52,437 research outputs found
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Pedro Bosch Gimpera
No full textThis article presents an intellectual profile of Pedro Bosch Gimpera. It reviews his academic training, the social and intellectual environment in which he grew up, his role in the institutionalization of Catalan archaeology, his theoretical outlook, and his long-term influence even after his exile.Este artículo presenta un perfil intelectual de Pedro Bosch Gimpera. Revisa su formación académica, el ambiente social e intelectual en el que se desarrolló, su papel en la institucionalización de la arqueología catalana, su perspectiva teórica y su influencia a largo plazo incluso tras su exilio
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Urinary porphyrin excretion in hepatitis C infection
No full textA high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive outpatients with chronic hepatitis C infection without signs of photosensitivity, using an ion-pair high performance liquid chromatography method. Increased total porphyrin excretion was found in 41 patients, with predominant excretion of coproporphyrins (whole study group: mean 146 mu g/g creatinine, interquartile range 76-186; normal <150), in 10 patients excretion exceeded 300 mu g/g creatinine. In the majority of all patients studied (75/100) an increased ratio of the relatively hydrophobic coproporphyrin isomer I to isomer III was found. In just one case, urinary porphyrin pattern characteristic for chronic hepatic porphyria was present (uroporphyrin > coproporphyrin, heptacarboxyporphyrin III increased) but the total porphyrin excretion was only slightly elevated in this case. In the whole group, total urinary porphyrin excretion correlated well with serum bilirubin and was inversely correlated with albumin and thrombin time. In conclusion, secondary coproporphyrinuria occurs frequently in heptatitis C infection, whereas in Germany, preclinical porphyria cutanea tarda seems to be rare in these patients
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No full textWe thank Kumar and colleagues for their interest in our new algorithm for risk-stratification in candidates to secondary prophylaxis of variceal bleeding. In this algorithm, patients that bleed without other manifestations of hepatic decompensation are classified as low-risk without measuring the hepatic venous pressure gradient (HVPG). Using our new algorithm, a large number of invasive and costly HVPG measurements can be saved. More importantly, the number of high-risk patients who did not rebleed during follow-up (the "grey zone") decreased from 43% to 23%, demonstrating great accuracy in selecting high-risk patients
Ambient temperature and prevalence of obesity in the Spanish population. [email protected] study
No full textValdés, S., Maldonado-Araque, C., García-Torres, F., Goday, A., Bosch-Comas, A., Bordiú, E., Calle-Pascual, A., Carmena, R., Casamitjana, R., Castaño, L., Castell, C., Catalá, M., Delgado, E., Franch, J., Gaztambide, S., Girbés, J., Gomis, R., Gutiérrez, G., López-Alba, A., Martínez-Larrad, M., Menéndez, E., Mora-Peces, I., Ortega, E., Pascual-Manich, G., Serrano-Rios, M., Urrutia, I., Vázquez, J.A., Vendrell, J., Soriguer, F., Rojo-Martínez, G
Onsite advanced biocleaning system for historical wall paintings using new agar-gauze bacteria gel
No full textAims This study reports the results of the application of a new agar-gauze biogel system activated with viable bacterial cells to altered wall paintings. Methods and Results Biocleaning using agar biogel and agar-gauze biogel systems was performed onsite by direct application to altered wall painting surfaces (25-1000 cm(2)). The treatments were performed for the restoration of two original Italian sites: (i) at the Vatican Museums, Cristo che salva Pietro dalle acque-La Navicella, a wall painting by Giovanni Lanfranco (1627-1628) and (ii) at Pisa Cathedral Cupola, Incarnato, a wall painting by Orazio Riminaldi (1593-1630) and his brother Girolamo Riminaldi. The novelty of this study is the use of viable Pseudomonas stutzeri A29 cells in an advanced agar-gauze biogel system and the short bio-application contact times of between 3 and 12 h. The historical artworks were altered by lipid and protein residues from past restoration, as confirmed by Py-gas chromatography-mass spectrometry and FT-IR data. The effectiveness of the biological treatment was assessed, and general considerations were discussed. Conclusions The short bio-application contact time of advanced agar-gauze gel activated with viable P. stutzeri cells makes this biotechnology promising as an alternative method to the traditional onsite cleaning techniques currently in use for altered historical wall paintings. Significance and Impact of the Study In this study, we report for the first time the biocleaning of altered materials located in vertical and vaulted areas using agar-gauze biogel with short application times. These findings are of great significance for future restoration activities and are crucial for determining the best preservation strategies in this field
Ramón Menéndez Fidai, Historia de España, t. II : España Romana (218 a. de J.-C.-414 de J.-C), avec la collaboration de P. Bosch Gimpera, P. Aguado Bleye, Manuel Torres, José M. Pabón, Pascual Galindo, José Ramón Mélida, José Ferrandis, Pedro G. de Artiñando, 1935
No full textSeston W. Ramón Menéndez Fidai, Historia de España, t. II : España Romana (218 a. de J.-C.-414 de J.-C), avec la collaboration de P. Bosch Gimpera, P. Aguado Bleye, Manuel Torres, José M. Pabón, Pascual Galindo, José Ramón Mélida, José Ferrandis, Pedro G. de Artiñando, 1935. In: Revue des Études Anciennes. Tome 39, 1937, n°1. pp. 74-77
Ramón Menéndez Fidai, Historia de España, t. II : España Romana (218 a. de J.-C.-414 de J.-C), avec la collaboration de P. Bosch Gimpera, P. Aguado Bleye, Manuel Torres, José M. Pabón, Pascual Galindo, José Ramón Mélida, José Ferrandis, Pedro G. de Artiñando, 1935
No full textSeston W. Ramón Menéndez Fidai, Historia de España, t. II : España Romana (218 a. de J.-C.-414 de J.-C), avec la collaboration de P. Bosch Gimpera, P. Aguado Bleye, Manuel Torres, José M. Pabón, Pascual Galindo, José Ramón Mélida, José Ferrandis, Pedro G. de Artiñando, 1935. In: Revue des Études Anciennes. Tome 39, 1937, n°1. pp. 74-77
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