76 research outputs found
Corria, Filiberto -- 1977-92 -- Correspondence, Individual -- letter, 1987-06-08
- Author
- Publication venue
- Publication date
- 08/06/1987
- Field of study
No full textLetter from Corria, C.M. Ramirez to Sabin, Albert B. dated 1987-06-08.Sabin Collection Fair Use Policy</a
A comparison of the moss floras of Chile and New Zealand
- Publication venue
- Publication date
- 01/01/2002
- Field of study
No full textChile and New Zealand share a common stock of 181 species of mosses in 94 genera and 34 families. This number counts for 23.3% of the Chilean and 34.6% of the New Zealand moss flora. If only species with austral distribution are taken into account, the number is reduced to 113 species in common, which is 14.5% of the Chilean and 21.6% of the New Zealand moss flora. This correlation is interpreted in terms of long distance dispersal resp. the common phytogeographical background of both countries as parts of the palaoaustral floristic region and compared with disjunct moss floras of other continents as well as the presently available molecular data
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
- Author
- Cutcliffe Lesley T.
- Rachel J Skilton
- Mabey David
- Barbeyrac B. de
- Peter Marsh
- Parkhill Julian,
- Lewis David A.,
- Speksnijder Arjen,
- Seth-Smith H.M.B.
- Spratt BG
- Morré Servaas A.,
- Skilton Rachel J.,
- de Barbeyrac Bertille,
- Unemo M
- Robert Brunham
- Peeling Rosanna W.
- Clarke I.N.
- Seth-Smith Helena MB
- de Vries HJC
- Harris Simon R
- Holland Martin J.
- Speksnijder A
- Brunham Robert
- Seth-Smith Helena M. B.
- de Vries Henry JC
- Bjartling Carina
- Bebear C.M.
- Bjartling C.
- Bertille de Barbeyrac
- Persson K
- Persson Kenneth
- Bebear CM
- Cutcliffe Lesley T.,
- Clerc Maite,
- Brunham R.
- Holland MJ
- Unemo Magnus
- Clerc Maïté
- Peeling Rosanna W.,
- Nicholas R Thomson
- Morré Servaas A.
- Marsh Peter
- de Vries H.J.
- Speksnijder A.
- Skilton RJ
- Clarke Ian N.
- Spratt Brian G.,
- Spratt Brian G
- Ian N Clarke
- Mabey D
- Clarke Ian N.,
- Marsh Peter,
- Lewis DA
- Seth-Smith HMB
- Harris S.R.
- de Vries Henry J.C.
- Lesley T Cutcliffe
- Julian Parkhill
- Mabey D.
- Bjartling C
- de Barbeyrac B.
- Solomon Anthony W
- de Vries Henry J. C.,
- Arjen Speksnijder
- Marsh P
- Parkhill Julian
- Maïté Clerc
- Clerc M.
- Clarke Ian N
- Bébéar Cecile M.,
- Persson K.
- Simon R Harris
- Lewis D.A.
- Thomson NR
- Anthony W Solomon
- Holland Martin J.,
- Thomson Nicholas R.,
- Mabey David,
- Vries H.J. de
- Cutcliffe LT
- Morre SA
- Parkhill J
- Persson Kenneth,
- Speksnijder Arjen
- Bébéar Cécile M
- Harris Simon R.
- Skilton R.J.
- Mabey David.
- Solomon A.W.
- Holland M.J.
- Seth-Smith Helena M.B.
- Marsh P.
- Kenneth Persson
- Helena M B Seth-Smith
- Solomon Anthony W.,
- Henry J C de Vries
- Skilton Rachel J.
- Harris SR
- Holland Martin J
- Bjartling Carina,
- Thomson Nicholas R
- Thomson Nicholas R.
- Brian G Spratt
- Carina Bjartling
- Solomon AW
- Lewis David A.
- Peeling Rosanna W
- Clarke IN
- Martin J Holland
- Solomon Anthony W.
- Spratt B.G.
- Harris Simon R.,
- David A Lewis
- Peeling RW
- Clerc M
- Brunham R
- Cutcliffe L.T.
- de Vries Henry J. C.
- Cécile M Bébéar
- Parkhill J.
- Magnus Unemo
- de Barbeyrac B
- Unemo M.
- Clarke I.
- Cutcliffe Lesley T
- Morre S.A.
- Spratt Brian G.
- de Barbeyrac Bertille
- Bébéar Cécile M.
- Thomson N.R.
- Brunham Robert,
- Seth-Smith Helena M. B.,
- Skilton Rachel J
- Lewis David A
- David Mabey
- Morré Servaas A
- Servaas A Morré
- Rosanna W Peeling
- Unemo Magnus,
- Publication venue
- Publication date
- 01/01/2012
- Field of study
No full textChlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b
Hundreds of variants clustered in genomic loci and biological pathways affect human height
- Author
- Lawrence Robert W
- Preuss M.
- Pastinen Tomi
- Cusi D.
- Ridker P.M.
- P. Elliott
- D. Absher
- Kwan T
- Assimes Themistocles L.
- Heid I. M.
- Ingelsson E.
- Elosua R.
- Jianjun Liu
- Sanna Serena
- Hall A.S. (Alistair)
- Boerwinkle E.
- Anneli Pouta
- Huikuri H.V. (Heikki)
- Qi L.
- Knowles JW
- Hayes Richard B
- Palmer L.J.
- Hicks Andrew A
- D. J. Hunter
- Hengstenberg Christian
- Palmer C.
- Nelis M
- Mari Nelis
- Glazer NL
- A. S. Hall
- A. U. Jackson
- Rafelt S
- Sanders A. R.
- A. T. Hattersley
- Smith AV
- Kaprio Jaakko
- Antti Jula
- Qi Lu
- Soumya Raychaudhuri
- Monda Keri L.
- Uitterlinden André G
- Turchin MC
- Perry J.R.
- Ardlie K. G.
- Lawrence Robert W.
- O´Connell J.R.
- S. Kathiresan
- Geus E.J.
- Sambrook Jennifer G.
- Stefansson K
- Willemsen G.A.H.M. (Gonneke)
- O'Donnell CJ
- Palmer Lyle J.
- Frayling Timothy M.
- M. den Heijer
- Wichmann H.E. (Heinz Erich)
- Bhangale T. (Tushar)
- Jianxin Shi
- Montgomery G.W.
- Igl W.
- Harris T.B. (Tamara)
- Haritunians T. (Talin)
- Geus E. J.
- Quertermous T.
- Waterworth D. (Dawn)
- Boomsma D. I.
- Atwood Larry D
- Sanders A.R.
- Smit J.H.
- Meurs J.B.J.
- Kilpeläinen T.O.
- Munroe PB
- Cupples L.A. (Adrienne)
- Pastinen T.
- A. R. Wood
- Mary F. Feitosa
- Larry D. Atwood
- Liu Jianjun
- Cusi D. (Daniele)
- Qi L
- Peters M. J.
- Rivadeneira F
- S. H. Wild
- K. B. Jacobs
- Tony Kwan
- Raychaudhuri Soumya
- Eero Kajantie
- Gyllensten Ulf,
- J. Hua Zhao
- Strachan David P.
- Schreiber S.
- Hall AS
- M. J. Caulfield
- Markku S. Nieminen
- Kwan T.
- Johnson T
- Penninx B.W.J.H.
- V. Steinthorsdottir
- Rudan I. (Igor)
- Workalemahu Tsegaselassie
- Shaun Purcell
- Kajantie E
- Kocher T
- O’Donnell Christopher J.
- Palmer Cameron
- K. G. Ardlie
- et al.
- Smith A.V. (Albert Vernon)
- Knowles J. W.
- Willem H. Ouwehand
- Ouwehand Willem H
- Hirschhorn J. N.
- Benjamin F. Voight
- Zillikens M. C.
- Tammesoo M.L.
- Dixon A.L.
- Mark Lathrop G.
- Alice M. Arnold
- Robertson N. R.
- Morris Andrew
- C. M. Lindgren
- Vitart Veronique
- Völzke H. (Henry)
- Johannes Kettunen
- Iribarren Carlos
- Johansson Åsa,
- Voight B. F.
- Kolcic I. (Ivana)
- Martin Nicholas G
- A. Johansson
- Musk AW
- Cupples L.A.
