control were evaluated by the chi (2) test. All statistical analyses were performed with SPSS 15.0 Software program. Frequency of the AA genotype was found to be significantly lower and the TT genotype significantly higher in the RHD group compared to controls (p = 0.002 and p = 0.018, respectively). The TT genotype was found to be significantly higher (26.8% vs. 9.1%, p = 0.009) and the AA genotype significantly lower (29.1% vs. 8.2%, p = 0.001) in the severe valvular disease (SVD) group compared to mild valvular disease group. In the SVD group, 79 patients had mitral balloon valvotomy and/or mitral valve replacement and had significantly higher TT genotype compared to patients with medical follow-up (30.4% vs. 19%, p = 0.001). The data demonstrated that TT genotype is associated with both RHD and the severity of RHD.Scientific Research Projects Coordination Unit of the Istanbul UniversityIstanbul University [6963]This study was supported by a grant from the Scientific Research Projects Coordination Unit of the Istanbul University (Project No. 6963)
The Adaption of Technology Integration Self-Efficacy Scale into Turkish
No full textanemonThe purpose of this study is to adapt theTechnology Integration Self-Efficacy Scale which was developed by Wang Ertmerand Newby (2004) into Turkish. Validity and reliability studies were carriedout on 748 pre-service teachers studying in Afyon Kocatepe University Facultyof Education. For construct validity, exploratory and confirmatory factoranalyses were applied and it was found similar to the original scale. Forreliability analysis, Cronbach Alpha reliability coefficient was calculated as.936. Item-total correlations coefficients of the scale ranged from .60 to.707. To measure the criterion referenced validity of the scale TechnologicalPedagogical Content Knowledge Scale which was developed by Kabakçı-Yurdakul, Odabaşı, Kılıçer, Çoklar, Birinci and Kurt (2012) was employed and correlationcoefficient was calculated as .74. Overall findings demonstrated that this scaleis valid and reliable instrument. Buaraştırmanın amacı, Wang, Ertmer ve Newby (2004) tarafından geliştirilenTeknoloji Entegrasyonuna Yönelik Öz-Yeterlik Algısı Ölçeği’ni Türkçe’yeuyarlamaktır. Ölçeğin geçerlik ve güvenirlik analizlerini yapmak için AfyonKocatepe Üniversitesi Eğitim Fakültesi’nde öğrenim gören 748 öğretmen adayındanveri toplanmıştır. Ölçeğin yapı geçerliği için açımlayıcı ve doğrulayıcı faktöranalizleri gerçekleştirilmiş ve benzer yapı elde edilmiştir. Ölçeğin güvenirlikanalizinde Cronbach Alfa İç Tutarlık katsayısı hesaplanmış ve 0.936 olarakbulunmuştur. Ölçeğin madde-toplam korelasyonları ise 0.60 ile 0.707 arasındadeğişmektedir. Ölçeğin ölçüt geçerliğinde Kabakçı-Yurdakul, Odabaşı, Kılıçer, Çoklar, Birinci ve Kurt (2012) tarafından hazırlanan Teknopedagojik EğitimYeterlikleri Ölçeği ile arasındaki korelasyon katsayısı 0.74 olarakbulunmuştur. Yapılan analizler sonucunda Teknoloji Entegrasyonuna YönelikÖz-Yeterlik Algı Ölçeği’nin Türk kültüründe geçerli ve güvenilir bir ölçmearacı olduğuna karar verilmiştir.40049
Open heart surgery in a patient with liver transplantation: A case report
No full textKaraciğer nakli olan hasta sayısı arttıkça, geç dönemde gelişen kalp ve diğer sistem patolojileri Damar Cerrahisi Kliniği, Florya, İstanbul, nedeniyle cerrahi uygulamaları da sıklaşmıştır. Karaciğer nakli olan hastalarda koroner arter hastalığının görülme oranı artmaktadır. Karaciğer transplantı hastaları, asemptomatik olsa bile, koroner arter hastalığı için yüksek risk alt grubudur. Karaciğer transplantı gerçekleştirilen bir Turkey. hastada koroner arter hastalığı gelişmesi, kötü bir prognostik faktördür; Bu nedenle, risk altındaki kişilerin belirlenmesi klinik önceliğe sahip olmalıdır. Bu çalışmamızda, on iki yıl önce karaciğer nakli uygulanan 68 yaşındaki bir erkek hastaya iskemik kalp hastalığı tanısı ile kardiopulmoner Çıkar Çatışması: Yazarlar çıkar çatışması.As the number of patients with liver transplantation increased, surgical applications were also frequent due to late-onset heart and other systemic pathologies. The incidence of coronary artery disease is increasing in patients with liver transplantation. Liver