73,928 research outputs found
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Letter from Carl Hayden to M. J. Riordan
No full textLetter from Carl Hayden to M. J. Riordan expressing his support for Coconino County in turning over the Bright Angel Trail to the federal government
Models for landslides induced by precipitation in Norway
No full textThis work summarizes the preliminary results of a post doc
project between University of Calabria and Norwegian
Geotechnical Institute (NGI). The topic is the development of
an integrated modeling to forecast rainfall fields and triggering
mechanisms of landslides. The activities are organized in three
research lines: (1) analysis and modeling of rainfall fields; (2)
development of a modeling for landslide initiation; (3)
integration between rainfall forecasting and landslide initiation
models.
The preliminary results reported in this paper are related to
the second research line, which comprises: a) development of a
physically and DEM based model at regional scale for
triggering of landslides; b) integration with
empirical/hydrological models for early warning purposes.
Concerning the former activity, the study area, formed or
not by different soil layers, has to be represented by a threedimensional
grid of cells; the study of the effects induced by
precipitation on slope stability has to be performed by using
models of infiltration and runoff generation, coupled with a
global stability analysis.
The basic idea of this second activity is to test the
feasibility of establishing relations between the results of
empirical approaches, and the output of physically based
models
Letter from M. J. Riordan, Arizona Lumber and Timber Company, to Carl Hayden
No full textLetter from M. J. Riordan to Carl Hayden expressing his opposition to the federal government's takeover of Bright Angel Trail
Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays
No full textThis Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within
expectations from the Standard Model
Implementation and optimization of the synthesis of dimeric peptides derived from the LfcinB sequence (20-30) with potential anticancer activity against breast cancer Inglés
No full textilustraciones, diagramasEl cáncer de mama es el tipo de neoplasia más diagnosticada en el mundo y la primera causa de muerte en mujeres, por lo cual es imperativo encontrar nuevos medicamentos que permitan combatir esta enfermedad de una manera eficiente y selectiva. La secuencia dimérica LfcinB (20-30)2: (RRWQWRMKKLG)2-K-Ahx ha demostrado ser promisoria en el desarrollo de nuevos agentes terapéuticos, ya que ejerce un potente efecto citotóxico in vitro contra líneas celulares derivadas de cáncer de mama. En esta investigación se sintetizaron, purificaron y caracterizaron once nuevos péptidos diméricos análogos a la secuencia LfcinB (20-30)2, en los cuales la posición central 26Met, fue reemplazada por diferentes aminoácidos, . Para cada péptido se evaluó su efecto citotóxico en las líneas celulares derivadas de cáncer de mama HTB-132 y/o MCF-7, encontrando que la posición 26 es un residuo crítico, ya que aumentar la hidrofobicidad de este, potencia significativamente el efecto citotóxico contra las líneas de cáncer. Los péptidos que presentaron mayor actividad fueron 26[F] LfcinB (20-30)2: (RRWQWRFKKLG)2-K-Ahx y 26[1-Nal] LfcinB (20-30)2: (RRWQWR-1-Nal-KKLG)2-K-Ahx. Estos péptidos análogos tuvieron valores de IC50 menores a 20 μM en las líneas MCF-7 y/o HTB-132, presentaron selectividad in vitro frente a eritrocitos y baja toxicidad en los modelos in vivo G. Mellonella y murino. Adicionalmente, generaron un tipo de muerte celular que involucra eventos de apoptosis extrínseca e intrínseca y no afectaron significativamente la membrana citoplasmática. Finalmente, se logró optimizar y escalar la síntesis del péptido 26[F] LfcinB
(20-30)2 hasta obtener 1.8 g, con el fin de contribuir al inicio de estudios que permitan el comienzo de fases preclínicas de esta molécula, ya que nuestros resultados sugieren que es una secuencia peptídica promisoria para el futuro desarrollo de medicamentos contra el cáncer de mama al igual que 26[1-Nal] LfcinB (20-30)2. (Texto tomado de la fuente)Breast cancer is the most diagnosed type of neoplasia in the world and the first cause of death in women, for which it is imperative to find new drugs that allow us to combat this disease in an efficient and selective manner. The dimeric sequence LfcinB (20-30)2: (RRWQWRMKKLG)2-K-Ahx has shown promise in the development of new therapeutic agents, as it exerts a powerful cytotoxic effect in vitro against cell lines derived from breast cancer. In this research, 11 new dimeric peptides analogous to the LfcinB (20-30)2 were synthesized, purified and characterized, in which the central position 26Met was replaced by amino acids of different chemical natures. For each peptide, its cytotoxic effect was evaluated in cell lines derived from breast cancer HTB-132 and/or MCF-7, finding that 26Met is a critical residue, since increasing its hydrophobicity significantly enhances the cytotoxic effect against cancer lines. The most potent peptides were 26[F] LfcinB (20-30)2: (RRWQWRFKKLG)2-K-Ahx and 26[1-Nal] LfcinB (20-30)2: (RRWQWR-1-Nal-KKLG)2 -K-Ahx. These analogous peptides had IC50 values lower than 20 μM in the MCF-7 and/or HTB-132 lines, they showed in vitro selectivity against erythrocytes and low toxicity in the in vivo G. Mellonella and murine models. Additionally, they generated a type of cell death involving extrinsic and intrinsic apoptotic events and did not significantly affect the cytoplasmic membrane. Finally, it was possible to optimize and scale the synthesis of the peptide 26[F] LfcinB (20-30)2 up to 1.8 g, in order to contribute to the start of studies that allow the start of preclinical phases of this molecule, since our Results suggest that it is a promising peptide sequence for the future development of drugs against breast cancer, such as 26[1-Nal] LfcinB (20-30)2.MinCiencias RC. No. 706-2018Dirección Académica - Universidad Nacional de Colombia (Beca Asistente Docente)Grupo de Investigación Síntesis y Aplicación de Moléculas PeptídicasDoctoradoDoctor en Ciencias - QuímicaMétodo científicoPéptidos Anticancerígeno
