546 research outputs found
Die konfokale Laserscan-Mikroskopie Merkmale der gesunden und psoriatischen Haut und Veränderungen der psoriatischen Haut unter einem modifizierten Goeckerman-Therapieregime
No full textfindings in normal and psoriatic skin and changes of psoriatic skin structure during a modified Goeckerman therapy regimen
No full textEinleitung: Psoriasis ist eine rezidivierende chronisch-entzündliche
Erkrankung der Haut, die mit einer deutlichen Beeinträchtigung der
Lebensqualität betroffener Patienten einhergeht. Den typisch veränderten
Kapillarschlingen der papillären Dermis in psoriatischer Haut wird eine
wichtige Rolle bei der Entstehung und Unterhaltung psoriatischer Hautläsionen
zugeschrieben. Diese Veränderungen der Hautgefäße werden durch die gesteigerte
Sekretion proangiogenetischer Faktoren aus den aktivierten Basalzellen, welche
die vergrößerten dermalen Papillen in psoriatischer Haut umgeben,
hervorgerufen. Es existieren keine Biomarker für ein standardisiertes
Monitoring der Psoriasis. Klinische Scores, die breite Anwendung im klinischen
Alltag und in klinischen Studien finden, sind sehr uneinheitlich und zeigen
große Schwächen bezüglich ihrer Validität. Material und Methoden: Mithilfe der
konfokalen Laserscan-Mikroskopie (CLSM) wurden die Strukturen der
Kapillarschlingen und der dermalen Papillen bei 5 gesunden Probanden mit denen
bei 13 Psoriasispatienten verglichen. Außerdem wurden psoriatische
Hautläsionen von 11 Patienten vor und nach einem modifizierten Goeckerman-
Therapieschema mithilfe der CLSM untersucht. Der klinische Hautzustand wurde
mit Hilfe von Psoriasis Area and Severity Index (PASI) dokumentiert, in
regelmäßigen Abständen wurde nach Therapieende der von den Patienten
ermittelte self-administered PASI erhoben. Ergebnisse: Die Hautkapillaren und
die dermalen Papillen waren signifikant erweitert in der psoriatischen Haut
(Kapillardurchmesser 24.3±2.3 µm, Papillendurchmesser 146.46±28.52 µm) im
Vergleich zur gesunden Haut (Kapillardurchmesser 9.5±1.8 µm,
Papillendurchmesser 69.4±17.1 µm). Im Laufe eines modifizierten Goeckerman-
Therapieschemas konnte eine prozentuale PASI Reduktion von 30 bis 90,4 %, eine
17 - 53.7-prozentige Reduktion der Kapillardurchmesser und eine 13.1 -
44.2-prozentige Reduktion der Papillendurchmesser gemessen werden.
Kapillardurchmesser und Papillendurchmesser am Ende der Therapie waren
signifikant höher als die Kapillardurchmesser und Papillendurchmesser in
gesunder Haut. Kapillar- und Papillendurchmesser korrelierten miteinander vor
(r= 0.63, p=0.014) und nach Therapie (r= 0.64, p=0.002). PASI-Werte waren
weitgehend unabhängig vom Kapillar- und Papillendurchmesser. Die klinische
Besserung (Reduktion PASI in %) korrelierte am besten mit der prozentualen
Reduktion des Papillendurchmessers (r= 0.63, p=0.03) und weniger mit der
prozentualen Reduktion des Kapillardurchmessers (r= 0.29, p=0.25). Die
Vorhersage der Rezidivwahrscheinlichkeit binnen eines Jahres nach Therapieende
anhand der Kapillardurchmesser und Papillendurchmesser nach Therapieende war
der Vorhersage der Rezidivwahrscheinlichkeit anhand des PASI am Therapieende
überlegen. Schlussfolgerung: CLSM ist eine viel versprechende nicht-invasive
Methode für die Evaluation der strukturellen Veränderungen in psoriatischer
Haut in vivo und für das Monitoring des Therapieerfolges auf zellulärer Ebene.