transplanted patients are a high risk subgroup for coronary artery disease, even if they are asymptomatic. Coronary artery disease is a predictor of poor outcomes in patients with liver transplantation; therefore, identiŞcation of those Sorumlu yazar / Corresponding author patients at risk for coronary artery disease should be a key clinical priority. In this study, it was Melike Elif Teker aimed to present coronary artery bypass grafting surgery in a 68-year-old male patient with previous ve Damar Cerrahisi Hastanesi, Eski Londra Asfaltı liver transplantation 12 years ago. Coronary artery bypass grafting operation was performed using left internal mammarian artery and autogenous vein graft for three vessels. There was no complication in the pre- and post-operative periods. Coronary artery bypass grafting operation can be performed safely for patients with previous liver transplantaion in experienced centers
Venture Capital Markets: A Cross Country Analysis
Get PDFAbstractVenture capital (VC) may be defined as a support to entrepreneurial talents and appetite by turning ideas and basic science into products and services which are expected to envy the world. Venture capital funds are able to build companies from the simplest form to mature organizations. Venture capital investors generally actively engage with management of the company by typically taking place on the board. Through the due diligence process the venture capital firms concentrate on the founders, the management team, the concept, the marketplace, the revenue model, the value-added potential of the firm, the amount of capital needed to heal the business and whether all these fit to the fund's objectives. Over the next three to eight years, the venture firm works with the founding entrepreneur/s to grow the company. Once a company funded by venture capital matures and becomes successful, venture funds generally exit by taking it public through an initial public offering (IPO) or by selling it to big companies. This allows the venture funds to be free from the previous investment and invest in the next generation of companies. United States, Europe, Israel, Canada, China and India have the most developed markets for venture capital environment. The size of the venture capital market is nowadays about 33.1 billion in 2013. Venture capital firms may invest in promising firms in stages of seed, first round, second round or later. The median investment amounts in the United States in 2013 are 2.5 million for first round, 10 for later stage. The most attractive sector for venture capital is information technology for the United States, Israel and Canada, invested over 4.8 billion in 2013
Öğretmen adaylarının teknoloji entegrasyonu öz-yeterlik algıları ve teknolojik pedagojik içerik bilgisi yeterlikleri arasındaki ilişkinin incelenmesi
No full textBu araştırmanın amacı öğretmen adaylarının teknoloji entegrasyonuna yönelik öz-yeterlik algıları ile teknopedagojik eğitim yeterliklerini çeşitli değişkenlere göre incelemek ve aralarındaki ilişkiyi belirlemektir.Araştırma tarama modelinde yürütülmüş olup, araştırmaya 2011-2012 bahar yarıyılında Afyon Kocatepe Üniversitesi Eğitim Fakültesi’nde öğrenim gören 748 öğretmen adayı katılmıştır.Bu araştırmada veriler kişisel bilgi formu, Teknopedagojik Eğitim Yeterlikleri Ölçeği ve Teknoloji Entegrasyonuna Yönelik Öz-Yeterlik Algısı Ölçeği ile toplanmıştır.Araştırmada veri toplama araçlarından elde edilen puanlar SPSS17.0 istatistik programı ile analiz edilmiştir. Verilerin analizinde aritmetik ortalama, yüzde, frekans, bağımsız örneklemler için t-testi, tek yönlü varyans analizi, korelasyon, çoklu doğrusal regresyon yöntemleri kullanılmıştır. Araştırmadan çıkan sonuçlar şöyledir: Öğretmen adaylarının teknopedagojik eğitim yeterliklerinin ileri düzeyde, alt boyutları uzmanlaşma, tasarım ve uygulama açısından ileri düzeyde, etik açısından orta düzeyde oldukları belirlenmiştir. Öğretmen adaylarının teknopedagojik eğitim yeterlikleri cinsiyete göre anlamlı bir şekilde farklılaşmamaktadır. Öğretmen adaylarının teknopedagojik eğitim yeterlikleri sınıf düzeylerine göre anlamlı bir şekilde farklılaşmaktadır. Öğretmen adaylarının bölüme göre