459 research outputs found
Atypisches Cogan Syndrom und Morbus Basedow: beiderseitige Ertaubung, Neuritis nervi optici und systemische Manifestationen bei einer Schwarzafrikanerin
No full textKasuistik: Wir berichten über den schubweisen, jahrelangen Krankheitsverlauf eines atypischen Cogan Syndroms einer 49-jährigen Kenianerin, die sich bei uns mit einer zunächst einseitigen akuten Ertaubung, Tinnitus und Gangunsicherheit bei vorbestehender mittelgradiger Innenohrschwerhörigkeit kontralateral vorstellte. Die Eigenanamnese gab Hinweise auf eine vor 17 Jahren durch Korticosteroide ausgeheilte Iritis. Weiterhin war die Patientin seit 9 Jahren wegen beiderseitig rezidivierenden Hörstürzen alio loco mehrmalig antiphlogistisch-rheologisch infundiert worden. Die akute Ertaubung führte zur stationären Aufnahme. Eine Tympanotomie mit Abdichtung des runden Fensters und die antiphlogistisch-rheologische Infusionstherapie blieben erfolglos. Das MRT-Schädel stellte eine Signalintensitätserhöhung okzipital links dar, die am ehesten einem ischämischen Herd entsprach und im Vergleich zum Vorbefund von 1998 neu war. Ein retrocochleäres Geschehen konnte ausgeschlossen werden. Das Routinelabor ergab keine wegweisenden Befunde. Die Luesserologie war negativ. Drei Monate später ertaubte die Patientin auf der Gegenseite. Weder operative noch konservative Therapien waren erfolgreich, so dass die Vorbereitungen zur Cochlea Implantation einseitig aufgenommen wurden. Ein Monat später beklagte die Patientin eine akute Sehverschlechterung ipsilateral, die durch eine Neuritis nervi optici erklärt werden konnte. Serologisch ergaben sich keine Hinweise auf eine Vaskulitis. Mit der neu aufgetretenen Augensymptomatik konnte erstmals die Diagnose eines Cogan Syndroms gestellt werden. Aufgrund der Gefahr einer Cochleaobliteration beim Cogan Syndrom entschlossen wir uns umgehend beiderseitig zu implantieren. Die Visusverschlechterung erholte sich ad integrum auf die hoch dosierte Kortikosteroidtherapie. Drei Monate postoperativ entwickelt die Patientin, trotz einer Prednisolon Erhaltungsdosis plötzlich eine Verschlechterung ihres Allgemeinzustandes mit Arthralgien der großen Gelenke. Gleichzeitig fielen im Serum um das 3- bis 5fach erhöhte freie Schilddrüsenhormonwerte auf bei massiv erniedrigtem TSH. Wir interpretieren den aktuellen Krankheitsverlaufverlauf als eine systemische Manifestation eines atypischen Cogan Syndroms, wobei eine hyperthyreote Stoffwechsellage in diesem Zusammenhang bisher nicht beschrieben wurde. Die mannigfaltigen Erscheinungsformen des atypischen Cogan Syndroms mit systemischem Verlauf erschweren die Erstdiagnosestellung. Darüber hinaus ist eine interdisziplinäre Strategieplanung hinsichtlich Diagnostik und Therapie unumgänglich
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Painful Red Eye in a 69-Year Old Female With Sensorineural Hearing Loss (Presentation Video)
No full textProptosis and loss of vision OSA 63-year old female with a 6-year history of ulcerative colitis and erythema nodosum. Previous history significant for bilateral hearing loss, diffuse headache preceded by intermittent vertigo and tinnitus.VA: 20/25 OD, 20/400 OS; IOP 54 ODBilateral mastoidosis; Pontine infarctsCorticosteroids; Immunosuppressive agents; Anti-bacterials agents1. Cogan, DG. Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms. Arch Ophthalmol, 3, 144-9, 1945. 2. Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature. Medicine, 59, 426-41, 1980. 3 Shah P, Luqmani RA, Murray PI, Honan WP, Corridan PGJ, Emery P. Posterior scleritis. An unusual manifestation of Cogan\u27s syndrome. Br J Rheumatol, 33, 774-5, 1994. 4. Grasland A, Pouchot J, Hachulla E, Blétry O, Papo T, Vinceneux P for the Study Group for Cogan\u27s Syndrome. Typical and atypical Cogan\u27s sydrome: 32 cases and review of the literature. Rheumatology (Oxford).43(8),1007-15, 2004. 5. Akbayir N, Calis AB, Alkim C, Sokmen HM, Erdem L, Ozbal A, Bolukbas F, Akbayir N. Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation. Dig Dis Sci 50(10), 1938-45, 2005
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Measurement of the time-dependent CP asymmetry in B0 -> J/ψ KS0 decays
No full textThis Letter reports a measurement of the CP violation observables SJ/ψK0S and CJ/ψK0S in the decay channel B0→J/ψK0S performed with 1.0 fb−1 of pp collisions at s√=7 TeV collected by the LHCb experiment. The fit to the data yields SJ/ψK0S=0.73±0.07(stat)±0.04(syst) and CJ/ψK0S=0.03±0.09(stat)±0.01(syst). Both values are consistent with the current world averages and within
expectations from the Standard Model
Measurement of the CP-violating phase \phi s in Bs->J/\psi\pi+\pi- decays
