87,800 research outputs found
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Supplemental material for Informing efficient pilot development of animal trauma models through quality improvement strategies
No full textSupplemental material for Informing efficient pilot development of animal trauma models through quality improvement strategies by Penny S Reynolds, Jacquelyn McCarter, Christopher Sweeney, Bassem M Mohammed, Donald F. Brophy, Bernard Fisher, Erika J Martin and Ramesh Natarajan in Laboratory Animals</p
The amyloid precursor protein is a conserved Wnt receptor
No full textThe Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be. We show that APP binds the Wnt ligands Wnt3a and Wnt5a and that this binding regulates APP protein levels. Wnt3a binding promotes full-length APP (flAPP) recycling and stability. In contrast, Wnt5a promotes APP targeting to lysosomal compartments and reduces flAPP levels. A conserved Cysteine-Rich Domain (CRD) in the extracellular portion of APP is required for Wnt binding, and deletion of the CRD abrogates the effects of Wnts on flAPP levels and trafficking. Finally, loss of APP results in increased axonal and reduced dendritic growth of mouse embryonic primary cortical neurons. This phenotype can be cell-autonomously rescued by full length, but not CRD-deleted, APP and regulated by Wnt ligands in a CRD-dependent manner.sponsorship: China Scholarship Council Tengyuan Liu Hersenstichting HS 2011(1)-46 Lee Fradkin Lebanese National Council for Scientific Research Maya Nicolas Vlaams Instituut voor Biotechnologie Bart De Strooper Bassem A Hassan Fondation Roger de Spoelberch 1911001IN Bassem A Hassan Agence Nationale de la Recherche ANR-10-IAIHU-06 Marie-Claude Potier Bassem A Hassan Fonds Wetenschappelijk Onderzoek G.0543.08 Bassem A Hassan Neuron-Glia Foundation 2003009NA Bassem A Hassan KU Leuven Methusalem Bart De Strooper Bassem A Hassan Nederlandse Organisatie voor Wetenschappelijk Onderzoek 40-00812-98-10058 Lee Fradkin Fonds Wetenschappelijk Onderzoek G.0680.10 Bassem A Hassan Fonds Wetenschappelijk On-G.0681.10 Bassem A Hassan derzoek Fonds Wetenschappelijk Onderzoek G.0503.12 Bassem A Hassan Agence Nationale de la Recherche ANR-11-INBS-0011-NeurATRIS Marie-Claude Potier Bassem A Hassan Agence Nationale de la Recherche ANR-12-MALZ-0004 Marie-Claude Potier Bassem A Hassan The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. (China Scholarship Council, Hersenstichting|HS 2011(1)-46, Lebanese National Council for Scientific Research, Vlaams Instituut voor Biotechnologie, Fondation Roger de Spoelberch|1911001IN, Agence Nationale de la Recherche|ANR-10-IAIHU-06, Agence Nationale de la Recherche|ANR-11-INBS-0011-NeurATRIS, Agence Nationale de la Recherche|ANR-12-MALZ-0004 Marie-Claude, Fonds Wetenschappelijk Onderzoek|G.0543.08, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Neuron-Glia Foundation|2003009NA, KU Leuven, Nederlandse Organisatie voor Wetenschappelijk Onderzoek|40-00812-98-10058, Medical Research Council|UKDRI-1004)status: Publishe
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
C3H7NO2S effect on concrete steel-rebar corrosion in 0.5 M H2SO4 simulating industrial/microbial environment
No full textThis paper investigates C3H7NO2S (Cysteine) effect on the inhibition of reinforcing steel corrosion in concrete immersed in 0.5 M H2SO4, for simulating industrial/microbial environment. Different C3H7NO2S concentrations were admixed, in duplicates, in steel-reinforced concrete samples that were partially immersed in the acidic sulphate environment. Electrochemical monitoring techniques of open circuit potential, as per ASTM C876-91 R99, and corrosion rate, by linear polarization resistance, were then employed for studying anticorrosion effect in steel-reinforced concrete samples by the organic hydrocarbon admixture. Analyses of electrochemical test-data followed ASTM G16-95 R04 prescriptions including probability distribution modeling with significant testing by Kolmogorov-Smirnov and student's t-tests statistics. Results established that all datasets of corrosion potential distributed like the Normal, the Gumbel and the Weibull distributions but that only the Weibull model described all the corrosion rate datasets in the study, as per the Kolmogorov-Smirnov test-statistics. Results of the student's t-test showed that differences of corrosion test-data between duplicated samples with the same C3H7NO2S concentrations were not statistically significant. These results indicated that 0.06878 M C3H7NO2S exhibited optimal inhibition efficiency η = 90.52±1.29% on reinforcing steel corrosion in the concrete samples immersed in 0.5 M H2SO4, simulating industrial/microbial service-environment
Biological responses of white sea bream (Diplodus sargus, Linnaeus 1758) and sardine (Sardine pilchardus, Walbaum 1792) exposed to heavy metal contaminated water
No full textThe aim of the present work was to assess, by rapid approach, the detoxification capacity and the genotoxicity caused by exposure of
some marine fish to polluted waters. The fish species selected for the study: White sea bream (Diplodus sargus, Linnaeus 1758) and