teknopedagojik eğitim yeterlikleri ve alt boyutları tasarım, uygulama, uzmanlaşma açısından anlamlı bir farklılaşma yoktur. Ancak, bölüme göre etik alt boyutunda anlamlı farlılık vardır. Öğretmen adaylarının teknoloji entegrasyonuna yönelik öz-yeterlik algıları yüksektir. Öğretmen adaylarının teknoloji entegrasyonuna yönelik öz-yeterlik algıları ve alt boyutu olan Bilgisayar Teknolojilerini Kullanma Öz-Yeterlik algıları açısından cinsiyete, sınıfa göre anlamlı bir şekilde farklılaşmakta, ancak bölüme göre anlamlı bir şekilde farklılaşmamaktadır. Öğretmen adaylarının teknoloji entegrasyonuna yönelik öz-yeterlik algıları ile teknopedagojik eğitim yeterlikleri arasında anlamlı, pozitif ve yüksek düzeyde bir ilişki vardır. Öğretmen adaylarının teknopedagojik eğitim yeterlikleri alt boyutları, tasarım, uygulama, etik ve uzmanlaşma birlikte teknoloji entegrasyonuna yönelik öz-yeterlik algısını yordamaktadır.AbstractThe purpose of this study was to examine the relationship between preservice teachers' perceptions of technology integration self-efficacy and technopedagogical knowledge competencies and identify relationship between them.The survey method has been used in this research and 748 preservice teacher attended the survey from Afyon Kocatepe University in spring of 2011-2012.Data was gathered with Individual Knowledge Form, “Technology Integration Self Efficacy Scale” and “Technological Pedagogical Content Knowledge Scale (TPACK-Deep Scale)” in this study.The data gathered from the measurement tools have been analyzed with the SPSS 17.0 Statistics Program. For data analysis, average, percentage, frequency, independent samples t-test, one way analysis of variance, correlation and multiple linear regression analysis methods has been used. The research results show that: Preservice teachers have high level technopedagogical knowledge competency; in sub dimensions of proficiency, design and exertion they have high level competency; in sub dimension of ethics they have average level competency. In terms of gender no significant difference was determined regarding preservice teachers’ technopedagogical knowledge competency. In terms of class no significant difference was determined regarding preservice teachers’ technopedagogical knowledge competency. In terms of deparment no significant difference was determined regarding preservice teachers’ technopedagogical knowledge competency except for sub dimension of ethics. Preservice teachers have high level perception of technology integration self-efficacy. In terms of gender and class there were significant differences between preservice teachers’ perception of technology integration self-efficacy and sub dimension of Perception of Computer Technology Use Self-Efficacy but in terms of deparment no significant difference was determined. There is a significant, positive and high level relationship between preservice teachers’ technopedagogical knowledge competency and perception of technology integration self-efficacy. The sub dimension of technopedagogical knowledge competency design, exertion, ethics and proficiency predict the perception of technology integration self-efficacy
Whether Development Indices Affect Economic Growth: A Cross-Country Analysis
Get PDFAbstractThis study aims to examine the relationship between economic growth and highly featured development indices using a cross sectional data of 12 countries from both developed and developing world between the years 2000 and 2013. The indices of corruption, democracy, freedom of press, human development, global competitiveness, economic freedom, and the featured development indicators of World Bank such as average schooling years, life expectancy, female labour force participation rate, health expenditures rate in GDP, export rate of high technology, and employment rate are used to investigate the relationship in between economic growth and development indices. In order to exploit this relationship, all individual indices are reformed to produce form a single index, what we call harmonic index. The findings show that the higher scores of harmonic Index are associated with higher GDP per capita all levels except Saudi Arabia