- Kähönen M.
- Ketkar S
- Lettre G
- Yurii S. Aulchenko
- Erdmann Je.
- Morris AP
- Christian Hengstenberg
- Wright A.F.
- E. Salvi
- Robert W. Lawrence
- Kilpeläinen TO
- J. Duan
- Jaakko Tuomilehto
- Riddertrale M.
- Robertson N.R.
- Thompson JR
- C. Rivolta
- Ana Marusic
- Charles C. White
- Lachlan Coin
- Gibson Q.
- Gudbjartsson Daniel
- Altmaier EL
- Wareham N.J.
- Weedon Michael N.
- T. O. Kilpeläinen
- Haiqing Shen
- Ulf Gyllensten
- Peter P. Pramstaller
- Wild S.H. (Sarah)
- Katja K. Aben
- Erdmann Jeanette
- Ngwa JS
- Chatterjee N
- I. M. Heid
- van Ommen GJ
- D. R. Nyholt
- David S. Siscovick
- Mosley Jr T.H.
- Weyant R.J.
- Salvi E. (Erika)
- E. Widen
- Zgaga L
- Heath A.C.
- Johan G. Eriksson
- Illig T.
- Hall Per
- Rafelt Suzanne
- Kilpelainen T. O.
- Nyholt D.R.
- Barbara McKnight
- Visscher PM
- M. Mangino
- Monda K.L.
- Hicks Andrew A.
- Jackson A.U.
- U. Sovio
- J. r. Mosley TH
- Ben Oostra
- Oskari Kilpeläinen Tuomas
- Pietiläinen Kirsi H
- Wilson James F
- Huikuri Heikki V
- Jennie Hui
- Peters Marjolein
- Tönjes A. (Anke)
- Völzke H
- Parker AN
- Ridderstråle M. (Martin)
- Liu J. (Jianjun)
- Schmidt C.O.
- Ripatti S.
- E. L. Altmaier
- de Geus EJC
- Heard-Costa Nancy L.
- Daniel Gudbjartsson
- Erdmann J
- Wright AF
- Aulchenko Y.S.
- Hottenga J.J.
- A. Petersmann
- Joel N. Hirschhorn
- Farrall M. (Martin)
- Iris M. Heid
- Palmer LJ
- Wood Andrew R
- Parker A. N.
- Cornelia M. van Duijn
- Hicks A.A.
- Beckmann Jacques S
- Geus Eco JC
- Almgren P. (Peter)
- Hirschhorn J.N. (Joel)
- Hua Zhao Jing
- Waterworth D.
- Florian Ernst
- Melander O
- Jacques S. Beckmann
- Stumvoll M. (Michael)
- Thorsteinsdottir U
- Polasek Ozren
- Eco J. C. Geus
- Hui J.N.
- Jarvelin MR
- Dixon Anna L.
- Salomaa V. (Veikko)
- Perry J. R.
- Eriksson J.G.
- Thorsteinsdottir U. (Unnur)
- Groop L. (Leif)
- Winkler T.W.
- Lorentzon Mattias,
- Stefan Schreiber
- Jackson Anne U
- Boucher G. (Gabrielle)
- Walters G. Bragi
- Steinthorsdottir V. (Valgerdur)
- Wiklund F. (Fredrik)
- Mueller M
- Julius Suh Ngwa
- Shi JX
- Sanders Alan R
- A. S. Havulinna
- Ferreira T.
- Barroso Ines
- Goddard M.E. (Michael)
- Collins FS
- Chatterjee N.
- Thor Aspelund
- E. Kajantie
- Heard-Costa NL
- Mosley Tom H., Jr.
- Zhao JH
- D. F. Levinson
- R. C. Kaplan
- Kaplan R.C.
- David J. Hunter
- Tom H. Mosley Jr
- Pramstaller PP
- Shi J.
- Mosley Tom H.
- Rissanen A
- Wilmar Igl
- Pouta A. (Anneli)
- Hayes Richard B.
- Visscher Peter M.
- Schmidt Carsten Oliver
- Kutalik Z. (Zoltán)
- Esko T. (Tõnu)
- Barroso I.E. (Inês)
- Elisabeth Widen
- Elliott P.
- J. Suh Ngwa
- North KE
- L. Qi
- Nyholt DR
- Wheeler Eleanor
- Hayes RB
- Jonathan P. Tyrer
- Pietilainen K.H. (Kirsi Hannele)
- McCarthy M.I. (Mark)
- Marjo-Riitta Jarvelin
- Spector Timothy D
- Duijn C.M. (Cornelia) van
- C. Gieger
- Grundberg E. (Elin)
- Gejman P.V. (Pablo)
- Weedon M. N.
- Suh Ngwa J.
- Mägi R.
- Beilby John P
- Kiemeney L.A.L.M.
- White C. C.
- Elosua Roberto
- L. Coin
- N. L. Glazer
- Tuomilehto J.
- Toenjes A
- A. R. Sanders
- U. Thorsteinsdottir
- L. Adrienne Cupples
- Deloukas P
- Vedantam S. (Sailaja)
- Smit Jan H.
- Hunter D.J. (David)
- Aben K. K.
- Launer L. J.
- Serena Sanna
- N. W. Rayner
- Heid I.M. (Iris)
- R. Mägi
- Ngwa J.S.
- Chasman D.I. (Daniel)
- Robertson Neil R
- E. Ingelsson
- Cameron Palmer
- Lango Allen H.
- Mohlke K.L.
- K. K. Aben
- Campbell Harry
- T. Bhangale
- Rayner Nigel W.
- Jan H. Smit
- Voight Benjamin F
- C. C. White
- Allen Hana Lango
- Shi J. (Jianxin)
- Segrè A.V. (Ayellet)
- Atwood L.D. (Larry)
- van Ommen G.J.
- Leena Peltonen
- Arnold A. M.
- Feitosa M.F. (Mary Furlan)
- Zgaga L. (Lina)
- M. Kayser
- Bergmann S
- F. Ernst
- Lawrence RW
- Kari Stefansson
- A. M. Arnold
- Steinthorsdottir V.
- N. Amin
- De Grandi Alessandro
- Hartikainen AL
- S. Schreiber
- Hu Frank B.
- Atwood Larry D.
- Ripatti S
- J. P. Beilby
- Hengstenberg C
- Lindgren Cecilia M
- Lorentzon M. (Mattias)
- Erdmann J. (Jeanette)
- Chasman DI
- L. Citterio
- Fox C.S.
- Vilmundur Gudnason
- A. L. Dixon
- Cristen J. Willer
- Thompson J.R.
- Michael A. Province
- Lathrop G.M. (Mark)
- van Ommen G. J.
- Ivana Kolcic
- Marusic A
- Wilson J.F.
- Samani N.J.
- Kathiresan S
- Petersmann Astrid
- Raitakari O.
- Konig I. R.
- T. Johnson
- Coin L. (Lachlan)
- D. Gudbjartsson
- Junttila M.J.
- Beilby JP
- Perry JB
- A. Dominiczak
- M. Farrall
- Soranzo N.
- Zoltán Kutalik
- Pouta A.
- Widen Elisabeth
- Rotter J. I.
- Walters G.B. (Bragi)
- Perry JR
- Ernst F
- Perola M. (Markus)
- Schmidt CO
- Wichmann HE
- Hall P.
- Zagato L.
- Preuss Michael
- Heather M. Stringham
- Segrè A.V.
- Pichler Irene
- Alistair S. Hall
- Mark I. McCarthy
- Bergman R. N.
- Ken Sin Lo
- Thompson J.R. (John)
- Gabrielle Boucher
- Kovacs P
- Spector Timothy D.
- Bergmann S.
- Kaprio J
- Smit J.H. (Jan)
- Farrall M.
- Frayling Timothy M
- Lokki Marja Liisa
- J. Erdmann
- Heath AC
- Van Meurs Joyce B J
- Tyrer J. P.
- Illig T
- Cupples L Adrienne
- Lo Ken Sin
- Aulchenko Yurii S.
- Cupples L. Adrienne
- Peden John F.
- Beckmann J.S. (Jacques)
- de Geus E.J.C.
