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Comparison of the quality of life and perceived social support of individuals with mental health disorders living in a nursing home and with family
No full textObjectives: This study aims to compare the perceived social support and quality of life in individuals with mental health disorders living in nursing home and with family. Methods: This study used relational screening model. The sample consisted of a total of 220 individuals with mental health disorders, including 110 living in eight private nursing homes in Konya, Adana, Antalya, and Yalova and 110 living with their families. Data were collected between October 2015 and April 2017 by using the Interview Form, Multidimensional Scale of Perceived Social Support (MSPSS), Quality of Life Index (QLI) (Wisconsin). Results: There was no significant difference between the QLI mean scores of mentally impaired patients living in nursing home and with family. However, those living with family had significantly higher mean scores on the QLI subscales of living situation and family relations, whereas those living in nursing home had significantly higher mean scores on the QLI subscales of social life and health. In addition, participants living in nursing home had significantly higher mean scores on the MSPSS subscales of significant person and friends, whereas those living with family had significantly higher mean scores on the MSPSS family subscale. There was a significant positive correlation between the groups’ social support and quality of life scale mean scores. Conclusion: Participants living with family had better family relationships and living conditions and more social support from the family, but fewer social circles. Those living in nursing homes had a better social life, more social support from friends and service providers, but fewer family relationships. The results of this study are considered important in terms of providing foresights to service providers, policy makers and researchers
Effectiveness of teaching with video models in teaching earthquake safety skills to students with autism spectrum disorder
No full textBu araştırmada, Otizm Spektrum Bozukluğu (OSB) olan öğrencilere deprem güvenliği becerilerinin öğretiminde video modelle öğretimin etkililiği sınanmış, becerinin kalıcılığı ve katılımcıların beceriyi farklı ortamlara genelleme durumları değerlendirilmiştir. Ayrıca bu çalışmada, uygulamanın yapıldığı okuldaki öğretmenlerden sosyal geçerlik verisi toplanmıştır. Çalışmanın katılımcıları, 16 yaşında OSB tanısı almış iki özel eğitim meslek okulu öğrencisinden oluşmaktadır. Videoda model olarak yer alan kişi, katılımcıların hafif düzey zihin yetersizliği bulunan bir akranıdır. Çalışmada tek denekli araştırma modellerinden davranışlar arası yoklama evreli çoklu yoklama modeli kullanılmıştır. Çalışma sonucunda video modelle öğretimin yaşam üçgeni oluşturma, acil toplanma alanına gitme ve afet çantası hazırlama becerisinin öğretiminde etkili olduğu belirlenmiştir. Ayrıca katılımcıların yedi, on dört ve yirmi bir gün sonra yapılmış olan kalıcılık oturumlarında, beceriyi sergilemeye devam ettikleri görülmüştür. Katılımcıların edindikleri beceriyi, öğretim ortamından farklı bir ortamda sergilemeleri ile genellemenin sağlandığı gözlenmiştir. Katılımcıların eğitim aldıkları okuldaki öğretmenlerden toplanan sosyal geçerlik verileri, öğretmenlerin çalışmaya yönelik düşüncelerinin olumlu yönde olduğunu göstermektedir. Videoda yer alan modelin katılımcıların akranı olması katılımcıların ilgilerini topladığı gözlemlenmiştir.In this study, the effectiveness of video model teaching in teaching earthquake safety skills to students with autism spectrum disorder was tested, the retention of the skill and the participants' generalization of the skill to different environments were evaluated. In addition, social validity data were collected from teachers at the school where the implementation was carried out. The participants of the study consisted of two 16-year-old special education vocational school students diagnosed with autism spectrum disorder. The model in the video was a peer of the participants with mild intellectual disability. In the study, the multiple probe model with inter-behavior probe phase, one of the