Subklinische Veränderungen der psoriatischen Haut nach klinischer Abheilung
stellen ein legitimes Therapieziel dar.Introduction: Psoriasis is a chronic recurring inflammatory skin disease with
a major impact on the quality of life of the afflicted patients. Several
findings indicate that the altered capillary loops in the papillary dermis of
psoriatic skin play an essential role in the pathogenesis and on the course of
the disease. Microvascular changes in psoriasis are caused by an elevated
production of pro-angiogenetic factors in the basal cells surrounding the
enlarged dermal papilla. Biomarkers do not exist for a standardized assessment
of psoriasis. Clinical scores, which are commonly used in the praxis and in
clincal studies, lack uniformity and their validity is questionable. Materials
and Methods: Confocal laser scanning microscopy (CLSM) was used to study the
structures of the capillary loops and dermal papillae in 5 healthy volunteers
and 13 psoriasis patients. Additionally, lesional skin of 11 psoriasis
patients was investigated using CLSM prior to and after a modified Goeckerman
therapy regimen. Clinical response was assessed using the Psoriasis Area and
Severity Index (PASI) and self-administered PASI was conducted in regular
intervals after the end of the treatment. Results: The capillary loops and the
dermal papilla were significantly enlarged in the psoriatic skin lesions
(diameters: 24.3±2.3 µm and 146.4±28.5 µm, respectively) in comparison to
healthy skin (diameters: 9.5±1.8 and 69.4±17.1 µm, respectively). Following a
modified Goeckerman therapy regimen, a 30% - 90.4% reduction of PASI, a 17 -
53.7% reduction of the feret capillary diameter and a 13.1 - 44.2% reduction
of the feret papillary diameter (p<0.0001) were measured. Capillary loops and
dermal papilla were still significantly enlarged after treatment when compared
to those in normal skin. Capillary and papillary diameter correlated with each
other before treatment (r= 0.63, p=0.014 ) and after treatment (r= 0.64,
p=0.002). PASI values were to a large extent independent of the capillary and
papillary diameter values. Clinical improvement (% reduction of PASI values)
correlated more with the normalization of the papillary structure (r= 0.63,
p=0.03) and correlated less with the normalization of the skin capillaries (r=
0.29, p=0.25). The predictability of a psoriasis recurrence within one year
after treatment was more reliable when based upon the capillary and papillary
diameters after treatment compared with the PASI values after treatment.
Conclusion: CLSM represents a promising non-invasive technique for evaluating
structural changes in psoriatic skin in vivo and for monitoring therapeutic
response on a cellular level. Subclinical changes in psoriatic skin after
therapy represent a legitimate goal for treatment
Product Market Fit Material Serat Rami Sebagai Elemen Material Berkelanjutan Pada Penerapan Desain Furniture
No full textThe proliferation of research and applications of sustainable materials within society has seen a notable increase, leading to constant updates in product segments featuring sustainable materials. This trend is further supported by the growing awareness among the public regarding environmental degradation. Ramie fiber is one such sustainable material serving as an alternative to the dependence on cotton materials in the textile industry. Collaborating with Armonie Ronche from Universitas Padjajaran, the author undertook a series of processes to implement ramie fiber in a furniture product, emphasizing the creation of products with good market value. Over a period of four months, the development process resulted in a living room set where a combination of hemp fiber and teak wood served as the primary elements in the design, globally marketable, and modern Jengki-style furniture.Maraknya riset dan aplikasi material berkelanjutan yang digunakan oleh masyarakat semakin tinggi yang terlihat selalu muncul pembaruan pada segmen produk dengan material berkelanjutan. Hal ini juga didukung oleh tingkat kesadaran masyarakat akan kerusakan yang terjadi pada lingkungan sekitar. Serat rami merupakan salah satu material berkelanjutan sebagai alternatif dari ketergantungan penggunaan material kapas yang ada pada industri tekstil. Bekerjasama dengan Armonie Ronche dari Universitas Padjajaran penulis melakukan serangkaian proses pengimplementasian serat rami pada sebuah produk furniture dengan mengedepankan produk yang memiliki nilai jual yang baik di masyarakat. Selama empat bulan proses pengembangan didapatkan sebuah set ruang keluarga dimana padu padan antara material rami dengan material jati sebagai elemen utama dalam perancangan mebel bergaya modern jengki yang siap dipasarkan secara global
The politics of heterodoxy and the Kina Rami ascetics of Banaras
