6,847 research outputs found
Integration and analysis of protein-protein and signalling networks to create graph dynamical systems
No full textUnderstanding networks of biological interactions is essential to all life sciences. Nowadays, a large amount of biological information is archived in diverse resources that often contain complementary information. Scientists have to search various data repositories in order to reconstruct, understand and speculate on the steps that lead to specific phenomena. The amount of digitalised interaction data has grown to such an extent that it is now advisable to integrate different kinds of data through computational means. Bioinformatics can offer tools and strategies to manipulate such information automatically. In order to address the need of integrating and retrieving structured protein interaction data, I implemented a new resource called mentha, which merges the data archived in different repositories in order to assemble large networks of protein interactions. This resource has low data redundancy and it assigns a reliability score to each interaction. mentha can be seen as a workbench to assemble custom protein-protein interaction networks. Furthermore, I contributed to the development of a new resource that archives manually curated signalling information. I investigated the possibility of exploiting the information contained in mentha to assemble signalling networks. I analysed strategies to automatically link proteins of interest with other relevant proteins in order to create a backbone to build graph dynamical systems that can represent biological signalling networks. I conclude that manually curated signalling information can be integrated with information inferred from interactomes where signal direction can be predicted using orientation algorithms, while signal effect can be derived from RNA interference screenings. Finally, I analysed the resulting biological models as graph dynamical systems. I transformed the topology of a signed oriented biological network into transition boolean functions and, using boolean formalism, I analysed dynamical networks to simulate biological behaviours
[Poesia] Três poemas de Alberto Secama
No full textThree poems by Alberto Secama. About the author: Alberto Secama is an Angolan poet who has poems published on many websites and on facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secamaTres poemas de Alberto Secama. Sobre el autor: Alberto Secama es un poeta angoleño que tiene poemas publicados en varios sitios y en el facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secamaTrês poemas de Alberto Secama. Sobre o autor: Alberto Secama é um poeta angolano que possui poemas publicados em vários sites e no facebook:https://www.facebook.com/Xungurra/abouthttp://www.pordentrodaafrica.com/cultura/africa-em-verso-rio-kwanza-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/africa-em-verso-zong-por-alberto-secamahttp://www.pordentrodaafrica.com/cultura/coluna-africa-em-verso-o-sol-la-fora-por-alberto-secam
A Wikipedia Based Map of Science
No full text15th January 2020 - A Map of Science. v. 1.0 Description:A network which shows the similarities among different branches of science. It's based on Wikipedia pages in outline of natural, formal, social and applied sciences plus Data Science, which is not yet included (18 Jan. 2020). All pages called "Outline of X" were ignored. Pages are pre processed to get the main content with regular expressions. Stop words removal, lemmatization with WordNetLemmatizer in NLTK. Edges represent cosine similarity and filtered calculating zscore leaving only edges with a zscore > 1.959964 . Isolated nodes were removed.Materials:R, python, igraph, nltk, d3, javascript, html, wikipedia Contact:Alberto Calderone - [email protected]:http://www.sinnefa.com/wikipediasciencemap/</div
Orizzonti mantovani. Spunti e dinamiche paesaggistiche ne L'Illustrissimo di Alberto Cantoni
No full textIn the literary production of Alberto Cantoni, short story writer and novelist between the nineteenth and twentieth centuries, the novel L'Illustrissimo is highly important both because it is the last publication of the author, from Pomponesco, a small town a few kilometers south of Mantua, both because it summarizes in a single text the different nuances and different directions that his writing has taken over the course of his literary career, also due to a writing and processing time that embraces the entire span of years of his career itself. In the foreground, in addition to the numerous and brilliant characters, one of the protagonists is the Mantuan landscape which, not a simple background, becomes a true literary parameter which in different and significant ways affects the purposes and mechanisms of the novel
mentha: a resource for browsing integrated protein-interaction networks
No full textAbout mentha
mentha archives evidence collected from different sources and presents these data in a complete and comprehensive way. Its data comes from manually curated protein-protein interaction databases that have adhered to the IMEx consortium. The aggregated data forms an interactome which includes many organisms. mentha is a resource that offers a series of tools to analyse selected proteins in the context of a network of interactions. Protein interaction databases archive protein-protein interaction (PPI) information from published articles. However, no database alone has sufficient literature coverage to offer a complete resource to investigate "the interactome".
mentha's approach generates every week a consistent interactome (graph). Most importantly, the procedure assigns to each interaction a reliability score that takes into account all the supporting evidence. mentha offers eight interactomes (Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli K12, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae) plus a global netowrk that comprises every organism, including those not mentioned. The website and the graphical application are designed to make the data stored in mentha accessible and analysable to all users
Plenary Session: Luis Alberto Urrea
No full texta) Plenary Session: Luis Alberto Urrea, Mexican American Chicago Writer
Luis Alberto Urrea is a 2005 Pulitzer Prize finalist for non-fiction and member of the Latino Literature Hall of Fame. He is a prolific and acclaimed writer who has used his dual-culture life border experiences to explore the complex and interconnected Mexican-US American reality. The critically acclaimed and best-selling Mexican-born author of 13 books, Urrea has won numerous awards for his poetry, fiction and essays.