single-subject research models, was used. As a result of the study, it was determined that teaching with the video model was effective in teaching the skills of forming a life triangle, going to the gathering area and preparing a disaster bag. In addition, it was observed that the participants continued to exhibit the skill in the retention sessions held seven, fourteen and twenty-one days later. It was observed that generalization was achieved when the participants exhibited the acquired skill in an environment different from the teaching environment. The social validity data collected from the teachers at the school where the participants received training showed that the teachers' opinions about the study were positive. It was observed that the fact that the model in the video was a peer of the participants aroused their interest
Study and analysis of COVID-19 in life-threatening situations using fractal fractional operator
No full textχχ1.Nowadays, the global community is faced with a significant responsibility in dealing with thedetection and mitigation of COVID-19. In this particular study, we propose a novel approach tomodeling the COVID-19 pandemic using a fractal fractional order SIDARTHE model, which has notbeen previously explored in the existing literature. We rigorously establish the existence of a stablesolution for this model. Our unique fractal and fractional order SIDARTHE model distinguishesbetween infected individuals based on their diagnosis and the severity of their symptoms. Thereproductive number and identifying potential equilibria for sensitivity analyses. To further inves-tigate the considered model, we delve into the existence and uniqueness of its solution throughthe application of fixed point theory. Furthermore, we employ Ulam-Hyers stability to conduct athorough stability analysis of the proposed model. In order to establish an iterative algorithm forthe proposed FFM system, we present a numerical scheme based on Lagrange interpolation. Ourfindings underscore the necessity of combining stringent social-distancing measures with wide-spread testing and contact tracing in order to bring an end to the ongoing COVID-19 pandemic
Change in the concentration of interleukin-10 and tumor necrosis factor-α in gingival crevicular fluid after probiotic use in patients undergoing treatment with fixed orthodontic appliances
No full textPurposeThis study aimed to evaluate the effect of the use of chewable probiotic tablets on interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) levels in gingival crevicular fluid (GCF) in patients undergoing treatment with fixed orthodontic appliances. MethodsThis prospective case-control study involved 60 patients undergoing treatment with fixed orthodontic appliances. Participants were divided into two groups. The test group was administered probiotic chewable tablets (Motiflor AS, Abfen Farma, Ankara, Turkey) once daily for 15 days, and the control group received routine orthodontic treatment without probiotics. GCF samples were collected from each participant at two time points: at the beginning of the treatment (T0) and on the 21st day (T1). Samples were obtained separately from all four canines using collection strips. The levels of IL-10 and TNF-alpha in GCF were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. Statistical tests were performed to assess the normality of the distribution of quantitative variables. All analyses were performed using GraphPad Prism (version 9.1.1, GraphPad Software, San Diego, CA, USA). Data normality was assessed using the Kolmogorov-Smirnov test. Friedman's test for repeated measures was employed, followed by Dunn's post hoc test. ResultsThe variability that was observed for the IL-10 cytokine levels in the control group was significantly higher than that for the test group (p < 0.05). IL-10 levels in the test group increased while the TNF-alpha levels decreased. T1/T0 ratio for TNF-alpha was found to be lower in the test group compared to the control group (p = 0.002). ConclusionThe results suggest that probiotic tablets may play a role in modulating IL-10 and TNF-alpha levels during orthodontic tooth movement. However, the current study was limited to the first 21 days of mechanical force application to the teeth, and it is recommended to investigate the long-term effects or other factors affecting cytokine changes in future studies