- Schreiber S
- Willemsen G.; id_orcid
- Prokopenko I
- Martina Müller
- M. Juhani Junttila
- Montgomery Grant W
- Citterio L.
- Alessandro De Grandi
- vVan Meurs JBJ
- Ferreira T. (Teresa)
- Samani Nilesh J
- Peltonen L. (Leena Johanna)
- Hattersley Andrew T
- Gudbjartsson D
- V. Mooser
- Richard B. Hayes
- Oliver Schmidt C.
- P. M. Visscher
- Boomsma Dorret I.
- McArdle W.L.
- Hirschhorn J.N.
- T. Illig
- Kovacs Peter
- Chatterjee Nilanjan
- Melander O.
- A. G. Uitterlinden
- Rissanen Aila
- Chen C. (Constance)
- Zitting P. (Paavo)
- H. Völzke
- H. Alavere
- Reedik Mägi
- Hayward Caroline
- Hofman A. (Albert)
- H. Watkins
- Eriksson J. G.
- Albert Hofman
- Hao K
- Voight B.F.
- Igl Wilmar
- Wild S. H.
- Andrea Maschio
- Boucher G
- T. Esko
- Martin N. G.
- Michael E. Goddard
- Caulfield MJ
- Haritunians T.
- Mosley T. H.
- Lyle J. Palmer
- Hottenga J. J.
- Kaplan Robert C
- Hottenga Jouke Jan
- Kayser Manfred
- Nancy L. Heard-Costa
- Hicks AA
- Aspelund T
- J. B. van Meurs
- Cusi D
- Weedon MN
- Rayner NW
- Watkins Hugh
- Christian Gieger
- Albrecht E
- Salem R.M. (Rany)
- John R. B. Perry
- Lathrop G.M.
- Anna Dominiczak
- Pellikka Niina
- C. Oliver Schmidt
- Michael Boehnke
- Jackson A. U.
- Hayes R.B.
- Spector T.D.
- Hoffman W. (Wolfgang)
- Loos R.J.F.
- Park Ju Hyun
- Koiranen M.
- J. Xu
- G. W. Montgomery
- L. Zagato
- Balmforth A. J.
- Kathiresan Sekar
- Wilson JF
- D.M. Cusi
- Aulchenko Yurii S
- Perry John RB
- Province Michael A
- Andrew T. Hattersley
- Knowles J.W. (Joshua)
- Inke R. König
- Rany M. Salem
- Raychaudhuri S
- Abecasis G. R.
- I. B. Borecki
- S. Haiqing
- Absher D.
- T. Workalemahu
- Johnson T. (Toby)
- Maschio A.
- Wilson J.F. (James)
- Zillikens MC
- Altmaier Elizabeth L.
- White C.C.
- Meitinger T. (Thomas)
- Weedon M.
- Cooper M.N. (Matthew)
- Rivolta C. (Carlo)
- Verlaan D. J.
- Peter Kovacs
- Wheeler E. (Eleanor)
- Robertson N.R. (Neil)
- Fox Caroline S
- Nyholt Dale
- A. Vernon Smith
- Gejman P. V.
- Uda M.
- Freimer Nelson B
- McArdle W. L.
- Altmaier E. L.
- M. N. Cooper
- Rivadeneira Ramirez F. (Fernando)
- McKnight Barbara
- V. Gudnason
- Harris Tamara B
- Peters M.J.
- Kathiresan S.
- Sin Lo K
- Kettunen Johannes
- Campbell H. (Harry)
- Wheeler E.
- Caulfield M. (Mark)
- L. J. Launer
- Boehnke M
- Ruth J. F. Loos
- Sanna S
- K. E. North
- H.-Erich Wichmann
- Wichmann H.-E.
- van Duijn C. M.
- Peltonen L
- Hu F.B.
- Cooper Matthew N
- Suzanne Rafelt
- Peden J. (John)
- Borecki Ingrid B.
- Kari E. North
- Purcell S.
- E. E. Schadt
- M. N. Weedon
- Huikuri HV
- Pellikka N.
- Schadt EE
- A. L. Hartikainen
- Vedantam Sailaja
- Eiriksdottir G
- Parker A.N. (Alex)
- Nelis M. (Mari)
- Perry John R. B.
- Martin Farrall
- Mooser Vincent
- Uitterlinden AG
- Illig T. (Thomas)
- Gejman Pablo V
- Zillikens M.C. (Carola)
- Sovio U
- Gieger C
- Chanock Stephen J
- Tamara B. Harris
- Wichmann H-Erich
- Ouwehand W.H. (Willem)
- Watkins H.
- Aspelund T. (Thor)
- Nelson B. Freimer
- S. I. Berndt
- Schlessinger D.
- White Charles C
- Winkler T.W. (Thomas)
- Altmaier E.L.
- Mark J. Caulfield
- Seppo Koskinen
- Atwood L. D.
- K. Hao
- van Duijn CM
- Schadt Eric E.
- Lawrence R.W. (Robert)
- K. L. Mohlke
- R. B. Hayes
- Vandenput Liesbeth
- Paul M. Ridker
- I. Rudan
- Jarvelin M.R.
- White CC
- Alan R. Sanders
- Salem Rany M.
- Chasman Daniel I
- R. W. Lawrence
- Kocher T. (Thomas)
- Wiklund F.
- Kolcic I.
- Havulinna A.S.
- Kocher T.
- Martin NG
- Ridker P. M.
- L. J. Palmer
- Johnson T.
- Salomaa V
- Sambrook J.G. (Jennifer)
- Schadt HE
- Jian Yang
- Yang Jian
- Steinthorsdottir V
- J. R. O'Connell
- Lambertus Kiemeney
- Winkler Thomas W.
- del Maschio A
- Kaplan Lee M.
- Province MA
- Rivolta C.
- Goddard Michael E
- Shuldiner A.R.
- Paré G.
- Workalemahu T
- Jula A. (Antti)
- Soranzo N. (Nicole)
- Nyholt Dale R
- Kaplan R.C. (Robert)
- Nicola Glorioso
- Koiranen Markku
- Uda Manuela
- John P. Beilby
- Kiemeney L
- Prokopenko Inga
- Parker Alex N.
- Oliver Schmidt Carsten
- Jian’an Luan
- Peters M.J. (Marjolein)
- Schmidt C. O.
- Bergmann Sven
- A. N. Parker
- Launer Lenore J.
- Fox C. S.
- Bergmann S.M. (Sven)
- Ouwehand W. H.
- Daniel I. Chasman
- Wichmann H. E.
- Loos R.J.F. (Ruth)
- E. K. Speliotes
- Wareham N.J. (Nick)
- Nieminen Markku S
- McKnight B. (Barbara)
- Salvi E
- Petersmann A.
- Erika Salvi
- Hunter David J
- Balmforth AJ
- Luan Jian’an
- Eriksson J.G. (Johan)
- Kiemeney L.A.L.M. (Bart)
- Alavere H. (Helene)
- W. Igl
- Esko T
- Almgren Peter,
- Rotter Jerome I
- Stefansson K. (Kari)
- Vincent Mooser
- Thompson John R.
- N. J. Samani
- Rissanen A.
- Themistocles L. Assimes
- P. Zitting
- Erdmann J.
- M. Nelis
- Rioux John D
- Aulchenko Y. S.
- van Meurs J. B.
- Laitinen J
- A. A. Hicks
- D. Waterworth
- Paavo Zitting
- Absher Devin
- Balmforth Anthony J
- G. J. van Ommen
- Aben Katja K.
- Pellikka N. (Niina)
- Muller M (Majon)
- A. Tönjes
- Mika Kähönen
- Uitterlinden A. G.
- Berndt S. I.
- Mooser V. (Vincent)
- Kilpeläinen Tuomas O
- Frayling T. M.
- Musk A.W. (Arthur)
- W. H. Ouwehand
- K. Sin Lo
- Stefansson H.
- Cupples LA
- Verlaan Dominique J
- Penninx Brenda W.
- Zgaga L.
- Beckmann J.S.
- B. W. Penninx
- Lettre G. (Guillaume)
- A. Metspalu
- Palmer C. (Cameron)
- H. E. Wichmann
- Jula A
- Penninx B.W.
- McCarthy M.I.
- Raychaudhuri S.
- Polasek O.
