53,345 research outputs found
“In dem Ozean vergessener Opfer die Spur einer jungen Frau zu finden". Memorie transculturali in "Sie kam aus Mariupol" di Natascha Wodin
No full textIn "Veniva da Mariupol" (Sie kam aus Mariupol, 2017) l’autrice/narratrice, nata in Germania da genitori di origine ucraina, si mette sulle tracce della madre, deportata in Germania come Zwangsarbeiterin. Ne emerge un impressionante e oscuro panorama del XX secolo. La giovane donna assiste alla caduta della sua famiglia aristocratica – nella quale ci sono anche antenati italiani – nel terrore stalinista, e nel 1944 arriva con il marito per il lavoro coatto in Germania, dove dopo la fine della guerra sarà una “displaced person”. Nella sua ricerca Wodin mostra come il passato e la storia, in una dimensione individuale che si fa collettiva, possano essere recuperati attraverso la narrazione da chi non è stato testimone e quali spazi di memoria transnazionali si configurino in questi drammatici movimenti da est a ovest. In questo modo si pone anche l’importante questione della natura delle dinamiche nazionali e transnazionali che possono impedire la competizione delle vittime attraverso memorie collegate: né per relativizzare la memoria della Shoah, né per banalizzare le ferite storiche di altri gruppi di vittime trascurati o rimossi dalla storia ufficiale
Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation
No full textCsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by transient ischaemia; this is believed to reflect inhibition of CyP-D, a mitochondrial isoform that facilitates formation of the permeability transition pore in the mitochondrial inner membrane. To evaluate this further, we have targeted CsA to mitochondria so that it becomes selective for CyP-D in cells. This was achieved by conjugating the inhibitor to the lipophilic triphenylphosphonium cation, enabling its accumulation in mitochondria due to the inner membrane potential. In a cell-free system and in B50 neuroblastoma cells the novel reagent (but not CsA itself) preferentially inhibited CyP-D over extramitochondrial CyP-A. In hippocampal neurons, mitochondrial targeting markedly enhanced the capacity of CsA to prevent cell necrosis brought about by oxygen and glucose deprivation, but largely abolished its capacity to inhibit glutamate-induced cell death. It is concluded that CyP-D has a major pathogenic role in ‘energy failure’, but not in glutamate excitotoxicity, where cytoprotection primarily reflects CsA interaction with extramitochondrial CyPs and calcineurin. Moreover, the therapeutic potential of CsA against ischaemia/reperfusion injuries not involving glutamate may be improved by mitochondrial targeting
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Letter from C. D. Dawson, Tusayan Copper Mining and Smelting, to Carl Hayden
No full textLetter from C. D. Dawson to Carl Hayden urging him to consider the rights of miners and farmers when drawing up the boundaries for the proposed park
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
No full textThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
D* (D)over-bar* molecule interpretation of Z(c)(4025)
No full textWe have used QCD sum rules to study the newly observed charged state Z(c)(4025) as a hidden-charm D*(D) over bar* molecular state with the quantum numbers I-G(J(P)) =1(+)(1(+)). Using a D*(D) over bar* molecular interpolating current, we have calculated the two-point correlation function and the spectral density up to dimension eight at leading order in alpha(s). The extracted mass is m(X) = (4.04 +/- 0.24) GeV. This result is compatible with the observed mass of Z(c)(4025) within the errors, which implies a possible molecule interpretation of this new resonance. We also predict the mass of the corresponding hidden-bottom B*(B) over bar* molecular state: m(Zb) = (9.98 +/- 0.21) GeV.Physics, Particles & FieldsSCI(E)[email protected]; [email protected]; [email protected]; [email protected]
Prompt charm production in pp collisions at √<span style="text-decoration:overline">s</span>=7 TeV
No full textCharm production at the LHC in pp collisions at s√=7 TeV is studied with the LHCb detector. The decays D0→K−π+, D+→K−π+π+, D⁎+→D0(K−π+)π+, D+s→ϕ(K−K+)π+, Λ+c→pK−π+, and their charge conjugates are analysed in a data set corresponding to an integrated luminosity of 15 nb−1. Differential cross-sections dσ/dpT are measured for prompt production of the five charmed hadron species in bins of transverse momentum and rapidity in the region 0<pT<8 GeV/c and 2.0<y<4.5. Theoretical predictions are compared to the measured differential cross-sections. The integrated cross-sections of the charm hadrons are computed in the above pT-y range, and their ratios are reported. A combination of the five integrated cross-section measurements gives
σ(cc¯)pT<8 GeV/c,2.0<y<4.5=1419±12(stat)±116(syst)±65(frag) μb,
where the uncertainties are statistical, systematic, and due to the fragmentation functions
Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function
No full textChronic cocaine use leads to pronounced alterations in neuronal functions in brain circuits associated with reward. In the present study, we examined in the rat midbrain the effects of acute, subchronic (5 days) and chronic cocaine treatments (14 days) on the gene expression of transcription factors involved in the development and maintenance of dopaminergic neurons. We show that chronic, but not acute or subchronic, cocaine administration downregulates Nurr1 and Pitx3 transcripts whereas En1 transcripts are upregulated. Conversely, Lmx1b and En2 transcripts are not affected by the drug treatment, indicating that the modulation of the midbrain transcription factors analyzed is highly selective. Interestingly, modification of the gene expression for these transcription factors persists in midbrain as long as two weeks after the last drug administration, suggesting that it may account for some of the enduring alterations in midbrain dopaminergic circuits associated with chronic cocaine us
Balance between excitation and inhibition controls the temporal organization of neuronal avalanches
No full textNeuronal avalanches, measured in vitro and in vivo, exhibit a robust critical behavior. Their temporal
organization hides the presence of correlations. Here we present experimental measurements of the
waiting time distribution between successive avalanches in the rat cortex in vitro. This exhibits a
nonmonotonic behavior not usually found in other natural processes. Numerical simulations provide
evidence that this behavior is a consequence of the alternation between states of high and low activity,
named up and down states, leading to a balance between excitation and inhibition controlled by a single
parameter. During these periods, both the single neuron state and the network excitability level, keeping
memory of past activity, are tuned by homeostatic mechanisms
Z(c)(3900) as a (D)over-barD* molecule from the pole counting rule
No full textA comprehensive study on the nature of the Zc(3900) resonant structure is carried out in this work. By constructing the pertinent effective Lagrangians and considering the important final-state-interaction effects, we first give a unified description to all the relevant experimental data available, including the J/psi pi and pi invariant mass distributions from the e(+)e(-) -> J/psi pi process, the h(c)pi distribution from e(+)e(-) -> h(c)pi pi, and also the D (D) over bar* spectrum in the e(+)e(-) -> D (D) over bar*pi process. After fitting the unknown parameters to the previous data, we search the pole in the complex energy plane and find only one pole in the nearby energy region in different Riemann sheets. Therefore, we conclude that Z(c)(3900) is of D (D) over bar* molecular nature, according to the pole counting rule method [Nucl. Phys. A543, 632 (1992); Phys. Rev. D 35, 1633 (1987)]. We emphasize that the conclusion based upon the pole counting method is not trivial, since both the D (D) over bar* contact interactions and the explicit Z(c) exchanges are introduced in our analyses andNational Nature Science Foundations of China (NSFC) [10925522, 11021092, 11575052, 11105038]; Natural Science Foundation of Hebei Province [A2015205205]; inoGerman Collaborative Research Center "Symmetries and the Emergence of Structure in QCD" [CRC 110]; DFG; NSFCSCI(E)ARTICLE119
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