91 research outputs found
Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor
No full textThe X-ray crystallographic structure of Torpedo californica acetylcholinesterase (TcAChE) in complex with the bifunctional inhibitor NF595, a potentially new anti-Alzheimer drug, has been solved. For the first time in TcAChE, a major conformational change in the peripheral-site tryptophan residue is observed upon complexation. The observed conformational flexibility highlights the dynamic nature of protein structures and is of importance for structure-based drug design. Copyright © 2006 American Chemical Society
L'Iconographie de la cathédrale disparue de Cambrai
No full textJ. Thiebaut, Iconography of the lost cathedral of Cambrai.
The Cambrai cathedral, destroyed under the Directory and the Empire, was one of the most important monuments of Northern France. The author, also author of a Ph. D thesis on this subject, draws here the conclusion of his research on the iconography of the cathedral. Documents already known for a long time had not been sufficiently studied ; but, first and foremost, the author succeeded in adding to the body of the known documents some new-found pieces which allowed him to make new hypotheses as to the interior disposition of the monument. Those new-found sketches were drawn under the Empire, at a time when one thought of the transforming the steeple into a monument dedicated to Fénelon ; the demolishing of the monument was then quite advanced.Thiébaut Jacques. L'Iconographie de la cathédrale disparue de Cambrai. In: Revue du Nord, tome 58, n°230, Juillet-septembre 1976. pp. 406-433
Influence of nutrient, pH and dissolved oxygen on the production of Metarhizium flavoviride Mf189 blastospores in submerged batch culture
No full textCorresponding author. fax: +33-3-8069-3229.E-mail address: [email protected] (A. Durand).International audienceThe influence of different parameters on the sporulation of Metarhizium flavoviride was studied during submerged cultures in shake flasks and in 5 l bioreactors. The screening in shake flasks of several carbon and nitrogen sources allowed the definition of an optimal medium, based on sucrose and brewer’s yeast with a C/N ratio of 1.6. With this medium, a production of 5.4 _ 108 blastospores per ml (Bspores ml_1) was obtained after 169 h of cultivation. The influence of pH and pO2 was independently studied in 5 l working volume bioreactors using the optimal medium. The best production was obtained with pH and pO2 regulated respectively to 7 and 100%. Finally, when the culture was grown under optimized conditions, the blastospores concentration increased 16-fold, with 1.1 109 Bspores ml-1 obtained after 144 h cultivation. This represents a gain of productivity of about 4.8 time
Socialization of Providencia stuartii Enables Resistance to Environmental Insults
No full textProvidencia stuartii is a highly social pathogen responsible for nosocomial chronic urinary tract infections. The bacterium indeed forms floating communities of cells (FCC) besides and prior-to canonical surface-attached biofilms (SAB). Within P. stuartii FCC, cells are riveted one to another owing to by self-interactions between its porins, viz. Omp-Pst1 and Omp-Pst2. In pathophysiological conditions, P. stuartii is principally exposed to high concentrations of urea, ammonia, bicarbonate, creatinine and to large variations of pH, questioning how these environmental cues affect socialization, and whether formation of SAB and FCC protects cells against those. Results from our investigations indicate that FCC and SAB can both form in the urinary tract, endowing cells with increased resistance and fitness. They additionally show that while Omp-Pst1 is the main gateway allowing penetration of urea, bicarbonate and ammonia into the periplasm, expression of Omp-Pst2 enables resistance to them
Towards an Emotionally Conscious Social Theory
No full textThis article attempts to contribute to the on-going discussion regarding the 'future of sociology and social theory' by suggesting that classical and contemporary social theories have yet to provide satisfactory accounts of the emotional components of human society. Following a discussion of how emotions have been downplayed in classical and contemporary theory, evidence is presented in support of a sociology that would include the study of emotions as part of broader studies of the social. A central proposition of this article is that the harmonization of studies of 'micro' and 'macro' realities would facilitate the development of a systems theory that neither excludes diversity nor minimizes the immutable emotional needs of individuals and their social systems. In support of the above argument, the author presents some new evidence pointing to the primacy of the human emotions across cultural boundaries.Social Theory, Sociology of Emotions, Self, Identity, Micro, Macro, Postmodernism.
Induced‐fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure‐based drug design
No full textThe sense of a beginning : Bakhtinian dialogic criticism on 'the gospel' in Mark.