Author Correction: Establishment and equilibrium levels of deleterious mutations in large populations (Scientific Reports, (2019), 9, 1, (10384), 10.1038/s41598-019-46803-7)
No full textThe original version of this Article contained errors. Affiliations 1 and 2 were reversed. Secondly, Affiliation 7 was incorrectly given as ‘Institute for Cellular and Molecular Medicine, Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, 0084, South Africa’. Thirdly, an affiliation was omitted for the author Michael S. Pepper, which is now listed as Affiliation 8. Fourthly, Affiliation 1 was omitted for the author Johan W. Viljoen. Finally, Augustinus J. van Zyl was incorrectly affiliated with ‘Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo’, Trieste, Italy.’ The correct author affiliations are listed below: Affiliation 1: Department of Electrical, Electronic and Computer Engineering, EBIT, University of Pretoria, Pretoria 0028, South Africa Johan W. Viljoen and J. Pieter de Villiers Affiliation 2: Development, Research and Technology Department, Hensoldt Optronics, Centu..
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
SCXRD dataset for "Cerium(iii) and 5-methylisophthalate-based MOFs with slow relaxation of magnetization and photoluminescence emission"
No full textDataset del artículo Pajuelo-Corral, Oier; Contreras, M. C.; Rojas, Sara; Choquesillo-Lazarte, Duane CSIC ORCID; Seco, José M.; Rodríguez-Diéguez, Antonio; Salinas-Castillo, Alfonso; Cepeda, Javier; Zabala-Lekuona, Andoni; Vitórica-Yrezábal, Iñigo J. Cerium(iii) and 5-methylisophthalate-based MOFs with slow relaxation of magnetization and photoluminescence emission. Dalton Transactions 53: 11750-11761 (2024)This work was supported by the Gobierno Vasco/Eusko Jaurlaritza (IT1755-22, IT1500-22), Red Guipuzcoana de Ciencia, Tecnología e Innovación (FA385/2023, DG23/16) and Junta de Andalucía (FQM-394, P21_00386 and ProyExcel_00386). The authors acknowledge the technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). S. R. thanks Ministerio de Ciencia e Innovación for a Ramón y Cajal contract (the publication is part of the grant RYC2021-032522-I funded by MCIN/AEI/10.13039/501100011033 and the European Union “Next Generation-EU”/PRTR”).Peer reviewe
J. M. Coetzee in Context and Theory
No full textNobel Laureate and the first author to win the Booker Prize twice, J.M. Coetzee is perhaps the world's leading living novelist writing in English. Including an international roster of world leading critics and novelists, and drawing on new research, this innovative book analyses the whole range of Coetzee's work, from his most recent novels through his memoirs and critical writing. It offers a range of perspectives on his relationship with the historical, political, cultural and social context of South Africa. It also contextualises Coetzee's work in relation to his literary influences, colonial and post-colonial history, the Holocaust and colonial genocides, the 'politics' and meaning of the Nobel prize in South Africa and Coetzee's very public move from South Africa to Australia. Including a major unpublished essay by leading South African novelist André Brink, this book offers the most up-to-date study of Coetzee's work currently available.Intro -- Contents -- Acknowledgements -- Biographies -- Introduction -- Part I: Context -- 1. Post-Apartheid Literature: A Personal View -- 2. Elizabeth Costello as Post-Apartheid Text -- 3. Coetzee and Gordimer -- 4. Wordsworth and the Recollection of South Africa -- 5. Border Crossings: Self and Text -- 6. Sex, Comedy and Influence: Coetzee's Beckett -- Part II: Theory -- 7. Writing Desire Responsibly -- 8. Literature, History and Folly -- 9. Queer Bodies -- 10. Eating (Dis)Order: From Metaphoric Cannibalism to Cannibalistic Metaphors -- 11. Acts of Mourning -- 12. Sublime Abjection -- 13. Authenticity: Diaries, Chronicles, Records as Index-Simulations -- 14. Disrupting Inauthentic Readings: Coetzee's Strategies -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- YNobel Laureate and the first author to win the Booker Prize twice, J.M. Coetzee is perhaps the world's leading living novelist writing in English. Including an international roster of world leading critics and novelists, and drawing on new research, this innovative book analyses the whole range of Coetzee's work, from his most recent novels through his memoirs and critical writing. It offers a range of perspectives on his relationship with the historical, political, cultural and social context of South Africa. It also contextualises Coetzee's work in relation to his literary influences, colonial and post-colonial history, the Holocaust and colonial genocides, the 'politics' and meaning of the Nobel prize in South Africa and Coetzee's very public move from South Africa to Australia. Including a major unpublished essay by leading South African novelist André Brink, this book offers the most up-to-date study of Coetzee's work currently available.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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