103 research outputs found
Mortaria Production at Pentney, in the Lower Nar Valley, West Norfolk
No full textThis paper presents the results of forty years of fieldwalking undertaken by Michael de
Bootman on a small part of his father’s farm at Pentney in the Lower Nar Valley, West
Norfolk. This remarkable period of concentrated and continuous fieldwalking has produced a
large assemblage of Roman mortaria fragments, including wasters. Although no excavation
has been undertaken, geophysical survey in the fieldwalked area revealed what is almost
certainly a kiln, possibly a pair, located centrally within a roadside trapezoidal enclosure.
The large fragmentary pottery assemblage, recovered from the ploughed land above the
kiln(s), forms a conservative group of primarily oxidised reeded-rim mortaria thought to
have been produced between the late third and fourth centuries AD. The pottery forms are
very similar to vessels produced in the Nene Valley (c. 55km to the west across the Fen basin)
so this report not only provides evidence for the local production of mortaria in West Norfolk
but also raises questions about the wider interconnectedness of pottery manufacture at this
time
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels
No full textThe relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and membrane-to-cytosol translocation of the fluorescent PIP2/inositol 1,4,5-trisphosphate (IP3)-binding peptide green fluorescent protein-tagged pleckstrin homology domain of phospholipase C (GFP-PLC delta-PH). The muscarinic receptor agonist oxotremorine-M produced parallel time- and concentration-dependent M-current inhibition and GFP-PLC delta-PH translocation; bradykinin also produced parallel time- dependent inhibition and translocation. Phosphatidylinositol-4-phosphate-5-kinase (PI5-K) overexpression reduced both M-current inhibition and GFP-PLC delta-PH translocation by both oxotremorine-M and bradykinin. These effects were partly reversed by wortmannin, which inhibits phosphatidylinositol-4-kinase (PI4-K). PI5-K overexpression also reduced the inhibitory action of oxotremorine-M on PIP2-gated G-protein-gated inward rectifier (Kir3.1/3.2) channels; bradykinin did not inhibit these channels. Overexpression of neuronal calcium sensor-1 protein (NCS-1), which increases PI4-K activity, did not affect responses to oxotremorine-M but reduced both fluorescence translocation and M-current inhibition by bradykinin. Using an intracellular IP3 membrane fluorescence-displacement assay, initial mean concentrations of membrane [PIP2] were estimated at 261 mu M (95% confidence limit; 192-381 mu M), rising to 693 mu M (417-1153 mu M) in neurons overexpressing PI5-K. Changes in membrane [PIP2] during application of oxotremorine-M were calculated from fluorescence data. The results, taken in conjunction with previous data for KCNQ2/3 (Kv7.2/Kv7.3) channel gating by PIP2 (Zhang et al., 2003), accorded with the hypothesis that the inhibitory action of oxotremorine-M on M current resulted from depletion of PIP2. The effects of bradykinin require additional components of action, which might involve IP3-induced Ca2+ release and consequent M-channel inhibition (as proposed previously) and stimulation of PIP2 synthesis by Ca2+-dependent activation of NCS-1
IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling
No full textBackground: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague. Methods: Bronchial reactivity was quantified in murine lung slices by digital video microscopy and acetylcholine (ACH)-induced Ca2+ signaling was measured in human airway smooth muscle cells (ASMC) using fluorescence microscopy. Results: IL-4 or IL-13 up to 50 ng/ml induced bronchial hyperreactivity. But after incubation with 100 ng/ml this effect was lost and bronchial responsiveness was again comparable to the control level. The effects of IL-4 and IL-13 on bronchial reactivity were paralleled by the effects on ASMC proliferation. Fifty nanograms per milliliter of IL-4 and IL-13 increased the Ca2+ response of human ASMC to ACH. At 100 ng/ml, however, the effects of the cytokines on the Ca2+ response were no longer evident. The expression of IL-13R alpha 2 increased with increasing concentrations of IL-4 or IL-13, reaching its maximum at 100 ng/ml. Blocking IL-13R alpha 2, the loss of the effect of IL-4 and IL-13 at 100 ng/ml on human ASMC proliferation and the ACH-induced Ca2+ response were no longer present. Conclusions: IL-4 and IL-13 induce bronchial hyperreactivity by changing the Ca2+ homeostasis of ASMC. These effects are counteracted by IL-13R alpha 2. The biological significance of IL-13R alpha 2 might be a protective function by regulating IL-13- and IL-4-mediated signal transduction and thereby limiting pathological alterations in Th2-mediated inflammatory diseases. Copyright (c) 2007 S. Karger AG, Basel