- Morris Andrew P.
- Cupples L. A.
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- Siscovick D.S. (David)
- Berndt S.I.
- Hall P
- De Grandi A
- Nieminen M.S.
- Glorioso N.
- Quertermous T. (Thomas)
- Hartikainen A.L.
- Ommen G.J. van
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- Samani Nilesh J.
- R. J. Weyant
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- Pichler I. (Irene)
- Hofman Bert
- Wright A. F.
- Watkins H
- Schadt H.E.
- Kolcic I
- L. Kiemeney
- Heath A.C. (Andrew)
- Eriksson Johan G.
- Kajantie E.
- Hui J. (Jennie)
- Nyholt D.R. (Dale)
- Carola Zillikens M.
- Feitosa Mary F.
- Caroline S. Fox
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- Grundberg Elin
- Wood A.R. (Andrew)
- Jorma Viikari
- Sinisalo J. (Juha)
- Heid IM
- Wichmann H.-Erich
- Uitterlinden André
- Kraft P
- Pouta Anneli
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- Ridker Paul M
- Arnold Alice M
- M. Müller
- Verlaan Dominique J.
- Elliott P. (Paul)
- Ziegler A. (Andreas)
- Sven Bergmann
- Johansson A
- Lathrop GM
- Gudmar Thorleifsson
- Coin L
- Peters Marjolein J
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- O'Donnell Christopher J.
- Richard N. Bergman
- M. J. Peters
- Jarvelin M-R
- Workalemahu T.
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- Hartikainen Anna Liisa
- Mangino Massimo
- de Geus E.J.C.; id_orcid
- Lokki M.L.
- Bragi Walters G
- Ohlsson Claes,
- Hicks A.A. (Andrew)
- Irene Pichler
- B. Oostra
- Ripatti S. (Samuli)
- Thompson J. R.
- Wild S.H.
- Gonneke Willemsen
- Abecasis Goncalo R.
- Mosley TH
- Albert Vernon Smith
- Ferreira T
- Hamsten A. (Anders)
- N. B. Freimer
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- van Meurs J.B.
- Massimo Mangino
- Aben K.K.
- A. V. Segrè
- Ouwehand WH
- Willemsen G
- Caroline Hayward
- Harris Tamara B.
- Hunter David J.
- Van Duijn Cornelia M.
- Boomsma D.I.; id_orcid
- Sanders AR
- O’Donnell C.J.
- Sin Lo Ken
- Jarvelin Marjo-Ritta
- Groop L. C.
- Harry Campbell
- Goddard ME
- Gudbjartsson D.F.
- T. Aspelund
- Strachan D.P.
- Launer LJ (Lenore)
- Schadt E. E.
- N. Chatterjee
- Peter Almgren
- Uitterlinden André; id_orcid
- J. Kaprio
- Farrall Martin
- Surakka I
- Cooper MN
- Kahonen Mika
- Veronique Vitart
- Rivadeneira F.
- Neil R. Robertson
- Viikari J
- Mooser V
- Rudan Igor
- I. Pichler
- Lokki M. L.
- Beckmann Jacques S.
- Zitting P.
- Michael C. Turchin
- Inês Barroso
- Wilson J. F.
- Levinson Douglas F
- van Ommen G.J.B
- Heid IM.
- Joyce B. J. van Meurs
- Kraft P. (Peter)
- Weedon Michael N
- P. Almgren
- Sovio U.
- Völzke H.
- König I.R.
- Estrada Karol
- Johnson Toby
- Heard-Costa N.L. (Nancy)
- J. Shi
- O'Donnell Christopher J
- Ke Hao
- Andrew R. Wood
- Meitinger T
- J. J. Hottenga
- Manfred Kayser
- P. Deloukas
- T. Quertermous
- Thorsteinsdottir U.
- N. Pellikka
- Eric E. Schadt
- Boomsma DI
- O. Melander
- Publication venue
- Publication date
- 01/01/2010
- Field of study
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Author correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
- Author
- Hagenaars S.P.
- Sundet Kjetil
- Rujescu D.
- Wagner H.
- Trompet S.
- Reinvang Ivar
- KWOK J. B.
- Marioni Riccardo E
- Knopman D.S.
- Boerwinkle E.
- Scott Rodney J.
- Böhmer AC
- Weir D.R.
- Oldmeadow C.
- Dale A.M.
- Ramirez A.
- Smith AV
- IKRAM M. A.
- Kaprio Jaakko
- Poldrack Russell A.
- Harris Sarah E
- Petrovic K.
- Longstreth Will T
- WILSON J. F.
- Conley ED
- CANNON T. D.
- Riedel-Heller Steffi G.
- Ikram M. Kamran
- HAGENAARS S. P.
- Deary Ian J
- Montgomery G.W.
- Heiss G
- Smith Albert V
- Schmidt Reinhold
- Assareh A.A.
- Espeseth T
- Kwok John B.
- Armstrong Nicola J.
- KNOPMAN D. S.
- Liu Tian
- STEFANIS N. C.
- Dale AM
- Koini Marisa
- Scholz M
- Kleineidam Luca
- Liewald David C.M.
- Lam M.
- Taylor Adele M
- Lee Teresa ; https://orcid.org/
- Sabb Fred W.
- Hansell Narelle K
- Bertram Lars
- van der Lee S.J.
- Wagner M.
- Yu J.
- Lehtimäki Terho
- Trollor Julian N.
- Mosley Thomas H
- Knowles E.
- Attia JR
- Thalamuthu Anbupalam
- Kähönen M
- Hill W David
- Taylor K.D.
- Tzourio C.
- Gale Catharine R
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- Kähönen M.
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- Dehghan Abbas
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- Ware Erin B.
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- Field of study
No full textChristina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)
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No full textChristina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article. © 2019, The Author(s)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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- Milani L. (Lili)
- David Meyre
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- Power C.
- Leach I.M. (Irene Mateo)
- Johansson A
- Gudmar Thorleifsson
- Edkins T. (Ted)
- Grallert Harald
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- J. Yang
- M. J. Peters
- Jarvelin M-R
- Workalemahu T.
- G. Cadby
- König I. R.
- Lindsay L Waite
- K. K. Ong
- S. E. Hunt
- Patricia B Munroe
- Stephens J.C.
- S. Edkins
- Keinanen-Kiukaanniemi S.M.
- Hovingh Kees G.
- Mangino Massimo
- Lokki M.L.
- Hicks A.A. (Andrew)
- Lyle J Palmer
- Ripatti S. (Samuli)
- Hunt S.E. (Sarah)
- J. H. Laitinen
- Wild S.H.
- Gonneke Willemsen
- Liang LM
- Abecasis Goncalo R.
- Albert Vernon Smith
- Bernhard R Winkelmann
- Ferreira T
- Hamsten A. (Anders)
- James F Wilson
- O Cookson W
- Stefansson K.
- van Meurs J.B.
- Meyre David
- Markku S Nieminen
- Publication venue
- Publication date
- 01/01/2013
- Field of study
No full textApproaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- Author
- Lawrence Robert W
- Shengxu Li
- Ridker P.M.
- Assimes Themistocles L.
- Ingelsson E.
- Van Meurs JBJ
- Sanna Serena
- Welch R
- Christopher C Holmes
- Teslovich Tanya M.
- Boerwinkle E.
- Anneli Pouta
- Qi L.
- Knowles JW
- Hicks Andrew A
- Palmer L.J.
- Hengstenberg Christian
- Nelis M
- Mari Nelis
- Glazer NL
- Kapur K. (Karen)
- Tiinamaija Tuomi
- Christine Cavalcanti-Proença
- Smith AV
- Visscher H.M.
- Day I.N.M.
- Steven A McCarroll
- Kaprio Jaakko
- Antti Jula
- Qi Lu
- Monda Keri L.
- Perry J.R.
- Thomas A Buchanan
- Lawrence Robert W.
- Platou C.P. (Carl)
- Geus E.J.
- Froguel P. (Philippe)
- Stefansson K
- Willemsen G.A.H.M. (Gonneke)
- Palmer Lyle J.
- Frayling Timothy M.
- Wichmann H.E. (Heinz Erich)
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- Nigel W Rayner
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- Smith GD
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- Eero Kajantie
- Gonçalo R Abecasis
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- Penninx B.W.J.H.