MBD2 inhibisyonunun fibroblast hücre hattı karakterine etkilerinin araştırılması
No full textEpigenetik düzenleyicilerden biri olan MBD2 proteini, metillenmiş DNA bölgelerine bağlanarak gen ifadesini kontrol etmede kritik öneme sahiptir. Özellikle hücre çoğalması, farklılaşma ve apoptoz gibi temel biyolojik süreçlerde etkili olan bu protein, kanser gibi epigenetik düzensizliklerin rol oynadığı hastalıkları moleküler düzeyde anlamak için önemli bir hedef olarak kabul edilmektedir. Bu bağlamda, MBD2 inhibitörü olarak tanımlanan bir küçük kimyasal molekül olan KCC-07'nin etkileri, fibroblast hücre hattı (HFF-1) üzerinde in vitro olarak araştırılmıştır. KCC-07'nin hücre canlılığı ve proliferasyonu üzerindeki sitotoksik etkileri WST-1 yöntemi ile değerlendirilmiş ve gen ekspresyon düzeyleri RT-qPCR analizi ile analiz edilmiştir. Bulgular, KCC-07'nin 50 ila 100 µM konsantrasyonlarında doz ve zamana bağlı olarak hücre proliferasyonunu inhibe ettiğini ve 24-48 saat içinde proliferasyonda önemli bir durma gözlemlendiğini göstermektedir. 100 µM dozunda bu inhibe edici etki 72 saate kadar devam ederken, 50 ve 75 µM'de 48 saat sonra bir iyileşme eğilimi gözlemlenmiştir. LC₅₀ değeri 71,55 ± 19,5 µM olarak hesaplanmıştır. Gen ekspresyon analizleri, MBD2 inhibisyonunun hTERT, NANOG, SOX2 ve COL1A1 gibi genlerin seviyelerini etkilediğini ortaya koymuştur. Elde edilen veriler, KCC-07 molekülünün MBD2 aracılığıyla fibroblast hücre davranışını modüle edebildiğini ve bu etkinin potansiyel terapötik uygulamalar açısından dikkate değer olduğunu göstermektedir. Çalışma, epigenetik hedefli terapötik yaklaşımlara ışık tutabilecek yeni bulgular sunmaktadır.The MBD2 protein, one of the epigenetic regulators, is critical in controlling gene expression by binding to DNA methylation. This protein, which is particularly effective in fundamental biological processes such as cell proliferation, differentiation, and apoptosis, is considered an essential target for understanding diseases involving epigenetic dysregulation, such as cancer, at the molecular level. In this context, the effects of KCC-07, a candidate molecule defined as an MBD2 inhibitor, were investigated in vitro on a fibroblast cell line (HFF-1). The cytotoxic effects of KCC-07 on cell viability and proliferation were evaluated using the WST-1 method, and gene expression levels were analyzed by RT-qPCR analysis. The findings indicate that KCC-07 inhibits cell proliferation in a dose- and time-dependent manner at concentrations ranging from 50 to 100 µM, with a significant arrest in proliferation observed within 24–48 hours. At a dose of 100 µM, this inhibitory effect persisted for up to 72 hours, while at 50 and 75 µM, a recovery trend was observed after 48 hours. The LC₅₀ value was calculated as 71.55 ± 19.5 µM. Gene expression analyses revealed that MBD2 inhibition affected the levels of genes such as hTERT, NANOG, SOX2, and COL1A1. The data obtained indicate that the KCC-07 molecule can modulate fibroblast cell behavior through MBD2, and this effect is noteworthy for potential therapeutic applications. The study presents new findings that may shed light on epigenetic-targeted therapeutic approaches
Influence of topological index on modulation instability in Kagome photonic lattice
No full textThis study explores the impact of the Kirchhoff index on modulation instability (MI) in Kagome photonic lattices with metamaterials. The unit cell of the lattice consists of three different waveguides with distinct optical properties, leading to a complex interplay between topology and nonlinearity. Our theoretical analysis reveals that the periodic MI exhibited by the lattice is suppressed as the Kirchhoff index of the discrete graph Laplacian of the lattice unit increases. Specifically, we find that a higher Kirchhoff index leads to a shrinking of the MI band and a decrease in the maximum gain. These findings provide valuable insights into the relationship between lattice topology and nonlinear optical behavior, shedding light on the intricate dynamics of MI in photonic lattices
Investigation of the effects of lower extremity parameters on balance in young individuals