Estudo do envolvimento iônico e de proteínas cinases no mecanismo de ação da 1-a,25(OH)2 vitamina D3, no influxo de cálcio em células de Sertoli e em testículos de ratos
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Bioquímica, Florianópolis, 2010Tendo em mente que a 1,25D3, produto final do metabolismo da vitamina D3 é essencial para a integridade do sistema reprodutor masculino, e que, a homeostase do Ca+2 desempenha papel chave em muitos processos envolvidos na espermatogênese, avaliamos o efeito em nível membranar da 1,25D3 sobre o metabolismo do Ca+2 em testículo inteiro e célula de Sertoli de ratos imaturos. Foi demonstrado que em após 60 minutos de pré-incubação com o hormônio, não hove variação da captação basal de 45Ca+2 nos tempos de incubação de 30, 60, 150, 300 e 600 segundos. No tempo de incubação de 60 segundos, foi verificado que a 1,25D3 tem a capacidade de aumentar a captação de 45Ca+2 do meio extracelular em diferentes doses em ambos modelos experimentais, sendo este evento independente da ação genômica. Em testículos, observou-se que doses entre 10-15M e 10-9M foram eficazes em aumentar a captação de 45Ca+2, sendo o maior efeito evidenciado da dose de 10-10M (106%). Utilizando esta dose, foi demonstrado que os canais de CCDV do tipo L e T são as principais vias de entrada do íon nas células testiculares, e que há necessidade da manutenção das correntes de K+ e Cl- para que ocorra este evento. Em células de Sertoli também não foi verificada a variação da captação basal de 45Ca+2. Neste sistema, foi verificado que no tempo de 60 segundos de incubação, o hormônio foi capaz de elevar a captação de 45Ca+2 entre as doses de 10-12M e 10-8 M, onde a dose de 10-12 M aumentou em torno de140% a capatação do íon. Já a dose de 10-10 M elevou em 89% o influxo do íon. Desta forma, utilizando a dose de 10-10 M, verificamos que as células de Sertoli comportam- se assim como os testículos: há necessitadade da ativação dos CCDV-L e T para a entrada do Ca+2 assim como das correntes de K+ e Cl-. Também foi verificado que em células de Sertoli há necessidade da ativação das proteínas PKC e p38MAPK para a capatação de Ca+2 estimulada pela 1,25D3. Alé, disso, as proteínas PI3K e ERK1/2 também estão em parte envolvidas neste processo. Por fim, avaliamos que a integridade dos microtúbulos e a atividade dos canais ClC3 faz-se necessária para que ocorra a entrada do íon nas células de Sertoli, sendo esta elevação do íon necessária para que ocorra o processo de secreção celular já demosntrada anteriormente pela 1,25D3
Estudo da atividade biológica de Baccharis articulata, Musa x paradisiaca e rutina na homeostasia da glicose em modelos experimentais in vivo e in vitro
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaA insulina é o principal hormônio anabólico responsável pelo controle da captação, utilização e armazenamento dos nutrientes celulares como carboidratos, proteínas e lipídios, sendo essencial para a manutenção da homeostasia da glicose, o crescimento e diferenciação celular. Defeitos na ação e/ou na secreção de insulina podem levar à hiperglicemia, característica da diabetes melito. A diabetes melito é uma patologia complexa e multifatorial de elevada morbidade e mortalidade e, por esse motivo, é considerada uma epidemia, caracterizando um problema de saúde pública mundial. Muitas plantas são conhecidas na medicina popular de diferentes culturas pelas propriedades hipoglicemiantes e tem um uso crescente no tratamento da diabetes. Os compostos fenólicos derivados de plantas, especialmente os flavonóides, apresentam diversas propriedades e tem um potencial terapêutico muito investigado. O presente trabalho teve como objetivo caracterizar o efeito de extratos e frações de Bacharis articulata (carqueja) e de Musa x paradisiaca (banana), assim como do flavonóide rutina, na homeostasia da glicose em modelos experimentais in vivo e in vitro. As duas espécies foram avaliadas quanto às atividades anti-hiperglicêmica e/ou hipoglicemiante na curva de tolerância à glicose e em modelos de diabetes induzidos experimentalmente, como a secreção de insulina, o conteúdo de glicogênio hepático e muscular, a inibição das enzimas ?