71,219 research outputs found

    The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy

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    The mind-boggling progress in the understanding of the molecular mechanisms underlying the long QT syndrome (LQTS) has been the subject of many articles and reviews. Still, when it comes to the management of the patients affected by this life-threatening disorder, too many errors still take place, both in the diagnostic process and in the therapeutic choices. The price of these errors is paid by the patients and their families. This review is not directed to the relatively small number of LQTS experts who know what to do. It does not deal with genetics, with epidemiology, or with the well-known clinical manifestations. We have focused solely on the approach to diagnosis and therapy and we have directed this review to the average clinical cardiologist who, in his/her practice, sees occasionally patients affected or suspected to be affected by LQTS; the cardiologist who may know enough to manage them but not enough to be completely confident on his/her most critical choices. We have provided our personal views without making any attempt to blend differences whenever present. On most issues we agree fully but where we do not, we make it clear to the reader by indicating who is thinking what. The result may be unconventional, but it mirrors the challenges, often severe, that we all face in managing and protecting these patients from sudden death while also helping them live and thrive despite their diagnosis. We trust that this unabashed presentation of our clinical approach will be useful for both cardiologists and patients

    Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′

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    First evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)

    Letter from Carl Hayden to M. J. Riordan

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    Letter from Carl Hayden to M. J. Riordan expressing his support for Coconino County in turning over the Bright Angel Trail to the federal government

    00-05 "Getting the Prices Wrong: The Limits of Market-Based Environmental Policy."

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    Market based policies are fast becoming the recommended policy panacea for all the world's environmental problems. Implicit in such recommendations is the theory that free markets, adjusted for externalities, can always create an "efficient" allocation of society's resources. As a result, many contemporary policymakers advocate rolling back regulations in order to let the market protect the environment. There is a fundamental distinction between the use of the market as a tool to help achieve society's goals, and as a blueprint for society's goals; the market is a reasonable policy tool but not a reasonable blueprint. The market as blueprint fails because there are significant public purposes that cannot be achieved by prices and markets alone. Five major arguments show that getting the prices right is often a narrow or meaningless objective; society may intentionally and appropriately choose to "get the prices wrong" in order to pursue more important goals.

    Letter from M. J. Riordan, Arizona Lumber and Timber Company, to Carl Hayden

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    Letter from M. J. Riordan to Carl Hayden expressing his opposition to the federal government's takeover of Bright Angel Trail

    Author Index- THE INFLUENCE OF COGNITIVE PSYCHOLOGY ON TESTING

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    Author Index- 8 pages A-Z A Abrahamsen, A. A., 234, 236, 237, 262, 265 Ackerman, P. L., 29, 37 Agrawal, N., 103, 136 Ahern, S., 121, 136 Ananda, S. M., 135, 136 Anastasi, A., 2, 8, 176, 184 Anderson, J. A., 19,38, 256, 263 Anderson, J. H., 44, 83 Anderson, J. R., 31, 36, 37, 44, 82, 154, 184, 195, 223, 230, 256, 263 Anderson, R., 54, 82 Arabie, P., 230, 231, 232, 241, 242, 245, 246, 247, 251, 253, 263, 264, 266 Arnkoff, D. B., 172, 184 Arnold, J. B., 234, 253, 262, 263 Atkinson, R. c., 135, 136, 137, 256, 263 ... Z Zelinski, E., 27, 3

    Author Index- THE INFLUENCE OF COGNITIVE PSYCHOLOGY ON TESTING

    No full text
    Author Index- 8 pages A-Z A Abrahamsen, A. A., 234, 236, 237, 262, 265 Ackerman, P. L., 29, 37 Agrawal, N., 103, 136 Ahern, S., 121, 136 Ananda, S. M., 135, 136 Anastasi, A., 2, 8, 176, 184 Anderson, J. A., 19,38, 256, 263 Anderson, J. H., 44, 83 Anderson, J. R., 31, 36, 37, 44, 82, 154, 184, 195, 223, 230, 256, 263 Anderson, R., 54, 82 Arabie, P., 230, 231, 232, 241, 242, 245, 246, 247, 251, 253, 263, 264, 266 Arnkoff, D. B., 172, 184 Arnold, J. B., 234, 253, 262, 263 Atkinson, R. c., 135, 136, 137, 256, 263 ... Z Zelinski, E., 27, 3

    Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays

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    This Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within expectations from the Standard Model

    Author Correction: Establishment and equilibrium levels of deleterious mutations in large populations (Scientific Reports, (2019), 9, 1, (10384), 10.1038/s41598-019-46803-7)

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    The original version of this Article contained errors. Affiliations 1 and 2 were reversed. Secondly, Affiliation 7 was incorrectly given as ‘Institute for Cellular and Molecular Medicine, Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, Pretoria, 0084, South Africa’. Thirdly, an affiliation was omitted for the author Michael S. Pepper, which is now listed as Affiliation 8. Fourthly, Affiliation 1 was omitted for the author Johan W. Viljoen. Finally, Augustinus J. van Zyl was incorrectly affiliated with ‘Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo’, Trieste, Italy.’ The correct author affiliations are listed below: Affiliation 1: Department of Electrical, Electronic and Computer Engineering, EBIT, University of Pretoria, Pretoria 0028, South Africa Johan W. Viljoen and J. Pieter de Villiers Affiliation 2: Development, Research and Technology Department, Hensoldt Optronics, Centu..

    Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV

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    The prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
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