69,641 research outputs found
Tachyglossus setosus Illig., Tasmania, ca. 1805 [picture] /
No full textTitle devised by cataloguer based on inscription.; Inscriptions: "Tachyglossus setosus Illig. Huet ad nat pinx. J.C. Bock sc."--Printed below image; "LXIII. c."--Printed top right.; Condition: Yellowing, edge tears.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn4771044; Purchased from Cabinet of Discoveries, ACT, 2010
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Dynamic ligand binding of dualsteric (allosteric/orthosteric) molecular probes controls the graded activation of muscarinic acetylcholine receptors
No full textWe investigated a class of bitopic (dualsteric) ligands of the M2 acetylcholine muscarinic receptor (M2AChR), i.e. compounds whose pharmacophoric groups are able to target the orthosteric as well as the allosteric binding site of the receptor.1,2 These model derivatives are composed of an allosteric fragment, an intermediate linker and an orthosteric moiety. As an example, ligands 1 and 2 incorporate the molecular portion of the allosteric compound Naphmethonium and the potent muscarinic agonist Iperoxo, which are connected by a flexible or a rigidified spacer group, respectively (Figure 1). These bipharmacophoric molecular probes were found to switch between two different binding orientations, resulting in both active and inactive populations of receptors bound by a given ligand, a behavior that has been termed dynamic ligand binding.3
Figure 1
In this study, pharmacological data analysis and computational simulations based on active and inactive M2AChR crystal structures led to identify two distinct binding topographies in a group of dualsteric partial agonists. One binding mode, which resembled that of the co-crystallized orthosteric ligand Iperoxo, engendered an agonist response. Conversely, dualsteric ligands binding to the allosteric site only showed a receptor-complex comparable to that of allosteric modulators. Thus, the observed agonist efficacies depended on the fraction of dualsteric (i.e. active) vs. purely allosteric (i.e. inactive) binding modes.4
References
1. Antony, J.; Kellershon, K.; Mohr-Andrä, M.; Kebig, A.; Prilla, S.; Muth, M.; Heller, E.; Disingrini, T.; Dallanoce, C.; Bertoni, S.; Schrobang, J.; Tränkle, C.; Kostenis, E.; Christopoulos, A.; Höltje, H.-D.; Barocelli, E.; De Amici, M.; Holzgrabe, U.; Mohr, K. FASEB J. 2009, 23, 442-450.
2. Bock, A.; Merten, N.; Schrage, R.; Dallanoce, C.; Bätz, J.; Klöckner, J.; Schmitz, J.; Matera, C.; Simon, K.; Kebig, A.; Peters, L.; Müller, A.; Schrobang-Ley, J.; Tränkle, C.; Hoffmann, C.; De Amici, M.; Holzgrabe, U.; Kostenis, E.; Mohr; K. Nat. Commun. 2012, 3:1044, doi: 10.1038/ncomms2028.
3. Bock, A.; Chirinda, B.; Krebs, F.; Messerer, R.; Bätz, J.; Muth, M.; Dallanoce, C.; Klingenthal, D.; Tränkle, C.; Hoffmann, C.; De Amici, M.; Holzgrabe, U.; Kostenis, E.; Mohr, K. Nat. Chem. Biol. 2014, 10, 18-20.
4. Bock, A.; Bermudez, M.; Krebs, F.; Matera, C.; Chirinda, B.; Sydow, D.; Dallanoce, C.; Holzgrabe, H.; De Amici, M.; Lohse, M.; Wolber, G.; Mohr, K. J. Biol. Chem., in press
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays
No full textThis Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within
expectations from the Standard Model
Increasing plurality and neglected pluralism. Religious diversity in the suburbs of Rome
No full textThe chapter offers an interpretation of the social and political constraints that affect the way religious diversity is addressed and prevented from blossoming into a pluralistic shared frame in Italy. We move from the renewed attention devoted to the 'spatialization of religion’ with the aim of presenting a contextualized understanding of ‘lived religious diversity’ in the urban space of Rome and critical reading of the normative – cultural and political – responses that are emerging around this phenomenon. Drawing on the data collected within the research project NEW2US at the University of Rome Tor Vergata, the analysis shows how, although attracted to a space – Rome –that is ideally generous towards the expression of ‘the religious’, recently established minorities struggle to carve out living spaces for themselves, and mostly remain segregated along the city’s margins. The ethnography that has been undertaken within the south-east area of Tor Sapienza digs into the deep and fatal intertwinement between radical alterity, marginality, and social tensions in order to give a possible explanation as to why in the Italian case religious pluralism is not yet entirely legitimated to consolidate as a means of action in the social and political sphere. Multiple religious perspectives are there to stay and their visibility is more and more evident. What is still lacking is a shared significance of that pluralism. Although in Rome it is a rather new phenomenon, the cases discussed in this chapter show that religious pluralism is conceived under a mainly religious/secularist dichotomy, either as a loosely knit pattern of competing revelations or as the sheer fragmented survival of a lost enchanted world
Letter from J. E. Gavin to Louis C. Cramton regarding Sale of Bright Angel Trail
No full textLetter from J. E. Gavin to Louis C. Cramton regarding the Bright Angel Trail controversy, including newspaper clipping
Stable isotopic methane (δ¹³CH4) records of ice core TALDICE
No full textd13CH4 data are measured using the system described in:
Schmitt, J., B. Seth, M. Bock, H. Fischer, "Online technique for isotope and mixing ratios of CH4, N2O, Xe and mixing ratios of organic trace gases on a single ice core sample", Atmospheric Measurement Techniques, 7/8, 2645-2665, 2014, doi:10.5194/amt-7-2645-2014
All data are free of krypton interference during the mass spectrometric analysis. For details see:
Schmitt, J., B. Seth, M. Bock, C. van der Veen, L. Möller, C. J. Sapart, M. Prokopiou, T. Sowers, T. Röckmann, H. Fischer, "On the interference of Kr during carbon isotope analysis of methane using continuous-flow combustion-isotope ratio mass spectrometry", Atmospheric Measurement Techniques, 6/1, 1425-1445, 2013, doi:10.5194/amt-6-1425-201
Stable isotopic methane (δ¹³CH4) records of ice core Vostok
No full textd13CH4 data are measured using the system described in:
Schmitt, J., B. Seth, M. Bock, H. Fischer, "Online technique for isotope and mixing ratios of CH4, N2O, Xe and mixing ratios of organic trace gases on a single ice core sample", Atmospheric Measurement Techniques, 7/8, 2645-2665, 2014, doi:10.5194/amt-7-2645-2014
All data are free of krypton interference during the mass spectrometric analysis. For details see:
Schmitt, J., B. Seth, M. Bock, C. van der Veen, L. Möller, C. J. Sapart, M. Prokopiou, T. Sowers, T. Röckmann, H. Fischer, "On the interference of Kr during carbon isotope analysis of methane using continuous-flow combustion-isotope ratio mass spectrometry", Atmospheric Measurement Techniques, 6/1, 1425-1445, 2013, doi:10.5194/amt-6-1425-201
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