No full textÇalışmanın amacı, genç bireylerde alt ekstremitedeki çeşitli parametrelerin statik ve dinamik denge üzerindeki etkisini belirlemekti. Araştırmada katılımcıların demografik bilgileri için sosyodemografik bilgi formu, eklem hareket açıklığının değerlendirilmesi için gonyometre, kas uzunluğunun değerlendirilmesi için kas kısalık testi, kas kuvvetinin değerlendirilmesi için dijital el dinamometre cihazı, vücut postürünün değerlendirilmesi için New York postür analizi, katılımcıların fiziksel aktivite düzeyini belirlemek için Uluslararası Fiziksel Aktivite Formu (kısa form), katılımcılarda pes planus varlığı ve derecesini belirlemek için naviküler düşme testi, ayak postürünü değerlendirmek için Ayak Postür İndeksi, dinamik denge için yıldız testi, statik denge için flamingo testi kullanıldı. Toplamda 50 katılımcı değerlendirildi. İstatistiksel analiz Statiscal Package for Social Sciences (SPSS) 22 versiyonu ile gerçekleştirildi. Verilerin normal dağılıma uygunluğunun tespiti için "Kolmogorov-Smirnov" testi kullanıldı. Elde edilen değerlerin anlamlı olup olmadığının yorumlanmasında 0.05 anlamlılık düzeyi ölçüt olarak kullanıldı. Olguların kas gücü ve esneklik değerleri ile denge performansları arasında anlamlı bir ilişki gözlemlendi (p0,05). Olguların alt ekstremite EHA değerleri ile denge performansları arasında ise anlamlı bir ilişki gözlemlenmedi (p>0,05).The aim of this study was to determine the effects of various lower extremity parameters on static and dynamic balance in young individuals. In the study, a sociodemographic information form was used to collect demographic data of the participants. A goniometer was used to assess joint range of motion, a muscle length test was employed to evaluate muscle tightness, and the Digital Handheld Dynamometer was used to measure muscle strength. Postural assessment was conducted using the New York Posture Rating Chart. The International Physical Activity Questionnaire (short form) was utilized to determine participants' physical activity levels. The navicular drop test was used to identify the presence and degree of pes planus, and the Foot Posture Index (FPI) was applied to assess foot posture. The Star Excursion Balance Test was used for dynamic balance evaluation, and the Flamingo Balance Test was used for static balance assessment. A total of 50 participants were evaluated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 22. A significance level of 0.05 was used to interpret whether the findings were statistically significant. A significant relationship was observed between the participants' muscle strength and flexibility values and their balance performance(p0,05). Additionally, no significant relationship was observed between the participants' lower extremity range of motion (ROM) values and their balance performance(p>0,05)
The relationship between watching mukbang videos and eating habits in adults
No full textBu çalışmada, yemek yeme yayınları olarak tanımlanan mukbang videolarını izleme sıklığının, yetişkin bireylerin beslenme alışkanlıkları ve yeme davranışları üzerindeki etkilerinin incelenmesi amaçlanmıştır. Çalışmaya, mukbang videoları izleyicisi olan, iletişim sıkıntısı olmayan ve besin seçimini kendi başına yapabilen 18-65 yaş aralığındaki 82 birey dahil edilmiştir. Araştırma verileri; Kişisel Bilgi Formu, Besin Tüketim Sıklığı, 24 Saatlik Geriye Dönük Besin Tüketim Kaydı, Üç Faktörlü Yeme Ölçeği (TFEQ-Tr21) kullanılarak elde edilmiştir. Katılımcıların 31'i nadiren, 30'u bazen ve 21'i sık sık mukbang izlediklerini belirtmiştir. Çalışma sonucunda, sık sık mukbang izleyen bireylerin vücut ağırlığı ve Beden Kütle İndeksi değerlerinin, nadiren izleyen bireylere göre istatistiksel olarak anlamlı düzeyde daha yüksek olduğu tespit edilmiştir (p0.05), kontrolsüz yeme ile mukbang izleme sıklığı arasında anlamlı bir ilişki gözlemlenmiştir; sık sık mukbang videosu izleyenlerin kontrolsüz yeme puanı nadiren izleyenlere göre istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur (p0.05), a significant association was observed between mukbang viewing and uncontrolled eating; frequent viewers had higher uncontrolled eating scores than rare viewers (p<0.05). The results of the study revealed that with the increase in mukbang viewing frequency, unhealthy eating habits increased, and eating behaviors were disrupted