No full textContemporary literary approaches have caused paradigm shifts in Biblical Studies in the last two decades as it appears in a great deal of Markan studies using narrative, reader-response, deconstructive, feminist, and new historicist approaches. However, literary studies on the Gospel of Mark have not taken into account theoretical questions underlying those approaches. As a result biblical critics are driven by new trends without ever having a chance to examine the critical baggage of the approaches. Consequently, there is a gap of communication between the old and the new one. Therefore this thesis is an attempt to meet the need of enhancing the quality of critical endeavour in biblical studies. In the light of most recent competing critical theories of literature, the first contribution of this thesis is the methodological finding that Bakhtinian dialogic criticism contains the most profound philosophical and practical foundations for solving some crucial theoretical problems in contemporary literary theories. It is a critique to a Saussurian linguistic system of language which becomes the very foundation of modern and postmodern literary criticism. Bakhtinian literary theory shifts the foundation of literary criticism on linguistic signs into the creative activity of the socio-cultural production of human communication. The shift into socio-cultural reality of language communication makes the notion of 'genre' very important to unlock the problem of text and context in literary studies. Since the Gospel of Mark has fascinated most literary critics in Biblical Studies, the problem of 'genre' of this gospel is chosen as the focus of this study. Secondly, as no agreement is reached as to what 'genre' the Gospel of Mark belongs, this thesis makes its contribution to the discussion by locating the problem of 'genre' of Mark in the context of genre theories and argues that the Bakhtinian suggestion to find genre in the socio-cultural sphere by analysing artistic intercourse between narrative agents in Mark has freed the competing analysis from the unresolved problem between the kerygmatic (content oriented) approach and the analogical (form oriented) approach. To achieve finding 'genre' in the socio-cultural sphere, this thesis focuses on Bakhtinian analysis of the process of artistic intercourse between narrative agents. The narrative communicative interrelationships between narrative agents is constructed in this thesis as a 'stereophonic' Bakhtinian model of dialogic communication. This model is an original contribution of this thesis for revising the traditional two dimensional model of narrative communication. Based on this dialogical model of communication, a special role is given to the Bakhtinian 'author-creator' in the realization process of genre through the interaction of polyphonic voices. Through the interaction of voices of the author-artist and the hero we are led to discover a relatively stable type of portraying and controlling reality in Mark, known as the genre of Roman 'satire'. The closest literary affinity is Satyrica by Petronius. This narrative strategy of 'satire' in Mark has its root in the prophetic discourse of the Old Testament which is saturating the speech of the narrator, John the Immerser, the centurion, the people, and even Jesus. Finally, the whole search for Markan 'genre' culminates in the analysis of the realization of genre through the analysis of Bakhtinian chronotope. The reality of the genre of Mark is its social reality that is in its role as dpxrj/ 'beginning'. As the Gospel of Mark proclaims itself as 'a beginning', it defines its claim of socio-cultural 'authority' in early Christianity. It is this 'sense of beginning' which enables the narrating and the narrated world of Mark to interact dialogically
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
No full textThe QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD
Reinardus 2
No full textItems include are:Jean Batany, Renart au XVe siècle: une réécriture du Livre des Bêtes de Raymond Lulle par Jean Juvénal des Ursins; Roger Bellon, L'art du remaniement. Les aventures de Primaut le loup dans les mss A et C; Issachar Ben-Ami, Le monde sacré et animal: contenu et message; Anne Cobby, The Fabliau of Le Prestre et le Chevalier: aspects of illumination and reflection; Jean Lacroix, Du Je à l'Autre ou: Le pacte autobiographique de la fable des animaux-qui-parlent: Rainaldo e Lesengrino; Brian Levy, Leading a merry dance: Le rondel des fabliaux; Marie-Thérèse Lorcin, Les revenants dans les fabliaux; Gianni Mombello, Un Recueil anonyme (Ph.-B. Moreau de Mauour?); Jean-Marc Pastré, Zoomorphisme et typologie littéraire: le personnage de Kunin dans le Reinhart Fuchs; Jacques Ribard, Et si les fabliaux n'etaient pas des contes à rire?; Luigi Sasso, La questione del genere nel Detto del gatto lupesco; Alain-Julien Surdel, Divertissement pascal et latinité médiévale. L'Ecbasis cuiusdam captivi per tropologiam; Patrice Uhl, Notes sur le Lignage du Limeçons armés dans les Fatrasies d'Arras; Erwin Verzandvoort, The Dutch Chapbooks of Reynaert de Vos and their Illustrations; Isabelle Weill, La Parodie de l'énonciation épique dans le Roman de Renart; Haijo J. Westra, The speech of animals in the Ysengrimus and the subversion of a Christian hierarchy of discourse; Charity Cannon Willard, Le bon chien Souillard; Book Review; Illustrations. See for the T of C: http://www.hull.ac.uk/Hull/FR_Web/content2.html.Language note: Bilingual: English/FrenchEdited by Brian Levy & Paul Wacker
Art and the artist in the literary works of Elsa Triolet
No full textThis thesis takes a representative selection of Triolet's works to study the themes of writing and creativity as they are presented in the novels. These are all portraits of artists and the accounts of the search for a synthesis of aesthetic freedom and ethical responsibility. It considers Triolet's importance as a foreign writer, adopting a new creative language to be adopted by a different cultural
environment, to be essential in understanding her importance to the French literary tradition. By emphasising her formative years in the avant-garde circles of prerevolutionary Russia, my study demonstrates her considerable contribution to the meeting of Russian and French aesthetic theories. I extend this with close textual
readings of certain works to demonstrate her techniques in novelistic construction which reveal many Formalist practices before Formalist works in translation made
their official influence on creative methods.
The introduction considers the reasons for Triolet's neglect as a writer. It then considers various contemporary and recent critical appraisals which indicate
the interest she has received until present and which allow me to define my own critical approach. Part One traces Triolet's literary evolution from her formative
years in Russia, through exile to her first publications in Russian. It then considers her insertion into French literary activity, and her association with the schools of
socialist realism and the "nouveau roman".
Part Two examines two traditional novels which portray the creative and metaphorical roles of the artist and his work, showing the constant conflict between private and public lives. In Part Three, I show how aspects of novelistic
traditionalism are gradually foregrounded so that the work develops a dual-sided character where it both narrates and examines the processes of its own narration. In Part Four, this move to highly self-conscious aesthetics demonstrates an idiosyncratic exploration of new paths for the novel that bring visual, auditive and cinematographic media into the traditional domain of written art. Accompanying
the very post-modernist experimentation, I show how this research within the novel into the novel's own future has an ethical and redemptive purpose whose final conclusion is that creativity and human freedom are inexorably interwoven
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