-glicosidases e a propriedade anti-glicação, assim como o conteúdo de flavonóides. Além disso, foi estudado o mecanismo de ação da rutina na captação de glicose e de cálcio em músculo sóleo, e também a secreção de insulina in vivo e o mecanismo de ação da rutina na captação de cálcio em ilhotas pancreáticas isoladas. Para tanto, foram utilizados ratos Wistar machos entre 50-55 dias de idade. Para a realização da curva de tolerância à glicose as coletas de sangue, para determinação da glicose e insulina sérica, foram realizadas nos tempos zero, 15, 30, 60, 120 e 180 minutos. Nos ensaios para a determinação do conteúdo de glicogênio os tecidos foram retirados dos animais 3 h após os tratamentos. As atividades das dissacaridases intestinais e a propriedade anti-glicação foram realizadas in vitro. A captação de 14C-glicose e de 45-cálcio (45Ca2+) foi estudada após a incubação do músculo sóleo com a rutina. As ilhotas pancreáticas foram isoladas e incubadas com 45Ca2+ e rutina, na presença ou não de diferentes inibidores e ativadores. Os extratos brutos, as frações n-butanol e residual aquosa de B. articulata e de M. x paradisiaca reduziram significativamente a glicemia de ratos normais hiperglicêmicos e potencializaram a secreção de insulina induzida por glicose. Além disso, observou-se um aumento no conteúdo de glicogênio no músculo sóleo e fígado após os tratamentos, principalmente com as frações n-butanol das duas espécies vegetais. Os extratos e as frações reduziram a atividade da maltase e preveniram a glicação. A rutina estimulou a captação de glicose e cálcio no músculo, estimulando a captação de glicose através da ativação de uma via insulinomimética e uma via independente da sinalização clássica da insulina. Além disso, a rutina estimulou a secreção de insulina in vivo e a captação de cálcio em ilhotas pancreática isoladas, atuando como um potencial agente secretagogo de insulina. Desta forma, apoiado nos resultados obtidos neste trabalho, propõe-se que as espécies vegetais, Baccharis articulata e Musa x paradisiaca, e o flavonóide rutina aqui estudados possam regular a homeostasia da glicose. Os mecanismos envolvem a inibição da enzima que permite a absorção intestinal da glicose, a inibição da glicação, o estímulo da secreção de insulina e o aumento na utilização de glicose pelos tecidos periféricos, evidenciando que estas duas espécies e a rutina podem atuar por múltiplos mecanismos de ação para regular a homeostasia da glicose e colaborar na prevenção das complicações da diabetes.Insulin is the main anabolic hormone responsible for controlling the uptake, use and storage of cellular nutrients such as carbohydrates, proteins and lipids. It is essential for the maintenance of glucose homeostasis, growth and cellular differentiation. Defects in action and / or secretion of insulin may lead to hyperglycemia, which characterizes diabetes mellitus. Diabetes mellitus is a complex and multifactorial disease with high morbidity and mortality, therefore is considered epidemic causing a public health problem worldwide. Many plants are known in folk medicine of different cultures for their hypoglycemic properties showing an increasing use in the treatment of diabetes. The plant-derived phenolic compounds, especially flavonoids, have several properties and their therapeutic potential has been investigated. The aim of this study was to characterize the effect of extracts and fractions of Baccharis articulata ("carqueja") and Musa x paradisiaca ("banana"), as well as the flavonoid rutin, in glucose homeostasis using in vivo and in vitro experimental models. Antihyperglycemic and / or hypoglycemic activity in the curve of glucose tolerance and in models of experimentally induced diabetes, insulin secretion, the hepatic glycogen content and muscle, inhibition of the enzymes á-glucosidases and anti-glycation property were investigated, as well as the content of flavonoids. In addition, was also studied the mechanism of action of rutin in glucose and calcium uptake in soleus muscle, and also the in vivo insulin secretion and the mechanism of action of rutin on calcium uptake in rat isolated pancreatic islets. For in vivo experiments, Wistar male rats with 50-55 days of age were used. To glycemia and serum insulin determination blood samples were collected at zero, 15, 30, 60, 120 and 180 min in glucose tolerance curve. Tissues were removed from animals 3 h after oral administration of treatments to determine glycogen contents. The intestinal disaccharidases activities and anti-glycation property were performed in vitro. The glucose and calcium uptake was studied after incubation of the soleus muscle with rutin, in the presence or not of different inhibitors