No full textThe Kina Rami, a sect of aghori ascetics, take their name from Kina Ram, a Rajput Sant of the seventeenth century. This thesis examines the history and reform of the Kina Ram sect while placing it within the larger framework of heterodox Shaivism. Using an anthropology of religion approach, the author uses fieldwork data and observations to discuss the sociopolitical issues related to extreme religious behavior within Indian religion and to mount a critique of scholarship that would seek to locate such behavior solely within the framework of Brahmanical Hinduism. Finally an overview is presented of the reform of the Kina Ram sect under the influence of the modern-day saint Avadhut Bhagwan Ram. The author demonstrates the contemporary use of traditional Kina Rami heterodox symbolism within the context of Avadhut Bhagwan Ram\u27s reformist organization, Sri Sarveshwari Samooh. While these reforms are demonstrated to be continuous with the traditional goals of the Kina Sect, they nonetheless represent a new compromise position in relation to the larger Brahmanical Hindu tradition
"Ramus Petri Rami" : figures martyrdom in the 1581 biography of Pierre de la Ramée by Nicolas de Nancel
No full textThis paper is devoted to the rhetorical analysis of Nicolas de Nancel’s Petri Rami Vita, which
is one of the most thorough biographies of Pierre de la Ramée (1515-1572), an early modern
French scholar, rhetorician, philosopher, and reformer of education. In the course of analysis,
the author points out intertextual relations between Nancel’s text and European tradition of
biographical writings which emerges from Plutarch’s Parallel Lives. The author reconstructs the
image of Ramus as a rhetorician and then concentrates his attention on the function and usefulness
of martyrological figures and images for further popularization of the Ramist doctrine
Covid-19 and the Host Community: Towards an Uncertain Future?
No full textThis chapter takes a close look at the resident community, which classify as ‘hosts’ in a tourism context as they are expected to host their ‘guest’counterparts. The author investigates the role of residents as hosts, their role during the Covid-19 pandemic and their likely role in the future concurrently. A case study conducted by Wassler and Talarico (2021) in the Italian city of Pisa is given as an example of the already evident impacts of the pandemic on resident attitudes towards tourists and tourism
Glacier : guided locally constrained counterfactual explanations for time series classification
No full textIn machine learning applications, there is a need to obtain predictive models of high performance and, most importantly, to allow end-users and practitioners to understand and act on their predictions. One way to obtain such understanding is via counterfactuals, that provide sample-based explanations in the form of recommendations on which features need to be modified from a test example so that the classification outcome of a given classifier changes from an undesired outcome to a desired one. This paper focuses on the domain of time series classification, more specifically, on defining counterfactual explanations for univariate time series. We propose Glacier, a model-agnostic method for generating locally-constrained counterfactual explanations for time series classification using gradient search either on the original space or on a latent space that is learned through an auto-encoder. An additional flexibility of our method is the inclusion of constraints on the counterfactual generation process that favour applying changes to particular time series points or segments while discouraging changing others. The main purpose of these constraints is to ensure more reliable counterfactuals, while increasing the efficiency of the counterfactual generation process. Two particular types of constraints are considered, i.e., example-specific constraints and global constraints. We conduct extensive experiments on 40 datasets from the UCR archive, comparing different instantiations of Glacier against three competitors. Our findings suggest that Glacier outperforms the three competitors in terms of two common metrics for counterfactuals, i.e., proximity and compactness. Moreover, Glacier obtains comparable counterfactual validity compared to the best of the three competitors. Finally, when comparing the unconstrained variant of Glacier to the constraint-based variants, we conclude that the inclusion of example-specific and global constraints yields a good performance while demonstrating the trade-off between the different metrics. © The Author(s) 2024.This work was funded in part by the Digital Futures cross-disciplinary research centre in Sweden, and the EXTREMUM collaborative project ( https://datascience.dsv.su.se/projects/extremum.html ).</p
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