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- Krzelj V.
- Workalemahu Tsegaselassie
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- Barroso I.E. (Inês)
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- Campbell Harry
- Bennett A.J.
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- Rayner Nigel W.
- Voight Benjamin F
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- Allen Hana Lango
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- van Ommen G.J.
- Dorret I Boomsma
- Leena Peltonen
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- Ferreira T. (Teresa)
- Samani Nilesh J
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- Kaisa Silander
- Boomsma Dorret I.
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- Michael Boehnke
- Gianluca Usala
- Spector T.D.
- Groves C.J. (Christopher)
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- Kvaloy K.
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- Jansson John-Olov
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- Isomaa B
- Narisu N.
- Silander K. (Kaisa)
- Winkler T.W. (Thomas)
- Platou C.G.P.
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- Seppo Koskinen
- Dei Mariano
- Chines P.S.
- van Duijn CM
- Schadt Eric E.
- Dei M. (Mariano)
- Vandenput Liesbeth
- Nicholas John Timpson
- White CC
- Chasman Daniel I
- Kolcic I.
- Havulinna A.S.
- Johnson T.
- Salomaa V
- Jian Yang
- Yang Jian
- Steinthorsdottir V
- Pedersen O. (Oluf)
- Winkler Thomas W.
- Kaplan Lee M.
- Hveem K. (Kristian)
- Goddard Michael E
- Moffatt M.F. (Miriam)
- Shuldiner A.R.
- Strawbridge Rona J.
- Jula A. (Antti)
- Workalemahu T
- Zondervan KT
- Hassanali N. (Neelam)
- Soranzo N. (Nicole)
- Platou C.G.
- Nyholt Dale R
- Syvanen Ann-Christine
- Kaplan R.C. (Robert)
- Uda Manuela
- Isomaa Bo
- Prokopenko Inga
- Parker Alex N.
- Francis S Collins
- Peters M.J. (Marjolein)
- Teslovich Tanya M
- Bergmann Sven
- Amy J Swift
- Lawlor Debbie A.
- Launer Lenore J.
- Bergmann S.M. (Sven)
- Loos R.J.F. (Ruth)
- Neville MJ
- Wareham N.J. (Nick)
- Nieminen Markku S
- Hunter David J
- Alavere H. (Helene)
- Chines Peter S
- Vatin V.
- Esko T
- Almgren Peter,
- Nicholas J Wareham
- Stefansson K. (Kari)
- Volpato Claudia B
- Bennett A.J. (Amanda)
- Bornstein S.R. (Stefan)
- Uitterlinden A
- Heiner Boeing
- Karl-Heinz Herzig
- Rissanen A.
- Laitinen J
- North K.E
- Paavo Zitting
- Absher Devin
- Molony C. (Cliona)
- Nicholson G. (Ggeorge)
- Schwarz P.E.
- Pellikka N. (Niina)
- Mika Kähönen
- H-Erich Wichmann
- Tthorleifsson G. (Ggudmar)
- Eerdos M.R. (Micheal)
- Kraja A.T.
- Kilpeläinen Tuomas O
- Brenda W Penninx
- O'Cconnell J.R. (Jeffrey)
- Wingerden S. van
- Cupples LA
- Penninx Brenda W.
- Zgaga L.
- Beckmann J.S.
- Lettre G. (Guillaume)
- Bruce M Psaty
- Palmer C. (Cameron)
- Jula A
- Penninx B.W.
- McCarthy M.I.
- John F Peden
- Morris Andrew P.
- Polasek O.
- Ong Ken K.
- Hansen T. (Torben)
- Koskinen S.
- Uitterlinden A.
- Claudia B Volpato
- Collins Francis S.
- Sinisalo Juha
- Weyant R.J. (Robert)
- Niina Pellikka
- Harris TB
- Allen HL
- Deloukas Panos
- Zondervan K.T. (Krina)
- Harris T.
- Wareham Nicholas J.
- O'Connell J.R.
- Laitinen Jaana
- Abecasis GR
- Oostra B.A. (Ben)
- Speliotes EK
- Karpe Fredrik
- Zhao J.H.
- Ludwig B
- Berndt SI
- Lantieri O
- Bouatia-Naji N
- Vitart V
- Liang L. (Liming)
- MAGIC
- Hayward C
- Rona J Strawbridge
- Borecki I.B. (Ingrid)
- Assimes Themistocles L
- Berndt S.
- Gyllensten U. (Ulf)
- Vedantam S
- Lina Zgaga
- Strachan DP
- Speliotes E.
- Glazer N.L.
- Balkau B. (Beverley)
- Luben Robert N.
- Assimes TL
- Kettunen J
- Bornstein Stefan R.
- Moffatt Miriam F.
- Themistocles L Assimes
- Schadt Eric E
- Spector TD
- Igor Rudan
- Smit JH
- McCarthy Anne
- Benjamin F Voight
- Berndt S.I.
- Nieminen M.S.
- Quertermous T. (Thomas)
- Hartikainen A.L.
- Yang J.A.
- Ommen G.J. van
- Jouke-Jan Hottenga
- van Meurs JB
- Hveem Kristian
- Jørgensen Torben
- Henry Völzke
- Hattersley Andrew T.
- Volpato C.B.
- Buchanan T.A.
- Tönjes A
- Jousilahti P.
- Geus Eco J C
- Peden JF
- Liang L.
- Kaakinen M
- Uda M. (Manuela)
- Lehtimäki T
- Strachan David P
- null null
- Tammesoo ML
- Abecasis G.R. (Gonçalo)
- Teder-Laving M.
- Hassanali N.
- Speliotes Elizabeth K
- Samani Nilesh J.
- Platou CGP
- Campbell H
- Pichler I. (Irene)
- Bouatia-Naji Nabila
- Chines P.S. (Peter)
- Hofman Bert
- Kolcic I
- Eriksson Johan G.
- Jousilahti P. (Pekka)
- Kajantie E.
- Hui J. (Jennie)
- Nyholt D.R. (Dale)
- Matthew N Cooper
- Anne McCarthy
- Feitosa Mary F.
- Michael Stumvoll
- Wood A.R. (Andrew)
- Jorma Viikari
- Gaget S.
- Sinisalo J. (Juha)
- Heid IM
- Day IN
- Kay-Tee Khaw
- Dei M.
- Teder-Laving Maris
- McCcarthy A. (Anne)
- Heyo K Kroemer
- Pouta Anneli
- Kraft P
- Khaw K-T
- Stark K.
- Kao W H Linda
- Leena Kinnunen
- Anke Tönjes
- Surakka I. (Ida)
- North K.E. (Kari)
- Iribarren C
- Ridker Paul M
- Arnold Alice M
- Shah Ebrahim
- Fu M.
- Heid I.
- Sven Bergmann
- Johansson A
- Gudmar Thorleifsson
- Lathrop GM
- Coin L
- Grallert Harald
- Peters Marjolein J
- Jarvelin M-R
- Workalemahu T.
- Fu Mao
- Havulinna Aki S
- John P Beilby
- Lawlor DA
- Patricia B Munroe
- Mangino Massimo
- de Geus E.J.C.; id_orcid
- Lokki M.L.
- Ohlsson Claes,
- Hicks A.A. (Andrew)
- Irene Pichler
- Lyle J Palmer
- Ripatti S. (Samuli)
- Wild S.H.
- Gonneke Willemsen
- Liang LM
- Christopher J Groves
- Abecasis Goncalo R.
- Albert Vernon Smith
- Hassanali Neelam
- Hamsten A. (Anders)
- Ferreira T
- James F Wilson
- Midthjell K.
- Stefansson K.
- Eiriksdottir G.
- van Meurs J.B.
- Sspeliotes E.K. (Eelizabeth)
- Markku S Nieminen
- Alan F Wright
- Johanna Kuusisto
- Massimo Mangino
- Caroline Hayward
- Willemsen G
- Harris Tamara B.
- Hunter David J.
- Teder-Laving M
- Eesko T. (Tõnu)
- Harry Campbell
- Goddard ME
- Jousilahti Pekka
- Nemesh J
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- Strachan D.P.
- Launer LJ (Lenore)
- Fisher Eva
- Cavalcanti-Proença C.