The effect of scapular stabilization exercises and scapular proprioceptive neuromuscular facilitation technique on pain, joint range of motion, functionality, scapular dyskinesia and proprioception in individuals with rotator cuff lesion
No full textBu çalışma, rotator manşet lezyonu olan bireylerde Skapular Proprioseptif Nöromuskuler Fasilitasyon (PNF) uygulamalarının ve Skapular Stabilizasyon egzersizlerinin ağrı, eklem hareket açıklığı, fonksiyonellik, skapular diskinezi ve propriosepsiyon üzerine etkilerini kıyaslamak amacıyla yürütüldü. Çalışmaya, Rotator Manşet Lezyonu tanısı almış, 18-65 yaş aralığında, omuz ağrısı olan 30 gönüllü katılımcı dahil edildi. Skapular Stabilizasyon grubuna (n=15); konvansiyonel tedaviye ek olarak skapular stabilizasyon egzersizleri, PNF grubuna (n=15) ise konvansiyonel tedaviye ek olarak skapular PNF patern ve teknikleri uygulandı. Araştırmada, bireylerin ağrı şiddetini değerlendirmek için Vizüel Analog Skala (VAS), eklem hareket açıklıklarını değerlendirmek için universal gonyometre, fonksiyonel durumlarını değerlendirmek için Kol, Omuz ve El Sorunları Anketi (DASH), skapular diskineziyi değerlendirmek için Lateral Skapular Kayma Testi (LSKT) ile Skapular Diskinezi Testi (SDT) ve propriosepsiyonu değerlendirmek için Aktif Açı Tekrarlama Testi kullanıldı. Verilerin istatistiksel analizi için SPSS V.27 programı kullanıldı. Çalışmamızın sonucunda her iki grupta da grup içi değerlendirmede ağrı, normal eklem hareket açıklığı, omuz fonksiyonları, skapular diskinezi varlığı ve propriosepsiyon duyusunda istatistiksel olarak anlamlı iyileşme saptandı (p0.05). Ancak konvansiyonel tedaviyle birlikte uygulanan skapular PNF patern ve tekniklerinin skapular diskinezinin iyileştirilmesinde ve propriosepsiyonun geliştirilmesinde, konvansiyonel tedaviyle birlikte uygulanan skapular stabilizasyon egzersizlerine kıyasla daha etkili bir yöntem olduğu tespit edildi (p0.05). On the other hand, scapular PNF patterns and techniques applied alongside conventional treatment were found to be a more effective method for improving scapular dyskinesia and proprioception compared to scapular stabilization exercises combined with conventional treatment (p<0.05). Keywords: Proprioception; Rotator Cuff Lesion; Scapula; Scapular PNF Technique; Scapular Stabilization Exercise
Kiperin Postbiotic Supplement-Enhanced Bacterial Supernatants Promote Fibroblast Function: Implications for Regenerative Medicine
No full textKiperin Postbiotics, defined as non-viable metabolic
products derived from probiotics, have gained attention as potential modulators of cellular
responses involved in tissue repair. This study aimed to evaluate the effects of a postbiotic
supplement (PS)—composed of inactivated strains of Escherichia coli, Lacticaseibacillus rhamnosus, and Lactiplantibacillus plantarum—on fibroblast function, particularly in the context
of bacterial secretomes from common pathogenic strains. Methods: Human fibroblast cell
lines (HFF-1 and CCD-18Co) were treated with cell-free supernatants (CFS) from E. coli
ATCC 25922, Staphylococcus aureus ATCC 29213, and Enterococcus faecalis ATCC 29212, either
alone or in combination with the PS. Assessments included cell count, migration (via scratch
assay), oxidative stress levels, and expression of immune-related genes (IL-6, IL-10, TNF-α,
DRD4). Results: CFS from E. faecalis significantly increased fibroblast counts, whereas
E. coli and S. aureus CFS reduced cell counts and elevated oxidative stress. Co-treatment
with PS reversed these effects in a strain-dependent manner by lowering oxidative stress
and partially restoring cell proliferation. Scratch assays demonstrated enhanced migration
in PS-treated fibroblasts. Gene expression analyses revealed no statistically significant
changes, though variable trends were observed across treatment groups. Conclusions:
PS may mitigate the harmful effects of certain bacterial secretomes while preserving or
enhancing beneficial ones. Its ability to reduce oxidative stress and promote fibroblast
proliferation and migration suggests a potential pro-regenerative role in vitro. Although
gene expression changes were limited, the results offer initial insights into the underlying
molecular responses influenced by postbiotic supplementation