and of 14C-glucose or calcium (45Ca2+). The pancreatic islets were isolated and incubated with 45Ca2+ and rutin in the presence or absence of various inhibitors or activators. The crude extracts and n-butanol and residual aqueous fractions of B. articulata and of M. x paradisiaca showed potential anti-hyperglycemic activity in hyperglycemic normal rats and potentiated glucose-induced insulin secretion. Additionaly, it was observed an increase on glycogen content in muscle and liver after treatments, mainly with the n-butanol fractions of two species. The extracts and fractions reduced the activity of maltase and prevented glycation. Also, rutin stimulated glucose and calcium uptake in soleus muscle, stimulating glucose uptake via activation of an insulin-mimetic and an insulin-independent signaling pathways. Additionally, rutin stimulated insulin secretion in vivo and calcium uptake in isolated pancreatic islets, as a potential insulin secretagogue agent. Thus, these results suggest that Baccharis articulata, M. x paradisiaca and rutin are able to regulate glucose homeostasis. The mechanisms involve the inhibition of the enzyme that allows the intestinal absorption of glucose, the inhibition of glycation, the stimulation of insulin secretion and increase in glucose utilization by peripheral tissues showed that these plant species and rutin may act by multiple mechanisms of action to regulate glucose homeostasis, thereby contributing to the prevention of diabetes-related complications
Alterações bioquímicas induzidas pelo herbicida glifosato-Roundup sobre células testiculares de ratos pré-púberes
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013.Nossos resultados demonstraram que a exposição aguda ao glifosato-Roundup induz estresse oxidativo e ativa múltiplas vias de resposta ao estresse culminando com a morte de células testiculares em ratos pré-púberes. O pesticida aumenta a concentração de Ca2+ intracelular através da abertura dos canais de Ca2+ dependente de voltagem tipo-L (CCDV-L) e da liberação de Ca2+ do retículo endoplasmático, levando a uma sobrecarga de Ca2+ intracelular, e morte celular. Estes eventos foram prevenidos pelos antioxidantes Trolox® e ácido ascórbico. A ativação das vias de sinalização da proteína cinase C (PKC), fosfatidilinositol-3-cinase (PI3K), proteínas cinases ativadas por mitógeno (MAPKs), tais como a ERK 1/2 e p38 MAPK, e fosfolipase C (PLC) estão envolvidas na indução do influxo de Ca2+, no aumento da atividade da gama-glutamiltransferase (GGT) e na morte celular. A indução de estresse oxidativo por glifosato-Roundup foi confirmada através da redução nos níveis de glutationa reduzida (GSH) e do aumento nos níveis de substâncias reativas ao ácido tiobarbitúrico (TBARS) e de carbonilação de proteínas. Além disso, a exposição ao pesticida afetou os sistemas de defesa antioxidante enzimáticos, acarretando em aumento na atividade das enzimas glutationa peroxidase, glutationa-redutase, glutationa-S-transferase, GGT, catalase, superóxido dismutase e glicose-6-fosfato-desidrogenase. A exposição aguda ao glifosato-Roundup também induziu ao aumento da atividade das aminotransferases AST e ALT. O aumento da atividade da GGT poderia levar a um aumento no "turnover" de GSH; no entanto, a diminuição na captação dependente de Na+ do aminoácido modelo 14C-?-methyl-amino-isobutyric acid (14C-MeAIB) em células testiculares pode estar relacionada a menor disponibilidade de aminoácidos para a síntese de novo de glutationa. O conjunto dos resultados demonstra que o herbicida glifosato-Roundup induz estresse oxidativo, aumenta a concentração de Ca2+ intracelular, ativa vias de transdução de sinais, e pode levar a morte de células testiculares. Apesar da dificuldade de extrapolação dos resultados obtidos em modelos animais para a condição humana, é possível que mecanismos semelhantes possam estar envolvidos na diminuição da capacidade reprodutiva em adultos jovens expostos ao glifosato-Roundup durante a infância e puberdade.Abstract : Our results show that acute glyphosate-Roundup exposure induces oxidative stress and activates multiple stress-response pathways leading to testicular cell death in prepubertal rat testis. The pesticide increased intracellular Ca2+ concentration by opening L-voltage-dependent Ca2+ channels (L-VDCC) and endoplasmic reticulum IP3 and ryanodine receptors, leading to an overload of Ca2 + within the cells, which set off oxidative stress and cell death. These events have been prevented by the antioxidants Trolox® and ascorbic acid. Activated protein kinase C (PKC), phosphatidylinositol-3-kinase (PI3K) and the mitogen-activated protein kinases (MAPKs), such as ERK1/2 and p38MAPK have played a role in eliciting Ca2+ influx, gamma-glutamyl transferase (GGT) activation and cell death. Roundup® reduced the levels of reduced glutathione (GSH) and increased the amounts of thiobarbituric reactive species (TBARS) and protein carbonyl, characterizing oxidative damage. Also, exposure to the pesticide has stimulated the activity of glutathione peroxidase, glutathione reductase, glutathione-S-transferase, gamma-glutamyl transferase (GGT), catalase, superoxide dismutase and glucose-6-phosphate dehydrogenase, supporting downregulated GSH levels. The glyphosate-Roundup acute exposition also leads to the induction of the transaminase AST e ALT. The GGT activity could lead to increased glutathione turnover; however, downregulation of the Na+-coupled 14C-á-methyl-amino-isobutyric acid (14C-MeAIB) accumulation in testicular cells has decreased the amino acid availability to GSH de novo synthesis. Overall, Roundup® toxicity was implicated in Ca2+ overload, cell signaling misregulation, stress response of the endoplasmic reticulum and/or depleted antioxidant defenses. Although extrapolation from animal models to the human condition should be taken with caution, it is feasible that similar mechanisms could underlie impaired reproduction capability in young male people associated with glyphosate-Roundup exposure during childhood and puberty
Understandings and social practices of medications for Zimbabwean households in New Zealand
No full textMedications are a central part of health care. How medications are understood and used by people in everyday life remains unclear. This study looks at understanding and social practices of medications in everyday life for Zimbabwean households in New Zealand. This project investigates understandings of medications and their use, taking account of all forms of medications, medical drugs, alternative medicines, traditional medicines and dietary supplements. Four Zimbabwean migrant families who all reside in Hamilton took part in this study. Data were collected using a variety of methods which included individual interviews with the families, household discussions, photographs, diaries, material objects, and media content to capture the complex and fluid nature of popular understandings and use of medications. This research provides insight into the cultural values and practices of these four families pertaining to how they acquired, used, shared, and stored indigenous and biomedical medications. Four key themes were identified: the preference of biomedical over traditional medications, storage, sharing and safety of medications; availability and affordability of medications; and the influence of the media in making decisions to purchase medications. Knowledge of how meanings are linked to the things people do with medications will inform strategies for ensuring that medication use is safe and effective
Constitutive IP<sub>3</sub> signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP<sub>3</sub> receptor disruptor BIRD-2
No full textAnti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)-mediated Ca2+-signaling. A peptide tool (Bcl-2/IP3R Disruptor-2; BIRD-2) was developed to abrogate the interaction of Bcl-2 with IP3Rs by targeting Bcl-2′s BH4 domain. BIRD-2 triggers cell death in primary CLL cells and in DLBCL cell lines. Particularly, DLBCL cells with high levels of IP3R2 were sensitive to BIRD-2. Here, we report that BIRD-2-induced cell death in DLBCL cells does not only depend on high IP3R2-expression levels, but also on constitutive IP3 signaling, downstream of the tonically active B-cell receptor. The basal Ca2+ level in SU-DHL-4 DLBCL cells was significantly elevated due to the constitutive IP3 production. This constitutive IP3 signaling fulfilled a pro-survival role, since inhibition of phospholipase C (PLC) using U73122 (2.5 µM) caused cell death in SU-DHL-4 cells. Milder inhibition of IP3 signaling using a lower U73122 concentration (1 µM) or expression of an IP3 sponge suppressed both BIRD-2-induced Ca2+ elevation and apoptosis in SU-DHL-4 cells. Basal PLC/IP3 signaling also fulfilled a pro-survival role in other DLBCL cell lines, including Karpas 422, RI-1 and SU-DHL-6 cells, whereas PLC inhibition protected these cells against BIRD-2-evoked apoptosis. Finally, U73122 treatment also suppressed BIRD-2-induced cell death in primary CLL, both in unsupported systems and in co-cultures with CD40L-expressing fibroblasts. Thus, constitutive IP3 signaling in lymphoma and leukemia cells is not only important for cancer cell survival, but also represents a vulnerability, rendering cancer cells dependent on Bcl-2 to limit IP3R activity. BIRD-2 seems to switch constitutive IP3 signaling from pro-survival into pro-death, presenting a plausible therapeutic strategy