- Peter Almgren
- Uitterlinden André; id_orcid
- Surakka I
- Cooper MN
- Kahonen Mika
- Veronique Vitart
- Rivadeneira F.
- James AL
- Viikari J
- Rudan Igor
- Smith George Davey
- Beckmann Jacques S.
- Luben RN
- Zitting P.
- Ingrid B Borecki
- Inês Barroso
- Jansson J.O.
- Ben-Shlomo Yoav
- Andrew R Wood
- Jan H Smit
- Neville M.J. (Matthew)
- Kraft P. (Peter)
- Weedon Michael N
- Sovio U.
- Estrada Karol
- Johnson Toby
- Lawlor Debbie A
- Strawbridge R.J. (Rona)
- Meitinger T
- Eeriksson J.G. (Johan)
- Teslovich T.M. (Tanya)
- Schwarz Peter EH
- Day Ian NM
- Thorsteinsdottir U.
- Molony Cliona
- Swift Amy J.
- Moffatt Miriam F
- Boomsma DI
- Bennett Amanda J.
- Nemesh James
- Mohlke KL
- Ingelsson E. (Erik)
- Cavalcanti-Proença C
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- Monda Keri L
- Sarah H Wild
- Philippe Froguel
- Yang J. (Joanna)
- Biffar R. (Reiner)
- Grässler J
- Weedon M.N. (Michael)
- Ridker P.M. (Paul)
- Järvelin M.R.
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- Psaty BM
- Hartikainen A-L
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- Bonnycastle Lori L.
- Willemsen G.
- Tuomi T
- Liang Liming
- Kolcic Ivana
- Lindgren C.M.
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- Kinnunen Leena
- Leitzmann Michael F.
- Jaakko Kaprio
- Quertermous T
- Boomsma D.I.
- Psaty B.M.
- Ulla Sovio
- Nieminen Markku S.
- Hansen Torben
- McCarthy A
- Raitakari O. (Olli)
- Sinisalo J
- Hofman A
- Sovio Ulla
- Geus E.J.C.
- Witteman Jacqueline C.
- Perry John R B
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- Welch R.P. (Ryan)
- Pramstaller Peter P
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- Charles C White
- Narisu N
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- Vitart V.
- Nyholt Dale R.
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- Pedersen O
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- Witteman J.C.M. (Jacqueline)
- Kapur K
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- Timpson N.J. (Nicholas)
- Lango Allen H
- James Alan L.
- Paré G
- O'Connell Jeffrey R.
- Weyant Robert J.
- Jian'an Luan
- Vollenweider P. (Peter)
- Krina T Zondervan
- Purcell S. (Shaun)
- Wendy L McArdle
- Polasek O
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- Eleanor Wheeler
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- McCarthy MI
- Kao WH Linda
- Gyllensten U.
- Leitzmann M.F. (Michael)
- Pramstaller P.P. (Peter Paul)
- Kähönen M
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- Kulzer Jennifer R.
- Liming Liang
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- Stringham Heather M.
- Launer L.J.
- Maris Teder-Laving
- Andrew A Hicks
- Chasman Daniel I.
- Mark J Caulfield
- Caulfield M.J.
- Usala G
- Fernando Rivadeneira
- Martin Ridderstråle
- Debbie A Lawlor
- Strawbridge R.J.
- George Davey Smith
- Sinisalo J.
- Daniel R Witte
- Paré G. (Guillaume)
- Uitterlinden Andre
- Mangino M
- Daniel I Chasman
- Almgren P
- Beilby J.P. (John)
- Robertson NR
- Jansson JO
- Ohlsson C. (Claes)
- Jouko Saramies
- Loos Ruth J. F.
- Schwarz Peter E. H.
- Stringham H.M. (Heather)
- Kovacs P.
- Cavalcanti-Proenca Christine
- Fisher E.
- Larry D Atwood
- Neville Matt J
- Ida Surakka
- Hunter DJ
- Lecoeur C. (Cécile)
- Schadt E.E.
- Loos RJF
- Munroe Patricia B.
- Purcell S
- Havulinna A.S. (Aki)
- Groves C.J.
- Collins F.S.
- Grässler Jürgen
- Estrada K.
- Palmer Lyle J
- George Nicholson
- Kraja AT
- Quertermous Thomas
- Gyllensten Ulf
- Morris A.D. (Andrew)
- Perola Markus
- Rayner N.W.
- Hottenga JJ (Jouke Jan)
- Groop Leif C
- Publication venue
- Publication date
- 01/01/2010
- Field of study
No full textWaist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- Author
- Cappuccio F. P.
- Lawrence Robert W
- Shengxu Li
- Preuss M.
- J. O. Jansson
- Zhang Q.
- Ridker P.M.
- MacCiardi F. (Fabio)
- P. Elliott
- Assimes Themistocles L.
- Bonnycastle Lori
- Heid I. M.
- Ingelsson E.
- Elosua R.
- Jianjun Liu
- T. Boes
- Boerwinkle Eeric
- Sanna Serena
- Welch R
- Hall A.S. (Alistair)
- Christina Barlassina
- Teslovich Tanya M.
- Boerwinkle E.
- Anneli Pouta
- Huikuri H.V. (Heikki)
- Knowles JW
- Hayes Richard B
- Qi L.
- Hicks Andrew A
- D. J. Hunter
- Palmer L.J.
- James Alan
- Hengstenberg Christian
- Nelis M
- Alibrandi MTS
- Mari Nelis
- Glazer NL
- Blakemore A.I.
- Peters Annette
- A. S. Hall
- A. U. Jackson
- Rafelt S
- Sanders A. R.
- A. T. Hattersley
- Tiinamaija Tuomi
- Smith AV
- Christine Cavalcanti-Proença
- Day I.N.M.
- M. Kaakinen
- Steven A McCarroll
- Kaprio Jaakko
- John Connell
- Antti Jula
- Qi Lu
- Soumya Raychaudhuri
- Preuss Micheal
- Monda Keri L.
- Savolainen M.J. (Markku)
- Perry J.R.
- Thomas A Buchanan
- D. Meyre
- Lawrence Robert W.
- Platou C.P. (Carl)
- S. Kathiresan
- Geus E.J.
- Devin M Absher
- Heid I
- Zhang QY
- Stefansson K
- Willemsen G.A.H.M. (Gonneke)
- Bergman Richard
- Palmer Lyle J.
- O'Donnell CJ
- Frayling Timothy M.
- Wichmann H.E. (Heinz Erich)
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- Jianxin Shi
- Montgomery G.W.
- Biebermann H. (Heike)
- Igl W.
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- Brenda W Penninx
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- A. Hofman
- D. S. Siscovick
- P. M. Ridker
- Ong Ken K.
- Tyrer JP
- Hansen T. (Torben)
- Wiegand S.
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- Uitterlinden A.
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- Jansson John Olov
- Collins Francis S.
- Sinisalo Juha
- J. P. Tyrer
- Weyant R.J. (Robert)
- Valle T. T.
- Niina Pellikka
- Homuth Georg
- Luan Jian'an
- Harris TB
- Allen HL
- T. Meitinger
- Duan J
- Susann Scherag
- Deloukas Panos
- Jarick Ivonne
- Wareham Nicholas J.
- Chanock SJ
- O'Connell J.R.
- K. Estrada
- Laitinen Jaana
- Abecasis GR
- Alibrandi M.T.
- Oostra B.A. (Ben)
- Speliotes EK
- Karpe Fredrik
- Timpson Nicholas J.
- Ludwig B
- Zhao J.H.
- Berndt SI
- S. Ketkar
- Koenig IR
- Lantieri O
- Bouatia-Naji N
- Connell J
- Vitart V
- Erdos M. R.
- M. Lorentzon
- Eelosua R. (Roberto)
- Liang L. (Liming)
- MAGIC
- Hayward C
- R. M. Watanabe
- Blakemore Alexandra I F
- Richard H Myers
- Borecki I.B. (Ingrid)
- Assimes Themistocles L
- Vedantam S
- Gyllensten U. (Ulf)
- Lina Zgaga
- Strachan DP
- GräÃler JÃ1⁄4rgen
- Absher D.M.
- Speliotes E.