sardine (Sardine pilchardus, Walbaum 1792) were collected from different sites of Alexandria, El-Max bay and Bahary, in Egypt. Results
of heavy metals analysis in sediment were: Al>Fe>Cr>Pb>Hg>Cd. Concerning detoxification analysis, fish collected from El-Max bay
encounter the highest liver enzyme activity of Glutathione S-Transferase. Also, genotoxicity was evaluated in liver, gills and muscle of fishes
collected and the results indicated that fish collected from El-Max bay has the highest levels of comets (DNA damage) when compared
to the other sites selected as reference. It can be concluded from our results that the different tissues examined have alteration of level
of detossification and comets as result of different degree of oxidative pollution insult. These biological responses may be considered for
rapid extimation of food oxidative damage as well as for environmental quality
Role of effective microorganisms on hematological and biochemical indices of cultured Oreochromis niloticus exposed to lead, copper, and cadmium under temperature variations
No full textThe freshwater environment suffers from a combination of stressors; pollution and global warming. Multiple effects of
copper sulfate, cadmium chloride, and lead nitrate Pb were studied on Nile tilapia under three
temperatures ranges, compared to bioremediation using effective microorganisms (EMs). The fish were divided into
eight groups, with each group exposed to three temperatures (24, 28, and 32°C). Water physicochemical parameters were
measured, and fish hematological, physiological, and biochemical changes were considered. Water quality parameters
revealed a significant increase in both electrical conductivity and total dissolved solids in the EM/Cu fish group in the
Cu fish group at 32°C. The chemical oxygen demand levels indicated a remarkable fluctuation with a slight decrease in
the control group (at 28°C) while reduced in the control and EM. The results were highly significant incomplete blood
cells, total red blood cell count, hemoglobin concentration (Hb), hematocrit, mean corpuscular Hb, mean corpuscular
Hb concentration, and total protein (g/dl) in the EM group and control group. It can be concluded that using EM in fish
farms (1:1000) could help fish adapt to different temperatures and reduce the effects of toxic pollutants
Author Correction: A global analysis of terrestrial plant litter dynamics in non-perennial waterways
No full text© 2018 The Author(s) In the version of this Article originally published, the affiliation for M. I. Arce was incorrect; it should have been:5Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Berlin, Germany. This has now been corrected in the online versions of the Article
Studies on Thermal Reactions and Sintering Behaviour of Red Clays by Irreversible Dilatometry
No full textThermal behavior of clays strongly influences that of ceramic bodies made thereof and hence, its study is must for assessing its utility in ceramic products as well as to set the body composition. Irreversible dilatometry is an effective thermal analysis tool for evaluating thermal reactions as well as sintering behavior of clays or clay based ceramic bodies. In this study, irreversible dilatometry of four red clay samples (S, M, R and G) of Gujarat region, which vary in their chemical and mineralogical compositions was carried out using a Dilatometer and compared. Chemical analysis and XRD of red clays were carried out. XRD showed that major clay minerals in S, M and R clays are kaolinite. However, clay marked R and G showed presence of both kaolinite and illite and / muscovite. Presence of non-clay minerals such as hematite, quartz, anatase were also observed in all clays. XRD results were in agreement with chemical analyses results. Rational analyses showed variation in amount of clay and non-clay minerals in red clay samples. Evaluation of dilatometric curves showed that clay marked as S, M and R exhibit patterns typical for kaolinitic clays. Variation in linear expansion (up to 550 degrees C) and shrinkage (above 550 degrees C) between these three clays was found to be related to difference in amount of quartz and kaolinite respectively. However, dilatometric curve of G exhibit a pattern similar to that for an illitic clay. This study confirmed that sintering of investigated kaolinitic and illitic and / muscovitic red clays initiates at above 1060 degrees C and 860 degrees C respectively and this behaviour strongly depends upon type and amount of minerals and their chemical compositions
Measurement of the CP-violating phase \phi s in Bs->J/\psi\pi+\pi- decays
No full textMeasurement of the mixing-induced CP-violating phase phi_s in Bs decays is of prime importance in probing new physics. Here 7421 +/- 105 signal events from the dominantly CP-odd final state J/\psi pi+ pi- are selected in 1/fb of pp collision data collected at sqrt{s} = 7 TeV with the LHCb detector. A time-dependent fit to the data yields a value of phi_s=-0.019^{+0.173+0.004}_{-0.174-0.003} rad, consistent with the Standard Model expectation. No evidence of direct CP violation is found
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