No full textMeasurement of the mixing-induced CP-violating phase phi_s in Bs decays is of prime importance in probing new physics. Here 7421 +/- 105 signal events from the dominantly CP-odd final state J/\psi pi+ pi- are selected in 1/fb of pp collision data collected at sqrt{s} = 7 TeV with the LHCb detector. A time-dependent fit to the data yields a value of phi_s=-0.019^{+0.173+0.004}_{-0.174-0.003} rad, consistent with the Standard Model expectation. No evidence of direct CP violation is found
Measurement of the CP-violating phase phi(s) in (B)over-bar(s)(0) -> J / psi pi(+)pi(-) decays
No full textThe mixing-induced CP -violating phase ϕs in View the MathML source and View the MathML source decays is measured using the J/ψπ+π− final state in data, taken from 3 fb−1 of integrated luminosity, collected with the LHCb detector in 7 and 8 TeV centre-of-mass pp collisions at the LHC. A time-dependent flavour-tagged amplitude analysis, allowing for direct CP violation, yields a value for the phase ϕs=70±68±8 mrad. This result is consistent with the Standard Model expectation and previous measurements
Measurement of the effective B_s^0 -> J/ψ K_S^0 lifetime
No full textThis paper reports the first measurement of the effective B_s^0 -> J/{\psi} K_S^0 lifetime and an updated measurement of its time-integrated branching fraction. Both measurements are performed with a data sample, corresponding to an integrated luminosity of 1.0 fb^{-1} of pp collisions, recorded by the LHCb experiment in 2011 at a centre-of-mass energy of 7 TeV. The results are: tau_J/{\psi}K_S^0 = 1.75 +/- 0.12 (stat) +/- 0.07 (syst) and BR(B_s^0 -> J/{\psi} K_S^0) = (1.97 +/- 0.23) X 10^{-5}.
For the latter measurement, the uncertainty includes both statistical and systematic sources
Measurements of the Lambda_b0 -> J/psi Lambda decay amplitudes and the Lambda_b0 polarisation in pp collisions at sqrt(s) = 7 TeV
No full textAn angular analysis of View the Λb0→J/ψΛ decays is performed using a data sample corresponding to 1.0 fb−11.0 fb−1 collected in pp collisions at s=7 TeV with the LHCb detector at the LHC. A parity violating asymmetry parameter characterising the View the Λb0→J/ψΛ decay of 0.05±0.17±0.070.05±0.17±0.07 and a View the Λb0 transverse production polarisation of 0.06±0.07±0.020.06±0.07±0.02 are measured, where the first uncertainty is statistical and the second systematic
Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation
No full textSchröder J, Maus I, Trost E, Tauch A. Complete genome sequence of Corynebacterium variabile DSM 44702 isolated from the surface of smear-ripened cheeses and insights into cheese ripening and flavor generation. BMC Genomics. 2011;12(1): 545.Corynebacterium variabile is part of the complex microflora on the surface of smear-ripened cheeses and contributes to the development of flavor and textural properties during cheese ripening. Still little is known about the metabolic processes and microbial interactions during the production of smear-ripened cheeses. Therefore, the gene repertoire contributing to the lifestyle of the cheese isolate C. variabile DSM 44702 was deduced from the complete genome sequence to get a better understanding of this industrial process. The chromosome of C. variabile DSM 44702 is composed of 3, 433, 007 bp and contains 3, 071 protein-coding regions. A comparative analysis of this gene repertoire with that of other corynebacteria detected 1, 534 predicted genes to be specific for the cheese isolate. These genes might contribute to distinct metabolic capabilities of C. variabile, as several of them are associated with metabolic functions in cheese habitats by playing roles in the utilization of alternative carbon and sulphur sources, in amino acid metabolism, and fatty acid degradation. Relevant C. variabile genes confer the capability to catabolize gluconate, lactate, propionate, taurine, and gamma-aminobutyric acid and to utilize external caseins. In addition, C. variabile is equipped with several siderophore biosynthesis gene clusters for iron acquisition and an exceptional repertoire of AraC-regulated iron uptake systems. Moreover, C. variabile can produce acetoin, butanediol, and methanethiol, which are important flavor compounds in smear-ripened cheeses. The genome sequence of C. variabile provides detailed insights into the distinct metabolic features of this bacterium, implying a strong adaption to the iron-depleted cheese surface habitat. By combining in silico data obtained from the genome annotation with previous experimental knowledge, occasional observations on genes that are involved in the complex metabolic capacity of C. variabile were integrated into a global view on the lifestyle of this species
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