Moderator: Dr. Héctor García, Loyola University Chicag
O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em LiteraturaA pretensão desta dissertação intitulada O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes é investigar a relação entre o sentir e o puro pensar, usando como referência a poesia O Guardador de Rebanhos, de Alberto Caeiro, que apresenta de forma evidente o tema; e como este assunto é tratado nas Meditações Metafísicas de René Descartes, também de forma claramente visível. Podemos perceber em ambos os autores, uma diplopia, uma espécie de duplo olhar sobre a relação sentir e puro pensar. No primeiro capítulo vou falar sobre a tese do duplo olhar de Descartes, a respeito da relação sentir e puro pensar na leitura de Merleau-Ponty, salientando a visão de natureza. No segundo capítulo, parto da leitura das três primeiras Meditações Metafísicas para caracterizar a tensão que se pode verificar entre Descartes e Alberto Caeiro quando se referem ao puro pensar. O foco principal de Descartes, nas três primeiras Meditações, é o pensar puro, e neste ponto Alberto Caeiro critica o pensar puro. No terceiro capítulo, analisando as três últimas Meditações, percebe-se que há uma virada no pensamento de Descartes, no qual o autor inverte seu ponto de vista, aproximando-se da idéia de Alberto Caeiro. No quarto capítulo, mostrarei a leitura que outros autores fazem acerca do sentir e do pensar na obra de Alberto Caeiro, mostrando que assim como Descartes, este também ostenta uma diplopia, não do sentir, mas do pensar. The pretension of this work entitled O duplo significado do sentir e do pensar nas obras de Alberto Caeiro e Descartes is to investigate the relationship between the feeling and the pure thinking, using as reference the poetry O Guardador de Rebanhos, by Alberto Caeiro, that presents in an evident way this theme; and as this subject is treated in René Descartes' Metaphysical Meditations, also in a clearly visible way. It is possible to notice in both authors, the diplopy, a sort of double look about the relationship between feeling and pure thinking. The thesis about Descartes'double look regarding the relation of feeling and pure thinking, in Merleau-Ponty reading, pointing out the nature vision, will be treated in the first chapter. In the second chapter, I start from the reading of the first three Metaphysical Meditations to characterize the tension that can be verified between Descartes and Alberto Caeiro when they refer to the pure thinking. Descartes' main focus in the first three Meditations is pure thinking and, in this point, Alberto Caeiro criticizes pure thinking. In the third chapter, analyzing the last three Meditations, it is possible to notice that there is an alteration in Descartes' thought, in which the author inverts his point of view, approaching of Alberto Caeiro's idea. In the fourth chapter, I will show the reading that other authors do concerning feeling and thinking in Alberto Caeiro's work, showing that as well as Descartes, this also shows a diplopy, not of feeling, but of thinking
Suplemento Especial La Corte Suprema: 160 años de Jurisprudencia (número completo)
No full textContenido: La Corte Suprema: 160 años de jurisprudencia / Bautista Cañón ; Sofía Calderone.-- “De primera mano”: una conversación con Rodolfo C. Barra / Bautista Cañón ; Sofía Calderone.-- La Corte Suprema desde la mirada de una jurista: un diálogo con María Angélica Gelli / Bautista Cañón ;Sofía Calderone.-- En los pasillos del cuarto piso: una conversación con Pablo G. Hirschmann / Bautista Cañón ;Sofía Calderone.-- De la Corte Suprema a las aulas: una conversación con Santiago Legarre / Bautista Cañón ;Sofía Calderone.-- En los detalles: la Corte Suprema bajo la lupa de Estela B. Sacristán / Bautista Cañón ;Sofía Calderone.-- De cara a la historia: una entrevista con Alfonso Santiago en los 160 años de la Corte Suprema / Bautista Cañón ;Sofía Calderone.-- Semblanza de los primeros jueces de la Corte Suprema /Alberto B. Bianchi.-- La primera sentencia de nuestra Corte Suprema y sus protagonistas / Enrique del Carril.-- El origen del control judicial de constitucionalidad en la Argentina / Manuel José García-Mansilla.-- Nacimiento de la competencia originaria por la materia, /Alberto F. Garay.-- Un legado en tomos: la publicidad de sentencias de la Corte
Suprema de Justicia de la Nación ayer y hoy / Florencia Ratti Mendaña ; Sofía Calderone.-- En disidencia. Historia del voto en soledad en la Corte Suprema / Jerónimo Lau Alberdi.-
Lobbying for change as a new theory and practice of active citizenship: author interview with Alberto Alemanno
No full textDo you believe that lobbying is a vehicle for representing the interests of some rather than all, meaning its actors can never be a force for good? Alberto Alemanno, author of Lobbying for Change: Find Your Voice to Create a Better Society, might convince you of the contrary. This interview with Barbara Aubin, LSE Public Affairs, reflects on the importance of engaging with our political representatives, holding them accountable and lobbying for the causes we deeply care about as fundamental elements of a healthy democracy
Bibliografia di Umberto Romagnoli
No full textA complete bibliography of Umberto Romagnoli writings, introduced by a few lines by editors of the Journal and completed by an essay by Alberto Mattei dealing with some technical aspects of the collection of the
bibliography interwoven with some scholarly life moments of the author
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