37,984 research outputs found
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
No full textCheetham and colleagues show that 3D retinal organoids lacking the RP2 protein develop rod photoreceptor degeneration that can be prevented with AAV gene augmentation for RP2
Charge ordering in manganates
No full textSeveral compounds are known to exhibit magnetoresistance, a change in electrical resistivity in the presence of magnetic field. Such materials are of interest both for technology and basic science. In their perspective, Rao and Cheetham discuss recent results on magnetoresistance in rare-earth manganate materials, which exhibit especially interesting fundamental physical phenomena
A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone
No full textLetters to the EditorC N Hahn, D M Ross, J Feng, A Beligaswatte, D K Hiwase, W T Parker, M Ho, M Zawitkowski, K L Ambler, G D Cheetham, Y K Lee, M Babic, C M Butcher, G A Engler, A L Brown, R J D'Andrea, I D Lewis, A W Schreiber, L B To and H S Scot
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
A density functional study of the high-pressure chemistry of MSiN2(M = Be,Mg, Ca)
No full textNormal pressure modifications and tentative high-pressure phases of the nitridosilicates MSiN2 with M = Be, Mg, or Ca have been thoroughly studied by density functional methods. At ambient pressure, BeSiN2 and MgSiN2 exhibit an ordered wurtzite variant derived from idealized filled β-cristobalite by a C1-type distortion. At ambient pressure, the structure of CaSiN2 can also be derived from idealized filled β-cristobalite by a different type of distortion (D1-type). Energy–volume calculations for all three compounds reveal transition into an NaCl superstructure under pressure, affording sixfold coordination for Si. At 76 GPa BeSiN2 forms an LiFeO2-type structure, corresponding to the stable ambient-pressure modification of LiFeO2, while MgSiN2 and CaSiN2 adopt an LiFeO2-type structure, corresponding to a metastable modification (24 and 60 GPa, respectively). For both BeSiN2 and CaSiN2 intermediate phases appear (for BeSiN2 a chalcopyrite-type structure and for CaSiN2 a CaGeN2-type structure). These two tetragonal intermediate structures are closely related, differing mainly in their c/a ratio. As a consequence, chalcopyrite-type structures exhibit tetrahedral coordination for both cations (M and Si), whereas in CaGeN2-type structures one cation is tetrahedrally (Si) and one bisdisphenoidally (M) coordinated. Both structure types, chalcopyrite and CaGeN2, can also be derived from idealized filled β-cristobalite through a B1-type distortion. The group–subgroup relation of the BeSiN2/MgSiN2, the CaSiN2, the chalcopyrite, the CaGeN2 and the idealized filled β-cristobalite structure is discussed and the displacive phase transformation pathways are illustrated. The zero-pressure bulk moduli were calculated for all phases and have been found to be comparable to compounds such as α- Si3N4, CaIrO3 and Al4C3. Furthermore, the thermodynamic stability of BeSiN2, MgSiN2 and CaSiN2 against phase agglomerates of the binary nitrides M3N2 and Si3N4 under pressure are examined
Giant magnetoresistance in transition metal oxides
No full textSome materials exhibit large changes in electrical resistance in the presence of a magnetic field, and this change can be used in applications from sensor technology to magnetic data storage. In their perspective, Rao and Cheetham discuss magnetoresistance in perovskite manganates, where the effect is unusually strong. Much has been learned about these materials, and this understanding is driving the search for new materials with even more impressive properties
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Correction to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19
No full textCorrection to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19. International Journal of Telerehabilitation, 13(1). https://doi.org/10.5195/ijt.2021.6371
The affiliation for each author was incorrectly stated as: Physical Medicine & Rehabilitation, Children’s Minnesota, Minneapolis, Minnesota, USA
The correct affiliation for each author is: Clinical Therapies, Nationwide Children’s Hospital, Columbus, Ohio, USA
The metadata for the original article has been corrected
Nanomaterials Chemistry: Recent Developments and New Directions
No full textRao CNR, Müller A, Cheetham AK, eds. Nanomaterials Chemistry: Recent Developments and New Directions. Weinheim: Wiley-VCH; 2007
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