- Cappuccio Francesco P
- Glazer N.L.
- Balkau B. (Beverley)
- Nieminen M.S
- Luben Robert N.
- Assimes TL
- Kettunen J
- D. M. Greenawalt
- Publication venue
- Publication date
- 01/01/2010
- Field of study
No full textObesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
- Author
- Steegers Eric AP
- Heinrich J (Joachim)
- Berry Diane J
- Freathy R.M.
- Lyon H.N. (Helen)
- Hypp??nen Elina
- Rivadeneira Ramirez F. (Fernando)
- Shields B.M.
- McCarthy Mark I
- Kerkhof M.
- Beate Glaser
- Anneli Pouta
- Surakka I.
- O'Reilly Paul F
- Palmer L.J.
- Dedoussis G.V. (George)
- Mook-Kanamori D.O. (Dennis)
- Taanila A. (Anja)
- Dedoussis George V
- Elliott Paul
- Leslie A Lange
- Knight B.A.
- Zhao J
- Coin L.J.M.
- Joel N Hirschhorn
- Vincent W V Jaddoe
- Shields Beverley M.
- Coin Lachlan ..J. M.
- Borja J.
- Mirna Kirin
- Bridget A Knight
- Peltonen L
- Uitterlinden Andre G.
- Holly J.M.P.
- Holly J.M.P. (Jeff)
- Postma Dirkje S.
- Marsh Julie A.
- Heinrich J. (Joachim)
- Evans D.
- Groves Christopher J
- Tiesler C. (Carla)
- Dedoussis G.
- the Early Growth Genetics (EGG) Consortium
- Craig E Pennell
- Widen E.
- Hakonarson Hakon
- Borja JB
- Koppelman Gerard H
- Froguel P. (Philippe)
- Heinrich Joachim
- Jarvelin M.
- Davey Smith George
- Willemsen G.A.H.M. (Gonneke)
- Holly Jeff M P
- Palmer Lyle J.
- Grant SFA
- Frayling Timothy M.
- Uitterlinden AG
- Susan M Ring
- Evans DM
- Timpson Nicholas J
- Linda S Adair
- Hofman A.
- David P Strachan
- Sovio U
- Eric A P Steegers
- Marika Kaakinen
- Holly Jeff M. P.
- Jaddoe Vincent W. V.
- Beverley M Shields
- Dedoussis GV
- Hartikainen Anna-Liisa
- Jarvelin Marjo-Riitta
- Surakka Ida
- Davey Smith G.
- Cecilia M Lindgren
- Zhang H
- Nigel W Rayner
- Cornelia M van Duijn
- Kirin Mirna
- de Geus Eco J C
- Pennell C.E.
- Smith GD
- Rivadeneira F
- van Duijn CM
- Lyon H.
- Kanoni S
- Warrington Nicole M.
- Strachan David P.
- Steegers Eric A. P.
- Genetic Investigation of ANthropometric Traits (GIANT) Consortium
- Jaddoe V.
- Maegi Reedik
- Ramasamy A
- Hyppönen E.
- Hyppoenen E
- Borja J.B. (Judith)
- van Duijn C.
- Kanoni S. (Stavroula)
- ? ?
- Diana L Cousminer
- Dedoussis George V.
- Duijn Cornelia
- Borja Judith B
- Matthew W Gillman
- Uitterlinden Andre G
- et al.
- Hakonarson H.
- de Geus EJ
- Hyppoenen Elina
- McCarthy MI
- Chen C.-M.
- Steegers Eric
- Hyppönen E. (Elina)
- Zhao Jianhua
- Hassanali N. (Neelam)
- Tiesler C.
- Power Chris
- Ring Susan M
- St. Pourcain M U B
- Borja J.B.
- Glaser B
- Warrington Nicole M
- Prokopenko Inga
- Pennell C.E. (Craig)
- The Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
- Groves Christopher J.
- de Geus E.
- Freathy Rachel M.
- Lyon HN
- Adair L.S.
- Fernando Rivadeneira
- George Davey Smith
- Freathy R M
- Jaddoe VW
- Kanoni S.
- Hyppönen Elina
- Haitao Zhang
- Jaddoe VWV
- Lyon Helen N
- Nicholas J Timpson
- Wijga AH
- Pennell Craig E
- Coin L.
- Cousminer D.L.
- Gillman M.
- Hartikainen A.-L.
- Bennett A.J. (Amanda)
- Jeff M P Holly
- Dennis O Mook-Kanamori
- Stavroula Kanoni
- Tiesler C
- Paul F O'Reilly
- Kerkhof M. (Marjan)
- Gillman MW
- Gillman M.W. (Matthew W.)
- Ida Surakka
- Chen C.M.
- van Duijn C.M.
- Elina Hyppönen
- Laitinen J
- Knight Bridget A
- Duijn C.M. van
- Coin LJ
- Wijga A.
- Groves C.J.
- Ring S.M.
- Uitterlinden A.G. (André)
- McArdle Wendy L.
- Freathy Rachel M
- Wilson James F
- Laitnen J
- Palmer Lyle J
- Marsh JA
- Mägi R
- Palmer L.
- Shields Beverley M
- Jaddoe Vincent WV
- Power C
- Paul Elliott
- Marsh J.
- Johan G Eriksson
- Rayner N.W.
- Deloukas P.
- Hottenga JJ (Jouke Jan)
- Hottenga J.J.
- Aulchenko Y.S.
- Frayling T.M. (Timothy)
- Kerkhof M
- Lange Leslie A.
- Kerkhof Marjan
- Palmer LJ
- Andre G Uitterlinden
- Anja Taanila
- Rachel M Freathy
- Wellcome Trust Case Control Consortium
- Hirschhorn J.N. (Joel)
- Palmer C. (Cameron)
- Frayling TM
- Rayner Nigel W
- Strachan D.
- Anna-Liisa Hartikainen
- Evans David
- McCarthy M.I.
- Palmer L J
- Jarvelin MR
- Coin Lachlan J. M.
- Adaikalavan Ramasamy
- Eco J C de Geus
- Uitterlinden A.
- van Duijn Cornelia M.
- McArdle W.L. (Wendy)
- Chen C. (Chao)
- Berry D.
- Eriksson J.G.
- Jarvelin M.-R.
- Berry D. (Diane)
- Hakonarson H
- Koppelman Gerard H.
- Coin LJM
- Deloukas Panos
- Cousminer D.L. (Diana)
- Laitinen Jaana
- Tikka-Kleemola P. (Päivi)
- Berry DJ
- Wijga A.H. (Alet)
- Hagen K. (Knut)
- Evans David M
- Wilson James F.
- George V Dedoussis
- Carla Tiesler
- The Wellcome Trust Case Control Consortium (WTCCC)
- Timpson Nicholas J.
- Wijga A.H.
- Smith A.V. (Davey)
- Hofman Albert
- Zhao JH
- Rayner N.W. (Nigel William)
- Nabila Bouatia-Naji
- Bouatia-Naji N
- Hirschhorn Joel N
- Lange Leslie A
- Evans David M.
- Geus E.J.C. de
- Coin Lachlan J M
- Cousminer Diana L
- Charoen P. (Pimphen)
- Strachan D.P. (David)
- Alet H Wijga
- Pouta A. (Anneli)
- Kanoni Stavroula
- Strachan DP
- Widen E. (Elisabeth)
- Koppelman Gerard H.; id_orcid
- Coin Lachlan JM
- Elisabeth Widen
- Elliott P.
- Chen Chih-Mei
- Jonathan P Bradfield
- Steegers-Theunissen R.P.M. (Régine)
- Laitinen J.
- Gillman Matthew W.
- Warrington NM
- M??gi Reedik
- Zhao J.
- Ramasamy A.
- McCarthy M.I. (Mark)
- Jianhua Zhao
- Marjo-Riitta Jarvelin
- Eriksson Johan G
- Aulchenko Y.S. (Yurii)
- Mohlke Karen L
- Evans D.M.
- Kirin M
- Panos Deloukas
- Mägi R.
- Cousminer Diana L.
- Hartikainen A.L.
- Koppelman G.H. (Gerard)
- Knight B.
- Warrington N.
- Dirkje S Postma
- Freathy R.
- Mohlke Karen L.
- Lindgren Cecilia M.