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion
No full textIn many cell types agonist-receptor activation leads to a rapid and transient release of Ca(2+) from intracellular stores via activation of inositol 1,4,5 trisphosphate (InsP(3)) receptors (InsP(3)Rs). Stimulated cells activate store- or receptor-operated calcium channels localized in the plasma membrane, allowing entry of extracellular calcium into the cytoplasm, and thus replenishment of intracellular calcium stores. Calcium entry must be finely regulated in order to prevent an excessive intracellular calcium increase. Junctate, an integral calcium binding protein of endo(sarco)plasmic reticulum membrane, (a) induces and/or stabilizes peripheral couplings between the ER and the plasma membrane, and (b) forms a supramolecular complex with the InsP(3)R and the canonical transient receptor potential protein (TRPC) 3 calcium entry channel. The full-length protein modulates both agonist-induced and store depletion-induced calcium entry, whereas its NH(2) terminus affects receptor-activated calcium entry. RNA interference to deplete cells of endogenous junctate, knocked down both agonist-activated calcium release from intracellular stores and calcium entry via TRPC3. These results demonstrate that junctate is a new protein involved in calcium homeostasis in eukaryotic cells
Percepción de la calidad de vida durante el aislamiento social por Covid-19 en Colombia
No full textDada la contingencia sanitaria y social en Colombia como situación novedosa,
se pretendió evaluar la percepción de la calidad de vida durante el inicio del ais lamiento social obligatorio en Colombia, producto de la estrategia gubernamental
ante la presencia del COVID-19. La información de las variables sociodemográficas
relacionadas con salud y calidad de vida se recogió a través de un instrumento
aplicado a 1456 colombianos. Se realizó un estudio de aplicación transversal, con
un alcance descriptivo correlacional. Se presentan para este documento la calidad
de vida en relación con sexo, edad, estado civil, nivel de escolaridad, teletrabajo/
telestudio, ocupación, número de personas a cargo y nivel de ingresos. Se obtuvieron
correlaciones directas entre calidad de vida y sexo, estado civil, nivel de escolaridad,
ingresos, personas a cargo, e inversas con edad, teletrabajo/telestudio y tener o no
hijos. Finalmente, los resultados indican que a mayor cantidad de responsabilidades
disminuye la calidad de vida en situación de confinamiento; la percepción de sentirse
acompañado puede fungir como un factor protector de la calidad de vida, y el nivel
de ingresos económicos es un determinante para la evaluación que se hace de ella.Abstract: The aim was to evaluate the perception of quality of life during compulsory social
isolation in Colombia, as a result of the Government strategy in the presence of
COVID-19. An instrument was applied that investigated sociodemographic, health
and quality of life variables in 1,456 Colombians residing in the country, of legal
age and who were complying with the isolation measure at home, belonging to the
32 departments that make up the Republic of Colombia, including Amazonas and
San Andrés and Providencia. A descriptive correlational cross-sectional design was
used, achieving an analysis of more than 180 variables. Given that only health and
quality of life results are presented in this document in relation to sex, age, marital
status, educational level, telework / remote study, occupation, the number of people
a position and children, it is considered as a preliminary report. Direct correlations
were obtained between quality of life and sex, marital status, level of education and
dependents, and inversely with age, telework / remote study and having or not having
children. Finally, it seems that the greater the number of responsibilities, the lower
the quality of life in a confined situation. Finally, it seems that the greater the number
of responsibilities, the lower the quality of life in a situation of confinement, the
perception of feeling accompanied can serve as a protective factor for the quality of
life and the level of economic income is a determining factor for the evaluation that
is made of it.1a ed
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