- Hattersley Andrew T.
- Deloukas P
- Kaakinen M
- Strachan David P
- Peltonen L.
- Glaser B.
- Shields B.M. (Beverley)
- Knight BA
- Kaakinen Marika
- Hassanali N.
- Freathy RM
- Chen CM
- Marsh Julie A
- Mohlke K.L.
- Freathy R.M. (Rachel)
- Bennett A.J.
- Bouatia-Naji Nabila
- Chen C-M
- O'Reily PF
- Hofman Bert
- Prokopenko I. (Inga)
- Rayner Nigel W.
- de Geus Eco JC
- Taanila Anja
- Bennett Amanda J
- Hartikainen A.
- Eriksson Johan G.
- Heinrich J.
- Leena Peltonen
- Dorret I Boomsma
- Chen C.
- Ramasamy Adaikalavan
- Andrew T Hattersley
- Rayner N.
- Adair L.
- Boomsma D.I. (Dorret)
- McArdle W L
- Lange LA
- Hartikainen AL
- Hottenga J.J. (Jouke Jan)
- Bradfield J.P. (Jonathan)
- Taanila A
- Berry D.J.
- Charoen Pimphen
- Uitterlinden André
- Steegers EA
- Mohlke K.L. (Karen)
- Pouta Anneli
- Lindgren Cecilia M
- Inga Prokopenko
- Mägi R. (Reedik)
- Chih-Mei Chen
- Maegi R
- Sovio U. (Ulla)
- Eriksson JG
- Gillman M.W.
- Smith G.D.
- Surakka I. (Ida)
- Hyppönen E
- Helen N Lyon
- Timothy M Frayling
- Steegers Eric A P
- Grant S.F.A.
- Frayling T.
- Diane J Berry
- Eriksson J.
- Lange L.
- Power C.
- Grant Struan F A
- Rivadeneira Fernando
- Elliott P. (Paul)
- Jan Hottenga J.
- Zhang H. (Haitao)
- Hattersley A.T.
- Kirin M. (Mirna)
- Grant S.F.A. (Struan)
- Willemsen Gonneke
- Zhang Haitao
- Wilson J.F.
- Jarvelin M-R
- Karen L Mohlke
- Knight Bridget A.
- Nicole M Warrington
- Mook-Kanamori DO
- Jarvelin M.-R. (Marjo-Riitta)
- The Genetic Investigation of ANthropometric Traits (GIANT) Consortium
- Coin L. (Lachlan)
- Marsh J.A.
- Mook-Kanamori Dennis O.
- Peltonen Leena
- Adair LS
- Warrington N.M.
- Pouta A.
- de Geus E.J.C.; id_orcid
- Widen Elisabeth
- Lyle J Palmer
- Glaser Beate
- Steegers E.A.P.
- Pennell Craig E.
- Lindgren C.M. (Cecilia)
- Heinrich J
- Gonneke Willemsen
- Christopher J Groves
- Mook-Kanamori D.
- Warrington N.M. (Nicole)
- Hassanali Neelam
- Ramasamy A. (Adaikalavan)
- Julie A Marsh
- Davey Smith G
- Adair L.S. (Linda)
- James F Wilson
- Lyon Helen N.
- Hakonarson H. (Hakon)
- Wilson James F; id_orcid
- Mook-Kanamor Dennis O.
- Kerhof M
- O'Reilly P.F.
- Hassanali N
- Cousminer DL
- Dedoussis G.V.
- Jaddoe Vincent W V
- Grant Struan F. A.
- McCarthy Mark I.
- Neelam Hassanali
- Frayling Timothy M
- Charoen P
- Willemsen G
- Borja Judith B.
- Boomsma D.I.; id_orcid
- Bradfield J.P.
- Ring S.
- Struan F A Grant
- Timpson NJ
- O'Reilly Paul F.
- Boomsma Dorret I
- Holly J.
- Hottenga JJ
- Grant S.
- Cousminer D.
- Pennell CE
- Aulchenko Yurii S.
- Boomsma D.
- Strachan D.P.
- Knight B.A. (Bridget)
- de Geus E.J.C.
- Bradfield JP
- Willemsen G.; id_orcid
- Prokopenko I
- Uitterlinden André; id_orcid
- Postma Dirkje S
- Surakka I
- Early Growth Genetics (EGG) Consortium
- Zhang H.
- Aulchenko Y.
- Yurii S Aulchenko
- Ring SM
- Rivadeneira F.
- Hottenga J.
- Bradfield Jonathan P
- Holly JM
- Pouta A
- Genetic Investigation of ANthropometric Traits (GIANT) Consortiu
- Peltonen L. (Leena Johanna)
- McCarthy M.
- Hattersley Andrew T
- Gillman Matthew W
- Hattersley A.T. (Andrew)
- Smith George Davey
- Postma D.S.
- Holly JMP
- Boomsma Dorret I.
- Hirschhorn J.N.
- McArdle W.L.
- Lange L.A. (Leslie)
- Reedik Mägi
- Prokopenko I.
- Bouatia-Naji N. (Nabila)
- Jaana Laitinen
- Charoen P.
- Hofman A. (Albert)
- Hattersley AT
- Adair Linda S.
- Mägi Reedik
- Sovio U.
- Zhao J.H. (Jing Hua)
- Groves C.
- Mook-Kanamori D.O.
- Kaakinen M.
- Albert Hofman
- Elliott P
- Amanda J Bennett
- Koppelman G.
- Mohlke K.
- Mook-Kanamori Dennis O
- Evans D.M. (David)
- Hakon Hakonarson
- Jaddoe V.W.V. (Vincent)
- Geus E.J.C. (Eco) de
- Koppelman GH
- Timpson N.
- Groves CJ
- Boomsma DI
- Bennett Amanda J.
- Lyon H.N.
- Grant SF
- Hattersley A.
- Mohlke KL
- McArdle Wendy L
- Pennell C.
- Steegers E.
- Grant Struan FA
- David M Evans
- Kirin M.
- Jaddoe Vincent
- Zhang HT
- Aulchenko YS
- Uitterlinden A.G.
- Hottenga Jouke Jan
- Philippe Froguel
- Koppelman G.H.
- Hirschhorn J.
- Jaddoe V.W.V.
- Rayner NW
- McArdle WL
- Power C. (Christopher)
- Steegers EAP
- Holly Jeff MP
- McArdle W.
- Hartikainen A-L
- Tiesler Carla
- Hirschhorn Joel N.
- Willemsen G.
- O'Reilly P.F. (Paul)
- Lindgren C.M.
- Bennett AJ
- Lindgren CM
- Groves C.J. (Christopher)
- Lange L.A.
- Boomsma D.I.
- Ulla Sovio
- De Geus EJC
- Bennett A.
- Hofman A
- Bradfield Jonathan P.
- Wilson JF
- Wijga Alet H.
- Postma D.
- Sovio Ulla
- Shields B.
- Kerkhof Marjon
- Aulchenko Yurii S
- Laitinen J. (Jaana)
- Frayling T.M.
- Froguel Philippe
- Bouatia-Naji N.
- Ring S.M. (Susan)
- de Geus Eco J. C.
- Ring Susan M.
- Lindgren C.
- Marsh J.A. (Julie)
- Widen E
- Bradfield J.
- Wilson J.
- Mook Dennis
- O'Reilly PF
- Joachim Heinrich
- Postma DS
- Chris Power
- Lachlan J M Coin
- Taanila A.
- Jouke Jan Hottenga
- Pimphen Charoen
- Adair Linda S
- Postma D.S. (Dirkje)
- Shields BM
- Timpson N.J. (Nicholas)
- Hirschhorn JN
- Wilson J.F. (James)
- Glaser B. (Beate)
- van Duijn Cornelia M
- Marjan Kerkhof
- Wendy L McArdle
- Kaakinen M. (Marika)
- Deloukas P. (Panagiotis)
- Wijga Alet H
- Froguel P.
- Timpson N.J.
- Judith B Borja
- Gerard H Koppelman
- Berry Diane J.
- O'Reilly P.
- Meta-Analyses of Glucose and Insulin-related traits Consortium
- Froguel P
- Publication venue
- Publication date
- 01/01/2010
- Field of study
No full textTo identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy
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